CN1431516A - Microhydrojet head and sprinkler using micro hydrojet head - Google Patents
Microhydrojet head and sprinkler using micro hydrojet head Download PDFInfo
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- CN1431516A CN1431516A CN 02100952 CN02100952A CN1431516A CN 1431516 A CN1431516 A CN 1431516A CN 02100952 CN02100952 CN 02100952 CN 02100952 A CN02100952 A CN 02100952A CN 1431516 A CN1431516 A CN 1431516A
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Abstract
The micro hydrojet head is utilized to jet preset quantitative liquid under control by the controller. The head includes the base and multiple tube assemblies. The base possessing the multiple through holes is connected to the controller electrically. The preset quantitative liquid is filled in the tube assemblies, which are installed in the through hole in detachable mode. With connected to the base electrically, the tube assemblies jet liquid under the control by the controller. The tube assemblies are replaceable. The sprinkler is suitable to biochemical analysis, including the controller, at least one micro hydrojet head, which is connected to the controller elctrically. The sprinkler uses the micro hydrojet head, where the replaceable capillary tubes are arranged in high density so as to solve the issue of cross-contamination of reagents.
Description
Technical field
The flusher that the present invention relates to a kind of little jet head and utilize this little jet head particularly can high density be arranged interchangeable kapillary little jet head thereon and the flusher that utilizes this little jet head about a kind of.
Background technology
Field at chemistry, medicine, biochemistry, material, often need parallel carry out a large amount of screening detection or chemical, biochemical reaction, for example combinatorial chemistry (combinatorial chemistry) must use the synthetic various chemicals of multiple monomer to develop for new medicament screen or new material.For example, gene wafer (biochip, DNA chip, cDNA chip) or protein chip (Protein chip) arrange that in the plane thousands of probe (probe) is in order to analytical control.For example,, different reagent must be added in the porous disc (micro plate), carry out biochemistry detection screening in (highthroughput screening) at a high speed.In these were used, it was exactly with multifarious reagent that a common point is arranged, and was transferred to the position that ad hoc fashion is arranged, to carry out follow-up reaction or analysis.
Transmission at present utilizes sprinkler (dispenser) to carry out mostly, and Fig. 1 a and Fig. 1 b are presented at a kind of known sprinkler that discloses in No. the 6001309th, the United States Patent (USP).This device 10 has the shell 12 that surrounds the capillary assembly, and shell 12 has the opening 14 that passes for kapillary 16, is provided with a pad 20 on shell 12 tops.Lid 22 uses when device 10 needs cleaning or filling, is provided with first pipeline 24 in lid 22, in order to when system need be evacuated or pressurize, cleans the solvent that adds; Second pipeline 28 is connected with vacuum source, and the 3rd pipeline 32 imports gaseous tension.Lid 22 and threaded line pipe 42 adjacency, threaded line pipe 42 is locked together in capillary housing 50 in the shell 12, and has the bearing 46 in order to accommodate sample.After cleaning, remove lid 22 to expose bearing 46, make it can accommodate sample.Bearing 46 has and meets opening 48 capillaceous, and sample can contact kapillary 16 by this, and moves in kapillary 16 by surface tension.Screw shell 50 has breach, to take in order to drive the electric wire 54 of converter 56.Converter 56 is near aperture 60, and the tube wall of kapillary 16 is very thin, moves so that it can shrink with the expansion of converter 56.
Fig. 2 is that storage subsystem 300 shows that in the mode of a plurality of (rack) each cabinet (bin) in frame comprises a plurality of dishes 302 at the sketch of the sprinkling system of No. the 6001309th, United States Patent (USP).Master controller 304 control total systems, under the signal of computer, one or more dish of 300 conveyances 302 is to the next stop 306 from the storage area.Standing 306 o'clock, mechanical arm 308 under the control of subsystem controller 309, utilize microtubule (micropipette tips) 310 from the liquid that coils 302 conveyance trace to being positioned at by one or more shower nozzle (jet) 312 on the Filling Station kept under subsystem controller 315 controls.In order to utilize jetting system again, to keep Filling Station and be provided with to keep and cover 316, retainer 318 is positioned on the jetting system 312 on the transmission pole 320, and jetting system 312 moves to testing station 322 under the control of subsystem controller 323 by this.If jetting system 312 is by the testing station, its nationality is moved into eject position 334 by transmission pole 320, and is moved on the substrate 336 by transmission pole 320 and retainer 318.Can begin to spray drop and the arrangement that obtains wanting at this jetting system.
With reference to figure 3, United States Patent (USP) discloses another kind of known flusher No. 6110426, and flusher 110 comprises reagent sprinkler 112, and it has capillary pipeline 114, in order to keep the amount of reagent 116.Pipeline is formed by a pair of member 112a, 112b, and it is shrinking near tip region 118 places.Most advanced and sophisticated 118, reagent forms male and fomale(M﹠F) (meniscus) 120, shown in Fig. 4 a, start this moment solenoid 122, with drawing piston 124, cause coupling member 126 move most advanced and sophisticated 118 fast near or away from substrate 130 surfaces 131.Substrate surface 131 is touched at the tip 118 of sprinkler 112 as a result, and this causes the liquid male and fomale(M﹠F) 120 in pipeline 114 to break, and liquid is contacted with substrate surface 131.Cause flow of liquid to most advanced and sophisticated 118 and the space on 131 on surface, so that liquid flows out pipeline 114, shown in Fig. 4 b by this.Fig. 4 c shows liquid flowing from tip 118 to substrate surface 131, forms drop 132 up to it.
Sprinkler must operate not making under the multiple different reagent cross pollution, and needs conversion reagent apace.
As mentioned above, the sprinkler that discloses in No. the 6001309th, the United States Patent (USP) is recycling, so it must clean and refill, and is easy to cause the problem of reagent cross pollution; In addition, owing to need maintaining, the whole operation time is tediously long and inconvenient, and cost will be improved.
Similarly, the sprinkler that discloses in No. the 6110426th, the United States Patent (USP) is a contact, so the problem of reagent cross pollution also is easy to produce.
Summary of the invention
The objective of the invention is the flusher a kind of little jet head to be provided and to utilize this little jet head in order to address the above problem, it can arrange interchangeable kapillary with high density on little jet head.
The flusher of another object of the present invention for a kind of little jet head being provided and utilizing this little jet head, it can solve the problem of reagent cross pollution.
In the present invention, provide a kind of little jet head, in order under the control of controller, spray both quantitative plural fluid, it comprises: have the substrate of a plurality of perforation, itself and controller electrically connect; And a plurality of pipe assemblies that are filled with set fluid respectively, it is arranged in the perforation in removable mode respectively, and electrically connects with substrate respectively, pipe assembly spray fluid under the control of controller wherein, and this pipe assembly is interchangeable.
As mentioned above, substrate is provided with at least one first holding section in perforation, and each pipe assembly is provided with at least one second holding section corresponding to first holding section, so that pipe assembly engages with substrate, wherein first holding section can be a depressed part, and second holding section can be a teat.Substrate is respectively equipped with at least one first pad in perforation, and each pipe assembly is provided with at least one second pad corresponding to first pad, wherein when pipe assembly inserts the perforation of substrate, and second pad and the first pad butt; Each pipe assembly comprises: be formed with the bearing of teat thereon, and be provided with second pad thereon, and have passage; In order to keep the kapillary of fluid, be arranged on an end of the passage of bearing; And the printed wafers head of the other end that is arranged on the passage of bearing, itself and the second pad butt, and be communicated with kapillary.
Each pipe assembly is marked with coding, in order to indicate the kind of filling fluid in it; Substrate is provided with first pick-up unit, in order to the Fluid Volume in the detector tube assembly; Each pipe assembly is provided with second pick-up unit, in order to the Fluid Volume in the detector tube assembly.
