CN1507860A - Complex prescription preparation of local application for promoting chronic wound healing - Google Patents
Complex prescription preparation of local application for promoting chronic wound healing Download PDFInfo
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- CN1507860A CN1507860A CNA031329659A CN03132965A CN1507860A CN 1507860 A CN1507860 A CN 1507860A CN A031329659 A CNA031329659 A CN A031329659A CN 03132965 A CN03132965 A CN 03132965A CN 1507860 A CN1507860 A CN 1507860A
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- aminoacid
- arginine
- wound
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Abstract
The present invention relates to a medicine composition for local application for promoting chronic wound (chronic ulcer and diabetic foot, etc.) healing and improving healing quality. It comprises at least one pharmaceutically-acceptable excipient, compound of additive, amino acid (arginine, arginine analogue or their derivative or their any salts or omithine, etc.), at least one compound for resisting inflammation and stopping pain and at least one compound for resisting mycetes. Said invented preparation for local application includes paste, gel, film, colloidal matter body or aerosol, etc.
Description
Technical field
The present invention relates to medical technical field, is the healing of a kind of promotion chronic wounds (chronic ulcer and diabetic foot etc.), and improves the method for healing quality.
Background of invention
Wound delayed healing, disunion or the chronic wounds such as bad that heals are clinical common and stubborn problems.The method of curing this class wound in recent years receives great concern.For example, Chinese application number 96198773.1＜the contain gel preparation of somatomedin 〉, Chinese application number 98813949.9＜application protease inhibitors for treating skin wounds 〉.The existing medicine that is used for acute (trauma wounds, operative incision) and chronic wounds (chronic ulcer and diabetic foot etc.) can not play accelerating wound and shorten the effect of healing time.Particularly the healing of chronic wounds is difficult more.Therefore studying the modification method of treatment chronic wounds, is a clinical difficult problem that needs solution to accelerate its healing.The inventor finds under study for action: add the healing that amino acidses such as arginine or wound topical application arginine all can promote wound in the diet.
Aminoacid such as arginine, it is synthetic to participate in protein in body, and the stimulating growth hormone discharges, and wound healing is had Nutrition.Amino-acid compounds such as arginine are the unique sources of NO in the body, expand local vascular, improve the blood deposition condition of wound.Amino-acid compounds such as arginine also can be used as the reinforcing agent of exempting from service, and increase the T cell function of exempting from service, and improve local anti-infection ability.
Up to now, also do not provide a suitable amino acid whose drug-supplying system that is used for the treatment of the injury place.Especially, expectation finds one can control aminoacid and discharge and adhere to or keep the drug-supplying system of considerable time with time of contact of increasing aminoacid and injury place at the injury place to the injury place.The present invention just is being based on above deficiency and the embodiment that proposes.
Summary of the invention
This part is based on a kind of new processing wound particularly Therapeutic Method and the goods of chronic wounds, the wound healing enhancer compositions of topical application.In order to reach these purposes, according to an aspect of the present invention, local application one seed amino acid promotes the healing and the healing quality of wound.
The local application amino acids
The indefiniteness example of amino acids comprises arginine, ornithine etc.This method comprises by patients ' demand uses a kind of step of the therapeutic agent that contains aminoacid (comprising one of arginine, ornithine analog or their derivant or their any salt etc.) of effective dose to it, wherein this aminoacid is locally applied to wound, it is synthetic that this amino acid participates in protein in body, the stimulating growth hormone discharges, and wound healing is had Nutrition.Amino-acid compounds such as arginine are the unique sources of NO in the body, expand local vascular, improve the blood deposition condition of wound.Amino-acid compounds such as arginine also can be used as the reinforcing agent of exempting from service, and increase the T cell function of exempting from service, and improve local anti-infection ability.Use aminoacid in wound surface, medicament can directly act on blood vessel, the muscle of wound.
Local application antifungal agent, antibiotic and anti-inflammation analgesia medicine
Fungus is easily grown in the long-time disunion of chronic wounds in its wound, increase the weight of skin ulcer.Therefore, Therapeutic Method also comprises local application antifungal agent, anti-inflammation analgesia medicine.These medicaments can be to antifungal, and the inflammatory exudation of wound surface alleviates the pain of wound, helps wound surface and uses the repair of aminoacid to wound.The indefiniteness example of local application antifungal agent comprises ketoconazole, fluconazol etc.The indefiniteness example of local application anti-inflammation analgesia medicine comprises nonsteroidal anti-inflammatory analgetics such as fragrant that acids, indoles, as anti-inflammation analgesia medicines such as diclofenac, piroxicams, and anti-inflammatory agents such as Sodium Aescinate.
On the one hand, feature of the present invention is the method that a kind of treatment has the patient of superficial cut, it is characterized in that, described method comprises a certain amount of aminoacid of local application, thereby strengthens the healing of described wound.Aminoacid can be arginine, ornithine, leucine, glutamic acid etc.This method also comprises uses a certain amount of anti-inflammation analgesia medicine, comprises nonsteroidal anti-inflammatory analgetics such as fragrant that acids, indoles.This method also comprises uses a certain amount of antifungal agent, as ketoconazole, fluconazol etc.
Another feature of the present invention is a kind of compositions that contains aminoacid, antifungal agent, anti-inflammation analgesia medicine.
On the other hand, feature of the present invention is a kind of goods, comprises packaging material and a certain amount of aminoacid.Described packaging material contain a label, and this label shows that described aminoacid is to be used for the treatment of the patient with wound, and the described aminoacid of the described amount of local application is to strengthen the healing of described wound.These goods also comprise a certain amount of antifungal agent, anti-inflammation analgesia medicine.
The indefiniteness example of these goods comprises that in one embodiment these goods are breast (ointment) agent.In second embodiment, these goods are gel.In the 3rd embodiment, these goods are spray.In the 4th embodiment, these goods are liposome.
The embodiment that below lists is used to illustrate the present invention.The present invention is not these embodiment limitations.
The specific embodiment
Embodiment 1
The arginine aerosol
Aerosol prepares according to the present invention.Ornithine 3%, clotrimazole 1%, F
1260%, water is an amount of.Ornithine, clotrimazole is soluble in water, filter, packing, every bottle is pressed into propellant F
1260%, promptly.
Embodiment 2
Arginine W/O gel
The W/O gel prepares according to the present invention.The oil mixture of spermol, eumulgin B3, isopropyl palmitate and ketoconazole is heated to 70 ℃, buffer is dissolved in 80 ℃ the deionized water, under gentle agitation, arginine is dissolved in the buffer.This buffer is added in the surfactant mixture, jumps a queue, be incubated in 75 ℃ until forming uniform molten mixture, under shaking, be chilled to room temperature, promptly.
Claims (17)
1. a treatment has the patient's of chronic superficial cut method, it is characterized in that described method comprises the aminoacid of the effective Wound healing and bone regeneration amount of local application, thereby promotes the healing of described wound.
2. the method for claim 1 is characterized in that, described aminoacid is arginine.Wherein arginine can comprise one of arginine analog or their derivant or their any salt.
3. the method for claim 1 is characterized in that, described aminoacid is ornithine.Wherein ornithine can comprise one of ornithine analog or their derivant or their any salt.
4. the method for claim 1 is characterized in that, described aminoacid is leucine.Wherein leucine can comprise one of leucine analog or their derivant or their any salt.
5. the method for claim 1 is characterized in that, described aminoacid is glutamic acid.Wherein glutamic acid can comprise one of glutamic acid analog or their derivant or their any salt.
6. the method for claim 1 is characterized in that, the antifungal agent of local application effective dose.
7. the method for claim 1 is characterized in that, the anti-inflammatory agent of local application effective dose.
8. the method for claim 1 is characterized in that, the Tri-Biocin of local application effective dose.
9. the method for claim 1 is characterized in that, described dispenser step is to pass through topical.
10. one kind contains packaging material and a certain amount of amino acid whose goods, it is characterized in that, described packaging material contain a label, and this label shows that described aminoacid is to be used for the treatment of the patient with wound, and the described aminoacid of the described amount of local application is to promote the healing of described wound.
11. goods as claimed in claim 7 is characterized in that, described aminoacid is arginine.
12. goods as claimed in claim 7 is characterized in that, described aminoacid is ornithine.
13. goods as claimed in claim 7 is characterized in that, described aminoacid is glutamic acid.
14. goods as claimed in claim 7 is characterized in that, described aminoacid is leucine.
15. goods as claimed in claim 7 is characterized in that, described goods also contain antifungal agent.
16. goods as claimed in claim 7 is characterized in that, described goods also contain anti-inflammatory agent.
17. goods as claimed in claim 7 is characterized in that, described goods are local application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031329659A CN1507860A (en) | 2002-10-24 | 2003-07-25 | Complex prescription preparation of local application for promoting chronic wound healing |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02145652.6 | 2002-10-24 | ||
| CN02145652 | 2002-10-24 | ||
| CNA031329659A CN1507860A (en) | 2002-10-24 | 2003-07-25 | Complex prescription preparation of local application for promoting chronic wound healing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1507860A true CN1507860A (en) | 2004-06-30 |
Family
ID=34276042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031329659A Pending CN1507860A (en) | 2002-10-24 | 2003-07-25 | Complex prescription preparation of local application for promoting chronic wound healing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1507860A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758302A (en) * | 2015-04-02 | 2015-07-08 | 成都汇智远景科技有限公司 | Compound oxytetracycline ointment |
| CN105769844A (en) * | 2016-05-25 | 2016-07-20 | 天津嘉氏堂医美科技有限公司 | Arginine-containing composition and preparation |
| CN105920660A (en) * | 2016-05-25 | 2016-09-07 | 天津嘉氏堂医美科技有限公司 | Composition and preparation for treating chronic wounds |
| CN105943528A (en) * | 2016-05-25 | 2016-09-21 | 天津嘉氏堂医美科技有限公司 | Composition for treating chronic wounds and preparation method |
-
2003
- 2003-07-25 CN CNA031329659A patent/CN1507860A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758302A (en) * | 2015-04-02 | 2015-07-08 | 成都汇智远景科技有限公司 | Compound oxytetracycline ointment |
| CN105769844A (en) * | 2016-05-25 | 2016-07-20 | 天津嘉氏堂医美科技有限公司 | Arginine-containing composition and preparation |
| CN105920660A (en) * | 2016-05-25 | 2016-09-07 | 天津嘉氏堂医美科技有限公司 | Composition and preparation for treating chronic wounds |
| CN105943528A (en) * | 2016-05-25 | 2016-09-21 | 天津嘉氏堂医美科技有限公司 | Composition for treating chronic wounds and preparation method |
| CN105943528B (en) * | 2016-05-25 | 2019-01-11 | 天津嘉氏堂医美科技有限公司 | Composition for treating chronic wounds and preparation method |
| CN105769844B (en) * | 2016-05-25 | 2019-01-11 | 天津嘉氏堂医美科技有限公司 | Arginine-containing composition and preparation |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |