CN1528323A - Medicinal composition for treating cardio-cerebrovascular diseases - Google Patents
Medicinal composition for treating cardio-cerebrovascular diseases Download PDFInfo
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- CN1528323A CN1528323A CNA200310100813XA CN200310100813A CN1528323A CN 1528323 A CN1528323 A CN 1528323A CN A200310100813X A CNA200310100813X A CN A200310100813XA CN 200310100813 A CN200310100813 A CN 200310100813A CN 1528323 A CN1528323 A CN 1528323A
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- Prior art keywords
- leaf
- stem
- radix ginseng
- salvianolic acid
- ginseng saponin
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Description
The red sage root is cut phenolic acid: become ginseng stem rate leaf saponin(e | ??????????2h | ????3d | ??????????????????????????????????????????????9d |
Normal saline administration group matched group group | Normal saline administration group matched group group | Normal saline administration group matched group group | |
????????????100s -110∶0???????20s -1????????????10s -1 | 7.79±0.2????7.32±0.6???7.57±0.8??????????????10.15±1.4????9.33±0.5??????8.35±1.0***???????10.89±0.7???9.57±1.0**?????9.04±0.8*** 12.51±3.2???11.75±2.5??11.05±1.5?????????????17.17±2.3????15.41±2.1?????14.20±2.5**???????20.31±2.5???17.99±2.4??????15.39±2.1*** 41.26±18.2??36.01±7.3??33.89±14.5????????????82.81±21.3???64.44±15.2????49.73±21.5**??????93.99±20.9??82.11±20.2?????55.25±12.1*** | ||
????????????100 -115∶1???????20s -1????????????10s -1 | 7.79±0.2????7.28±0.4???7.57±0.8??????????????10.15±1.4????8.56±0.4 **???8.35±1.0 ***??????10.89±0.7????9.14±0.3 ***???9.04±0.8 ***12.51±3.2???11.32±2.1??11.05±1.5?????????????17.17±2.3????15.21±2.1 **??14.20±2.5 **??????20.31±2.5???16.52±2.2 **???15.39±2.1 ***41.26±18.2??36.41±9.1??33.89±14.5????????????82.81±21.3???60.45±17.6 **?49.73±21.5 **?????93.99±20.9??63.78±20.1 **??55.25±12.1 *** | ||
????????????100s -110∶1???????20s -1????????????10s -1 | 7.79±0.2????7.15±0.5???7.57±0.8??????????????10.15±1.4????8.37±0.6 ***??8.35±1.0 ***??????10.89±0.7????9.08±0.6 ***???9.04±0.8 ***12.51±3.2???10.81±2.2??11.05±1.5?????????????17.17±2.3????14.64±2.2 **??14.20±2.5 **??????20.31±2.5???14.99±2.3 ***??15.39±2.1 ***41.26±18.2??32.32±8.1??33.89±14.5????????????82.81±21.3???55.21±14.1 **?49.73±21.5 **?????93.99±20.9??55.22±23.1 ***?55.25±12.1 *** | ||
????????????100s -17∶1????????20s -1????????????10s -1 | 7.79±0.2????7.27±0.76??7.57±0.8??????????????10.15±1.4????8.32±0.5 ***??8.35±1.0 ***???????10.89±0.7???8.43±0.6 ***???9.04±0.8 ***12.51±3.2???10.41±2.2??11.05±1.5?????????????17.17±2.3????14.26±1.4 **??14.20±2.5 **??????20.31±2.5???14.22±2.4 ***??15.39±2.1 ***41.26±18.2??32.39±8.8??33.89±14.5????????????82.81±21.3???50.07±14.1 **?49.73±21.5 **?????93.99±20.9??53.35±18.8 ***?55.25±12.1 *** | ||
????????????100s -15∶1????????20s -1????????????10s -1 | 7.79±0.2????7.11±0.5???7.57±0.8??????????????10.15±1.4????8.22±0.6 ***???8.35±1.0 ***??????10.89±0.7???8.44±0.8 ***???9.04±0.8 ***12.51±3.2???10.43±2.1??11.05±1.5?????????????17.17±2.3????14.18±1.9 ***??14.20±2.5 **??????20.31±2.5???13.86±2.2 ***??15.39±2.1 ***41.26±18.2??32.01±8.6??33.89±14.5????????????82.81±21.3???48.98±12.7 ***?49.73±21.5 **?????93.99±20.9??49.53±23.2 ***?55.25±12.1 *** |
????????100s -13∶1????20s -1????????10s -1 | 7.79±0.2?????7.65±0.7?????7.57±0.8?????10.15±1.4????8.06±0.4 ***???8.35±1.0 ***??10.89±0.7????8.12±0.6 ***???9.04±0.8 ***12.51±3.2????10.41±1.4 **?11.05±1.5????17.17±2.3????13.02±1.0 ***??14.20±2.5 **??20.31±2.5????14.00±2.1 ***??15.39±2.1 ***41.26±18.2???32.01±7.2????33.89±14.5???82.81±21.3???47.22±16.8 ***?49.73±21.5 **?93.99±20.9???47.01±23.2 ***?55.25±12.1 *** |
????????100s -11∶1????20s -1????????10s -1 | 7.79±0.2?????7.64±0.6?????7.57±0.8?????10.15±1.4????8.50±1.2 **????8.35±1.0 ***??10.89±0.7????9.23±0.8 ***???9.04±0.8 ***12.51±3.2????11.34±2.4????11.05±1.5????17.17±2.3????14.58±2.2 **???14.20±2.5 **??20.31±2.5????15.44±2.2 ***??15.39±2.1 ***41.26±18.2???34.55±11.1???33.89±14.5???82.81±21.3???64.47±16.9?????49.73±21.5 **?93.99±20.9???63.86±16.0 ***?55.25±12.1 *** |
