CN1456215A - Preparing method for nourishing stomach pills - Google Patents
Preparing method for nourishing stomach pills Download PDFInfo
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- CN1456215A CN1456215A CN 03118495 CN03118495A CN1456215A CN 1456215 A CN1456215 A CN 1456215A CN 03118495 CN03118495 CN 03118495 CN 03118495 A CN03118495 A CN 03118495A CN 1456215 A CN1456215 A CN 1456215A
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- volatile oil
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- yangweishu
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Abstract
A Chinese medicine "Yangweishu tablet" for nursing stomach is prepared from 11 Chinese-medicinal materials through pulverizing them except dodder seed, decocting or steaming twice to collect volatile oil, mixing voltaile oil, cyclodextrin and alcohol, concentrating the decoction or steaming liquid and spray drying, mixing all together, adding additive, tabletting and coating.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine tablet, relates in particular to the preparation method of YANGWEISHU sheet.
Background technology
Tablet is a kind of pharmaceutical formulation commonly used, according to the relevant drug act of China, changing dosage form needs as a kind of new drug research, and the original dosage form of YANGWEISHU sheet is: yangweishu capsules, and listed China's Drug Standard of Ministry of Public Health of the Peoples Republic of China (in " Chinese traditional patent formulation preparation " the 13) in.The technology features of former dosage form is that whole medical materials (ten simply) decocting in the prescription boils two decoction liquor of taking second place and is condensed into thick paste, incapsulates after drying.Volatile ingredient total loss during its defective is to write out a prescription, and in its quality standard, there is the significant drawbacks that influences quality in the indefiniteness quantitative target.Have significant drawback influence quality based on capsule, we use modern pharmaceutical technology and mirror survey means this product technology are done the improvement of necessity, thereby and the quality of product is carried out overall monitor guarantee that product quality benefits the common people.
Summary of the invention
The purpose of this invention is to provide a kind of preparation method of YANGWEISHU sheet, improve the quality of products, satisfy needs of medical treatment better.
The objective of the invention is such realization:
The preparation method of YANGWEISHU sheet comprises the steps:
One, the prescription of YANGWEISHU sheet is formed:
Radix Codonopsis 187g～374g Pericarpium Citri Reticulatae 157g～314g Rhizoma Polygonati (steaming) 187g～374g
Rhizoma Dioscoreae 187g～374g Rhizoma Zingiberis 76g～152g Semen Cuscutae 187g～374g
The Rhizoma Atractylodis Macrocephalae (stir-fry) 187g～374g Radix Scrophulariae 187g～374g Fructus Mume 233g～466g
Fructus Crataegi 233g～466g Radix Glehniae 187g～374g
Right amount of auxiliary materials is made 1000 altogether.
Its optimum formula is:
Radix Codonopsis 187g Pericarpium Citri Reticulatae 157g Rhizoma Polygonati (steaming) 187g Rhizoma Dioscoreae 187g Rhizoma Zingiberis 76g Herba cuscutae
The sub-187g Rhizoma Atractylodis Macrocephalae (stir-fry) 187g Radix Scrophulariae 187g Fructus Mume 233g
Fructus Crataegi 233g Radix Glehniae 187g right amount of auxiliary materials is made 1000 altogether.
Two, YANGWEISHU sheet preparation technology
Technology one, ten Herba indigoferae Pseudotinctoriae are cleaned respectively, remove impurity, it is standby to be up to the standards; Except that Semen Cuscutae, all the other ten flavor medicine mixed powders are broken into coarse powder, decoct with water secondary (Semen Cuscutae is decocted a drug wrapped) 1.5 hours for the first time in will writing out a prescription, 1 hour for the second time, collecting decoction filtered, clear liquid is concentrated into the thick paste that relative density is 1.25～1.32 (60 ℃), adds appropriate amount of auxiliary materials, mixing, granulate, drying adds appropriate amount of auxiliary materials mixing, tabletting, coating again, quality inspection, packing promptly.
Technology two, ten Herba indigoferae Pseudotinctoriae are cleaned respectively, remove impurity, it is standby to be up to the standards; Except that Semen Cuscutae, all the other ten flavor medicine mixed powders are broken into coarse powder, decoct with water secondary (Semen Cuscutae is decocted a drug wrapped) 1.5 hours for the first time in will writing out a prescription, 1 hour for the second time, collecting decoction filtered, it is the concentrated solution of 1.05～1.15 (50 ℃) that thin film concentration becomes relative density, and spray drying is collected dried cream powder, add appropriate amount of auxiliary materials, mixing is granulated, drying adds appropriate amount of auxiliary materials mixing, tabletting, coating again, quality inspection, packing promptly.
Technology three, ten Herba indigoferae Pseudotinctoriae are cleaned respectively, remove impurity, it is standby to be up to the standards; Except that Semen Cuscutae, all the other ten flavor medicine mixed powders are broken into coarse powder, add water steaming and decocting (Semen Cuscutae is decocted a drug wrapped) secondary in will writing out a prescription, and it is standby to collect volatile oil; Merge secondary boiled liquid, filter, it is the concentrated solution of 1.05～1.15 (50 ℃) that the clear liquid thin film concentration becomes relative density, spray drying, and it is standby to collect dried cream powder; The volatile oil of collecting becomes the volatile oil alcoholic solution or becomes the cyclodextrin of volatile oil clathrate standby with cyclodextrin inclusion compound with an amount of dissolve with ethanol; Get above-mentioned dried cream powder and add the appropriate amount of auxiliary materials mixing, granulate, drying adds volatile oil alcoholic solution or cyclodextrin of volatile oil clathrate and appropriate amount of auxiliary materials mixing, tabletting, coating, and quality inspection, packing is promptly.
Three, by technology one, two, three prepared coated tablet, be Film coated tablets, its film-coat material all adopts stomach dissolution type film-coat pre-mixing agent (Opadry).
Added adjuvant can be microcrystalline Cellulose, polyvinylpolypyrrolidone, carboxymethylstach sodium, 30 POVIDONE K 30 BP/USP in the prescription
30, any or multiple mixing in the micropowder silica gel, low-substituted hydroxypropyl cellulose, starch, dextrin, magnesium stearate uses.
The technology Chinese crude drug is ground into coarse powder and was generally 5～20 order coarse powder, is preferably 10 order coarse powder.
The extraction of volatile oil in the technology can be extracted fully or with supercritical process with the way of distillation and be extracted.
Cyclodextrin of volatile oil clathrate preparation in the technology, cyclodextrin can be adopted any in beta-schardinger dextrin-or the hydroxyl beta-schardinger dextrin-; The ratio of volatile oil and beta-schardinger dextrin-is 1: 6-15cm/g, optimal proportion are 1: 10 (ml/g); The ratio of volatile oil and hydroxyl beta-schardinger dextrin-is 1: 3-12cm/g, optimal proportion are 1: 5.5 (ml/g).
In the technology one, the relative density of thick paste is 1.25～1.32 (60 ℃), and optimal proportion is 1.28～1.30 (60 ℃).
In the technology two, three, the relative density of concentrated solution is 1.05～1.15 (50 ℃), and best relative density is 1.10 (50 ℃).
In the technology two, three, the spray drying inlet temperature is 100～200 ℃, and leaving air temp is 50～150 ℃, and best inlet temperature is 160 ℃, and leaving air temp is 100 ℃.
Its quality control mainly is discriminating, inspection, three aspects of assay, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi, Pericarpium Citri Reticulatae, Rhizoma Zingiberis, Semen Cuscutae in the prescription is carried out thin layer differentiate; Heavy metal, arsenic salt are carried out limit examine, and be controlled at disintegrate in 10 minutes; Naringin in the Pericarpium Citri Reticulatae is carried out quantitatively.
This invention its superiority compared with the prior art is: production technology more becomes to improving rationally, quality standard improves greatly, makes product that the qualitative, quantitative control method of science be arranged, and makes the quality of product that guarantee arranged.
The specific embodiment
The optimum implementation of this invention is that ten Herba indigoferae Pseudotinctoriae are cleaned respectively, removes impurity, and it is standby to be up to the standards; Except that Semen Cuscutae, all the other ten flavor medicine mixed powders are broken into coarse powder, add water steaming and decocting (Semen Cuscutae is decocted a drug wrapped) secondary in will writing out a prescription, and it is standby to collect volatile oil; Merge secondary boiled liquid, filter, it is the concentrated solution of 1.05～1.15 (50 ℃) that the clear liquid thin film concentration becomes relative density, spray drying, and it is standby to collect dried cream powder; The volatile oil of collecting becomes the volatile oil alcoholic solution or becomes the cyclodextrin of volatile oil clathrate standby with cyclodextrin inclusion compound with an amount of dissolve with ethanol; Get above-mentioned dried cream powder and add the appropriate amount of auxiliary materials mixing, granulate, drying adds volatile oil alcoholic solution or cyclodextrin of volatile oil clathrate and appropriate amount of auxiliary materials mixing, tabletting, coating, and quality inspection, packing is promptly.
Claims (1)
1, the preparation method of YANGWEISHU sheet is characterized in that it may further comprise the steps:
(1) ten flavor medicines employings except that Semen Cuscutae were ground into 5-20 order coarse powder in the prescription, and the best is that to be ground into 10 purpose coarse powder standby.
(2) Semen Cuscutae with standby coarse powder and other cloth bag decocts/steaming and decocting.
(3) the secondary decocting boil/collect volatile oil in the secondary water digestion process, it is that the thick extractum/secondary water boiling liquid of 1.28～1.30 (60 ℃) is condensed into relative density 1.10 fluid extracts that the secondary water decoction is condensed into relative density, it is standby to be spray dried to dried cream powder.
(4) it is standby that the volatile oil employing cyclodextrin of collecting in the prescription is made the cyclodextrin of volatile oil clathrate.
(5) volatile oil of collecting in the prescription adopts an amount of dissolve with ethanol to become the volatile oil alcoholic solution standby.
(6) added adjuvant can be microcrystalline Cellulose, polyvinylpolypyrrolidone, carboxymethylstach sodium, 30 POVIDONE K 30 BP/USP in the prescription
30, any/multiple mixing in the micropowder silica gel, low-substituted hydroxypropyl cellulose, starch, dextrin, magnesium stearate uses.
(7) coating material of tablet adopts stomach dissolution type film-coat pre-mixing agent (Opadry).
(8) (1), (2), (3), (4), (5), (6), (7) standby composition are fed intake by national standard prescription consumption, mixing, tabletting, coating are made the YANGWEISHU sheet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118495 CN1456215A (en) | 2003-01-16 | 2003-01-16 | Preparing method for nourishing stomach pills |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118495 CN1456215A (en) | 2003-01-16 | 2003-01-16 | Preparing method for nourishing stomach pills |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1456215A true CN1456215A (en) | 2003-11-19 |
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ID=29411308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03118495 Pending CN1456215A (en) | 2003-01-16 | 2003-01-16 | Preparing method for nourishing stomach pills |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1456215A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102805186A (en) * | 2012-07-27 | 2012-12-05 | 蚌埠丰润食品有限公司 | Hawthorn stomach-invigorating lollipop |
-
2003
- 2003-01-16 CN CN 03118495 patent/CN1456215A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102805186A (en) * | 2012-07-27 | 2012-12-05 | 蚌埠丰润食品有限公司 | Hawthorn stomach-invigorating lollipop |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |