CN1452937A - Three-wavelength celebral tissue blood oxygen content monitor - Google Patents
Three-wavelength celebral tissue blood oxygen content monitor Download PDFInfo
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- CN1452937A CN1452937A CN 02115760 CN02115760A CN1452937A CN 1452937 A CN1452937 A CN 1452937A CN 02115760 CN02115760 CN 02115760 CN 02115760 A CN02115760 A CN 02115760A CN 1452937 A CN1452937 A CN 1452937A
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Abstract
The three-wavelength cerebral tissue blood oxygen content monitor is one instrument for non-destructive optical monitoring of the blood oxygen content in cerebral tissue. The monitor consists of probe part, analogue circuit part and microcomputerized processing system. It features that in the probe part, the two light beams from two light sources irradiate cerebral tissue alternately; after scattering of the cerebral tissue, three single-wavelength light beams of different wavelengths are received via three optical filters and optoelectronically converted into electric signals; and the electric signals are fed to the analogue circuit part and microcomputerized processing system successively for automatic processing. The instrument has the functions of remote and real-time monitoring, storing, printing and reporting the cerebral tissue blood oxygen content information and may be used as one clinical wardship instrument.
Description
The invention belongs to Medical Instruments and detection method in the biomedical engineering field.
The patient of the M-C focal disease of brain, its pathological changes basis is closely related with relative blood, the oxygen content variation of cerebral hemispheres tissue, and its running parameter both can reflect the course of disease of disease and lapse to, and also can point out the doctor in time to formulate the rescue scheme.
One. characteristics of the present invention are: utilize the near infrared spectrum zone light absorption characteristics (as Fig. 1) of each wave band Oxygenated blood red eggs white (HbO2) and deoxyhemoglobin (Hb) in 550nm-805nm and 805nm-1000nm scope respectively, surveying with near infrared light three-wavelength noinvasive triage on the basis of blood oxygen of brain content, develop specific light detection probe, set up the relatively computing formula of the relative blood of two cerebral hemispheres, oxygen content, long-range, as to monitor and store, report, transmit patient's cerebral tissue in real time oxygen content information.
(1) according to the blood changes of contents and the low oxygen containing feature of focal focus, monitors brain blood, oxygen content with the method that compares two cerebral hemisphere oxygen content.Fig. 1 is Oxygenated blood red eggs white (HbO2) and deoxyhemoglobin (Hb) the absorption curve figure to the 500nm-1200nm near infrared light, and its cross point is about 805nm.The computing formula of blood, oxygen evaluation criterion is as follows: A. blood cubage formula
A. the Ipsilateral height contains blood k
1I
Suffer from 805-x+ k
2I
Suffer from 805+y+ I
Suffer from 805＜k
1I
Strong 805-x+ k
2I
Strong 805+y+ I
Strong 805
Δ OD＜-the low blood k that contains of 0.05b. Ipsilateral
1I
Suffer from 805-x+ k
2I
Suffer from 805+y+ I
Suffer from 805＞k
1I
Strong 805-x+ k
2I
Strong 805+y+ I
Suffer from 805
Δ OD＞0.035B. oxygen content computing formula a. Ipsilateral anoxia
B. the Ipsilateral oxygen content is normal
I value in the above formula is receiving light power.X, Y are natural number, and X should be less than 245 greater than 5, and Y should be less than 200 greater than 5,
Wherein: I suffers from 805-x: be illustrated in Ipsilateral 805-X place receiving light power and handle the signal of telecommunication that obtains through analogue circuit
I suffers from 805+y: be illustrated in Ipsilateral 805+Y place receiving light power and handle the signal of telecommunication that obtains through analogue circuit
I is good for 805-x: be illustrated in strong side 805-X place receiving light power and handle the signal of telecommunication that obtains through analogue circuit
T is good for 805+y: be illustrated in strong side 805+Y place receiving light power and handle the signal of telecommunication that obtains through analogue circuit
According to computing formula, (1) Ipsilateral cerebral anoxia
(2) Ipsilateral cerebral ischemia Δ OD＞0.035 (3) Ipsilateral cerebral blood stasis Δ OD＜-0.09
Two. apparatus structure
The present invention selects 805nm and above and following each wavelength development instrument of 805nm, the instrument primary structure as shown in Figure 2, the probe segment input, select tungsten lamp as the ripple wideband light source, form single wavelength receptor jointly by photodiode and wave filter, signal enters after the instrument, enters analog circuit that difference-anti-phase-three grades of low passes of homophase are amplified, amplification is adjustable and is input to microcomputer through A/D converter and carries out full automatic treatment, and power supply is designed to the instrument power supply.
