CN1541697A - Chinese traditional medicine soft capsule for treating chronic cholecystitis and gallstone, and its preparation - Google Patents
Chinese traditional medicine soft capsule for treating chronic cholecystitis and gallstone, and its preparation Download PDFInfo
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- CN1541697A CN1541697A CNA2003101134289A CN200310113428A CN1541697A CN 1541697 A CN1541697 A CN 1541697A CN A2003101134289 A CNA2003101134289 A CN A2003101134289A CN 200310113428 A CN200310113428 A CN 200310113428A CN 1541697 A CN1541697 A CN 1541697A
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- soft capsule
- oleum menthae
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- gelatin
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- 239000007901 soft capsule Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 239000003814 drug Substances 0.000 title abstract description 18
- 201000001352 cholecystitis Diseases 0.000 title abstract description 11
- 206010008617 Cholecystitis chronic Diseases 0.000 title abstract description 9
- 208000001130 gallstones Diseases 0.000 title abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 41
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 14
- 239000008158 vegetable oil Substances 0.000 claims abstract description 14
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 3
- 229920000159 gelatin Polymers 0.000 claims description 23
- 108010010803 Gelatin Proteins 0.000 claims description 22
- 239000008273 gelatin Substances 0.000 claims description 22
- 235000019322 gelatine Nutrition 0.000 claims description 22
- 235000011852 gelatine desserts Nutrition 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 13
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 12
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 8
- 238000011068 loading method Methods 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 239000003292 glue Substances 0.000 claims description 6
- 238000005213 imbibition Methods 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000008188 pellet Substances 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 238000006356 dehydrogenation reaction Methods 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 239000010692 aromatic oil Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000004382 potting Methods 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 abstract description 12
- 239000003921 oil Substances 0.000 abstract description 5
- 235000019198 oils Nutrition 0.000 abstract description 5
- 239000002775 capsule Substances 0.000 abstract description 3
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 4
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 4
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 4
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000002386 leaching Methods 0.000 abstract 1
- 230000000873 masking effect Effects 0.000 abstract 1
- 201000001883 cholelithiasis Diseases 0.000 description 10
- 210000000232 gallbladder Anatomy 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 210000004185 liver Anatomy 0.000 description 8
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 7
- 210000000941 bile Anatomy 0.000 description 7
- 239000007902 hard capsule Substances 0.000 description 7
- 238000012856 packing Methods 0.000 description 5
- 239000000341 volatile oil Substances 0.000 description 5
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229940041616 menthol Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 2
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229930007503 menthone Natural products 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000000197 Acute Cholecystitis Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010008614 Cholecystitis acute Diseases 0.000 description 1
- -1 Dichlorodiphenyl Acetate Chemical compound 0.000 description 1
- 235000001878 Mentha haplocalyx Nutrition 0.000 description 1
- 244000280293 Mentha haplocalyx Species 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001989 choleretic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
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- 235000006694 eating habits Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 208000020694 gallbladder disease Diseases 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
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- 238000009499 grossing Methods 0.000 description 1
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- 210000004072 lung Anatomy 0.000 description 1
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- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
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Abstract
The soft Chinese medicine capsule for treating chronic cholecystitis and gall-stone consists of soft capsule coating and contained matter. The contained matter includes dementholized mint oil and medicinal supplementary material capable of being mixed homogeneously with dementholized mint oil, and the supplementary material is selected from polyglycol-400, Tween-80, glycerine, vegetable oil, etc. The preparation has effectively controlled volatilization of dementholized mint oil, stable quality, homogeneously distributed medicine component, fast leaching, high bioavailability, and well masking of the special smell of dementholized mint oil for easy taking.
Description
Technical field:
The present invention relates to a kind of is the soft capsule preparation and preparation method thereof of active component with the Oleum menthae, belongs to medical technical field.
Background technology:
Chronic cholecystitis is a common clinical, and frequently-occurring disease belongs to the traditional Chinese medical science " gallbladder-distention ", " hypochondriac pain " category.Pathogenesis is smooth or unhygienic diet because of the melancholy of feelings will, disturbs on the greasy or blood of surfeit, causes the stagnation of QI knot of liver and gall.Hyperamization is become silted up by the stagnation of QI, becomes silted up and heat-transformation, and heat is pented up with spleen is wet, becomes the disease of dampness-heat in the liver and gallbladder.Courage stagnation of QI and blood may bring about pain, bile flow backwards then yellow, do not loose if heat is long-pending, and the fire-transformation that then suppurates, excessive noxious heat expands and goes into blood vessel.If it is not smooth that bile becomes silted up for a long time, condensing forms sandstone.Work as QI stagnation of the liver and galibladder, during damp and hot heap soil or fertilizer over and around the roots resistance, the liver failing to maintain the normal flow of QI then, the gallbladder disalignment is clear, makes pathogenic fire derived from stagnation of liver-QI, decocts the bile of pent-up, forms sandstone, burn gallbladder film.Mainly be summed up as: the stagnation of QI, damp and hot, the stasis of blood is turbid.Cholelithiasis also can belong to Chinese medicine " hypochondriac pain ", " yellow cellulitis " category.Traditional Chinese medical science ancient literature has the record of many similar cholelithiasis.The gallbladder being attached to the liver, liver and gall are the exterior and the interior each other, and gallbladder is " mansion of middle essence ", and bile is borrowed " gas after the liver overflows in gallbladder, builds up to form ".In China, along with improving constantly of people's living standard, the change of dietary habit, the relative incidence rate of cholelithiasis has been the tendency of obvious change, and in China, the relative incidence rate of cholelithiasis rises year by year in some big cities, and is existing near level of developed countries.
The etiology that modern medicine proposes chronic cholecystitis mainly contains at present: gallbladder stream stasis, bacterial infection, Metabolic disorder, neurological disorders and the change of bile chemical analysis etc.Also can delay outbreak repeatedly by acute cholecystitis.In recent years propose adiposis patient again and do not eat the cause of disease that breakfast is chronic cholecystitis.In addition, clinical confirmation has 70% patient to merge cholelithiasis.
Western medicine is by antiinflammatory, and expansion gallbladder, biliary tract and the about flesh of expansion are treated cholecystitis or calculus, serious armrest art.But Western medicine is taken for a long time, and side effect is big, and patient is difficult to tolerance.Clinical practice proves, uses the western medicine effect undesirable merely.Treat one of this sick main method and Chinese medicine is China, advantage more and more is subjected to attracting attention of common people to Chinese medicine because of its special effect, toxic and side effects be little etc.
Herba Menthae is the dry aerial parts of labiate Herba Menthae Mentha haplocalyxBriq., and is cool in nature, and acrid in the mouth is returned lung, Liver Channel, now records in " one one of Chinese pharmacopoeia version in 2000, Oleum menthae is the volatile oil that extracts from Herba Menthae.The modern pharmacology effect studies show that Herba Menthae Haplocalycis volatile oil and wherein main component more powerful function of gallbladder promoting, lithodialysis, analgesia and antiinflammatory action are arranged.The main component menthol of Herba Menthae Haplocalycis volatile oil and menthone 260mM/kg give rat oral, show as more powerful choleretic effect.Give menthol after 3 ~ 4 hours, the bile output, increase by 4 times approximately, and effect subsequently weakens.Menthone has similar action and more lasting, and the bile output increases by 50～100% approximately after taking medicine 5 hours.Have experiment to show, pure Oleum menthae can be that to be dissolved into diameter be about 2mm to the mixed type cholelithiasis of 7mm with diameter.There is bibliographical information Oleum menthae Dichlorodiphenyl Acetate to cause the mouse writhing reaction obvious suppression effect is arranged.Be the compound menthol injection of main component according to another report with the Mentholum, be used to local postoperative analgesia clinically as long-acting local anaesthesia preparation, respond well, and effect is lasting.Folium Menthae extract 250mg/ml lumbar injection is 60%～100% to the bullate suppression ratio of rat carrageenan foot, and main effective ingredient is a menthol.
The DANSHU JIAONANG of present clinical use is hard capsule, and the principal agent composition is exactly an Oleum menthae in its prescription, and content is white glossy granule, the special fragrance of tool, acrid in the mouth, cold.Function is a liver-smoothing, qi-regulating, function of gallbladder promoting.DANSHU JIAONANG has been put into national basic medical insurance medicine catalogue as the Chinese patent medicine commonly used of liver-gallbladder disease.In recent years, obtained application more and more widely clinically.Though the clinical practice of DANSHU JIAONANG is fine, but as principal agent is the capsule of volatile oil, exist following significant disadvantages: (1) is owing to the Oleum menthae in the DANSHU prescription volatilizees easily, so, when being made into common hard capsule preparation, will inevitably lose its effective ingredient in the pelletization, affect the treatment.Although DANSHU JIAONANG has been controlled its content by assay, the loss in the preparation process has at least also caused the waste of resource.(2) because Oleum menthae has special fragrance, and common hard capsule preparation can not well be covered up, so, brought certain inconvenience for patient's medication.(3) the common hard capsule preparation of DANSHU is because seal is bad, and Oleum menthae is volatile, causes the medicine instability.In addition, for volatile oil, also there are shortcomings such as content distribution is inhomogeneous, bioavailability is low with making hard capsule after its granulation.
Summary of the invention:
The purpose of this invention is to provide a kind of is the treatment chronic cholecystitis of main component, the Chinese medicinal soft capsule preparation of cholelithiasis with the Oleum menthae.
It is the treatment chronic cholecystitis of main component, the preparation method of cholelithiasis Chinese medicinal soft capsule preparation with the Oleum menthae that another object of the present invention provides a kind of.
The Chinese medicinal soft capsule preparation of treatment chronic cholecystitis of the present invention, cholelithiasis, form by soft capsule shell and content, content is made up of Oleum menthae and pharmaceutic adjuvant, pharmaceutic adjuvant be can with the aqueous material of active component Oleum menthae mix homogeneously, be selected from PEG400 (PEG400), Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, fragrant wet goods, the weight proportion of active component and pharmaceutic adjuvant, be Oleum menthae by weight: pharmaceutic adjuvant=1: 0.5-1: 5; Wherein in every soft capsule, the content of Oleum menthae is by the normal capsules grain, and every contains Oleum menthae 0.02～0.2 gram; Soft capsule shell prepares with conventional method, is generally filled a prescription in certain proportion by gelatin, G ﹠ W and makes, and by weight, gelatin, G ﹠ W preferred proportion are 10: 3.1～4.0: 7-15.
Soft capsule of the present invention is preferably filled a prescription and consisted of every soft capsule and contain: Oleum menthae 0.02～0.2 gram, PEG400 or vegetable oil are the 0.01-0.5 gram; Be more preferably Oleum menthae 0.08～0.12 gram, PEG400 or vegetable oil are the 0.05-0.3 gram; Particularly preferred is Oleum menthae 0.1 gram, and PEG400 or vegetable oil are the 0.08-0.15 gram, and even with the mixture content of adjuvant by the principal agent of this ratio preparation, good fluidity is fit to pack into, and the soft capsule loading amount of preparation is accurate, even.
Chinese medicinal soft capsule preparation of the present invention can adopt following method preparation: get gelatin, G ﹠ W respectively, make its abundant imbibition with adding an amount of water in the gelatin earlier, insert in the glue pot behind glycerol and the remaining water mixing and be heated to uniform temperature, add expansible gelatin, after fully stirring, leave standstill, insulation, standby; Get Oleum menthae and pharmaceutic adjuvant respectively, fully stir and make mix homogeneously, the medicinal liquid for preparing is poured in the pellet processing machine, regulate loading amount, the hothouse drying is put in typing, packing, promptly.
