CN1460524A - Alpha-allyl glucoside surface modified artifical lens and its making method - Google Patents
Alpha-allyl glucoside surface modified artifical lens and its making method Download PDFInfo
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- CN1460524A CN1460524A CN 03129205 CN03129205A CN1460524A CN 1460524 A CN1460524 A CN 1460524A CN 03129205 CN03129205 CN 03129205 CN 03129205 A CN03129205 A CN 03129205A CN 1460524 A CN1460524 A CN 1460524A
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- lens
- intraocular lens
- allyl glucoside
- allyl
- glucoside
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Abstract
Said artificial lens contains hydrophobic lens optial portion and ansa. The external surface of the lens optical portion and ansa are equipped with molecular layer of alpha-allyl glucoside monomer respectively, and its preparation method includes the following steps: using hydrophobic material to make it into artificial lens, soaking said artificial lens in anhydrous ethanol for 24 hr. and then washing it for 1-3 min. by using ultrasonic cleaning instrument, then washing it in triple distilled water, soaking and drying it, coating a layer of alpha-allyl glucoside monomer on its surface, then placing said artificial lens in plasma generator to make polymerization for 1-60 min., taking out it and soaking it in triple distilled water for 72 h. so as to remove unconverted monomer, finally vacuum drying and packaging.
Description
Technical field
The present invention relates to a kind ofly can be used to replace the intraocular lens of intra-ocular lens containing phacoemulsification cataract extraction in interior ECCE.Especially a kind of improved biocompatible intraocular lens and manufacture method thereof.
Background information
Present two class intraocular lenss commonly used in clinical, one class is to be the hydrophilic intraocular lens that material is made with hydrogel and hydrophilic acrylate, and another kind of is to be the hydrophobic intraocular lens that material is made with silicon gel, hydrophobic acrylate or polymethyl methacrylate.Above-mentioned arbitrary class intraocular lens is implanted the interior 1-2 of human lens cyst membrane after week, i.e. tunica film close parcel.Intraocular lens's front surface contacts with iris closely with lens epithelial cells under the anterior capsule, the rear surface only contacts with the back cyst membrane that does not originally have the lens epithelial cells growth.The intraocular lens of this moment stimulates adjacent tissue as external foreign body, thereby produces special pathological change; Especially relevant with front surface pathological change stimulates the lens epithelial cells degeneration as intraocular lens's front surface, causes the anterior capsule muddiness; Stimulate iris to cause macrophage deposition, anterior chamber's scintillation, posterior synechia etc.; And front surface contacts with corneal endothelium, also can cause endothelium toxic reaction etc.
In recent years the intraocular lens's hydrophiling of Chu Xianing or the process for modifying surface of hydrophobization are by plasma generator or ozonator the intraocular lens surface to be handled.In cell in vitro experiment, animal body, confirm that it is a kind of practicable technology experiment or the clinical observation.Have excellent biological compatibility though a kind of polymethyl methacrylate intraocular lens of heparinization is proved, cost an arm and a leg, so also can not get extensive use.
Summary of the invention
The present invention will overcome above-mentioned the deficiencies in the prior art, the intraocular lens of a kind of α-pi-allyl glucoside finishing is provided, so that this intraocular lens can alleviate postoperative and the relevant pathological change in the forward and backward surface of intraocular lens, thereby better biocompatibility is arranged; And make its manufacture method have the cost of scientific and reasonable, practical, easily manufactured, cost less, lower-price characteristic.
The intraocular lens of α of the present invention-pi-allyl glucoside finishing, it includes the lens optic and the loop of hydrophobic material, it is characterized in that: the outer surface at lens optic and loop all has α-monomeric molecular layer of pi-allyl glucoside.
The artificial crystalline lens of the present invention with α-monomeric molecular layer of pi-allyl glucoside also can only be distributed on whole outer surfaces of the front surface of lens optic and loop; Also can be distributed on the full surface of the ring surface of lens optic front surface periphery and loop.
The artificial crystalline lens of the present invention, the hydrophobic material of its lens optic is polymethyl methacrylate preferably.