This three-wavelength cerebral tissue blood, oxygen content monitor are made up of probe segment, analogue circuit part and microprocessor system, it is characterized in that:
A. probe segment: by light source voltage frequency controller 28 by alternately providing noinvasive light source (1), (2) by micro-processor controlled electrical switch 29, the light that send light source (1), (2) is through biological tissue's scattering, accept single wavelength light of three kinds of different wave lengths respectively by three groups of optical filters (3), (4), (5), these three kinds single wavelength light signals become the signal of telecommunication through opto-electronic conversion (6), (7), (8), deliver to artificial circuit part after amplifying:
B. artificial circuit part: three road signals of telecommunication by probe segment output send differential amplifier circuit (13) to disturb with filtering common mode disturbances, ambient light, eliminate the uneven influence that the back level is handled on three road signals of probe and lead, a high input impedance is provided simultaneously; Through the gain of secondary low pass amplifying circuit (14), (15), (16) conditioning signal, frequency band is selected in below the 40HZ then, after secondary low-pass filtering (17), (18), (19) filtering 50HZ interfering signal, signal is delivered to microprocessor system again.
Further feature of the present invention is that described two kinds of single wavelength light wavelengths except that 805nm are 550-805nm and 805-1000nm scope, and for example can select two kinds of single wavelength light wavelengths for use is 770nm and 875nm.
Further feature of the present invention is: the structure of described probe segment is made up of three cavitys of separating mutually, be respectively arranged with the noinvasive light source, this noinvasive light source can be selected the electric filament lamp of the 960mW of 3.5mm for use, the optical filter of 805nm, the optical filter of 875nm, the optical filter of 770nm posts optical-electrical converter 6,7,8 at the back side of three tablet filters, the probe segment front should coincide with tested position skin surface.
Below in conjunction with accompanying drawing embodiments of the invention are described further.
Fig. 1 is the absorption curve of the white and deoxyhemoglobin of Oxygenated blood red eggs to the 500nm-1200nm near infrared light.
Fig. 2 is circuit theory diagrams of the present invention
Fig. 3 is the structural representation of probe segment
Fig. 4 is a light source voltage frequency control circuit schematic diagram
See also Fig. 2, microprocessor system is partly adopted in digital processing, three road A/D conversion 20 links to each other with artificial circuit part, and signal sent into PC microcomputer 22, microcomputer 22 has regular display 24 and laser printer 21, accept the control of keyboard 23 simultaneously, result of calculation is read or is write from memorizer 25.
Probe segment, mainly by noinvasive light source 1,2,770nm optical filter 3,875nm optical filter 4,805nm optical filter 5, optical-electrical converter 6,7,8 and high power are amplified 9,10,11 and are formed.Wherein do not have the wound light source and can select the 960mW electric filament lamp of Ф 3.5mm for use, and the luminous voltage of lamp and frequency are controlled by the light source voltage frequency control circuit, 770nm optical filter 3,875nm optical filter 4,805nm optical filter 5 is connected with optical-electrical converter 6,7,8 respectively, optical-electrical converter 6,7,8 is connected with amplifier 9,10,11, the common circuit of forming probe, and circuit is hidden in the back side of optical filter.Signal was as Fig. 3 below probe was outside, was attached to when testing on the skin when following, can isolate the interference of ambient light at its peripheral jut, and intermediary jut can be isolated the direct effect of light source to optical filter, to the back side thorough seal of popping one's head in.
Principle based on the dual wavelength detection: artificial circuit part mainly amplifies 13, three road secondary low passes by difference and amplifies 14,15,16, and three road secondary low-pass filtering 17,18,19 constitute.Difference amplification 13 links to each other with probe by 9 core flat conductors 12, and the signal of telecommunication of coming in popping one's head in send difference to amplify 13, amplify 14,15,16 through the secondary low pass then, send into microprocessor system through secondary low-pass filtering 17,18,19 again and carry out digital processing.
The light source voltage FREQUENCY CONTROL partly sees also Fig. 4: described probe segment, produce the clock pulses of the square wave of frequency adjustable by square-wave generator 1 as frequency divider 2 and 3, frequency divider 2 is sent to clock square wave frequency division later on the drive circuit 4 of bulb, the pulse voltage that modulating voltage drive circuit 4 output amplitudes are adjustable, this pulse voltage is luminous by single-pole double throw electrical switch 5 rear drive bulbs, and the square-wave signal behind frequency divider 3 frequency divisions controls bulb A by the switching direction of control single-pole double throw electrical switch 5 and bulb B is alternately luminous.