The aforementioned tube assembly can be piezoelectric type hydrojet form, thermal bubble type hydrojet form or clearance type (slit) hydrojet form.
In the present invention, provide a kind of flusher, be suitable in the biochemical analysis, comprising: controller, and in order in biochemical analysis, to spray at least one little jet head of both quantitative reagent to the substrate, itself and controller electric connection; Little jet head comprises: have the substrate of a plurality of perforation, itself and controller electrically connect; And a plurality of pipe assemblies that are filled with set reagent respectively, it is arranged in the perforation in removable mode respectively, and electrically connects with substrate respectively, wherein when basal surface during to substrate, pipe assembly sprays reagent under the control of controller, and pipe assembly is interchangeable.
Little jet head of the present invention and utilize the flusher of this little jet head to overcome the many defectives in the known technology, described flusher breaks away from engaging by little jet head teat and depressed part, when the fluid in the kapillary uses up, replaceable pipe assembly; This pipe assembly can be designed to independent replacement, group's replacement or whole group and replace, in order to use based on different demands; Described fluid during the change fluid, only needs to replace whole pipe assembly for being filled in advance in the pipe assembly; And the present invention has avoided the fluid cross pollution.
Description of drawings
Fig. 1 a shows the synoptic diagram of the known sprinkler that discloses in No. the 6001309th, the United States Patent (USP);
Fig. 1 b is presented at the sectional view of the sprinkler that shows among Fig. 1 a;
Fig. 2 shows the synoptic diagram of the known sprinkling system that discloses in No. the 6001309th, the United States Patent (USP);
Fig. 3 shows the synoptic diagram of another the known flusher that discloses in No. the 6110426th, the United States Patent (USP);
Fig. 4 a-4c shows the synoptic diagram that utilizes flusher shown in Figure 3 to make drop;
Fig. 5 a, 5b show the synoptic diagram of little jet head of the present invention;
Fig. 6 shows the three-dimensional exploded view of pipe assembly of the present invention;
Fig. 7 shows the synoptic diagram of flusher of the present invention.
Drawing reference numeral explanation 10,112, sprinkler 12, shell 14,48, opening 16,224, kapillary 20, pad 22, lid 24, first pipeline 28, second pipeline 32, the 3rd pipeline 42, threaded line pipe 46, bearing 50, capillary housing 54,420, electric wire 56, converter 60, aperture 110,500, flusher 114, capillary pipeline 116, reagent 118, most advanced and sophisticated 120, male and fomale(M﹠F) 122, solenoid 124, piston 126, coupling member 130,336,410, substrate 131, surface 132, drop 200, little jet head 210, substrate 211, perforation 212, first holding section (depressed part) 213, first pad 214, the 3rd pad 220, pipe assembly 221, second holding section (teat) 222, second pad 223, bearing 2231, passage 225, printed wafers 2251, nozzle 226, coding 300, storage subsystem 302, dish 304, master controller 306, stand 308, mechanical arm 309,315,323, subsystem controller 310, microtubule 312, shower nozzle 316, keep and cover 318, retainer 320, transmission pole 322, testing station 334, eject position 400, controller
Embodiment
Below, accompanying drawings little jet head of the present invention and the embodiment that utilizes the flusher of this little jet head.
With reference to figure 5a, 5b, little jet head 200 of the present invention is sprayed both quantitative plural fluid in order under the control of controller (not graphic), and comprises a substrate 210 and a plurality of pipe assembly 220.Substrate 210 and controller electrically connect, and have a plurality of perforation 211, a plurality of first holding sections (depressed part) 212 that form respectively near perforation 211, be separately positioned on a plurality of first pads 213 in the perforation 211 and be separately positioned on substrate 210 a plurality of the 3rd pads 214 on every side.
Two depressed parts 212 are respectively formed at each perforation both sides of 211, and the 3rd pad 214 electrically connects with first pad 213, so that the pipe assembly 220 that controller can be braked in the perforation 211 that is inserted in substrate 210 via the 3rd pad 214 and first pad 213.
Pipe assembly 220 is filled with set fluid respectively in advance, and it is arranged in the perforation 211 of substrate 210 in removable mode respectively, and electrically connects with substrate 210 via first pad 213 respectively; With reference to figure 6, each pipe assembly 220 is provided with at least one second holding section (teat) 221 corresponding to depressed part 212, corresponding at least one second pad 222, a bearing 223, a kapillary 224 and a printed wafers head (Print chip head) 225 of first pad 213.
Specifically, teat 221 engages with the depressed part 212 of substrate 210 so that pipe assembly 220 engages with substrate 210; When pipe assembly 220 inserts the perforation 211 of substrate 210, second pad 222 and first pad, 213 butts; Bearing 223 is formed with teat 221 thereon, and is provided with second pad 222 thereon, and has passage 2231; Kapillary 224 is in order to keep fluid, and it is arranged on an end of the passage 2231 of bearing 223; Printed wafers 225 is arranged on the other end of the passage 2231 of bearing 223, itself and second pad, 222 butts, and be communicated with kapillary 224.Printed wafers 225 is provided with nozzle 2251, and it is communicated with kapillary 224, and the fluid in kapillary 224 can be sprayed via nozzle 2251, arranges by this, and pipe assembly 220 can be via substrate 210 transmitting fluids.
It should be noted, be housed in fluid in the kapillary 224 and be by the friction force between the surface tension of the surface nature of kapillary 224 and fluid and keep, in order to increase friction force, glue or oily mater can be added to the filling end of kapillary 224, so that fluid can not leak from the filling end of kapillary 224; In addition, glue or oily mater can't mix with fluid.
In this embodiment, first holding section is that the mode with a depressed part forms, and form and second holding section is a mode with a teat, but this is not limited to this, for example, both can be exchanged, and perhaps utilizes other engaging mode.
Each pipe assembly 220 is marked with coding 226, in order to indicate the kind of filling fluid in it; Substrate 210 is provided with first pick-up unit (not graphic), in order to the Fluid Volume in the detector tube assembly 220; Each pipe assembly 220 is provided with second pick-up unit (not graphic), in order to the Fluid Volume in the detector tube assembly 220.
Will be appreciated that pipe assembly 220 can be piezoelectric type hydrojet form, thermal bubble type hydrojet form or clearance type (slit) hydrojet form.
Little jet head 200 of the present invention has following advantage:
1, by teat 221 and depressed part 212 are broken away from engaging, when the fluid in the kapillary 224 used up, pipe assembly 220 was interchangeable.It should be noted pipe assembly 220 based on different demands, also can be designed to independent replacement, group's replacement or whole group and replace, in order to use; Above-mentioned group replaces and means that preestablishing a plurality of specific tube assemblies is a group, when desire is replaced, is about to whole group and all replaces.
2, fluid when need change fluid, can directly be replaced whole pipe assembly 220 for being filled in advance in the pipe assembly 220; And
3, because need not clean and refill, little jet head can be avoided the problem of fluid cross pollution.
With reference to figure 7, the invention provides a kind of flusher 500, in its suitable biochemical analysis, comprise a controller 400 and at least one little jet head 200; By controller 400, flusher 500 can be controlled one or more little jet head 200 simultaneously; In biochemical analysis, little jet head 200 was sprayed on both quantitative plural reagent to one substrate 410, and it electrically connects via an electric wire 420 and controller 400; Little jet head 200 is filled with set reagent in advance, and when substrate 410 was faced in the substrate 210 of little jet head 200, pipe assembly 220 sprayed reagent via substrate 210 under the control of controller 400.
By flusher 500 of the present invention, the rig for testing that is utilized in biochemical analysis (assays/kits) can be made under high productivity easily.
Though the present invention discloses as above with preferred embodiment, it is not that to this area those of ordinary skill, the variations and modifications of being done all should be included within design of the present invention and the protection domain in order to qualification the present invention.
Claims (22)
1, a kind of little jet head in order under the control of a controller, is sprayed both quantitative plural fluid, it is characterized in that comprising:
One substrate has a plurality of perforation, and electrically connects with this controller; And
A plurality of pipe assemblies are filled with set fluid respectively, and are arranged in the perforation in removable mode respectively, and electrically connect with this substrate respectively, wherein this pipe assembly under the control of this controller, spray fluid, and this pipe assembly is interchangeable.
2, little jet head as claimed in claim 1 is characterized in that: this substrate is provided with at least one first holding section in this perforation, and each pipe assembly is provided with at least one second holding section corresponding to this first holding section, so that this pipe assembly engages with this substrate.
3, little jet head as claimed in claim 2 is characterized in that: this first holding section is a depressed part, and this second holding section is a teat.
4, little jet head as claimed in claim 3, it is characterized in that: this substrate is respectively equipped with at least one first pad in perforation, and each pipe assembly is provided with at least one second pad corresponding to this first pad, wherein when this pipe assembly inserts the perforation of this substrate, this second pad and the first pad butt.
5, little jet head as claimed in claim 4 is characterized in that: each this pipe assembly comprises:
One bearing is formed with teat thereon, and is provided with second pad thereon, and has a passage;
One kapillary in order to keep this fluid, is arranged on an end of the passage of this bearing; And
One printed wafers head is arranged on the other end of the passage of this bearing, with this second pad butt, and is communicated with this kapillary.
6, little jet head as claimed in claim 1, it is characterized in that: each pipe assembly is marked with a coding, in order to indicate the kind of filling fluid in it.
7, little jet head as claimed in claim 1 is characterized in that: this substrate is provided with one first pick-up unit, in order to the Fluid Volume in the detector tube assembly.
8, little jet head as claimed in claim 1 is characterized in that: each pipe assembly is provided with one second pick-up unit, in order to the Fluid Volume in the detector tube assembly.
9, little jet head as claimed in claim 1 is characterized in that: pipe assembly is respectively piezoelectric type hydrojet form.
10, little jet head as claimed in claim 1 is characterized in that: pipe assembly is respectively thermal bubble type hydrojet form.
11, little jet head as claimed in claim 1 is characterized in that: pipe assembly is respectively clearance type hydrojet form.
12, a kind of flusher that utilizes the described mini sprinkler of claim 1 is suitable in the biochemical analysis, is characterised in that: comprising:
One controller; And
At least one little jet head, in order to spray in this biochemical analysis on both quantitative plural reagent to one substrate, itself and this controller electrically connects, and comprises:
One substrate has a plurality of perforation, and electrically connects with this controller; And
A plurality of pipe assemblies are filled with set reagent respectively, and are arranged in the perforation in removable mode respectively, and electrically connect with this substrate respectively, wherein when this basal surface during to this substrate, pipe assembly sprays these reagent under the control of this controller, and pipe assembly is interchangeable.
13, flusher as claimed in claim 12 is characterized in that: this substrate is provided with at least one first holding section in perforation, and each pipe assembly is provided with at least one second holding section corresponding to this first holding section, so that pipe assembly engages with this substrate.
14, flusher as claimed in claim 13 is characterized in that: this first holding section is a depressed part, and this second holding section is a teat.
15, flusher as claimed in claim 14, it is characterized in that: this substrate is respectively equipped with at least one first pad in perforation, and each pipe assembly is provided with at least one second pad corresponding to this first pad, wherein when pipe assembly inserts the perforation of this substrate, second pad and the first pad butt.
16, flusher as claimed in claim 15 is characterized in that: each pipe assembly more comprises:
One bearing is formed with these teats thereon, and is provided with second pad thereon, and has a passage;
One kapillary in order to keep this reagent, is arranged on an end of the passage of this bearing; And
One printed wafers head is arranged on the other end of the passage of this bearing, with the second pad butt, and is communicated with this kapillary.
17, flusher as claimed in claim 12, wherein each pipe assembly is marked with a coding, in order to indicate the kind of filling reagent in it.
