CN1450118A - Process for preparing medical polyacrylamide aquogel - Google Patents
Process for preparing medical polyacrylamide aquogel Download PDFInfo
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- CN1450118A CN1450118A CN 02116547 CN02116547A CN1450118A CN 1450118 A CN1450118 A CN 1450118A CN 02116547 CN02116547 CN 02116547 CN 02116547 A CN02116547 A CN 02116547A CN 1450118 A CN1450118 A CN 1450118A
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- aquogel
- polyacrylamide
- medical
- hydrogel
- acrylamide monomer
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Abstract
The preparation method of medical polyacrylamide aquogel is characterized by that according to the medical application of aquogel, specially to the application of internal damaged region to be filled with said aquogel and special requirements of acrylamide monomer low residue in said aquogel said invention uses organic solvent to extract the aquogel obtained when the polymerization reaction is completed, at the same time uses ultrasonic wave to make radiation so as to quickly and competely remove the acrylamide monomer from it so as t obtain the invented medical polyacrylamide aquogel.
Description
Technical field:
The present invention relates to a kind of high molecular polymer, particularly a kind of hydrogel that can be used as medical uses such as human body packing material.
Technical background:
Cross-linked polyacrylamide gel uses as medical material one section development course.Comparatively sophisticated use-pattern is useful on various electrophoresis processes, as English Patent 4746551; Coated material is as German Patent 1594389.
In the last few years, this hydrogel was filled in the human body defect as the shaping and beauty material, by extensive concern.As Chinese patent 94195147, English Patent 2164343A.As this kind purposes, the product of having got permission to use at home has from " the hero Er Fale " of Ukraine and " Elipten AG " of domestic production.
Those skilled in the art knows that polyacrylamide hydrophilic gel is used for medical, and is particularly as repair materials in the human body, very strict to the content requirement that has Cytotoxic acrylamide monomer in the hydrogel.Existing standard is to be lower than 10 of the gel weight of using
-6But only finish Chinese patent 99116009 and 94195147 hydrogels for the normally used polymerization process of representative are not reach this requirement far away.The monomer content of this moment is generally 5 * 10
-4, i.e. 5/1000ths " water-soluble polymers " (chemical industry press 1998 publish the 140th page).Yet at some documents, though comprise that all calling oneself what provide in the above-mentioned patent documentation is medical hydrogel of polyacrylamide, the manufacturing processed that provides terminates in polyreaction and finishes.All do not provide and finally reach the complete technical scheme that can be used as the curable product grade.Although after aforesaid English Patent and German Patent have been put down in writing polyreaction and finished, wash resulting hydrogel with water, in actual production and infeasible.It is all clear to set foot in the person skilled in art, and when polyreaction finished, what obtain was not have mobile solid colloid material.If this colloid is soaked again, also to inhale some water and continue swellings, though and final density loss, but still be can not the mobile colloid.Water can not enter and flows out colloid in the mobile mode.Certainly just be with the intravital monomer of not plastic emitting.Why the method that is soaked in water can make hydrogel inner propene amide monomer reduce to some extent, is because colloid is under water, for remaining monomer in the colloid provides the place by the balanced diffusion of molecular motion.It is a kind of remaining monomer disengaging colloidal condition that helps.But this process is extremely slow, wants to make the product after the polymerization reach medical standard with this kind means, and flushing several times or can take effect in tens hours anything but.This is nonsensical in actual production.
Summary of the invention:
The objective of the invention is to provide and a kind ofly remove the method that has neither part nor lot in the polymeric acrylamide monomer in the polyacrylamide hydrophilic gel, thereby obtain a kind of complete preparation process of medical cross-linked polyacrylamide gel.
Technical scheme of the present invention is: will in the prior art be monomer and linking agent commonly used with the acrylamide, and initiator, the hydrogel after the distilled water polyreaction adds organic solvent extraction and uses the ultrasonic wave radiation simultaneously.Aforesaid organic solvent can be methyl alcohol, ethanol, acetone etc., first-selection ethanol.
Positively effect of the present invention is: can be fast and remove acrylamide monomer more up hill and dale, obtain the polyacrylamide hydrophilic gel product of medical quality at an easy rate.Analyzing after tested to make the acrylamide monomer content in the hydrogel reduce to 10
-7Below.Be equivalent to allow below 1/10th of medical residual quantity, compare by analysis, removing monomeric speed is 50 times that wash.
The physical and chemical index of products obtained therefrom of the present invention is:
(1) outward appearance: transparent, colourless gel, the outer impurity of nothing.
(2)PH： 7-7.5。
(3) heavy metal Pb content 0.04PPM.
(4) refractive index: 1.3375-1.3385.
(5) chemical structure is identified: cross-linked polyacrylamide (IR)
(6) remaining acrylamide monomer content range: 0.0000016%-0.000002%
(7) thermostability: 300 ℃.(DSC differential thermal analysis).
(8) chemical stability: after boiling water boiled, IR identified that chemical structure does not change.
(9) oxidation capacity: maximum 0.2mg/ rises O2.
(10) bromination ability: maximum 0.1mg/ rises Br.
As for the animal and the clinical experiment of this hydrogel, existing document record is as Chinese patent 94195147.The resulting the finished product of method that adopt because of the present invention have the people of chemical knowledge can not think other chemical reactions are arranged and produce undesirable substance slightly again.Therefore can be with approved pharmacological evaluation process and result in existing other documents as the medical foundation of product of the present invention, as the drug study content in the Chinese patent 94195147.Therefore, the present invention can take length no longer for this reason.
Embodiment:
With 25 gram acrylamides, 18 milliliter 1% N, the trolamine aqueous solution of the N-ethylene bisacrylamide aqueous solution and 8 milliliter 1% mixes in one liter of reaction flask, impurity screening, add 10 milliliter 0.5% the Ammonium Persulfate 98.5 aqueous solution and 04% aqueous solution of sodium bisulfite then, add aseptic redistilled water, make cumulative volume reach 982 milliliters, removed deoxidation in logical nitrogen 10-20 minute, under 2.5-30 ℃, insulation reaction 20-24 hour, just obtain containing the gel of 2.5% cross-linked polyacrylamide.Add 3 liters of left and right sides concentration then and be about 70% ethanolic soln in the container of dress hydrogel, use wavelength 40KHZ simultaneously, ethanolic soln is changed in the ultrasonic radiation of power 100W 40 minutes during this period 3-4 time.Water in the treating processes in the hydrogel is sucked out gradually, and the polyacrylamide molecular contraction finally becomes the powdery precipitation.Leach powder, get the dry product polyacrylamide, can add water-soluble expanding according to the concentration of used hydrogel before using.Just obtain the hydrogel of required usefulness, more than promptly finish enforcement of the present invention.
The present invention in force, the add-on of ethanolic soln can be selected in 1-5 times of scope of colloid volume, if each amount of alcohol added is bigger, changes number of times and can reduce.The ultrasonic wave wavelength can be selected at 20-60KHZ, and power can be selected in the 50-200W scope.Treatment time is selected according to the variation and the purity requirement of above parameters.
Claims (1)
- A kind of preparation method of medical hydrogel of polyacrylamide, comprise in the prior art, with acrylamide monomer and linking agent commonly used, initiator, hydrogel after the distilled water polyreaction is used organic solvent extraction, and uses the ultrasonic wave radiation simultaneously, leach sedimentary polyacrylamide, add the water-soluble medical aquogel that is expanded into according to needed concentration again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02116547 CN1450118A (en) | 2002-04-08 | 2002-04-08 | Process for preparing medical polyacrylamide aquogel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02116547 CN1450118A (en) | 2002-04-08 | 2002-04-08 | Process for preparing medical polyacrylamide aquogel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1450118A true CN1450118A (en) | 2003-10-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02116547 Pending CN1450118A (en) | 2002-04-08 | 2002-04-08 | Process for preparing medical polyacrylamide aquogel |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1300221C (en) * | 2005-01-25 | 2007-02-14 | 天津大学 | Process for preparing rapidly responsive pH sensitive hydrogel |
| CN101864136A (en) * | 2010-06-09 | 2010-10-20 | 中国科学院深圳先进技术研究院 | Ultraphonic elastic imaging body model and preparation method thereof |
| CN101070365B (en) * | 2007-05-22 | 2011-08-31 | 华南理工大学 | N-isopropyl acrylamide thermosensitive aquagel and its microwave radiation preparing method |
| WO2013131215A1 (en) | 2012-03-06 | 2013-09-12 | 中国科学院理化技术研究所 | Polymer micro-needle array chip, preparation process and use thereof |
| CN105754037A (en) * | 2016-04-06 | 2016-07-13 | 深圳市独生物科技有限公司 | Biodegradable cross-linking agent, polyacrylamide hydrogel and preparation method |
| CN112675366A (en) * | 2020-12-28 | 2021-04-20 | 广州市荔湾区人民医院 | Preparation method of holographic six-dimensional delamination Qing Ou Ke Ou stripping solution |
-
2002
- 2002-04-08 CN CN 02116547 patent/CN1450118A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1300221C (en) * | 2005-01-25 | 2007-02-14 | 天津大学 | Process for preparing rapidly responsive pH sensitive hydrogel |
| CN101070365B (en) * | 2007-05-22 | 2011-08-31 | 华南理工大学 | N-isopropyl acrylamide thermosensitive aquagel and its microwave radiation preparing method |
| CN101864136A (en) * | 2010-06-09 | 2010-10-20 | 中国科学院深圳先进技术研究院 | Ultraphonic elastic imaging body model and preparation method thereof |
| CN101864136B (en) * | 2010-06-09 | 2012-01-04 | 中国科学院深圳先进技术研究院 | Ultraphonic elastic imaging body model and preparation method thereof |
| WO2013131215A1 (en) | 2012-03-06 | 2013-09-12 | 中国科学院理化技术研究所 | Polymer micro-needle array chip, preparation process and use thereof |
| CN105754037A (en) * | 2016-04-06 | 2016-07-13 | 深圳市独生物科技有限公司 | Biodegradable cross-linking agent, polyacrylamide hydrogel and preparation method |
| CN112675366A (en) * | 2020-12-28 | 2021-04-20 | 广州市荔湾区人民医院 | Preparation method of holographic six-dimensional delamination Qing Ou Ke Ou stripping solution |
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