The intraocular lens's of α of the present invention-pi-allyl glucoside finishing manufacture method, be to make the intraocular lens with hydrophobic transparent polymer material earlier, and place dehydrated alcohol to soak 24h this lens optic and loop, then in ultrasonic washing instrument, clean 1-3min, after this rinsing in tri-distilled water, immersion, and vacuum drying; After the drying, be coated with one deck α-pi-allyl glucoside monomer in its surface, place plasma generator to carry out polymerization this intraocular lens then; The polymeric time is 1-60min, takes out after polymerization finishes, and soak 72h again in tri-distilled water, to remove unpolymerized α-pi-allyl glucoside monomer; Carry out vacuum drying at last, and after drying, pack.The initiation power of above-mentioned plasma generator is that 600W, vacuum are 50-60Pa, and the gas in it is air or nitrogen.
The intraocular lens's of above-mentioned α-pi-allyl glucoside finishing manufacture method, after also can in plasma generator, disposing, it is directly immersed α-pi-allyl glucoside aqueous solution of 0.2g/ml, and under 60-70 ℃ temperature water-bath 24h, make α-pi-allyl glucoside monomer-grafted in polymethyl methacrylate artificial intraocular lenses's surface; Put into tri-distilled water after the water-bath again and soak 72h,, carry out vacuum drying at last again, and after drying, pack at once to remove unpolymerized α-pi-allyl glucoside monomer.
The artificial lenticular manufacture method of above-mentioned the present invention also can be before placing the plasma generator polymerization, just to being coated with α-pi-allyl glucoside monomer on the front surface of lens optic and the loop.
The invention has the beneficial effects as follows: 1) because α-pi-allyl glucoside monomer molecule of modifying on the intraocular lens surface has no stimulation to human tissue cell, so make the artificial crystalline lens of the present invention have better biocompatibility; 2) the present invention is also because of the good hydrophilic property of α-pi-allyl glucoside, and it is hydrophilic that hydrophobic intraocular lens's front surface is become, thereby can alleviate its postoperative complication relevant with front surface; Therefore 3) the inventive method science, feasible can make the intraocular lens of α of the present invention-pi-allyl glucoside finishing; And carrying out polymerization in plasma generator, existing to carry out the method for surface modification by chemical technology simple, when in plasma generator, introducing hydrophilic group simultaneously, any objectionable impurities can be do not brought into yet, therefore the security reliability of the artificial crystalline lens of the present invention in medical transplanting can be guaranteed; 3) the inventive method has adopted simple and easy to do plasma processes, thus can produce in batches, thus reduced cost, cheap.
Below will and contrast accompanying drawing, the present invention will be further described below by embodiment.
Description of drawings
Fig. 1 and Fig. 2 are respectively the front view of intraocular lens after amplification of α of the present invention-pi-allyl glucoside finishing and the cutaway view of bowing;
Fig. 3 and Fig. 4 are respectively the front view of another embodiment of the present invention after amplification and the cutaway view of bowing;
Fig. 5 is the plasma generator sketch map in use in the manufacture method of the present invention;
Fig. 6 is intraocular lens's sketch map during by miniature masking device clamping in plasma generator in the present embodiment 2.
The specific embodiment
The intraocular lens of embodiment 1. present embodiments α-pi-allyl glucoside finishing, its structure can be seen from Fig. 1 and Fig. 2, the lens optic 1 and the loop 2 that include hydrophobic material, and all have the monomeric molecular layer 3 of α-pi-allyl glucoside at the outer surface of lens optic 1 and loop 2.Because α-pi-allyl glucoside is a kind of sugar, and the glycan molecule constituent, little to the stimulation of human tissue cell of human body cell film just, so the artificial crystalline lens of the present invention will have better biocompatibility; The hydrophilic of α-pi-allyl glucoside also can alleviate relevant with the front surface after surgery complication of the artificial crystalline lens of the present invention in addition; In a word, it has improved existing intraocular lens's postoperative pathological symptom effectively.
Present embodiment intraocular lens's manufacture method is: make crystalline lens with hydrophobic transparent polymer material earlier, and place dehydrated alcohol to soak 24h this lens optic and loop, then in ultrasonic washing instrument, clean, use tri-distilled water rinsing, immersion then, and behind vacuum drying, evenly be coated with one deck α-pi-allyl glucoside monomer at its outer surface, again it is placed plasma generator, within it after the polymerization, the rinsing of reuse tri-distilled water, soak 72h, last vacuum drying, pack.Situation can see from Fig. 5 that plasma generator is elongate tubular when the intraocular lens used in plasma generator, and transparent crystalline lens 1 is positioned on the interior supporting plate of generator and between yin, yang two electrodes; After the energized, vacuum pump make gas from upper right pipe suck, the pipe in left side extracts out.Its power is that 600w, radio frequency are 13.5kHz, gas is that nitrogen (also can be air), gas pressure are 20-60Pa in it.Tri-distilled water is meant the water of continuous still three times, and it is in order to remove unpolymerized α-pi-allyl glucoside monomer in this example.