18, flusher as claimed in claim 12 is characterized in that: this substrate is provided with one first pick-up unit, in order to the amount of reagent in the detector tube assembly.
19, flusher as claimed in claim 12 is characterized in that: each pipe assembly is provided with one second pick-up unit, in order to the amount of reagent in the detector tube assembly.
20, flusher as claimed in claim 12 is characterized in that: little jet head is respectively piezoelectric type hydrojet form.
21, flusher as claimed in claim 12 is characterized in that: little jet head is respectively thermal bubble type hydrojet form.
22, flusher as claimed in claim 12 is characterized in that: little jet head is respectively clearance type hydrojet form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02100952 CN1225657C (en) | 2002-01-08 | 2002-01-08 | Microhydrojet head and sprinkler using micro hydrojet head |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02100952 CN1225657C (en) | 2002-01-08 | 2002-01-08 | Microhydrojet head and sprinkler using micro hydrojet head |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1431516A true CN1431516A (en) | 2003-07-23 |
| CN1225657C CN1225657C (en) | 2005-11-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02100952 Expired - Fee Related CN1225657C (en) | 2002-01-08 | 2002-01-08 | Microhydrojet head and sprinkler using micro hydrojet head |
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| CN (1) | CN1225657C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100457978C (en) * | 2005-12-29 | 2009-02-04 | 上海工程技术大学 | Device and method for controlling jet nozzle precision motion by microcomputer |
| CN102435726A (en) * | 2010-09-23 | 2012-05-02 | 财团法人工业技术研究院 | Chemical or biochemical analysis device and chemical or biochemical analysis method |
| CN105709867A (en) * | 2014-12-03 | 2016-06-29 | 艾博生物医药(杭州)有限公司 | Method for adding a trace amount of liquid through two liquid spray pens |
| CN105709866A (en) * | 2014-12-03 | 2016-06-29 | 艾博生物医药(杭州)有限公司 | Controller for controlling liquid addition of two liquid spray pens |
| WO2021002072A1 (en) * | 2019-07-04 | 2021-01-07 | 国立研究開発法人日本原子力研究開発機構 | Liquid phase ejection nozzle |
| CN114040817A (en) * | 2019-04-18 | 2022-02-11 | 戈拉特有限公司 | Self-cleaning nozzle |
-
2002
- 2002-01-08 CN CN 02100952 patent/CN1225657C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100457978C (en) * | 2005-12-29 | 2009-02-04 | 上海工程技术大学 | Device and method for controlling jet nozzle precision motion by microcomputer |
| CN102435726A (en) * | 2010-09-23 | 2012-05-02 | 财团法人工业技术研究院 | Chemical or biochemical analysis device and chemical or biochemical analysis method |
| CN105709867A (en) * | 2014-12-03 | 2016-06-29 | 艾博生物医药(杭州)有限公司 | Method for adding a trace amount of liquid through two liquid spray pens |
| CN105709866A (en) * | 2014-12-03 | 2016-06-29 | 艾博生物医药(杭州)有限公司 | Controller for controlling liquid addition of two liquid spray pens |
| CN105709866B (en) * | 2014-12-03 | 2019-05-14 | 艾博生物医药(杭州)有限公司 | A kind of controller controlling two hydrojet adding liquid |
| CN105709867B (en) * | 2014-12-03 | 2019-05-17 | 艾博生物医药(杭州)有限公司 | A method of micro liquid is added by two hydrojet pens |
| CN114040817A (en) * | 2019-04-18 | 2022-02-11 | 戈拉特有限公司 | Self-cleaning nozzle |
| WO2021002072A1 (en) * | 2019-07-04 | 2021-01-07 | 国立研究開発法人日本原子力研究開発機構 | Liquid phase ejection nozzle |
| JP2021010861A (en) * | 2019-07-04 | 2021-02-04 | 国立研究開発法人日本原子力研究開発機構 | Nozzle for ejecting liquid phase |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1225657C (en) | 2005-11-02 |
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