CN1524850A - Histone de-acetylase inhibitor, preparation and application of pharmaceutical preparations of the same - Google Patents
Histone de-acetylase inhibitor, preparation and application of pharmaceutical preparations of the same Download PDFInfo
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- CN1524850A CN1524850A CNA031468411A CN03146841A CN1524850A CN 1524850 A CN1524850 A CN 1524850A CN A031468411 A CNA031468411 A CN A031468411A CN 03146841 A CN03146841 A CN 03146841A CN 1524850 A CN1524850 A CN 1524850A
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Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Compound | The GI of different tumour cells 50(μM) * | ||||||||
??U2OS | ????HeLa | ??DU-145 | ??SMMC-7721 | ??HepG2 | ??293 | ??MCF-7 | ????231 | ??H292 | |
?HYM0504 | ????50 | ????50 | ????50 | ????50 | ????50 | ??50 | ????50 | ????50 | ????50 |
?HYM0505 | ????5 | ????25 | ????50 | ????5 | ????16 | ??20 | ????25 | ????20 | ????40 |
?HYM0512 | ????50 | ????50 | ????50 | ????50 | ????50 | ??50 | ????50 | ????50 | ????50 |
?HYM0513 | ????50 | ????50 | ????50 | ????50 | ????50 | ??50 | ????50 | ????50 | ????50 |
Compound | The GI of different tumour cells 50(μM) * | ||||||||
??LNCaP | ?SK-N-SH | ??PANC-1 | ??SK-OV-3 | ???SGC-7901 | ?Raji | ???HL-60 | ???28SC | ?Jurkat | |
?HYM0504 | ????50 | ????50 | ????50 | ????50 | ????50 | ??50 | ????50 | ????50 | ????50 |
?HYM0505 | ????32 | ????50 | ????50 | ????50 | ????50 | ??2.5 | ????0.63 | ????2.5 | ????3.2 |
?HYM0512 | ????50 | ????50 | ????50 | ????50 | ????50 | ??50 | ????20 | ????50 | ????50 |
?HYM0513 | ????50 | ????50 | ????50 | ????50 | ????50 | ??50 | ????50 | ????50 | ????50 |
Claims (11)
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CNB031468411A CN100455564C (en) | 2003-09-12 | 2003-09-12 | Histone de-acetylase inhibitor, preparation and application of pharmaceutical preparations of the same |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009067856A1 (en) * | 2007-10-26 | 2009-06-04 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Histone deacetylase inhibitor, composition and use thereof |
CN101397295B (en) * | 2008-11-12 | 2012-04-25 | 深圳微芯生物科技有限责任公司 | 2-dihydroindolemanone derivates as histone deacetylase inhibitor, preparation method and use thereof |
CN102936215A (en) * | 2012-11-09 | 2013-02-20 | 怀化学院 | Synthesizing method for 2-sulfydryl-N-(6-(3-arylurea) hexyl) amide |
CN102020638B (en) * | 2009-09-16 | 2013-05-08 | 深圳微芯生物科技有限责任公司 | 2-indolinone derivative with protein kinase inhibition activity and histone deacetylase inhibition activity and preparation method and application thereof |
WO2016206138A1 (en) * | 2015-06-23 | 2016-12-29 | 清安医药科技武汉有限公司 | Histone deacetylase inhibitor and preparation method and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6174905B1 (en) * | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
JP2001081031A (en) * | 1999-08-30 | 2001-03-27 | Schering Ag | Benzamide derivative-containing preparation having improved solubility and oral adsorption |
PE20020354A1 (en) * | 2000-09-01 | 2002-06-12 | Novartis Ag | HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS |
-
2003
- 2003-09-12 CN CNB031468411A patent/CN100455564C/en not_active Expired - Lifetime
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009067856A1 (en) * | 2007-10-26 | 2009-06-04 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Histone deacetylase inhibitor, composition and use thereof |
CN101827811B (en) * | 2007-10-26 | 2013-12-04 | 浙江海正药业股份有限公司 | Histone deacetylase inhibitor, preparation and use thereof |
CN101397295B (en) * | 2008-11-12 | 2012-04-25 | 深圳微芯生物科技有限责任公司 | 2-dihydroindolemanone derivates as histone deacetylase inhibitor, preparation method and use thereof |
CN102020638B (en) * | 2009-09-16 | 2013-05-08 | 深圳微芯生物科技有限责任公司 | 2-indolinone derivative with protein kinase inhibition activity and histone deacetylase inhibition activity and preparation method and application thereof |
CN102936215A (en) * | 2012-11-09 | 2013-02-20 | 怀化学院 | Synthesizing method for 2-sulfydryl-N-(6-(3-arylurea) hexyl) amide |
CN102936215B (en) * | 2012-11-09 | 2013-12-25 | 怀化学院 | Synthesizing method for 2-sulfydryl-N-(6-(3-arylurea) hexyl) amide |
WO2016206138A1 (en) * | 2015-06-23 | 2016-12-29 | 清安医药科技武汉有限公司 | Histone deacetylase inhibitor and preparation method and use thereof |
CN106317175A (en) * | 2015-06-23 | 2017-01-11 | 清安医药科技武汉有限公司 | Histone deacetylase inhibitor and preparation method and application thereof |
CN106317175B (en) * | 2015-06-23 | 2020-01-31 | 杨思遥 | Histone deacetylase inhibitor and preparation method and application thereof |
Also Published As
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