CN1482622A - Process for making gold nanometer probe - Google Patents
Process for making gold nanometer probe Download PDFInfo
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- CN1482622A CN1482622A CNA031283322A CN03128332A CN1482622A CN 1482622 A CN1482622 A CN 1482622A CN A031283322 A CNA031283322 A CN A031283322A CN 03128332 A CN03128332 A CN 03128332A CN 1482622 A CN1482622 A CN 1482622A
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- sodium borohydride
- probe
- citric acid
- trisodium citrate
- solution
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- Manufacture Of Metal Powder And Suspensions Thereof (AREA)
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Abstract
The invention relates to a method for making gold nanometer probe comprising, mixing chlorauric acid and citric acid trisodium in water, then adding in the citric acid trisodium solution of sodium borohydride, adding eicosane group sodium sulphate at the same time of adding in the citric acid trisodium solution of sodium borohydride, thus achieving the gold nanometer probe with particle diameter of 4-6 nanometer. The small particle size gold nanometer particle prepared by the method in accordance with the invention has small particle diameter and good monodispersity.
Description
Technical field
The present invention relates to a kind of preparation method of gold nano-probe, is exactly that the preparation particle diameter is 4～6 gold nano-probe by the influence of SDS to gold atom depositional mode and gold nano nucleus growth behavior specifically.
Background technology
Quantum size effect that golden nanometer particle has and high-specific surface area cause it to produce performances such as many special light, electricity, catalysis, thereby are widely used in many high-technology fields such as biomarker, DNA sensor, molecular recognition, nano-electrode.Because the golden nanometer particle of small particle diameter has preferably penetrability, has special electrology characteristic in electronics research in cytochemistry, so the technology of the golden nanometer particle that preparation size is little, monodispersity is good seems important day by day.
In the prior art, the preparation particle diameter is during less than the golden nanometer particle of 10nm, usually use in water or oil phase with strong reductant (sodium borohydride, ascorbic acid etc., used sodium borohydride is prepared with citric acid three sodium solution usually) with the chemical reduction method of gold chloride reaction, but along with reducing of nano particle diameter, dispersion degree worse and worse.Along with nano particle diameter reduces, specific surface area increases simultaneously, surfactancy increases, and nano-particle solution stability reduces easily assembles.Although can stop the gathering of particle by coverings such as adding mercapto alkane compound and organic polymers.But the combining relatively firmly of covering and golden nanometer particle (as forming the Au-S key) in these methods divides the period of the day from 11 p.m. to 1 a.m to be restricted at further modified biological.
Summary of the invention
Problem to be solved by this invention is exactly: a kind of method for preparing the small particle diameter gold nano-probe is provided, and the gold nano-probe particle diameter of this method preparation is less and monodispersity good.
Technical scheme provided by the invention is: a kind of method for preparing gold nano-probe, gold chloride is mixed in water with trisodium citrate, the citric acid three sodium solution that adds sodium borohydride then, its key is: add lauryl sodium sulfate in the citric acid three sodium solution that adds sodium borohydride, and obtain the gold nano-probe that particle diameter is 4～6 nanometers, wherein, the addition of lauryl sodium sulfate is 0.3～3 times of gold chloride quality.
In the above-mentioned reaction solution, the mol ratio of gold chloride and trisodium citrate is 1: 35-1: 40, be preferably 1: 38.8; The mass ratio of sodium borohydride and trisodium citrate is 1: 40-5: 40, be preferably 3: 40.
The citric acid three sodium solution of used sodium borohydride is the sodium borohydride solution of suggestion with the 0.075wt% of the trisodium citrate preparation of 1wt%.
The present invention is at NaBH
4Utilize of the electrostatic adsorption of anionic SDS water-wet side in the reducing process to the golden nanometer particle surface, suppressed gold atom sedimentation velocity, limited the growth rate of nucleus, and in the golden nanometer particle propagation process, stoped the generation of new nucleus, improved the monodispersity of small particle diameter golden nanometer particle effectively, and the particle diameter of gained golden nanometer particle is little, is 4～6 nanometers.The golden nanometer particle of the present invention's preparation has biological affinity preferably to protein remains.
Description of drawings
Accompanying drawing is the TEM figure (scale is 50nm) of the gold nano-probe of the present invention's preparation.
Embodiment
The preparation of small particle diameter gold nano-probe: the HAuCl of 50 μ L 1wt%
4Mix with the water of 4.5mL and place round-bottomed flask to stir, add the trisodium citrate of the 38.8mmol/L of 5mL behind the 1min.Stir 1min again, add the 0.075wt%NaBH of 50 μ L with the preparation of 38.8mmol/L trisodium citrate
4(NaBH
4Solution and lauryl sodium sulfate mix quick adding, and the addition of lauryl sodium sulfate is 0.3～3 times of gold chloride quality), continue to stir 5min then, filter and promptly get the gold nano-probe that required particle diameter is 4～6 nanometers.Observed result such as accompanying drawing under transmission electron microscope (TEM), it is good that the present invention makes small particle diameter gold nano-probe monodispersity.
Claims (4)
1. method for preparing gold nano-probe, gold chloride is mixed in water with trisodium citrate, the citric acid three sodium solution that adds sodium borohydride then, it is characterized in that: in the citric acid three sodium solution that adds sodium borohydride, add lauryl sodium sulfate, the addition of lauryl sodium sulfate is 0.3～3 times of the gold chloride quality, and obtains the gold nano-probe that particle diameter is 4～6 nanometers.
2. method according to claim 1 is characterized in that: in the reaction solution, the mol ratio of gold chloride and trisodium citrate is 1: 35-1: 40, and the mass ratio of sodium borohydride and trisodium citrate is 1: 40-5: 40.
3. method according to claim 2 is characterized in that: the mol ratio of gold chloride and trisodium citrate is 1: 38.8, and the mass ratio of sodium borohydride and trisodium citrate is 3: 40.
4. according to claim 1 or 2 or 3 described methods, it is characterized in that: the citric acid three sodium solution of used sodium borohydride is the sodium borohydride solution with the 0.075wt% of the trisodium citrate preparation of 1wt%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03128332 CN1244111C (en) | 2003-07-17 | 2003-07-17 | Process for making gold nanometer probe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03128332 CN1244111C (en) | 2003-07-17 | 2003-07-17 | Process for making gold nanometer probe |
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| Publication Number | Publication Date |
|---|---|
| CN1482622A true CN1482622A (en) | 2004-03-17 |
| CN1244111C CN1244111C (en) | 2006-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03128332 Expired - Fee Related CN1244111C (en) | 2003-07-17 | 2003-07-17 | Process for making gold nanometer probe |
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| Country | Link |
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| CN (1) | CN1244111C (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1623781A2 (en) * | 2004-07-26 | 2006-02-08 | Korea Research Institute of Standards and Science | Gold nanoparticles and method of synthesizing the same |
| CN100431754C (en) * | 2007-03-02 | 2008-11-12 | 江南大学 | Process for preparing gold nano particle by using aqueous phase soft mould plate method |
| CN102221614A (en) * | 2011-03-28 | 2011-10-19 | 山东大学 | Analysis method for identifying effect target of small molecular compound by using gold nanoprobe |
| CN102507858A (en) * | 2011-10-25 | 2012-06-20 | 广东省药品检验所 | Rapid screening method of illegally-recycled waste cooking oil |
| CN102706866A (en) * | 2012-05-18 | 2012-10-03 | 中国科学院宁波材料技术与工程研究所 | Detection reagent for rapidly detecting multiple single metal ions, preparation and application thereof |
| CN101551385B (en) * | 2007-09-03 | 2014-07-16 | 深圳市人民医院 | Double labelling Nano-Au probe and preparation method |
| CN105675602A (en) * | 2016-03-10 | 2016-06-15 | 河南科技学院 | Manganese ion detection method and detection probe |
| CN109724971A (en) * | 2019-02-01 | 2019-05-07 | 莱华尔科技有限公司 | A kind of preparation method and applications of the food sensing solution using gold nanoparticle |
| US20210402472A1 (en) * | 2018-11-21 | 2021-12-30 | University Of Leeds | Nanomaterials |
-
2003
- 2003-07-17 CN CN 03128332 patent/CN1244111C/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1623781A3 (en) * | 2004-07-26 | 2006-06-07 | Korea Research Institute of Standards and Science | Gold nanoparticles and method of synthesizing the same |
| EP1623781A2 (en) * | 2004-07-26 | 2006-02-08 | Korea Research Institute of Standards and Science | Gold nanoparticles and method of synthesizing the same |
| CN100431754C (en) * | 2007-03-02 | 2008-11-12 | 江南大学 | Process for preparing gold nano particle by using aqueous phase soft mould plate method |
| CN101551385B (en) * | 2007-09-03 | 2014-07-16 | 深圳市人民医院 | Double labelling Nano-Au probe and preparation method |
| CN102221614A (en) * | 2011-03-28 | 2011-10-19 | 山东大学 | Analysis method for identifying effect target of small molecular compound by using gold nanoprobe |
| CN102507858A (en) * | 2011-10-25 | 2012-06-20 | 广东省药品检验所 | Rapid screening method of illegally-recycled waste cooking oil |
| CN102507858B (en) * | 2011-10-25 | 2014-10-22 | 广东省药品检验所 | Rapid screening method of illegally-recycled waste cooking oil |
| CN102706866A (en) * | 2012-05-18 | 2012-10-03 | 中国科学院宁波材料技术与工程研究所 | Detection reagent for rapidly detecting multiple single metal ions, preparation and application thereof |
| CN102706866B (en) * | 2012-05-18 | 2014-12-03 | 中国科学院宁波材料技术与工程研究所 | Detection reagent for rapidly detecting multiple single metal ions, preparation and application thereof |
| CN105675602A (en) * | 2016-03-10 | 2016-06-15 | 河南科技学院 | Manganese ion detection method and detection probe |
| CN105675602B (en) * | 2016-03-10 | 2019-01-04 | 河南科技学院 | A kind of manganese ion detection method and detection probe |
| US20210402472A1 (en) * | 2018-11-21 | 2021-12-30 | University Of Leeds | Nanomaterials |
| CN109724971A (en) * | 2019-02-01 | 2019-05-07 | 莱华尔科技有限公司 | A kind of preparation method and applications of the food sensing solution using gold nanoparticle |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1244111C (en) | 2006-03-01 |
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