????????100s -10∶10???20s -1????????10s -1 | 7.79±0.2?????7.37±0.2?????7.57±0.8?????10.15±1.4????9.48±0.7???????8.35±1.0 ***??10.89±0.7????9.88±1.0???????9.04±0.8 ***12.51±3.2????12.87±2.4????11.05±1.5????17.17±2.3????16.65±2.2??????14.20±2.5 **??20.31±2.5????18.89±2.2??????15.39±2.1 ***41.26±18.2???37.46±7.1????33.89±14.5???82.81±21.3???69.65±11.9?????49.73±21.5 **?93.99±20.9???88.02±12.3?????55.25±12.1 *** |
Radix Salviae Miltiorrhizae is annotated 100s -1Penetrate liquid 20s -1????????10s -1 | 7.79±0.2?????7.44±0.6?????7.57±0.8?????10.15±1.4????9.25±0.6???????8.35±1.0 ***???10.89±0.7???9.77±0.8???????9.04±0.8 ***12.51±3.2????11.64±2.1????11.05±1.5????17.17±2.3????16.51±1.5??????14.20±2.5 **???20.31±2.5???17.22±2.0??????15.39±2.1 ***41.26±18.2???35.67±14.4???33.89±14.5???82.81±21.3???72.33±13.9?????49.73±21.5 **??93.99±20.9??76.28±247??????55.25±12.1 *** |
Radix Ginseng stem 100s -1Leaf saponin 20s -1Injection 10s -1 | 7.79±0.2?????8.22±1.2?????7.57±0.8?????10.15±1.4????9.55±0.9???????8.35±1.0 ***???10.89±0.7???9.86±0.8???????9.04±0.8 ***12.51±3.2????11.64±2.7????11.05±1.5????17.17±2.3????16.71±2.0??????14.20±2.5 **???20.31±2.5???18.78±2.4??????15.39±2.1 ***41.26±18.2???36.35±9.9????33.89±14.5???82.81±21.3???65.22±11.9?????49.73±21.5 **??93.99±20.9??88.65±24.1?????55.25±12.1 *** |
Salvianolic acid: stem and leaf of Radix Ginseng saponin | ????????????2h | ???????????3d | ?????????????????????????????????????9d |
Normal saline group administration group matched group | Normal saline group administration group matched group | Normal saline group administration group matched group | |
??10∶0 | 4.93±0.2???4.78±0.6??4.52±0.3??????????????5.14±0.4????4.42±0.5 **???4.22±0.5 ***????5.22±0.4????4.87±0.5 **???4.19±0.4 *** | ||
??15∶1 | 4.93±0.2???4.64±0.4??4.52±0.3??????????????5.14±0.4????4.34±0.4 ***??4.22±0.5 ***????5.22±0.4????4.44±0.4 ***??4.19±0.4 *** | ||
??10∶1 | 4.93±0.2???4.72±0.2??4.52±0.3??????????????5.14±0.4????4.27±0.4 ***??4.22±0.5 ***????5.22±0.4????4.20±0.5 ***??4.19±0.4 *** | ||
??7∶1 | 4.93±0.2???4.76±0.4??4.52±0.3??????????????5.14±0.4????4.26±0.5 ***??4.22±0.5 ***????5.22±0.4????4.14±0.4 ***??4.19±0.4 *** | ||
??5∶1 | 4.93±0.2???4.70±0.3??4.52±0.3??????????????5.14±0.4????4.20±0.4 ***??4.22±0.5 ***????5.22±0.4????4.08±0.5 ***??4.19±0.4 *** | ||
??3∶1 | 4.93±0.2???4.56±0.5??4.52±0.3??????????????5.14±0.4????4.12±0.3 ***??4.22±0.5 ***????5.22±0.4????4.01±0.4 ***??4.19±0.4 *** | ||
??1∶1 | 4.93±0.2???4.64±0.3??4.52±0.3??????????????5.14±0.4????4.28±0.6 ***??4.22±0.5 ***????5.22±0.4????4.18±0.6 ***??4.19±0.4 *** | ||
??0∶10 | 4.93±0.2???4.82±0.4??4.52±0.3??????????????5.14±0.4????4.87±0.4??????4.22±0.5 ***????5.22±0.4????4.88±0.4 **???4.19±0.4 *** | ||
Radix Salviae Miltiorrhizae Injection | 4.93±0.2???4.65±0.6??4.52±0.3??????????????5.14±0.4????4.56±0.5 **???4.22±0.5 ***????5.22±0.4????4.48±0.5 ***??4.19±0.4 *** | ||
RENSHEN JINGYEZAOGAN ZHUSHEYE | 4.93±0.2???4.83±0.5??4.52±0.3??????????????5.14±0.4????4.89±0.3??????4.22±0.5 ***????5.22±0.4????4.77±0.4 ***??4.19±0.4 *** |
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB200310100813XA CN100415241C (en) | 2003-10-03 | 2003-10-03 | Medicinal composition for treating cardio-cerebrovascular diseases |
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CNB200310100813XA CN100415241C (en) | 2003-10-03 | 2003-10-03 | Medicinal composition for treating cardio-cerebrovascular diseases |
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CN1528323A true CN1528323A (en) | 2004-09-15 |
CN100415241C CN100415241C (en) | 2008-09-03 |
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CNB200310100813XA Expired - Fee Related CN100415241C (en) | 2003-10-03 | 2003-10-03 | Medicinal composition for treating cardio-cerebrovascular diseases |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101292987B (en) * | 2007-04-29 | 2010-06-30 | 北京本草天源药物研究院 | Pharmaceutical combination |
CN102058599A (en) * | 2009-11-17 | 2011-05-18 | 中国科学院上海药物研究所 | Salvianolate, and preparation method and application thereof |
CN105287670A (en) * | 2015-10-19 | 2016-02-03 | 遵义医学院 | Application of total saponins of Ginseng stems and leaves |
WO2016033727A1 (en) * | 2014-09-01 | 2016-03-10 | 广州市香雪制药股份有限公司 | Medicine for preventing and treating vascular diseases and preparation method thereof |
-
2003
- 2003-10-03 CN CNB200310100813XA patent/CN100415241C/en not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101292987B (en) * | 2007-04-29 | 2010-06-30 | 北京本草天源药物研究院 | Pharmaceutical combination |
CN102058599A (en) * | 2009-11-17 | 2011-05-18 | 中国科学院上海药物研究所 | Salvianolate, and preparation method and application thereof |
CN102058599B (en) * | 2009-11-17 | 2014-06-04 | 中国科学院上海药物研究所 | Salvianolate, and preparation method and application thereof |
WO2016033727A1 (en) * | 2014-09-01 | 2016-03-10 | 广州市香雪制药股份有限公司 | Medicine for preventing and treating vascular diseases and preparation method thereof |
CN105287670A (en) * | 2015-10-19 | 2016-02-03 | 遵义医学院 | Application of total saponins of Ginseng stems and leaves |
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Publication number | Publication date |
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CN100415241C (en) | 2008-09-03 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
ASS | Succession or assignment of patent right |
Owner name: HEKANG PHARMACEUTICAL LLC, CHENGDU Free format text: FORMER OWNER: LI WENJUN Free format text: FORMER OWNER: CHEN JIN Effective date: 20050826 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20050826 Address after: High tech Zone Gaopeng Avenue in Chengdu city in Sichuan province No. 5, park B block, floor 3 Applicant after: Hekang Medicine Industry Co., Ltd., Chengdu Address before: 2, building 6, building 12, building 7, wash Bridge Street, No. 6-11, Sichuan, Chengdu, Wuhou District Applicant before: Li Wenjun Co-applicant before: Chen Jin |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C57 | Notification of unclear or unknown address | ||
DD01 | Delivery of document by public notice |
Addressee: Hekang Medicine Industry Co., Ltd., Chengdu Document name: Second notice of examination advice |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20081205 Address after: Room 420, Goldman Sachs center, No. 2 Gaosheng East Road, Sichuan, Chengdu Patentee after: Chen Jin Address before: High tech Zone of Chengdu City, Sichuan Province, Gaopeng Road No. 2 Patentee before: Hekang Medicine Industry Co., Ltd., Chengdu |
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ASS | Succession or assignment of patent right |
Owner name: CHEN JIN Free format text: FORMER OWNER: HEKANG PHARMACEUTICAL LLC, CHENGDU Effective date: 20081205 |
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EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Chengdu Jinhua Pharmaceutical Co., Ltd. Assignor: Chen Jin Contract fulfillment period: 2009.3.18 to 2019.3.17 Contract record no.: 2009510000135 Denomination of invention: Cardiac and cerebral vascular disease treating medicinal composition Granted publication date: 20080903 License type: Exclusive license Record date: 20091029 |
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LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.3.18 TO 2019.3.17; CHANGE OF CONTRACT Name of requester: CHENGDU JINHUA PHARMACEUTICAL CO., LTD Effective date: 20091029 |
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DD01 | Delivery of document by public notice |
Addressee: Chen Jin Document name: Notification of Termination of Patent Right |
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C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080903 Termination date: 20121003 |