CN1438902A - Medicine delivery device with replaceable cooperating moudles and method of making same - Google Patents

Medicine delivery device with replaceable cooperating moudles and method of making same Download PDF

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Publication number
CN1438902A
CN1438902A CN01811782A CN01811782A CN1438902A CN 1438902 A CN1438902 A CN 1438902A CN 01811782 A CN01811782 A CN 01811782A CN 01811782 A CN01811782 A CN 01811782A CN 1438902 A CN1438902 A CN 1438902A
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China
Prior art keywords
module
replaceable
replaceable module
delivery device
user
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CN01811782A
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Chinese (zh)
Inventor
拉尔斯·彼德·克里特莫斯
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Novo Nordisk AS
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Novo Nordisk AS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/12General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/586Ergonomic details therefor, e.g. specific ergonomics for left or right-handed users

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The invention relates to: a medication delivery device and a method of making such a device. The object of the present invention is to provide a handy medication delivery device that may be easily adjusted to the different needs of a given user in different situations and to the different needs of different users, and which is economic from a production point of view. The problem is solved in that it comprises a basis module (1) and one or more replaceable modules (2, 3, 4, 5, 6), each of which is adapted to cooperate mechanically and/or electronically with the basis module to provide a specific function, and the basis module includes resources that are jointly used by the replaceable modules. This has the advantage of providing a rational concept for economically supplying high quality, mass-produced devices capable of being customized to individual users' needs for functionality by avoiding the duplication of key components. The invention may be used in injector type, medication pump type, inhaler or spray type devices for delivering a discrete dose or a continuous dose of a medication to a user.

Description

A kind of delivery device and method for making thereof that has interchangeable synergism module
Technical field
The present invention relates to be used for extremities for medical.
The present invention is specifically related to a kind of delivery device.
The invention still further relates to a kind of method of making delivery device.
Description of Related Art
The people that adopt several conveyer devices to take medicine for often having to, the different choice to treatment under different situations can be easily.
And,, importantly can customize the device that satisfies any potential buyer's needs and hope (comprising the directed function of design more), and obtain scale and benefit simultaneously for the manufacturer of delivery device.
US5,925,021A discloses a kind of delivery device, and it uses microprocessor and display to write down, analyze and manifests the various data that relate to medication management.It provides a kind of single, device of integrating of carrying out multiple function.
WO99/59657A discloses the armarium that a kind of patient of confession is used for carrying out the diabetes autotherapy.Various functional element are linked together in the device of a compactness naturally.During use, each functional element is individually used.
Of the present invention open
The problem of prior art is that these multi-function devices provide than required more function under definite situation, thereby is complicated operation, and has bigger volume and more expensive than necessity, or the like.Comprise that non-synergistic effect that can single use, these devices that health connects individual unit can carry easily, and guarantee to have the necessary function unit, but because these devices have to by mechanical separation and independently operated, so be to use inconvenient.
The purpose of this invention is to provide a kind of delivery device easily, it can be regulated at an easy rate with given user's the different needs and the different needs of different user under the suitable different situations, thereby sees that from the angle of making this is economical.
This can obtain according to the present invention, wherein this device comprises a basic module and one or more replaceable module, in this one or more replaceable module each all is suitable for this basic module machinery and/or electric synergism so that specific function to be provided, and this basic module comprise can be by the common resource of using (resources) of these replaceable modules.
The term that adopts in current context " delivery device " refers to inhaler of a kind of syringe-type device (for example pen-type injector or atomizing syringe) that is used for carrying discontinuous liquid medicine dosage (may with the form of little drop), a kind of drug efflux pump that is used for carrying continuously liquid medicine, a kind of discontinuous or continuous drug dose that is used for carrying gasification or atomizing or powder type etc.
The term that adopts in current context " replaceable module " refers to according to being added in described module on the basic module easily at the needs to user under the stable condition or removing.That is, each replaceable module can exchange mutually with a different replaceable module, and this different replaceable module provides different functions together with basic module.And, pass through it with combined based on same basic module (or some basic modules) from one or more replaceable module of " standard " module collection, the manufacturer of delivery device can make several different devices " model ", and obtains to use the combination interests of building block (or building block) and can it be manufactured in the mode of economy.In addition, because the modular mode of this device of structure, each module all has standard mechanical and (if relevant) electrical interface with basic module and other replaceable module effect, so just can buy the device of minimal structure according to his or she current needs, and subsequently in this way to this device " upgrading " for the user.