In the above-mentioned manufacture process, can be according to the different materials of lens optic, be chosen at the required different time of cleaning in the ultrasonic washing instrument, in plasma generator polymeric different time, the former chooses in the time range of 1-3min; The latter then chooses in the time range of 1-60min.The material of lens optic is to adopt weak hydrophobic polymethyl methacrylate, because of it is a kind of product comparatively widely, and the polymethyl methacrylate of heparinization, in clinical observation, has higher biocompatibility, can alleviate the macrophage deposition, anterior chamber's scintillation, posterior synechia, symptoms such as corneal endothelium toxic reaction and anterior capsule muddiness, and behind this modification technology, can make it reach the biocompatibility similar to the polymethyl methacrylate of heparinization.
The intraocular lens of embodiment 2. present embodiments is identical with embodiment 1, with the embodiment 1 different method of being.The part that its method is different is: the crystalline lens that disposes in plasma generator directly immerses α-pi-allyl glucoside aqueous solution of 0.2g/ml, and under 60-70 ℃ temperature water-bath 24h, make α-pi-allyl glucoside monomer-grafted in polymethyl methacrylate artificial intraocular lenses's surface; After this, it is put into airtight tube and carry out water-bath; Put into tri-distilled water after the water-bath again and soak 72h,, carry out vacuum drying at last again, and after drying, pack at once to remove unpolymerized α-pi-allyl glucoside monomer.
Different is for the intraocular lens of embodiment 3. present embodiments and embodiment 1: the intraocular lens with α-monomeric molecular layer of pi-allyl glucoside, only be distributed on whole outer surfaces of the front surface of lens optic and loop.Its rear surface still keeps its hydrophobicity, to alleviate the complication relevant with its postoperative and rear surface.
The difference of the method for present embodiment method and embodiment 1 and embodiment 2 is: it is before placing the plasma generator polymerization, the miniature masking device 4 that can clamp the intraocular lens is installed in this plasma generator earlier, the central area of lens optic front surface can be covered in this device top, intraocular lens's whole rear surface has been covered in the bottom, so that can not handle because of being capped in modification this central area and rear surface, so make the intraocular lens who makes only on the circumferential annular face of front surface, form hydrophilic monomer molecule layer, and central area and rear surface still keep the original hydrophobicity of intraocular lens.The scope of its central area can be that diameter is the disc of 2-4mm.
Claims (10)
1, the intraocular lens of a kind of α-pi-allyl glucoside finishing, it includes the lens optic (1) and the loop (2) of hydrophobic material, it is characterized in that: the outer surface at lens optic and loop all has α-monomeric molecular layer of pi-allyl glucoside (3).
2, intraocular lens according to claim 1 is characterized in that: said α-monomeric molecular layer of pi-allyl glucoside (3) only is distributed on whole outer surfaces of the front surface of lens optic (1) and loop (2).
3, intraocular lens according to claim 1 is characterized in that: said α-monomeric molecular layer of pi-allyl glucoside (3) only is distributed on the full surface of peripheral ring surface of lens optic front surface (1) and loop (2).
4, according to claim 1 or 2 or 3 described intraocular lenss, it is characterized in that: the hydrophobic material of said lens optic is a polymethyl methacrylate.
5, the intraocular lens's of a kind of α according to claim 1-pi-allyl glucoside finishing manufacture method is: make the intraocular lens with hydrophobic transparent polymer material earlier, and place dehydrated alcohol to soak 24h this lens optic and loop, then in ultrasonic washing instrument, clean 1-3min, after this rinsing in tri-distilled water, immersion, and vacuum drying; After the drying, evenly be coated with one deck α-pi-allyl glucoside monomer, place plasma generator to carry out polymerization this intraocular lens then on its surface; The polymeric time is 1-60min, after finishing, polymerization takes out, and in tri-distilled water, soak 72h again, to remove unpolymerized α-pi-allyl glucoside monomer, thereby the outer surface that makes lens optic and loop all has the artificial crystalline lens of the present invention of α-monomeric molecular layer of pi-allyl glucoside, carry out vacuum drying at last, and after drying, pack.
6, the intraocular lens's of α according to claim 5-pi-allyl glucoside finishing manufacture method, it is characterized in that: the said coating after α-the monomeric intraocular lens of pi-allyl glucoside disposes in plasma generator, directly immerse in α-pi-allyl glucoside aqueous solution of 0.2g/ml, and under the temperature of (60-70) ℃ water-bath 24h, α-pi-allyl glucoside is grafted on intraocular lens's the outer surface; Put into tri-distilled water after the water-bath again and soak 72h,, carry out vacuum drying at last again, and after drying, pack at once to remove unpolymerized α-pi-allyl glucoside monomer.
7, according to claim 5 or 6 described intraocular lenss' manufacture method, it is characterized in that: the said painting process that places before the plasma generator, just to being coated with α-pi-allyl glucoside monomer on the front surface of lens optic and the loop.
8, manufacture method according to the described intraocular lens of claim 5, it is characterized in that: scribbled α-monomeric intraocular lens of pi-allyl glucoside before putting into plasma generator, the miniature masking device (4) that can clamp the intraocular lens is installed in this plasma generator earlier, this device covers the central area of lens optic front surface with its top, intraocular lens's whole rear surface has been covered in the bottom, so that can not handle because of being capped in modification this central area and rear surface, so make the intraocular lens who makes only on the circumferential annular face of front surface, form hydrophilic monomer molecule layer, and central area and rear surface still keep the original hydrophobicity of intraocular lens.
9, according to the intraocular lens's of claim 5 or 6 or 8 described α-pi-allyl glucoside finishing manufacture method, it is characterized in that: the hydrophobic material of said lens optic is a polymethyl methacrylate.
10, the intraocular lens's of α according to claim 7-pi-allyl glucoside finishing manufacture method, it is characterized in that: the hydrophobic material of said lens optic is a polymethyl methacrylate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03129205 CN1200739C (en) | 2003-06-10 | 2003-06-10 | Alpha-allyl glucoside surface modified artifical lens and its making method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03129205 CN1200739C (en) | 2003-06-10 | 2003-06-10 | Alpha-allyl glucoside surface modified artifical lens and its making method |
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| Publication Number | Publication Date |
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| CN1460524A true CN1460524A (en) | 2003-12-10 |
| CN1200739C CN1200739C (en) | 2005-05-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 03129205 Expired - Lifetime CN1200739C (en) | 2003-06-10 | 2003-06-10 | Alpha-allyl glucoside surface modified artifical lens and its making method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100344269C (en) * | 2005-06-09 | 2007-10-24 | 浙江大学医学院附属第二医院 | Flexible artificial crystalline lens with phospholipin surface finish and manufacturing method thereof |
| CN104352289A (en) * | 2014-10-27 | 2015-02-18 | 浙江大学 | Intraocular lens loaded with drug slow-releasing thin layers on loop surfaces |
| WO2017017243A1 (en) * | 2015-07-30 | 2017-02-02 | Centre National De La Recherche Scientifique | Novel method for the polymerisation of sugars |
-
2003
- 2003-06-10 CN CN 03129205 patent/CN1200739C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100344269C (en) * | 2005-06-09 | 2007-10-24 | 浙江大学医学院附属第二医院 | Flexible artificial crystalline lens with phospholipin surface finish and manufacturing method thereof |
| CN104352289A (en) * | 2014-10-27 | 2015-02-18 | 浙江大学 | Intraocular lens loaded with drug slow-releasing thin layers on loop surfaces |
| WO2017017243A1 (en) * | 2015-07-30 | 2017-02-02 | Centre National De La Recherche Scientifique | Novel method for the polymerisation of sugars |
| FR3039548A1 (en) * | 2015-07-30 | 2017-02-03 | Centre Nat De La Rech Scient (C N R S) | NEW PROCESS FOR POLYMERIZING SUGARS |
| CN107922511A (en) * | 2015-07-30 | 2018-04-17 | 国家科学研究中心 | New method for sugar polymerization |
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| Publication number | Publication date |
|---|---|
| CN1200739C (en) | 2005-05-11 |
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Granted publication date: 20050511 |