The content of Chinese medicinal soft capsule of the present invention is a volatility oily liquid, so the content and the stability of control medicine are particularly important.Because the content of Chinese medicinal soft capsule of the present invention is by Oleum menthae and the mixed uniformly liquid of oily adjuvant, so uniformity of dosage units will be better than the hard capsule preparation with solid adjuvant material absorption far away.Stability test also shows in addition, originally the main component Mentholum content in the Oleum menthae is the Chinese medicinal soft capsule of the present invention of 32.8mg/ grain, through the investigation that keeps sample of 12 months room temperatures, content still has the 32.7mg/ grain, content does not almost change, and DANSHU YINGJIAONANG through 12 months room temperature keep sample investigate after, Mentholum content is then reduced to the 26.5mg/ grain by original 30.6mg/ grain, content has descended about 13.4%.Show that more than the content of Chinese medicinal soft capsule of the present invention is even, good stability.
The present invention makes the appropriate soft capsule of proportioning with new preparation technique with Oleum menthae, compares with existing hard capsule, has following tangible advantage: (1) has effectively controlled the volatilization of the Oleum menthae in the prescription, and quality is more stable.(2) well covered up the special fragrance of Oleum menthae, so brought very big convenience for patient's medication.(3) dispersion of medicine, stripping is fast, the bioavailability height.(4) side effect is little.(5) soft capsule with method preparation provided by the invention can reduce irritating abnormal smells from the patient in preparation process, reduces and pollutes.(6) overcome the difficulty that volatility big product is difficult to make soft capsule.(7) prolonged the storage life.(8) easier absorption.(9) better efficacy.
The specific embodiment:
The following example is intended to further describe for example the present invention, rather than limits the present invention by any way.Principal agent in following examples, adjuvant source:
| Title | The source | Specification (standard) |
| Oleum menthae | Nantong Herba Menthae factory | Meet Chinese Pharmacopoeia version regulation in 2000 |
| Gelatin | Qingdao gelatin Co., Ltd | Meet Chinese Pharmacopoeia version regulation in 2000 |
| Vegetable oil | Grain and oil company limited in Shanghai is good | Q/TEFO?5 |
| Glycerol | HeFei University of Technology's chemical reagent | Meet Chinese Pharmacopoeia version regulation in 2000 |
Embodiment 1:
Get gelatin 1000g, glycerol 400g, water 1000g makes its abundant imbibition with the water that adds 300g in the gelatin earlier, insert in the glue pot behind glycerol and the remaining water mixing and be heated to 70 ~ 80 ℃, add expansible gelatin, after fully stirring, leave standstill, 60 ℃ of insulations, standby; Get each 100g of Oleum menthae and vegetable oil respectively, fully stir and make mix homogeneously, the medicinal liquid for preparing is poured in the pellet processing machine, the adjusting loading amount is 0.2g, and the hothouse drying is put in typing, packing, promptly.
Embodiment 2:
Get gelatin 1000g, glycerol 300g, water 800g makes its abundant imbibition with the water that adds 300g in the gelatin earlier, insert in the glue pot behind glycerol and the remaining water mixing and be heated to 70 ~ 80 ℃, add expansible gelatin, after fully stirring, leave standstill, 60 ℃ of insulations, standby; Get each 100g of Oleum menthae and vegetable oil respectively, fully stir and make mix homogeneously, the medicinal liquid for preparing is poured in the pellet processing machine, the adjusting loading amount is 0.3g, and the hothouse drying is put in typing, packing, promptly.
Embodiment 3:
Get gelatin 1000g, glycerol 400g, water 900g makes its abundant imbibition with the water that adds 300g in the gelatin earlier, insert in the glue pot behind glycerol and the remaining water mixing and be heated to 70 ~ 80 ℃, add expansible gelatin, after fully stirring, leave standstill, 60 ℃ of insulations, standby; Get Oleum menthae 100g and vegetable oil 200g respectively, fully stir and make mix homogeneously, the medicinal liquid for preparing is poured in the pellet processing machine, the adjusting loading amount is 0.3g, and the hothouse drying is put in typing, packing, promptly.
Embodiment 4:
Get gelatin 1000g, glycerol 300g, water 1000g makes its abundant imbibition with the water that adds 300g in the gelatin earlier, insert in the glue pot behind glycerol and the remaining water mixing and be heated to 70 ~ 80 ℃, add expansible gelatin, after fully stirring, leave standstill, 60 ℃ of insulations, standby; Get Oleum menthae 100 and 100g PEG400 respectively, fully stir and make mix homogeneously, the medicinal liquid for preparing is poured in the pellet processing machine, the adjusting loading amount is 0.2g, and the hothouse drying is put in typing, packing, promptly.
Claims (10)
1, a kind of is the Chinese medicinal soft capsule preparation of active component with the Oleum menthae.
2, soft capsule preparation according to claim 1 is characterized in that, is made up of soft capsule shell and content, wherein contains active component Oleum menthae 0.02～0.2 gram in every soft capsule.
3, soft capsule preparation according to claim 2 is characterized in that, soft capsule content is made up of Oleum menthae and pharmaceutic adjuvant, and Oleum menthae is 1 with the ratio of pharmaceutic adjuvant weight: 0.5-1: 5.
4, soft capsule preparation according to claim 3, wherein said pharmaceutic adjuvant are selected from PEG400 (PEG400), Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil.
5, soft capsule preparation according to claim 2 is characterized in that, soft capsule shell by gelatin, G ﹠ W with 10: 3.1～4.0: the weight ratio of 7-15 is made.
6, soft capsule preparation according to claim 3 is characterized in that, every soft capsule contains: Oleum menthae 0.02～0.2 gram, PEG400 or vegetable oil or their mixture are the 0.01-0.5 gram.
7, soft capsule preparation according to claim 6 is characterized in that, every soft capsule contains: Oleum menthae 0.08～0.12 gram, PEG400 or vegetable oil or their mixture are the 0.05-0.3 gram.
8, soft capsule preparation according to claim 7 is characterized in that, every soft capsule contains: Oleum menthae 0.1 gram, PEG400 or vegetable oil or their mixture are the 0.08-0.15 gram.
9, the preparation method of the described Chinese medicinal soft capsule preparation of claim 1, it is characterized in that, get gelatin, G ﹠ W, make its abundant imbibition with adding an amount of water in the gelatin earlier, insert in the glue pot and heating behind the water mixing of glycerol and remainder, add expansible gelatin, after fully stirring, leave standstill, insulation, standby; Get Oleum menthae and pharmaceutic adjuvant, fully stir and make mix homogeneously, the medicinal liquid for preparing is poured in the pellet processing machine, regulate loading amount, the hothouse drying is put in typing.
10, the preparation method of claim 9, wherein pharmaceutic adjuvant is PEG400 or vegetable oil or their mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101134289A CN1327857C (en) | 2003-11-10 | 2003-11-10 | Chinese traditional medicine soft capsule for treating chronic cholecystitis and gallstone, and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101134289A CN1327857C (en) | 2003-11-10 | 2003-11-10 | Chinese traditional medicine soft capsule for treating chronic cholecystitis and gallstone, and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1541697A true CN1541697A (en) | 2004-11-03 |
| CN1327857C CN1327857C (en) | 2007-07-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2003101134289A Expired - Fee Related CN1327857C (en) | 2003-11-10 | 2003-11-10 | Chinese traditional medicine soft capsule for treating chronic cholecystitis and gallstone, and its preparation |
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| CN (1) | CN1327857C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1311827C (en) * | 2005-06-27 | 2007-04-25 | 宛六一 | Gatifloxacin soft capsule and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528445A (en) * | 2003-10-21 | 2004-09-15 | 李昕琦 | Preparation method of medicine for treating gallbladder diseases |
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- 2003-11-10 CN CNB2003101134289A patent/CN1327857C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1311827C (en) * | 2005-06-27 | 2007-04-25 | 宛六一 | Gatifloxacin soft capsule and preparation method thereof |
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| Publication number | Publication date |
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| CN1327857C (en) | 2007-07-25 |
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