This basic module comprises the primary element of delivery device.Some or all primary elements of this basic module can be made by different replaceable modules and be used to provide different functions.
As required, the probability of this delivery device of flexible configuration has following advantageous combination:
Can satisfy the needs of unique user, this need come from the at home use relative with the outer use of being in of short term variations picture and come from owing to the secular change in development and change such as treatment, new functional modules.
Can constitute the production of delivery device around the functional module of limited quantity.The idea that this just provides a kind of rational faculty is used for supplying economically high-quality, mass-produced device, and by avoiding duplicating of critical component, this device can customize the functional requisite in unique user, still keeps the modular construction of this device simultaneously.
When this basic module comprise the device that is used for fixing a cartridge case at least, be used for be included in the described cartridge case part or all of medicine from described cartridge case pass to user's device, when being used for admitting the device of one or more replaceable module and being used for device to basic module and these replaceable modules supply electric energy, just guarantee to provide to be used for dosage is transported to user's the basic element of character from cartridge case, this basic element of character comprises that being used for excitation (energize) medicine transmits and the device of other electronic unit supply electric energy in all basic modules and replaceable module to the user.
When this basic module also comprises the electronic installation that is used for monitoring and control drug delivery process and is used for communicating with replaceable module and user, just guarantee that one function can be driven and control by electricity, this just improves reliability and accuracy on the whole, and guaranteeing can combine with user's input from the data of difference in functionality module produces intelligent result and improves the comfortable and safe of user, also guarantees to produce the historical record of medication management process.
In a preferred embodiment, described cartridge case can be replaced, and has an outlet and a movable wall, thereby when Way out moves, this movable wall just impels content by outside the described outlet expelling tube.
When the outlet of described cartridge case is connected on the replaceable conduit, and describedly be used for transmitting that the device of medicine is suitable to carry out work in a continuous manner to the user, make the outlet of medicine by described conduit be discharged from tube when outer, just guarantee that successive dosage form (profile) is transported to the user.
In a preferred embodiment, be used for from the described device of described cartridge case to user's transmitting portions or whole medicines, at least comprise piston rod, electrically driven (operated) actuating device that can be operated to mesh and move described movable wall and be used for from the driving device of described electrically driven (operated) actuating device to described piston rod transmitting movement.
Be used for admitting the device of replaceable module to comprise the device that is used for admitting and fixing described replaceable module when described to basic module machinery, and when being used for providing device on the described device of electric energy, just guarantee to be used for replaceable module machinery and electric coupling one " standard " interface on basic module are provided with the electronic installation and being used to that described replaceable module is connected electrically in basic module.If this power supply device is provided by the form with set of cells, just guarantee that then this device can use " move in ", and the battery technology (based on rechargeable or non-rechargeable battery) of guaranteeing the to use standard battery technology that is used for mobile phone as exploitation provides the supply of energy.
In a preferred embodiment, the electronic installation that is used for monitoring and control drug delivery process and is used for communicating with replaceable module and user is comprised in self replaceable modules.
When described electronic installation comprise at least be used for by control have described piston rod movable wall move the device of controlling delivered dose, promptly by via being used for controlling electrically driven (operated) actuating device to the driving device of described piston rod transmitting movement from described electrically driven (operated) actuating device; With the device that is used for monitoring corresponding to the described mobile conveying medication amount of described movable wall; For the device of user with the input data; Be used for storing the storage device of data; Be used for the device that communicates with replaceable module; Be used for controlling the device of basic module and replaceable module function; Be used for handling the input data, handle the blood processor that the data that receive from replaceable module and processing are stored in data in the described storage device; When being used for manifesting the display of described data, just guarantee that the dosage of carrying controlled by electricity, compare with pure mechanical means and just improved accuracy, and guarantee to produce used medicine in time with current in tube the record etc. of residual drug amount.But also guarantee from each functional module of this conveyer device and from the information of user input by centralized stores and analysis, and guarantee to be transmitted on this basis, and relevant information is provided to the user for the control signal of each independent replaceable module.Guarantee in addition to carry out this each replaceable module of conveyer device correct function inspection and with the synergism of basic module, and be can give the alarm under the situation of negating or the behavior of locking scheme in check result.
When comprising in described cartridge case is placed in the described device that is used for fixing replaceable cartridge case, described electronic installation is used for reading item of information destination device on the replaceable cartridge case, when being used for handling this item of information destination device, just guarantee to read and check that the process of cartridge case content can automatization, thereby cause safe coefficient higher in the disposal of this medicine.
When the suitable reception of described electronic installation includes the particular subscriber unit of user data, functional audit program and subscriber authorisation program, just guarantee customizing in single, the commutative unit of the data that the current structure and the optional indication user who comprises of actual user's particular data, this device have licensing function, provide this each replaceable module of conveyer device correct function and with the inspection of synergistic inspection of basic module and user identity (ID), use with the unauthorized that prevents this conveyer device.As an alternative, when power supply opening, this blood processor can be suitable for according to including the basic module of software and the current structure that replaceable module is determined this device.
In a preferred embodiment, described particular subscriber unit is a circuit card.
When replaceable module can be selected from the group of being made up of following modules:
The replaceable module that comprises the system that is used for monitoring blood glucose;
Comprise and be used for the replaceable module of system of continuous measurement blood glucose;
Comprise the replaceable module that is used to provide the modem that communicates with data communication network;
Comprise and be used for carrying out the replaceable module of the communication interface of radio communication with miscellaneous equipment;
Comprise and be used for the replaceable module that is fixed with line interface that communicates with one or more personal computer, photographing unit, TV Monitor, acoustic equipment, phone, mobile phone;
The replaceable module that comprises function of cellular phone;
The replaceable module that comprises speaker;
Comprise microphone, speaker and processor and be used for providing the replaceable module of the software of sound interface for speech recognition;
The replaceable module that comprises the device that is used for monitoring cartridge case temperature and content thereof;
The replaceable module that comprises the device that is used for monitoring and control cartridge case temperature and content thereof;
But be included in after definite setting-up time or when the phenomenon of determining occurs, be used to provide the replaceable module of the device of optional acoustics or vibration or optical signalling;
Be used for vibrating the device of cartridge case content and be used to provide showing that alarm signal that setting-up time disappears is to guarantee the replaceable module of the correct blended device of cartridge case component but comprise;
Comprise to be used for surveying the device that this delivery device shakes and to be used to provide and show and carry out a certain amount of alarm signal of shaking to guarantee the replaceable module of the correct blended device of cartridge case component;
Comprise and be used for drug conveying is controlled at the replaceable module of the software of the speed that can set, controlled markers, maximum delivery dosage etc.;
Comprise the replaceable module that is used for producing by the software of the record of definite user's regulation phenomenon of delivery device monitoring;
The replaceable module that comprises the software that is used for controlling user identity (ID);
The replaceable module that comprises the display of suitable left hand use;
The replaceable module that comprises the display of suitable right hand use;
Comprise by the device of controlling described transmission medicine in the mode that continuous pumping is provided to come through the replaceable module of a conduit to the device of user's delivery of specific doses type,
Just guarantee that this delivery device can be shaped as the different device based on the wide region function of standardized building block.
When this basic module and these replaceable modules are configured with replaceable cover, just guarantee the design of this delivery device or the instant needs that outward appearance can be adjusted to be fit to the user, for example, be complementary etc. with the drug of topical application (dress).
When this basic module comprises the function of can be locked and only can using for the user by unique software key and/or software upgrading, just guarantee that several functions are provided in the single module, if suitable, the input of special key words and/or the renewal of software are all depended in the use of each function.This may interrelate in/eclipsed certain function combination relevant with quilt in hardware and/or software implementation.
The present invention also provides a kind of method of making delivery device.When this method comprises the following steps:
(a) determine and structure comprise common source a basic module and
(b) determine and construct one or more replaceable module, each in this one or more replaceable module all suit with this basic module mechanical and electric synergism with provide specific function and
(c) as required, the structure of selecting to determine on may the basis of function function (function) and
(d) by making up the device that corresponding basic module and one or more replaceable module constitute this decision function of realization.
Changing under the situation that function needs, but repeating step (c) and (d),
Can obtain as above identical advantage with claim 1.
