CN1426818A - Urinary bladder float slow release medicine - Google Patents
Urinary bladder float slow release medicine Download PDFInfo
- Publication number
- CN1426818A CN1426818A CN 01131873 CN01131873A CN1426818A CN 1426818 A CN1426818 A CN 1426818A CN 01131873 CN01131873 CN 01131873 CN 01131873 A CN01131873 A CN 01131873A CN 1426818 A CN1426818 A CN 1426818A
- Authority
- CN
- China
- Prior art keywords
- release body
- release
- urine
- urinary bladder
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Media Introduction/Drainage Providing Device (AREA)
- External Artificial Organs (AREA)
Abstract
A slow-releasing medicament floating on urine in urinary bladder for diagnosing, treating and preventing the diseases in urinary system and reproductive system is composed of a slow-releasing medicine, dual-cavity catheter for delivering the said medicine into the urinary bladder, and optional magnetic substance for attaching the said medicine onto the inner surface of urinary bladder. Its advantage is durable acting, low concentration, and little unto ward effect.
Description
The present invention relates to a kind of new technical scheme, is a kind of new administrated method of diagnosis, prevention and treatment urinary system, reproductive system diseases specifically.
At present when treatment urinary system, reproductive system diseases, major part all is systemic administration (oral, intramuscular injection, intravenously administrable), easily causes untoward reaction such as liver, renal damage or gastrointestinal upset, and urinary system, reproductive system active drug concentration are also very low; Sometimes carry out the irrigation of bladder administration, its bladder concentration has temporarily improved, but the back medicine of urinating excretes, and duration of efficacy is short, more than two kinds of medications all undesirable, and administration number of times is many, and is loaded down with trivial details, untoward reaction is many, patient is painful big.Now also do not find and the similar patent of urinary bladder float slow release medicine through the Searches of Patent Literature.
The objective of the invention is to overcome the defective of existing treatment diseases of genito-urinary system, provide a kind of per urethra disposable administration longer duration, topica concentration height, no systemic adverse reactions, convenience, reliably and can be used as a kind of urinary bladder float slow release medicine of prevention and diagnoses and treatment.
The present invention realizes that according to following technical proposals urinary bladder float slow release medicine is made up of release body and double lumen catheter, and the release body can be made of solid, liquid even gas; Also can will add magnetisable material in the release body in addition again by passive being adsorbed onto on the wall of urinary bladder such as the underpants that has magnetisable material of body surface corresponding site or belts.If release body solid can be made into pill, pill can be made up of three parts, that is: (1) top layer part: be made of lubricant and disinfectant, its function is a pill when entering bladder by urethra, reduces friction and carries out partly sterilised; (2) medicine body portion: constitute by substrate and medicine, the basic feature of this part is that relative density is little than urine, available various technology makes the relative density of pill less than urine, as: foaming makes the inner uniform distribution bubble of pill, if relative density is low than urine after substrate and the medicine simple mixing, then can directly use, substrate adopts slow release, controlled-release material, slowly discharge medicine wherein when in urine, dissolving, can in the specific long period, keep local active drug concentration, needs according to clinical treatment, can select for use various specific host materials to produce the different urinary bladder float slow release medicine of the length course of treatment, the medicine of this part can single medicine also can be the compound medicine that is made of multiple medicine; (3) core: be made of harmless dyestuff, be positioned at the centre of pill, this part contacts with urine when medicine has dissolved substantially, and urine dyes, finishes with the prompting drug release when urinating.
Release body in addition, also can be made into liquid dosage form: as Emulsion, oil preparation, water preparation etc., some drugs and some Emulsion or oil preparation etc. are mixed, can be made into the relative density medicament low than urine, swim on the urine, experiment is learnt: some drugs and iodized oil are mixed, be injected into the rabbit intravesical, in 3 days to 7 days even take the X-ray sheet more over a long time, also have iodized oil to exist; Also can in the release body, add the material that has affinity interaction with the wall of urinary bladder mucosa, make it to combine, and reach the purpose of not discharging after the release with urine with the wall of urinary bladder mucosa.
In order to carry the double lumen catheter of pill, its front end is an inner concave capsule, in order to embrace solid release pill, is thereafter two not connected tracts and two external capsules that are attached thereto, and also has an interior urine output hole.External capsule also shouldn't, wherein intercommunication links to each other a tract with external capsule with inner concave wall, gassy or liquid in its lacuna, the extruding external capsule makes the inner concave capsule projection and pill is pushed intravesical, another tract be positioned at pill and the inner concave capsule urine output hole after tight and link to each other with another external capsule intercommunication, after pill and inner concave capsule entered bladder fully, urine can flow into external capsule by interior urine output hole enter intravesical with prompting pill, inner concave capsule.If non-solid release body can get final product by interior urine output hole injection or with other catheter.
Fig. 1 is urinary bladder float slow release medicine solid pill signal full figure of the present invention.
Fig. 2 is a solid pill structural representation of the present invention.
The present invention is further illustrated below in conjunction with accompanying drawing.The solid urinary bladder float slow release medicine is made up of pill 1 and double lumen catheter 2, and pill 1 is by top layer part 9, and medicine body portion 10 and core 11 are formed.
Double lumen catheter 2 front ends are the inner concave capsules 3 that embrace pill 1, thereafter by not connected two tracts 4,7 and the external capsule 5,8 that is attached thereto, also have an interior urine output hole 6 to form, tract 4 communicates with external capsule 5 with inner concave capsule 3 and links to each other, and tract 7 communicates with external capsule 8 with forward interior urine output hole 6 and links to each other.
Pill 1 and inner concave capsule 3 per urethram mouthful insert urethra during use, gassy or liquid in tract 4, inner concave capsule 3 and the external capsule 5, urine promptly flows into the tract 7 from interior urine output hole 6 after pill 1, inner concave capsule 3, interior urine output hole 6 enter bladder, and then flow in the external capsule 8, illustrate that pill puts in place, at this moment can push external capsule 5 increase pressures and make capsula interna 3 projection and pill is pushed bladder and separate, extract double lumen catheter 2 then to get final product with double lumen catheter; If when pill 1 is non-solid, external capsule 8 can be cut off, use syringe, inject intravesical along tract 7 and interior urine output hole 6.
Claims (2)
1, the present invention is that a kind of new administrated method urinary bladder float slow release medicine of a kind of diagnosis, prevention and treatment urinary system, reproductive system diseases is made up of release body (1) and double lumen catheter (2); It is characterized in that:
A, use various fabrication techniques and go out the slow releasing preparation of relative density, inject the top that floats on urine behind the bladder, when urinating and be not excreted, and slowly discharge medicine, reach long lasting purpose less than urine.Can in urinary bladder float slow release medicine, add magnetisable material in case of necessity or have material with the mucous membrane of urinary bladder adsorption function; Release body (1) can be solid, liquid, gas, if solid can be made into the release body (1) be made up of three parts promptly: top layer part (9): be made of lubricant and disinfectant; Medicine body portion (10): constitute by substrate and medicine, can be made into slow release, controlled release form; Core (11): constitute by dyestuff.If liquid (that is: Emulsion, oil preparation, water preparation) can be in the same place as substrate and some slow releasing agent some Emulsion, oil preparation, water preparation with drug regimen, make liquid release body (1), if gas can be made gas release body (1) with after the some drugs gasification.
B, release body (1) are no matter be solid, liquid or gas, and its relative density all will be made the dosage form lower than urine, so that swim on the urine; Picture Emulsion, oil preparation, the gas dosage form is generally all low than urine specific gravity, when if the relative density of release body (1) is higher than urine, the material lower than urine relative density can be joined in the release body (1), such as: it is medium that the micro-bubble of gas is distributed in release body (1), also magnetisable material can be joined in the release body (1), add magnetic underpants or belt etc. at the corresponding body surface of human body position then, with it passive being adsorbed on the wall of urinary bladder, in addition, also release body (1) can be made the release body (1) that has affinity with the wall of urinary bladder mucosa, such as modes such as antigen-antibody combinations, initiatively be adsorbed on the wall of urinary bladder mucosa.When urinating, be unlikely a release body (1) and excrete like this.Also can only select one of them part or two parts for use, also can three parts all use just like (1) three part of the described release body of A.
2, urinary bladder float slow release medicine as claimed in claim 1, it is characterized in that, it is that the inner concave capsule (3) that embraces release body (1) communicates with tract (4) external capsule (5) and links to each other that solid release body (1) is sent to its front end of intravesical double lumen catheter (2), interior urine output hole (6) and tract (7), external beam (8) communicates continuous, in addition, tract (7) and interior urine output hole (6) are located at release body (1) and inner concave capsule (3) afterwards, can fill with liquid or gas in inner concave capsule (3), tract (4) and the external capsule (5); External capsule (5), (8) also shouldn't, inner concave capsule (3) also can be made into the siphunculus of no inner concave capsule cyst wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01131873 CN1426818A (en) | 2001-12-20 | 2001-12-20 | Urinary bladder float slow release medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01131873 CN1426818A (en) | 2001-12-20 | 2001-12-20 | Urinary bladder float slow release medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1426818A true CN1426818A (en) | 2003-07-02 |
Family
ID=4670937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01131873 Pending CN1426818A (en) | 2001-12-20 | 2001-12-20 | Urinary bladder float slow release medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1426818A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102172418A (en) * | 2011-02-18 | 2011-09-07 | 上海交通大学医学院附属新华医院 | Acellular matrix material capable of sustainedly releasing growth factors |
| CN104174110A (en) * | 2013-05-23 | 2014-12-03 | 微创心脉医疗科技（上海）有限公司 | Medicine balloon and preparation method thereof |
| CN104288095A (en) * | 2014-01-15 | 2015-01-21 | 南京大学 | Floating gel for delivering pharmacological active substances in bladder and pharmaceutical preparation thereof |
| CN115737589A (en) * | 2022-10-14 | 2023-03-07 | 中山大学 | Adhesive drug microsphere, preparation method thereof and application thereof in bladder perfusion treatment |
-
2001
- 2001-12-20 CN CN 01131873 patent/CN1426818A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102172418A (en) * | 2011-02-18 | 2011-09-07 | 上海交通大学医学院附属新华医院 | Acellular matrix material capable of sustainedly releasing growth factors |
| CN104174110A (en) * | 2013-05-23 | 2014-12-03 | 微创心脉医疗科技（上海）有限公司 | Medicine balloon and preparation method thereof |
| CN104288095A (en) * | 2014-01-15 | 2015-01-21 | 南京大学 | Floating gel for delivering pharmacological active substances in bladder and pharmaceutical preparation thereof |
| CN104288095B (en) * | 2014-01-15 | 2017-07-07 | 南京大学 | A kind of floating gel and its pharmaceutical preparation for delivering pharmacological active substance in bladder |
| CN115737589A (en) * | 2022-10-14 | 2023-03-07 | 中山大学 | Adhesive drug microsphere, preparation method thereof and application thereof in bladder perfusion treatment |
| CN115737589B (en) * | 2022-10-14 | 2024-06-04 | 中山大学 | Adhesive medicinal microsphere, preparation method thereof and application thereof in bladder perfusion treatment |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7815928B2 (en) | Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parenteral administration and preparation process | |
| AU742061B2 (en) | Device for local administration of solid and semisolid formulations, sustained-release formulations for parenteral administration and method of preparation | |
| AU642704B2 (en) | Long-term delivery device including loading dose | |
| TWI643623B (en) | Composition for the treatment of fistula | |
| JP6600256B2 (en) | Drug delivery system and method for the treatment of bladder dysfunction and other lower urinary tract diseases through the use of trospium | |
| KR102383496B1 (en) | Drug delivery systems and methods for treatment of prostate disease comprising gemicitabine | |
| US9333329B2 (en) | Vaginal carrier for the controlled release of substances | |
| KR20160124425A (en) | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine | |
| CN1938040A (en) | Oxytocin controlled release formulations and methods of using same | |
| CN1426818A (en) | Urinary bladder float slow release medicine | |
| CN102258458A (en) | Rectal in-situ gel for abating fever and preparation method thereof | |
| KR20210039403A (en) | How to treat overactive bladder with trospium | |
| ES2307896T3 (en) | USE OF 4- (2-FLUOROPHENYL) -6-METHYL-2- (1-PIPERAZINYL) TIENO (2,3-D) -PIRIMIDINE FOR THE TREATMENT OF URINARY INCONTINENCE. | |
| Jennings et al. | Successful treatment of feline pancreatitis using an endoscopically placed gastrojejunostomy tube | |
| CN2507477Y (en) | Urinary bladder float | |
| CN104288095B (en) | A kind of floating gel and its pharmaceutical preparation for delivering pharmacological active substance in bladder | |
| CN2827420Y (en) | Urinary bladder floating device for treating urinary system disease | |
| Alvan et al. | The pharmacokinetic profile of oxazepam | |
| Theeuwes et al. | Applications of osmotic drug delivery | |
| CA2556405A1 (en) | Method of preventing, medicating and/or treating hypocalcaemia of domestic mammal | |
| CN110267703A (en) | Drug delivery device and method | |
| AU2004240186B2 (en) | Device for local administration of solid or semi-solid formulations and delayed-release formulations for parenteral administration and preparation process | |
| AU779691B2 (en) | Device for local administration of solid and semisolid formulations, delayed-release formulations for parenteral administration and method of preparation | |
| Parrish et al. | Seeking Enteral Autonomy with Teduglutide | |
| CN111544402A (en) | Novel medicament with pill placed in penis, preparation method and medicament placing device thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |