CN1486984A - Prepn process of pipecolinate - Google Patents
Prepn process of pipecolinate Download PDFInfo
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- CN1486984A CN1486984A CNA021308063A CN02130806A CN1486984A CN 1486984 A CN1486984 A CN 1486984A CN A021308063 A CNA021308063 A CN A021308063A CN 02130806 A CN02130806 A CN 02130806A CN 1486984 A CN1486984 A CN 1486984A
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Abstract
The present invention is the preparation process of ethyl-4-[[1-[(4-fluorophenyl)methyl]-1-hydro-benzimidazole-2-radical] amino]-1-pipecolinate with 1-(4-fluorobenzyl)-2-chlorobenzimidazole(FBI)and ethyl-4-aminopiperidyl carbamate (APC) as material.
Description
Technical field
The present invention relates to the preparation of compound, more particularly, relate to 1-(4-luorobenzyl)-2-chloro benzimidazole (the English abbreviation: FBI) and ethyl 4-amino piperidine carbamate (the English abbreviation: APC) be feedstock production ethyl 4-[[1-[(4-fluorophenyl) methyl]-1-hydrogen-benzimidazolyl-2 radicals-yl] amino]-1-piperidines acid esters (English abbreviation: NEC).
Background technology
NEC is the important intermediate of Claritin, NEC synthetic method [the United States Patent (USP): 4 of Johson ﹠ Johnson's report, 835,161] in, be by the at high temperature clean reaction of 1-(4-luorobenzyl)-2-chloro benzimidazole (FBI) and ethyl 4-amino piperidine carbamate (APC) is obtained product.The main drawback of this reaction is that transformation efficiency is low, even (120 ℃, 43 hours) productive rate is very low under very violent condition, synthetic route is as follows:
The weakness of above technology can be summarized as follows:
(1) the clean hybrid reaction of starting raw material FBI and APC is solidified in reaction process easily, and the multipotency of transformation efficiency reaches 65～75%.In last handling process, must introduce purification process.
(2) long reaction time, productive rate is low, has only 40.5%.
(3) too many unnecessary excess reagent is as 2.5eq.APC.
(4) in the separation and purification process, extract as solvent with trichloromethane.
Sepracor company in 1999 reported the synthetic NEC of coupling method novel method (Chris H.S., Yaping H., Tingjian X., et, al., Tetrahedron Letters, 40 (1999), 6875-6879), its synthetic route is as follows:
Consider boiling point and solubility problem, make solvent with DGME in the synthetic method of the said firm's report, add lutidine alkali, and make catalyzer, improved reaction yield, shortened the reaction times with KF.Synthetic method than Johson ﹠ Johnson's report is improved, and we can say that this technology is a good technology really.
Also there are some inevitable shortcomings but found through experiments this technology, are summarized as follows:
(1) 2,6-lutidine (lutidine) costs an arm and a leg, and consumption is very big in reaction, makes cost very high.Lutidine has very big bad smell in addition, is a kind of injuries to operator, and environment is also caused certain pollution.
(2) this reaction requires very strictly for the amount of KF and water, and KF requires 0.3eq., and water requires to add 1wt%, many has lacked all not all rightly, and productive rate is understood far short of what is expected.This requirement is done little reaction and can be reached in the laboratory, but is difficult to control in industrial production.
Summary of the invention
The present invention has overcome above preparation method's deficiency, through repeatedly experiment repeatedly, provide a kind of new, be applicable to the synthetic method of suitability for industrialized production fully.
Adopt following steps:
Nitrogen protection, DGME makes solvent, 0.3eqKF/1%H
2O makees catalyzer, and 150～160 ℃, 2 hours.
The characteristics of novel process
(1) reaction raw materials obtains easily, i.e. " 1-(4-luorobenzyl)-2-benzyl chloride base imidazoles " (being called for short FBI), can be by BI with synthetic to fluorobenzyl chloride, the free alkali purity of gained FBI reaches 95～96% (HPLC normalization methods, but do not have crystal formation), once can get colourless transparent crystal with second eyeball recrystallization, purity reaches more than 98%.
(2) this technology can directly be used the free alkali of FBI, needn't make hydrochloride, has simplified technology.
(3) make solvent with DGME, with amount seldom (FBI (g)/DGME (mL)=1: 1), defective (150～160 ℃ of the high temperature of clean reaction in the direct linked reaction have been overcome, thereby easily solidify to increase and stir difficulty, reach 40 hours reaction times), this point is consistent with the synthetic method of Sepracor company.
(4) use 0.3eqKF/1%H
2O makees catalyzer (the amount requirement to KF is not very strict, and the amount of water can be dissolved KF and be got final product); Temperature is brought up to 150～160 ℃ (can reach fully in the production, and DGME boiling point height, can meet the demands), has shortened the reaction times greatly, only needs 2 hours, has improved yield.
(5) removed expensive unpleasant lutidine, reduced more than 100 yuan of raw materials cost, reduced environmental pollution, simplified operating procedure, this is a very large improvement.
(6) logical nitrogen protection in the reaction process has improved product quality and purity.
In a word, simplified technology by improvement.The novel process proof is practical, has not only shortened the reaction times, has improved product purity, and yield is brought up to 87-89 (+5) %.
Embodiment
Embodiment 1
Free alkali 20.8 grams of FBI are dissolved in 20mLDGME; be heated to 30～45 ℃ of stirring and dissolving; adding the APC16.52 gram stirred 2～3 minutes; add entry 0.8 gram Potassium monofluoride 1.4 grams; finish and vacuumize (0.06～-0.05MPa) three times; each benefit is gone into pure nitrogen gas, is warming up to 150～160 ℃ of 2 hours react completely (HPLC monitoring reaction processes) of reaction under the positive pressure of nitrogen protection then.Add toluene 80mL dilution after being cooled to 50～60 ℃, add 4% NaOH solution (200 gram) then, continue to stir 10～15 minutes at 35～40 ℃.Be cooled to 0～5 ℃ and stirred 2～3 hours in this temperature.Solid product (NEC) is collected in vacuum filtration, use EtOH/4%NaOH solution (2 * 20 milliliters) and water (2 * 30 milliliters) flushing product then, dry air, get product NEC (NEC) 27.7 grams, yield 87.6%, chemical purity 99.1%, 180.3～182.8 ℃ of fusing points.
Claims (3)
1. one kind prepares ethyl 4-[[1-[(4-fluorophenyl) methyl]-1-hydrogen-benzimidazolyl-2 radicals-yl] amino]-method of 1-piperidines acid esters (NEC); carry out chemical reaction by 1-(4-luorobenzyl)-2-chloro benzimidazole (FBI) and ethyl 4-amino piperidine carbamate (APC); it is characterized in that; adopt nitrogen protection; DGME makes solvent, 0.3eqKF/1%H
2O makees catalyzer.
2. according to the described a kind of ethyl 4-[[1-[(4-fluorophenyl for preparing of claim 1) methyl]-1-hydrogen-benzimidazolyl-2 radicals-yl] amino]-method of 1-piperidines acid esters (NEC), it is characterized in that temperature of reaction is 150～160 ℃.
3. according to the described a kind of ethyl 4-[[1-[(4-fluorophenyl for preparing of claim 1) methyl]-1-hydrogen-benzimidazolyl-2 radicals-yl] amino]-method of 1-piperidines acid esters (NEC), it is characterized in that the reaction times is 1～3 hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02130806 CN1223590C (en) | 2002-09-30 | 2002-09-30 | Prepn process of pipecolinate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02130806 CN1223590C (en) | 2002-09-30 | 2002-09-30 | Prepn process of pipecolinate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1486984A true CN1486984A (en) | 2004-04-07 |
| CN1223590C CN1223590C (en) | 2005-10-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02130806 Expired - Fee Related CN1223590C (en) | 2002-09-30 | 2002-09-30 | Prepn process of pipecolinate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1223590C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014201972A1 (en) * | 2013-06-17 | 2014-12-24 | 上海汇伦生命科技有限公司 | Benzimidazole-2-piperazine heterocyclic compound, pharmaceutical composition thereof, preparation method and use thereof |
-
2002
- 2002-09-30 CN CN 02130806 patent/CN1223590C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014201972A1 (en) * | 2013-06-17 | 2014-12-24 | 上海汇伦生命科技有限公司 | Benzimidazole-2-piperazine heterocyclic compound, pharmaceutical composition thereof, preparation method and use thereof |
| US10196381B2 (en) | 2013-06-17 | 2019-02-05 | Shanghai Huilun Life Science &Technology Co., Ltd | Benzimidazole-2-piperazine heterocyclic compound, pharmaceutical composition containing the same, preparation method and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1223590C (en) | 2005-10-19 |
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Owner name: TASLY HOLDING GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TASLY GROUP CO., LTD. |
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Address after: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Patentee after: TASLY HOLDING GROUP CO., LTD. Address before: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Patentee before: Tianjin Tasly Group Co., Ltd. |
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| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20040407 Assignee: Tianshili Diyi Pharmaceutical Ind Co., Ltd., Jiangsu Assignor: TASLY HOLDING GROUP CO., LTD. Contract record no.: 2015320000357 Denomination of invention: Prepn process of pipecolinate Granted publication date: 20051019 License type: Exclusive License Record date: 20150521 |
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Granted publication date: 20051019 Termination date: 20170930 |