When the step that determines functional structure as required with to constitute a step that realizes the device of this decision function be that user by this device is when carrying out, the needs that just can guarantee to satisfy unique user are possible, it comes from the at home use relative with the outer use of being in of short term variations picture and comes from the secular change that changes owing in treatment, new functional module development etc.
When the step that determines functional structure as required with to constitute a step that realizes the device of this decision function be when being carried out by the manufacturer of this device or supplier, just can center on the production of delivery device of the functional module formation different structure of limited quantity.This supplies high-quality, mass-produced device economically with regard to the idea that a kind of rational faculty is provided, and by avoiding duplicating of critical component, this device can customize the functional requisite in unique user.
Also comprise the step that locks this device when this method, so that this device can not be separated into it and form module the time by the user, the correct function of resulting device such as delivery reliability just can guarantee by the manufacturer of this device/supplier, and needn't carry out special testing procedure before using this device.
Brief description of drawings
Below in conjunction with preferred embodiment and with reference to accompanying drawing the present invention is described more comprehensively, wherein:
Fig. 1 represents according to injection device of the present invention;
Fig. 2 represents the preferred embodiment that comprises the basic module of the basic resources that is used for dosed administration according to of the present invention;
Fig. 3 represents the preferred embodiment that comprises the basic module of the basic resources that is used for dosed administration and electronic processing device according to of the present invention;
Fig. 4 represents to be used for controlling drug delivery process and the electronic installation of the basic module that is used for communicating with replaceable module and user;
Fig. 5 represents a kind of selection according to replaceable module of the present invention; With
Fig. 6 represents the preferred embodiment according to method of the present invention.
For clarity sake these accompanying drawings are schematically and simplify, and their only expression and ignored other details for understanding the details of the present invention for necessity.In entire portion, identical reference marker is used to identical or corresponding parts.
The detailed description of embodiment
Based on the module of an electromechanical units and a processing unit is the elementary cell among the embodiment below the present invention, on this elementary cell, be connected with different replaceable modules and provide different application, as BGM, be used for sound interface of cripple visually etc., wherein this electromechanical units is used for moving a piston rod in having the replaceable tube of outlet, and this processing unit and I/O parts one are used from control drug delivery process etc.
Fig. 1 represents to illustrate its modular structure according to injection device of the present invention.
Fig. 1 a represents basic module 1 and multiple replaceable module 2,3,4,5,6, wherein this basic module 1 comprises course of conveying and its and controls necessary basic machinery and electric resources, and each resource with this basic module in its replaceable module 2,3,4,5,6 realizes specific function.These replaceable modules can comprise hardware (with optional software) module 2,3,4 or software module (software module) 5,6 completely.The specific cover module that is used for limiting this delivery device visual effect is represented as 7,8,9.This cover can have different colors, can be made by the different materials with different surfaces and profile.Cover can be installed in manufacturing process, so that this device is from the cover of standard or preliminary election, the cover of this standard or preliminary election can replaced by other cover after a while according to user's selection then.The material of cover can have different special properties, for example elasticity or photism or water proofing property etc.This cover can constitute blocking water of this delivery device or watertight housing.
In Fig. 1 b, represent a kind of delivery device of forming by the software module 5 in basic module 1, two replaceable hardware modules 3 and 4 and these basic module memorizeies of packing into.This device is utilized cover module 8,9 and finishes.
In Fig. 1 c, represent a kind of by basic module 1, three 2,3 and 4 and one of replaceable hardware modules delivery device that software module 6 in replaceable module 4 memorizeies forms of packing into.This device is utilized cover module 7,9 and finishes.
Delivery device among Fig. 1 b and the 1c can be constructed according to his or she current needs together by the user of this device, or as selecting the supplier by this device to construct together.
Fig. 2 represents according to being used for the preferred embodiment of basic module of basic resources of dosed administration of the present invention comprising.
Fig. 2 represents to be used for an embodiment according to the basic module 1 of pen type injection device of the present invention, one of them columniform replaceable cartridge case 12 is set in the corresponding receiver devices 11, and this replaceable cartridge case 12 has outlet 121 and has the lid that is shaped as piston 122 at its relative end at the one end.For the outlet 121 of cartridge case 12, this receiving system has an opening 111 at the one end, and for piston rod 15, this receiving system has an opening 112 at its other end.Should suitablely interact with piston is formed with one 180 ° bending with the piston rod of mobile piston, so that compact structure more to be provided.But it also can be used as a normal straight piston rod and realizes.A motor 13 obtains the energy by electric conductor 18 from battery or set of cells 17, the engagement of corresponding driving device (not shown) is with mobile piston bar vertically on itself and driving device 14 and the piston rod, thus mobile piston and impel medicine by exporting outside 121 expelling tubes.In Fig. 2, this basic module is suitable for the injection device of pen type, and the form of disposable pin is adopted in outlet, but also can adopt the form of less disposable pipe under the situation of atomizing syringe.Piston rod 15 is columniform and axially hard, but radially give prominence to (salient) and dispose the screw thread (not shown), this screw thread is configured to be delivered to driving device 14 on the piston rod 15 with moving from motor 13 with a corresponding driving nut and a corresponding synergism gear (not shown), wherein this drive nut disposes a gear (not shown) in its periphery, and this synergism gear is positioned on the motor.Be used for admitting the device 16 of replaceable module (for example 2 among Fig. 1,3,4) to comprise the electrical interface 161 that adopts one or more binding post form, be used for giving these replaceable module power supplies, and the data transaction between basic module and these replaceable modules (referring to Fig. 3) is provided by electric conductor 18.
Fig. 3 represents according to being used for the preferred embodiment of basic module of basic resources of dosed administration and electronic processing device of the present invention comprising.
Except the feature of Fig. 2, Fig. 3 also comprises electronic installation 31, is used for monitoring and control administration process, and is used for and replaceable module (for example 2 among Fig. 1,3,4) and telex network.Be used for being connected 32 with electric wire and be included in from electronic installation 31 to electrical interface 161 to replaceable module and to motor from the replaceable module received signal to replaceable module and motor transmission signal.This electronic installation 31 comprises blood processor (311 among Fig. 4), this blood processor is suitable to given specification, by means of motor 13 and driving device 14, thus the process that exact dose is carried in 33 controls that moves of coming control piston by accurate mobile piston bar.
Fig. 4 represents to be used for to control drug delivery process and and is used for electronic installation with the basic module of replaceable module and telex network.
Electronic installation 31 according to basic module of the present invention comprises processor 311, storage device 313 (easily memorizer (for example RAM) and the non-volatile memorizer that loses), be used for display 315 to user's explicit user input and result, be used for reading item of information destination device 316 on the cartridge case 12, supply the user input device 312 (for example keyboard that possibility is limited) of user input data and comprise specific user's data, the control unit 314 of optional functional testing procedure and subscriber authorisation (authorization) program can adopt the form of circuit card (being similar to the SIM of mobile phone).Battery 17 is connected 18 with being used for to what electronic installation 31, motor 13 and replaceable module 2 were powered, together with being used for communicating between processor 311, motor 13 and replaceable module information project is also illustrated in Fig. 4 from the holding wire 32 that cartridge case 12 is delivered to corresponding sensing device 316.
Fig. 5 represents the selection according to replaceable module of the present invention.
Fig. 5 grass has been painted various replaceable modules, just can be made of according to delivery device of the present invention in conjunction with basic module (referring to Fig. 1-3) these replaceable modules.These replaceable modules of briefly describing in Fig. 5 are only represented some examples, and the exhaustive list of corresponding module in the scope of the invention is not provided:
The replaceable module 201 that comprises the system that is used for monitoring blood glucose.
Comprise and be used for the replaceable module 202 of system of continuous measurement blood glucose.
Comprise the replaceable module 203 that is used to provide the modem that communicates as the Internet or any other local or global metadata communication network with data communication network.This module can be used to download software on this device, be used for long-range this device of inspection function, remote diagnosis and can make subscriber authorisation (authorization) etc.
Comprise and be used for carrying out the replaceable module 204 of the communication interface of radio communication with miscellaneous equipment.This module realizes that one or more carries out the standard of radio communication, for example bluetooth standard, radio modem, infrared communication etc. with miscellaneous equipment.
Comprise and be used for the replaceable module that is fixed with line interface 205 that same or a plurality of personal computers, photographing unit, TV Monitor, acoustic equipment, phone, mobile phone communicate.This module comprises corresponding rosette interface.
The replaceable module 206 that comprises function of cellular phone.
The replaceable module 207 that comprises speaker.
Comprise microphone, speaker and processor and be used to speech recognition that the replaceable module 208 of the software of sound interface is provided.This module for example realizes sound interface to handicapped people visually.
The replaceable module 209 that comprises the device that is used for monitoring cartridge case temperature and its content.Whether this module for example purpose is to provide about the current minimum of filling that cartridge case exposed and the information of maximum temperature to the user, available to determine this cartridge case.
The replaceable module 210 that comprises the device that is used for monitoring and control cartridge case temperature and content thereof.This module for example purpose is to determine that the current medicine of filling is available, and has nothing to do with temperature (in the boundary of determining) that this device is experienced.
But be included in after definite setting-up time or when the phenomenon of determining occurs, be used to provide the replaceable module 211 of the device of optional acoustics or vibration or optical signalling.This module purpose is to help the user to observe definite given pattern along with chronotherapy.
Be used for vibrating the device of cartridge case content and be used to provide showing that alarm signal that setting-up time disappears is to guarantee the replaceable module 212 of the correct blended device of cartridge case component but comprise.
Comprise to be used for surveying the device that this delivery device shakes and to be used to provide and show and carry out a certain amount of alarm signal of shaking to guarantee the replaceable module 213 of the correct blended device of cartridge case component.
Comprise and be used for cartridge case is controlled at the replaceable module 214 of the software of the speed that can set, controlled markers (for may using of replaceable module 211), maximum delivery dosage etc.This module purpose is to control the drug delivery process of (minimum and maximum) time, delivered dose etc. between relevant transporting velocity type, conveying.
Comprise be used for producing by the software of the record of definite user's regulation phenomenon of delivery device monitoring for containing module 215.The corresponding phenomenon of this class is the possible temperature of the time of drug conveying, corresponding amount, Drug therapy, for the input (physiology/psychentonia etc.) of given delivery user corresponding information.
Comprise by the character that requires the user to import predefined procedure and control user identity (ID) to prevent the replaceable module 216 of the software that this device unauthorized uses.
The replaceable module 217 that comprises the display of suitable left hand use.
The replaceable module 218 that comprises the display of suitable right hand use.
Comprise by control the device that transmits medicine in the mode that continuous pump mode is provided to be connected a conduit in the cartridge case outlet to the replaceable module 219 of the device of user's delivery of specific doses type through at one end having the syringe needle and the other end.The purpose of this module is need to be used to the drug conveying experience to determine the situation of time quantum (opposite with the injection-type conveying, as generally to experience several seconds).
Fig. 6 represents the preferred embodiment according to the inventive method.
Fig. 6 makes a kind of method of delivery device with modular mode diagram.This method starts from 61, by execution in step 62, determines and construct one to comprise essential part and shared resource as described in the claim 2-12 and the basic module shown in Fig. 1-4.So far parallel or subsequently, execution in step 63 is promptly determined and is constructed one or more replaceable module, and wherein each all suit, and mechanical and electric synergism provides specific function with basic module.The example of this class replaceable module is disclosed in the claim 13 and relevantly with Fig. 5 comes into question in the above.Next, execution in step 64 is promptly according to the structure that need select to decide function based on possible function (for example, between these functions of being explained by the replaceable module of just having mentioned).This step can be carried out by the user, and the user selects the corresponding construction for given situation, is perhaps carried out with the needs that satisfy specific user's section (segment) at definite device corresponding function by the manufacturer of this device or supplier.Then, execution in step 65, promptly by combination corresponding basic module and one or more replaceable module (as summarize above and paint Fig. 5 medium-height grass) constitute or construct a device of realizing this decision function.
If the user has the set (collection) of the replaceable module of realizing various functions, then can execution in step 66 determine whether current structure is fit to current needs.If OK, this process is stopped at 67 places; If current structure is improper, repeating step 64 and 65 then.As an alternative, determining whether current structure is fit to back a kind of method of current needs can be from putting 68, and this point 68 represents that users wonder whether this device meets the common situation of these situation needs.