In sum: the detailed operation principle of the present invention is as follows: probe is placed patient's forehead optical filter position alignment nose center line, probe flat eyebrow peak, lower edge, fix it, light source 1,2 light is through tissue scatter and reflection, through 760nm optical filter 3,805nm optical filter 4 and 860nm optical filter 5, produce three single wavelength light, through photovoltaic converter 6,7,8, produce the three road faint signals of telecommunication, amplify 9 through high power again, 10,11, through lead 12 signal of telecommunication is sent into difference and amplify 13, simultaneously its light source 1,2 voltage and pulse frequency are accepted the control of light source voltage FREQUENCY CONTROL 28 circuit.Difference amplification 13 makes that problems such as the resistance of probe segment is inaccurate, the imbalance of lead, long line adding noise are solved preferably.Amplify 13 through difference simultaneously and remove common mode disturbances, enter the secondary low pass and amplify 14,15,16, the Gain Adjustable that the secondary low pass is amplified, to adapt to specific human needs, and the frequency band that the secondary low pass is amplified is selected in below the 40HZ, can remove the interference of 50HZ and improve the reliability of instrument work, signal after the amplification is through secondary low pass filter 17,18,19 filtering, microcomputer 22 controls three road A/D converters 20 carry out A/D conversion and sampling, sampled result is sent into microprocessor system carry out data analysis, calculate, and the result is shown that in display 24 user can pass through keyboard 23, under the control of microcomputer 20, the result is preserved.Whole calculating is to finish automatically under the programme-control of microcomputer 20 fully.
The present invention is through hospital general, Wuhan, the military region, Guangzhou clinical trial certificate. Have following advantage:
1. there is not wound. It contacts with human body only has the probe optical filter, contact portion to human body do not have any electromagnetism, Mechanical damage, its light source voltage can injured skin and human tissue organs below 800MW;
2. accuracy rate height. Adopt two light source list probes alternately to detect bilateral brain brain blood, oxygen parameter, illumination frequently Rate is 2Hz, can wait to be considered as the bilateral brain and to shine synchronously sampling, avoided brain moment blood oxygen to change and the probe gradation solid Surely the sampling error that causes adopts the microcomputer automatical analysis to process simultaneously, and disposable automatic generation analysis result is got rid of The subjectivity error of subjective diagnosis, accuracy rate of diagnosis is improved;
3. brain blood oxygen Waveform Input microcomputer is analyzed, with the oxygen content of blood and blood oxygen wave form varies twice ginseng Number monitor cerebral blood oxygen has it to arrive part than the unexistent Independence of other brain blood oxygen detection, has improved the accuracy of instrument;
4. "dead" infringement. Adopt inky, optical source wavelength owing to act on the optical signal of human body In the 550nm-1000nm scope, work, to the "dead" infringement of human body;
5. cheap, easy to use, can be used as the monitoring of brain tissue blood, oxygen content and brain tumor generaI investigation Instrument.
Claims (6)
1, this three-wavelength cerebral tissue blood, the oxygen content monitor is made up of probe segment, analogue circuit part and microprocessor system, it is characterized in that:
A. probe segment: by light source voltage frequency controller 28 by alternately providing noinvasive light source (1), (2) by micro-processor controlled electrical switch 29, the light that send light source (1), (2) is through biological tissue's scattering, accept single wavelength light of three kinds of different wave lengths respectively by three groups of optical filters (3), (4), (5), these three kinds single wavelength light signals become the signal of telecommunication through opto-electronic conversion (6), (7), (8), deliver to artificial circuit part after amplifying.
B. artificial circuit part: three road signals of telecommunication by probe segment output send differential amplifier circuit (13) to disturb with filtering common mode disturbances, ambient light, eliminate the uneven influence that the back level is handled on two paths of signals of probe and lead, a high input impedance is provided simultaneously; Through the gain of secondary low pass amplifying circuit (14), (15), (16) conditioning signal, frequency band is selected in below the 40HZ then, after two utmost point low-pass filtering (17), (18), (19) filtering 50HZ interfering signal, signal is delivered to microprocessor system again.
2. require described three-wavelength cerebral tissue blood according to right 1, the oxygen content monitor is characterized in that described 805nm and other two kinds single wavelength light wavelengths are 500-805nm and 805-1000nm scope,
3. require described three-wavelength cerebral tissue blood according to right 2, the oxygen content monitor is characterized in that described three kinds of light wavelengths are 770nm, 805nm and 875nm.
4. require described three-wavelength cerebral tissue blood according to right 1 or 2, the oxygen content monitor is characterized in that: described probe segment, produce the clock pulses of the square wave of frequency adjustable by square-wave generator 1 as frequency divider 2 and 3, frequency divider 2 is sent to clock square wave frequency division later on the drive circuit 4 of bulb, the pulse voltage that modulating voltage drive circuit 4 output amplitudes are adjustable, this pulse voltage is luminous by single-pole double throw electrical switch 5 rear drive bulbs, and the square-wave signal behind frequency divider 3 frequency divisions controls bulb A by the switching direction of control single-pole double throw electrical switch 5 and bulb B is alternately luminous.
5. require described three-wavelength cerebral tissue blood according to right 1 or 2, the oxygen content monitor is characterized in that: the structure of described probe segment is made up of three cavitys of separating mutually, be respectively arranged with the noinvasive light source, this noinvasive light source can be selected the electric filament lamp of the 800mw of 3.5mm for use, the optical filter of 805nm, the optical filter of 875nm, the optical filter of 770nm, post optical-electrical converter 6,7,8 at the back of the body of three tablet filters, the probe segment front should coincide with tested position skin surface.
6. require described three-wavelength cerebral tissue blood, oxygen content monitor it is characterized in that according to right 1 or 2: the computing formula of the blood oxygen evaluation criterion after analog circuitry processes is as follows:
A. blood cubage formula
A. the Ipsilateral height contains blood I
Suffer from 805+ k
1I
Suffer from 805-x+ k
2I
Suffer from 805+y＜I
Strong 805+ k
1I
Strong 805-x+ k
2I
Strong 805+y
Δ OD＜-the low blood I that contains of 0.05h. Ipsilateral
Suffer from 805+ k
1I
Suffer from 805-x+ k
2I
Suffer from 805+y＞I
Strong 805+ k
1I
Strong 805-x+ k
2I
Strong 805+y
Δ OD＞0.035B. oxygen content computing formula a. Ipsilateral anoxia
B. the Ipsilateral oxygen content is normal
I value in the above formula is receiving light power.X, Y are natural number,
Wherein:
I suffers from 805-x: be illustrated in Ipsilateral 805-X place receiving light power and handle the signal of telecommunication that obtains through analogue circuit
I suffers from 805+Y: be illustrated in Ipsilateral 805+Y place receiving light power and handle the signal of telecommunication that obtains through analogue circuit
I is good for 805-x: be illustrated in strong side 805-X place receiving light power and handle the signal of telecommunication that obtains through analogue circuit
I is good for 805+Y: be illustrated in strong side 805+Y place receiving light power and handle the signal of telecommunication that obtains through analogue circuit
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02115760 CN1239125C (en) | 2002-04-26 | 2002-04-26 | Three-wavelength celebral tissue blood oxygen content monitor |
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|---|---|---|---|
| CN 02115760 CN1239125C (en) | 2002-04-26 | 2002-04-26 | Three-wavelength celebral tissue blood oxygen content monitor |
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| CN1452937A true CN1452937A (en) | 2003-11-05 |
| CN1239125C CN1239125C (en) | 2006-02-01 |
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|---|---|---|---|
| CN 02115760 Expired - Fee Related CN1239125C (en) | 2002-04-26 | 2002-04-26 | Three-wavelength celebral tissue blood oxygen content monitor |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579021A (en) * | 2012-02-13 | 2012-07-18 | 叶继伦 | System and method for measuring pulse blood oxygen |
| CN104382604A (en) * | 2014-12-02 | 2015-03-04 | 重庆名希医疗器械有限公司 | Noninvasive brain blood oxygen parameter measuring method |
| WO2015161687A1 (en) * | 2014-04-24 | 2015-10-29 | 辛勤 | Method for measuring blood oxygen saturation and portable device |
-
2002
- 2002-04-26 CN CN 02115760 patent/CN1239125C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579021A (en) * | 2012-02-13 | 2012-07-18 | 叶继伦 | System and method for measuring pulse blood oxygen |
| WO2015161687A1 (en) * | 2014-04-24 | 2015-10-29 | 辛勤 | Method for measuring blood oxygen saturation and portable device |
| CN104382604A (en) * | 2014-12-02 | 2015-03-04 | 重庆名希医疗器械有限公司 | Noninvasive brain blood oxygen parameter measuring method |
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| Publication number | Publication date |
|---|---|
| CN1239125C (en) | 2006-02-01 |
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Address after: 430074 hi tech medical apparatus Park, No. 818, hi tech Avenue, East Lake New Technology Development Zone, Hubei, Wuhan Province, B8-A4, B4, C4 Patentee after: Wuhan sea digital medical Polytron Technologies Inc Address before: Building 2903A room 430072 rich Hubei province Wuhan Wuluo Road No. 717 MB Patentee before: Wuhan E-Sea Digital Engineering Co., Ltd. |
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Granted publication date: 20060201 Termination date: 20200426 |
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