If this device is assembled by the manufacturer of device or supplier, manufacturer or the supplier function in order to guarantee that this device is correct then, what be concerned about is to guarantee that the user can not dismantle these modules and they are assembled once more (their " lockings " being in the same place by machinery or electricity).As selection, can be by this device power supply be realized audit program.
Represented some preferred embodiments in front, but should emphasize that the present invention is not limited thereto, but be embodied in by following claims the alternate manner in definite purport scope.For example, on the electronic installation that is used for controlling drug delivery process etc., be the basic module of part.If possible, as fruit instant and/or economy, it is part replaceable module also, is divided into several replaceable modules.Only relate to a basic module equally, in the above embodiments.Yet, a core (for example, comprising that more or less basic circuit is as electroacoustic interface, particular power source etc.) that can form this delivery device in the different basic modules of selective several.

Claims (19)

1. delivery device, it is characterized in that this device comprises a basic module (1) and one or more replaceable module (2,3,4,5,6), each in this one or more replaceable module all is suitable for basic module machinery and/or electric synergism so that specific function to be provided, and this basic module comprise can be by the common resource of using of these replaceable modules.
2. according to the delivery device of claim 1, it is characterized in that this basic module (1) comprises the device (11) that is used for fixing a cartridge case (12) at least, is used for transmitting the device (13 that is included in part or all medicine (123) the described cartridge case (12) from described cartridge case to the user, 14,15), be used for admitting one or more replaceable module (2,3,4,5,6) device (16) and be used for to this basic module and the device of electric energy is provided to these replaceable modules.
3. according to the delivery device of claim 1 or 2, it is characterized in that this basic module (1) also comprises the device that is used for monitoring and control drug delivery process and is used for communicating with replaceable module and user.
4. according to the delivery device of claim 2 or 3, it is characterized in that described cartridge case (12) is interchangeable and has outlet (121) and a movable wall (122), when along outlet (121) when direction moves, this movable wall (122) just impels content (123) by outside described outlet (121) expelling tube (12).
5. according to the delivery device of claim 4, the outlet (121) that it is characterized in that described cartridge case (12) is connected on the replaceable conduit, and the described device (13 that is used for transmitting medicine to the user, 14,15) suit to carry out work in a continuous manner, make medicine (123) be discharged from outside the tube (12) by the outlet of described conduit.
6. according to each delivery device among the claim 2-4, it is characterized in that being used for from the described device (13 of described cartridge case (12) to user's translator unit or whole medicines (123), 14,15) comprise that at least one can be operated to engagement and moves piston rod (15), electrically driven (operated) actuating device (13) of described movable wall (122) and be used for from the driving device (14) of described electricity driving actuating device (13) to described piston rod (15) transmitting movement
7. according to each delivery device among the claim 2-6, it is characterized in that the described device (16) that is used for admitting replaceable module comprises is used for admitting and the device of fixing described replaceable module to basic module machinery, and be used for described replaceable module (2,3,4,5,6) be connected electrically in the electronic installation (31 of basic module (1), 32) go up and be used to provide device on the described device (17,18) of electric energy.
8. according to each delivery device among the claim 3-7, it is characterized in that being used for monitoring, control drug delivery process and be used for being comprised in the replaceable module of itself with the electronic installation (31,32) that replaceable module and user communicate.
9. according to each delivery device among the claim 3-8, it is characterized in that described electronic installation (31,32) comprise at least by control have described piston rod (15) movable wall (122) move the device (33) of controlling delivered dose, promptly by controlling electricity to the driving device (14) of described piston rod (15) transmitting movement and drive actuating device (13) by means of drive actuating device (13) from described electricity; With the device that is used for monitoring corresponding to the conveying injection volume of described movable wall (122) described mobile (33); Be used for importing the device (312) of data for the user; Be used for storing the storage device (313) of data; Be used for the device (311,312) that same replaceable module (2,3,4,5,6) communicates; Be used for controlling the device (314) of basic module and replaceable module function; Be used for handling the input data, handle the blood processor (311) that the data that receive from replaceable module and processing are stored in the data in the described storage device; With the display that is used for manifesting described data (315).
10. according to each delivery device among the claim 3-9, it is characterized in that described electronic installation (31) is used for reading replaceable cartridge case (12) and goes up item of information destination device (316) and be used for handling this item of information destination device (311) when comprising in described cartridge case is placed in the described device (11) that is used for fixing replaceable cartridge case.
11., it is characterized in that the suitable particular subscriber unit (314) that includes user data, functional audit program and subscriber authorisation program that receives of described electronic installation according to each delivery device among the claim 3-10.
12., it is characterized in that described particular subscriber unit (314) is a circuit card according to the delivery device of claim 11.
13., it is characterized in that in the group that the optional free following modules of these replaceable modules forms according to each delivery device among the claim 1-12:
The replaceable module (201) that comprises the system that is used for monitoring blood glucose;
Comprise and be used for the replaceable module (202) of system of continuous measurement blood glucose;
Comprise the replaceable module (203) that is used to provide the modem that communicates with data communication network;
Comprise and be used for carrying out the replaceable module (204) of the communication interface of radio communication with miscellaneous equipment;
Comprise and be used for the replaceable module that is fixed with line interface (205) that communicates with one or more personal computer, photographing unit, TV Monitor, acoustic equipment, phone, mobile phone;
The replaceable module (206) that comprises function of cellular phone;
The replaceable module (207) that comprises speaker;
Comprise microphone, speaker and processor and be used for providing the replaceable module (208) of the software of sound interface for speech recognition;
The replaceable module (209) that comprises the device that is used for monitoring cartridge case temperature and content thereof;
The replaceable module (210) that comprises the device that is used for monitoring and control cartridge case temperature and content thereof;
But be included in after definite setting-up time or when the phenomenon of determining occurs, be used to provide the replaceable module (211) of the device of optional acoustics or vibration or optical signalling;
Be used for vibrating the device of cartridge case content and be used to provide showing that alarm signal that setting-up time disappears is to guarantee the replaceable module (212) of the correct blended device of cartridge case component but comprise;
Comprise to be used for surveying the device that this delivery device shakes and to be used to provide and show and carry out a certain amount of alarm signal of shaking to guarantee the replaceable module (213) of the correct blended device of cartridge case component;
Comprise and be used for drug conveying is controlled at the replaceable module (214) of the software of the speed that can set, controlled markers, maximum delivery dosage etc.;
Comprise the replaceable module (215) that is used for producing by the software of the record of definite user's regulation phenomenon of delivery device monitoring;
The replaceable module (216) that comprises the software that is used for controlling user identity (ID);
The replaceable module (217) that comprises the display of suitable left hand use;
The replaceable module (218) that comprises the display of suitable right hand use;
Comprise by the device of controlling described transmission medicine in the mode that continuous pumping is provided to come through the replaceable module (219) of a conduit to the device of user's delivery of specific doses type.
14., it is characterized in that this basic module and these replaceable modules dispose replaceable cover (7,8,9) according to each delivery device among the claim 1-13.
15., it is characterized in that this basic module comprises the function of can be locked and only can using for the user by unique software key and/or software upgrading according to each delivery device among the claim 1-14.
16. a method of making delivery device is characterized in that comprising following steps:
(62) determine and structure comprise common source a basic module and
(63) determine and construct one or more replaceable module, each in this one or more replaceable module all suit with this basic module mechanical and electric synergism with provide specific function and
(64) as required, select may the basis of function on the decision function structure and
(65) by making up the device that corresponding basic module and one or more replaceable module constitute this decision function of realization.
Under the situation that the change function needs, but repeating step (64) and (65).
17. according to the method for the making delivery device of claim 16, it is characterized in that determining as required the step (64) of functional structure and constituting a step (65) that realizes the device of this decision function is by user's execution of this device.
18. according to the method for the making delivery device of claim 16, it is characterized in that determining as required the step (64) of functional structure and constituting a step (65) that realizes the device of this decision function is by the manufacturer of this device or supplier's execution.
19. the method according to the making delivery device of claim 18 is characterized in that this method also comprises the step that locks this device, forms module so that this device can not be separated into it by the user.
CN01811782A 2000-05-30 2001-05-29 Medicine delivery device with replaceable cooperating moudles and method of making same Pending CN1438902A (en)

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RU2002135588A (en) 2004-07-10
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AU2001263767A1 (en) 2001-12-11
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DE60132583T2 (en) 2009-01-29
ZA200209480B (en) 2003-11-21

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