CN1424900A - Topical skin composition - Google Patents
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- CN1424900A CN1424900A CN00818601A CN00818601A CN1424900A CN 1424900 A CN1424900 A CN 1424900A CN 00818601 A CN00818601 A CN 00818601A CN 00818601 A CN00818601 A CN 00818601A CN 1424900 A CN1424900 A CN 1424900A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/38—Percompounds, e.g. peracids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
Abstract
A topical skin composition that includes a complex containing an effective amount of selected components to provide a defense against the various pathway mechanisms of reactive oxygen species. The composition is directed to the prevention of the adverse or detrimental effects of reactive oxygen species. The figure shows the results of skin erythema of a subject exposed to UV radiation after an application of the formulation in example 4.
Description
Background of invention
Because aging relates to human body, so, increased for the research of aging along with aged tendency of population.For example, treatment shows as the skin aging that fine rule, wrinkle etc. occur and has caused a large amount of concerns.People solve old and feeble skin symptom for example fine rule, wrinkle, loose and hyperpigmentation by for example operation of several different methods, laser therapy and cosmetic.Cosmetic treatment comprises the influence of using multiple cream and lotion to change skin aging.Many bibliographical informations of the prior art use single solvent to prevent a kind of in the middle of several harmful old and feeble influences.For example, a kind of strategy is to use one or more hydroxy acid or tretinoin to come the regrowth of chafe cell, and does not use other component.This method has shortcoming, because it does not recognize that aging is to be caused by the multiple factor in the multiple source illeffects to skin, is to cause skin lesion via multiple simultaneous infringement approach.
Another field that causes a large amount of concerns is free radical, active oxygen species (" ROS ") and other oxidisability species (" OOS ") to the influence of the human body that comprises skin.These entities have related to the various skin state, comprise the general aging, contact dermatitis, wrinkle, inflammation of photodamaged, skin and to the infringement of skin histology.
The ROS species comprise superoxides (O
2 -), hydrogen peroxide (H
2O
2), peroxy (HO
2And RO
2), alkyl peroxide (R
2O
2), hydroxy radical (OH), alkoxy free group (OR) and singlet oxygen.The OOS species comprise hypohalogenous acids (HOX) (wherein X is chlorine, bromine, iodine), Z-amine (wherein Z is the chemical compound that contains chlorination or ammonification amine), nitric oxide (NO), ammonia, cyclo-oxygenase, phospholipase A
2, phospholipase C and transition metal.
It is believed that various ROS directly or as intermediate act on cell membrane, bring adverse effect to skin.Therefore, local skin treatment compositions and the method for anti-various ROS need be provided.In addition, the such compositions of expectation can be repaired the infringement that is caused by ROS.
Summary of the invention
The present invention relates to contain the complex of the selected component of effective dose with the various pathway mechanisms of anti-ROS.The invention still further relates to the method for handling skin.Specifically, the present composition and method relate to the unfavorable or illeffects that prevents ROS.
The invention still further relates to the compositions of the infringement that reparation causes by ROS.
Complex composition of the present invention generally contains at least a anti-superoxides component, at least a resistive to hydrogen peroxide component, at least a anti-hydroxy radical component and optional at least a chain termination (chain breaker) component that contains.
In one embodiment, the present composition also contains the energy-producing component of accessory cell, the auxiliary synthetic component of collagen and auxiliary or the component of cytoactive is provided.
The accompanying drawing summary
Accompanying drawing 1 expression be that the application on human skin of using preparation of the present invention is exposed to increasing of erythema after UV30 minute.
Accompanying drawing 2 expression be that the application on human skin of using preparation of the present invention is exposed to increasing of erythema after UV10 hour.
Detailed Description Of The Invention
The invention provides the local skin complex composition, described composition provides the defense mechanism of anti-multiple ROS.
Complex composition of the present invention generally contains at least a anti-superoxides component, at least a resistive to hydrogen peroxide component, at least a anti-hydroxy radical component and optionally contains at least a chain terminating agent. In one embodiment, the present composition also contains the synthetic component of the energy-producing component of auxiliary cell, auxiliary collagen and auxiliary or the component of cytoactive is provided.
But the present composition also comprises cosmetic or pharmaceutically suitable carrier. When having carrier, it is about 10% that described compound accounts for about 0.01%-of composition total weight, preferably accounts for about 1%-about 7% of composition total weight. Be described in more detail below the specific components of compound.
Anti-superoxides component
This component generally comprises has the active material of anti-superoxides, particularly has the material of superoxide dismutase activity.In other words, it comprises the component of energy catalytic disproportionation reaction.For example, it comprises superoxide dismutase (SOD), and by the group modified SOD of grafting polyalkylene oxide, Polyethylene Glycol, polysaccharide or acidylate, the salt of SOD contains the material of such SOD product, porphorins and have the active material of superoxide dismutase sample.In this respect, it is included in the product of mentioning among the EP223257, and the related content of the document is introduced the present invention with for referencial use.
Variant that above-mentioned all superoxide dismutase and those skilled in the art can release from document and coordinate can be suitable for being used for the present invention as SOD.In addition, they can have separate sources.
For example, they can be animal (cattle, pig etc.), people's (blood) or plant (fungus, algae, Herba Spinaciae etc.).They can also be obtained by antibacterial or yeast, perhaps obtain by the biotechnology approach.
The case description of the SOD that can use in the present invention is in U.S. patent 5,526,507, and the content of the document is introduced the present invention with for referencial use.
SOD accounts for about 0.01%-about 5% of complex weight.The content of SOD in complex is preferably about 2% weight of about 0.1%-.
The resistive to hydrogen peroxide component
This component generally is mercaptan or thiol derivative.In the context of the invention, term mercaptan is meant to be characterized as to have-organic compound of SH.Thiol derivative is such organic compound, the derivant of reservation-SH, or wherein-SH is converted to-thioether or the thiol ester of SR.
The chemical compound identical with mercaptan of the present invention or thiol derivative is those by being formed by mercaptan or thiol derivative via the tautomerism of hydrogen bond, hydration or other spontaneous rearrangement, dimerization reaction, oligomerization.If derivant is by for example alkyl migration and being in the balance with isomer of dissimilar rearrangements, then this isomer is considered as being included in mercaptan of the present invention and the thiol derivative.
Suitable mercaptan and thiol derivative can comprise captopril; cysteamine; ergothioneine; mercapto-propionyl-glycin; penicillamine; the N-acetylcysteine; the S-acetylcysteine; N; S-diacetyl cysteine; N; S-diacetyl cysteine amide; ethycysteine; N-acetylcysteine ethyl ester; S-acetylcysteine ethyl ester; N, S-diacetyl ethycysteine; thioglycolic acid; cysteine; homocysteine; glutathion; thioglycerol; thiomalic acid; 2 mercaptopropionic acid; the 3-mercaptopropionic acid; thiodiglycol; 2 mercapto ethanol; dithiothreitol, DTT (dithioreitol); thioxanthene; thiosalicylic acid; thiolactic acid; propane thioic acid; thiodiglycolic acid; thioctic acid; but with their used for cosmetic salt.
But used for cosmetic salt used herein includes but not limited to alkali metal salt, for example sodium salt, lithium salts, potassium salt and rubidium salt; Alkali salt, for example magnesium salt, calcium salt and strontium salt; Nontoxic heavy metallic salt, for example aluminum salt and zinc salt; Boron salt; Silicon salt; Ammonium salt; Trialkyl ammonium salts, for example leptodactyline and triethyl ammonium salt, and tetraalkylphosphoniusalts salts.
The content of resistive to hydrogen peroxide component in complex is to account for about 5%, preferred about 2.5%, the 0.1%-about 1% more preferably from about of about 0.01%-of about 0.001%-of complex weight.
Anti-hydroxy radical component
Anti-hydroxy radical component can comprise one or more following components: tocopherol, Tocopheryl derivatives, tetrahydrochysene two Resina Ferulae acyl group methane, Semen Vitis viniferae extract, green tea extract, turmeric acid, vanidene (curcuminoids), tetrahydrochysene vanidene (tetrahydrocurcuminoids), catechin, epicatechin 3-0-gallate and polyhydric phenols, oligomeric proanthocyanidins, bioflavonoids, flavonoid and their mixture.
Tocopherol (vitamin E) and derivant thereof for example ester of tocopherol can be used for the present composition.Suitable tocopherol comprises monomethyl, dimethyl or the triethyl group derivant of tocol, includes but not limited to alpha-tocopherol, betatocopherol, Gamma-Tocopherol, Delta-Tocopherol, ε-tocopherol, ζ-tocopherol and η-tocopherol.The ester of suitable tocopherol includes but not limited to tocopherol acetas, tocopherol succinate, tocopherol benzoate, tocopherol propionic ester, tocopherol sorbic acid ester, tocopherol oleate, tocopherol milk surum acid esters, Vitamin E linoleate, tocopheryl nicotinate and 2-ethylhexanoate.
When the tocopherol or derivatives thereof was included in the complex of the present invention, its level with about 10%-about 98% was used.
Tetrahydrochysene two Resina Ferulae acyl group methane and/or Rhizoma Curcumae Longae extract also can the about 0.1%-of complex weight be about 20%, preferably the level of about 1%-about 10% is included in the complex to account for.
The complex of Semen Vitis viniferae extract and Semen Vitis viniferae extract and phospholipid also can be used for the present invention valuably.Semen Vitis viniferae extract comprises for example mixture of epicatechin, proanthocyanidin and catechin of polyhydric phenols.U.S. patent 4,963, described the suitable Semen Vitis viniferae extract and the complex of phospholipid in 527, and the content of the document is introduced the present invention with for referencial use.
In the time of in being incorporated into complex, the about 0.001%-of complex weight is about 5%, preferably the amount of about 0.01%-about 2.5% exists to account for for the complex of Semen Vitis viniferae extract or itself and phospholipid.
Can comprise green tea extract with the Semen Vitis viniferae extract same amount.
Flavonoid and bioflavonoids also can be used for the present invention.It has been reported in Bravo, Polyphenols:Chemistry, Dietary Sources, Metabolism, andNutritional Significance, Nutrition Reviews, Vol.56, No.11,317-33 (November, 1998) in, the content of the document is introduced the present invention with for referencial use, and flavonoid can be divided into following 13 classes again:
Flavonoid generally has diphenyl propane (C
6-C
3-C
6) common structure, and constitute by two aromatic rings that connect via 3 carbon atoms, described 3 carbon atoms form oxygen heterocycle usually.Basic structure is as follows:
Flavonoid sometimes is present in the plant as aglycone, though find as glycoside derivates under their most situations.
Be applicable to that certain kinds flavone of the present invention includes but not limited to rutin, citrin, quercitin, hesperidin, naringen, taxifolin, catechin, epicatechin, eriodictyol, naringenin, troxerutin, chrysin, tangeritin (tangeretin), luteolin, table training catechin, table training Catechin 3-gallate, fisetin, kaempferol, galangin, the training catechuic acid, the epicatechin gallate, the celery flavin, diosmetin, myricetin, the dyestuff isoflavone, daidzein, or derivatives thereof.
Flavonoid can derive from any suitable source.Preferred source is a citrus.
When flavonoid was included in the complex, about 0.001%-of complex weight was about 20%, preferably the level of about 0.01%-about 10% exists to account for for it.
Can also comprise for example palmityl hydroxypropyl trimethylammonium amylopectin of other specific components.In one embodiment, palmityl hydroxypropyl trimethylammonium amylopectin can be mixed with tea extract.They can exist with the amount that accounts for the about 0.001%-of complex weight about 2%.
The chain termination component
The chain termination component can comprise and the identical component of above-mentioned anti-hydroxy radical component.Therefore, one or more above-mentioned anti-hydroxy radical components can also play the chain termination component.The chain termination antioxidant is that Once you begin lipid peroxidation is the component of terminating chain reaction.
As mentioned above, complex composition of the present invention can also be included as the infringement that reparation causes by ROS and the component of selecting.In one embodiment, at least a component that provides cellular energy to generate, the synthetic component of at least a auxiliary collagen and at least a component of assisting or cytoactive being provided are provided the present composition.Component can be used separately like this, perhaps unites use as required.
Cellular energy generates component
Ideal cellular energy generates component and comprises ubiquinone.Ubiquinone extensively is present in antibacterial, fungus, yeast, plant and the animal.Known different plant species produces the isotype with different number isoprene units (n).For example, in certain micro-organisms, the number of isoprene unit is 6 (Q
6), in plant, the number of isoprene unit is 9 (Q
9), in the people, the number of isoprene unit is 10 (Q
10).Ubiquinone
10Or 2, the function of 3-dimethoxy-5-methyl-6-decaprenyl benzoquinone is recovery and keeps and breathe and promotion ATP generation aspect the energy supplement of cytoactive.The derivant that also can use ubiquinone is pantothenylol for example.
Cellular energy generates for example ubiquinone of component
10Content in complex is to account for about 10%, the preferred about 0.01%-about 5% of about 0.001%-of complex weight.
Collagen synthesizes component
In order to repair the infringement that causes by ROS, wish to add the synthetic component of promotion collagen.Existing people proposes to comprise that the hydroxy acid of α and beta hydroxy acid can be used for promoting collagen synthetic.Therefore, the present invention relates to comprise one or more α or beta hydroxy acid.Suitable example comprises lactic acid, malic acid, glycolic, citric acid and salicylic acid.
In addition, have been found that ascorbic acid (vitamin C) and derivant thereof promote collagen synthetic.Can be used for ascorbic acid derivates of the present invention and comprise alone or in combination all enantiomer.Ascorbic acid preferably provides with levo form.In addition, the ascorbic acid or derivatives thereof can be water-soluble or oily molten form.
The non-exclusive example of vitamin C (ascorbic acid) derivant has for example Arrcostab of L-ascorbic acid, and wherein moieties has 8-20 carbon atom.For these esters, they can be selected from fatty-acid monoester, diester, three esters or four esters of ascorbic acid.For example, these esters include but not limited to ascorbic palmitate, the lauric acid acid ascorbyl ester, the myristic acid acid ascorbyl ester, ascorbyl stearate, two ascorbic palmitate, two lauric acid acid ascorbyl esters, two myristic acid acid ascorbyl esters, distearyl acid acid ascorbyl ester, three ascorbic palmitate, three lauric acid acid ascorbyl esters, three myristic acid acid ascorbyl esters, three ascorbyl stearates, four ascorbic palmitate (tetrahexydecyl ascorbate), April the cinnamic acid acid ascorbyl ester, four myristic acid acid ascorbyl esters, four ascorbyl stearate Palmic acid L-acid ascorbyl esters, different Palmic acid L-acid ascorbyl ester, two Palmic acid L-acid ascorbyl esters, isostearic acid L-acid ascorbyl ester, distearyl acid L-acid ascorbyl ester, two isostearic acid L-acid ascorbyl esters, myristic acid L-acid ascorbyl ester, different myristic acid L-acid ascorbyl ester, 2 ethyl hexanoic acid L-acid ascorbyl ester, two 2 ethyl hexanoic acid L-acid ascorbyl esters, oleic acid L-acid ascorbyl ester, with two oleic acid L-acid ascorbyl esters, tetrahexydecyl ascorbate; The phosphate ester of L-ascorbic acid, for example L-ascorbic acid-2-phosphate ester and L-ascorbic acid-3-phosphate ester; The sulfuric ester of L-ascorbic acid is L-Ascorbic acid 2-sulfate and L-ascorbic acid-3-sulfuric ester for example; They and alkaline-earth metal be the salt of calcium and magnesium for example.
For these salt, they can be selected from phosphate and sulfate, preferably phosphate.Ascorbic acid phosphate is selected from L-ascorbic acid 3-phosphate, L-ascorbic acid 2-phosphate, L-ascorbic acid 3-pyrophosphate and two (L-ascorbic acid 3,3-) phosphate usually.Ascorbic acid phosphate is preferably magnesium ascorbyl phosphate or sodium ascorbyl phosphate; More preferably magnesium ascorbyl phosphate.Equally, ascorbate sulfate is selected from L-ascorbic acid 3-sulfate, L-AA-2-s, L-ascorbic acid 3-pyrosulfate and two (L-ascorbic acid 3,3-) sulfate usually.
The synthetic component of collagen for example ascorbic acid and the content of derivant in complex thereof is to account for about 10%, the preferred about 0.01%-about 5% of about 0.001%-of complex weight.
The cytoactive component
It is believed that biostearin can influence cytoactive, therefore wish to comprise biostearin in the complex of the present invention.Biostearin comprises retinol, retinal (axerophthal) and retinyl ester for example retinyl acetate, butanoic acid retinyl ester, Vitamin A propionate, sad retinyl ester, lauric acid retinyl ester, retinyl palmitate, oleic acid retinyl ester and linoleic acid retinyl ester.
Therefore the biostearin Diazolidinyl Urea wishes this possible stimulation is reduced to minimum level it to be incorporated in the complex of the present invention.Perhaps, can add in compositions stimulates demulcent assist to prevent to bring to user over-drastic uncomfortable, and the while might make the dosage that can improve biostearin.Such stimulation demulcent includes but not limited to that ceramide, false vitalility are through amide, fatty acid, cholesterol, phospholipid, pantothenylol, oat extract, allantoin, Semen Ginkgo, Radix Glycyrrhizae extract, Flos Inulae, Radix Ginseng, false tilia etc.
The cytoactive component for example biostearin the about 0.001%-of complex weight is about 10%, preferably the level of about 0.01%-about 5% is incorporated in the complex to account for.
Complex composition of the present invention is general and pharmaceutically acceptable or but used for cosmetic excipient or carrier mix.But complex composition of the present invention can be mixed with solution, gel, lotion, cream, unguentum, oil in water emulsion, water in oil emulsion or other pharmaceutically acceptable or used for cosmetic dosage form.Complex composition of the present invention can also contain central known conventional cosmetic components, as long as they bring adverse effect for required effect.
But diluent, dispersant or the carrier of pharmaceutically acceptable or other material that the used for cosmetic excipient plays a part to exist in the complex composition are to promote its distribution to complex composition when being applied on the skin.
Vehicles other than water can comprise liquid or solid emollient, solvent, wetting agent, thickening agent and powder.For example, can use following carrier separately, perhaps use the combination of one or more following carriers.
Carrier also can comprise propellant for example propane, iso-butane, dimethyl ether, carbon dioxide, nitric oxide; With solvent for example ethanol, isopropyl alcohol, acetone, glycol monomethyl ether, DEGMBE, or the powder for example aluminium-magnesium silicate, organically-modified montmorillonitic clay, aluminium hydrosilicate, sootiness silicon dioxide, carboxy vinyl polymer, sodium carboxymethyl cellulose, ethylene glycol monostearate of Chalk, Pulvis Talci, bleaching earth, Kaolin, starch, natural gum, colloidal silica, sodium polyacrylate, tetraalkyl and/or trialkyl aryl terre verte, chemical modification.
Emollient, for example stearyl alcohol; one castor oil acid glyceride; ermine oil; spermol; the isostearic acid isopropyl ester; stearic acid; the Palmic acid isobutyl ester; Standamul 7061; oleyl alcohol; isopropyl laurate; lauric acid hexyl ester; decyl oleate; octadecane-2-alcohol; different spermol; EICOSANOL; tadenan; cetin; silicone oil is dimethyl polysiloxane for example; n-butyl sebacate; isopropyl myristate; isopropyl palmitate; isopropyl stearate; butyl stearate; Polyethylene Glycol; 2,2'-ethylenedioxybis(ethanol).; lanoline; Oleum Cocois; Semen Maydis oil; Oleum Gossypii semen; olive oil; palm-kernel oil; rapeseed oil; safflower oil; late cherry oil; Oleum Glycines; sunflower seed oil; American Avocado Tree oil; sesame seed oil; Oleum Cocois; Oleum Arachidis hypogaeae semen; Oleum Ricini; Acetylated lanolin alcohols.; vaseline; mineral oil; butyl myristate; isostearic acid; Palmic acid; the linoleic acid isopropyl ester; Lauryl lactate; Tetradecyl lactate; decyl oleate; myristyl myristate.
" emollient " used herein is meant the material that is used to prevent or alleviate drying and protection skin.It is known that a variety of suitable emollients are arranged, and can be used for the present invention.Sagarin, Cosmetics, Science and Technology, 2nd Edition, Vol.1, pp.32-43 (1972) has described the example of wide variety of suitable emollients, and the document is introduced the present invention with for referencial use.
The present composition can be chosen wantonly and comprise for example inorganic or organic sunscreen agent of sunscreen to prevent the illeffects of over-exposure in sunlight during using complex composition of the present invention.The example of suitable sunscreens is included in those that describe among the U.S.OTC Sunscreen Monograph, and its content is introduced the present invention with for referencial use.
Therefore, the present composition can comprise the organic sunscreen agent of 0.1-10%, preferred 1-5% weight.
The present composition also can choose wantonly comprise ferrum oxide that titanium dioxide that mean diameter is 1-300nm or zinc oxide, mean diameter are 1-300nm, silicon dioxide that mean diameter is 1-100nm for example sootiness silicon dioxide as sunscreen.Should be pointed out that silicon dioxide can provide the protective effect that prevents infrared radiation when being used as component in Emulsion of the present invention.
Can use the superfine titanic oxide of two kinds of forms, but but i.e. water dispersed titanium dioxide and oil dispersed titanium dioxide.But the water dispersed titanium dioxide is superfine titanium dioxide granule, described granule not coating or with the material coating to bring the water-wetted surface characteristic to granule.The example of such material comprises aluminium oxide and aluminium silicate.But the oil dispersed titanium dioxide is superfine titanium dioxide, and described particle performance goes out the hydrophobic surface characteristic, and for this purpose, the available metal soap for example aluminium stearate, Aluminum trilaurate, zinc stearate or organosilicone compounds with its coating.
" superfine titanic oxide " is meant that the mean diameter of titanium dioxide granule is lower than 100nm, is preferably 10-40nm, 15-25nm most preferably.Can choose the total amount that is included in the titanium dioxide in the present composition wantonly and be the 1-25%, the preferred 2-10% that account for composition weight, be desirably 3-7%.
Optional skin beneficiating material and cosmetic auxiliary agent
Suitable especially composition forms is an Emulsion, and its medium oil or oily material (emollient) exist so that water in oil emulsion or oil in water emulsion to be provided with emulsifying agent usually.
Compositions also comprises water, and the content of water is up to 95% usually, is preferably 5-95% weight.
Silicone surfactant
The present composition also can be chosen wantonly and comprise the high molecular weight silicone surfactant that also plays the emulsifying agent effect, to replace above-mentioned optional surfactant, perhaps also comprises described silicone surfactant except above-mentioned optional surfactant.
Silicone surfactant can be that molecular weight is 10,000-50, the heavy polymer of 000 dimethyl polysiloxane and polyoxyethylene and/or polyoxypropylene side chain.When using, convenient for the purpose of, dimethylpolysiloxanepolymer polymer is general to be provided as the dispersion in volatile siloxane, described dispersion comprises for example polymer of 1-20% volume and the volatile siloxane of 80-99% volume.Ideally, dispersion is made of the polymer that is dispersed in the volatile siloxane of 10% volume.
The example of the dispersive volatile siloxane of polysiloxane polymer can be comprised polydimethylsiloxane (pentamer and/or hexamer).
Preferred silicone surfactant is ring first silicone and diformazan silicone copolyol, for example derives from the DC 3225C Formulation Aid of DOW CORNING.Another kind is a lauryl first silicone copolyol, for example also derives from the DC Q2-5200 of Dow Corning.
In the time of in being present in compositions, the content of silicone surfactant be generally account for Emulsion weight be up to 25%, preferred 0.5-15%.
Other cosmetic auxiliary agent
The example that can choose the usual auxiliaries of use wantonly comprises antiseptic, for example p-Hydroxybenzoate; Antioxidant, for example butylated hydroxytoluene; Wetting agent, for example glycerol, ethoxylated glycerol glycereth-26, sorbitol, 2-Pyrrolidone-5-formates, dibutyl phthalate, gelatin, Polyethylene Glycol PEG200-600 for example for example; Has for example buffer agent of triethanolamine or sodium hydroxide of alkali; Wax is Cera Flava, ceresine, paraffin for example; Plant extract is Aloe, Centaurea cyanus, Hamamelis virginiana, elderflower, Fructus Cucumidis sativi for example; And Barbados's cherry fermentate, thickening agent; Active reinforcing agent; Coloring agent; And spice.The cosmetic auxiliary agent can constitute the surplus of compositions.
May also wish to mix antiinflammatory and/or counter-stimulus.Natural antiinflammatory and/or counter-stimulus are preferred.For example, can use Radix Glycyrrhizae and extract thereof, glycyrrhizic acid dipotassium, Herba bromi japonici and oat extract, candelilla wax, α bisabolol, Aloe, Manjistha (from Rubia plant, particularly Radix Rubiae, extracting) and Guggal (from Myrrha platymiscium, particularly guggal resin, extracting).
Can also use for example hyaluronic acid of skin conditioning agent, its derivant and salt, comprise hyaluronate sodium, the for example laughable pit of plant extract, Guarana Ammopiptanthus mongolicus (guarana mate), algae extract, with for example ceramide, glycoceramides, false vitalility are through amide, sphingolipid for example sphingomyelins, cerebroside, thioester and ganglioside, sphingol, dihydrosphingosine, phytosphingosine, phospholipid to the material of skin beneficiating, they can use separately or use in mixture.Also fatty acid and these combinations of substances to skin beneficiating can be used.For example, ceramide and glycoceramides are included in U.S. patent 5,589,178,5,661, and those that describe in 118 and 5,688,752 are introduced the present invention with for referencial use with the relevant portion of these documents.For example, the false vitalility is included in U.S. patent 5,198,210,5,206 through amide, and those that describe in 020 and 5,415,855 are introduced the present invention with for referencial use with the relevant portion of these documents.
The following example illustrates but is not restriction the present invention.Except as otherwise noted, otherwise all marks and percentage ratio all be by weight.
Embodiment 1
Be by topical skin composition of the present invention below.
| Component | ????Wt.％ |
| Distilled water | ????56.595 |
| Anti-superoxides component (superoxide dismutase) | ????0.005 |
| Resistive to hydrogen peroxide component (glutathion) | ????0.2 |
| Anti-hydroxy radical component (tocopherol acetas) | ????1.0 |
| Anti-hydroxy radical component (tocopherol) | ????0.2 |
| Anti-hydroxy radical component (tetrahydrochysene two Resina Ferulae acyl group methane) | ????0.1 |
| Anti-hydroxy radical component (Fructus Vitis viniferae (Fructus Vitis viniferae) seed extract (﹠) phospholipid | ????0.1 |
| Anti-hydroxy radical component (bioflavonoids) | ????0.1 |
| Anti-hydroxy radical component (palmityl hydroxypropyl trimethylammonium amylopectin/glycerol cross linked polymer (with) lecithin (with) tea extract) | ????0.1 |
| Emollient | ????21.5 |
| Wetting agent | ????5.205 |
| Emulsifying agent | ????2.3 |
| Skin conditioning agent | ????0.1 |
| Sunscreen (UVA) | ????3.0 |
| Sunscreen (UVB) | ????7.5 |
| Thickening agent | ????0.3 |
| The pH regulator agent | ????0.3 |
| Antiseptic | ????1.25 |
| Spice | ????0.1500 |
| Altogether | ????100.000 |
Embodiment 2
Be topical skin composition below according to an embodiment of the present invention.In this embodiment, compositions provides the protective effect of anti-ROS, and includes the component that helps to repair the infringement that ROS causes.
| Component | ????Wt％ |
| Distilled water | ????57.635 |
| Anti-superoxides component (superoxide dismutase) | ????0.005 |
| Resistive to hydrogen peroxide component (glutathion) | ????0.2 |
| Anti-hydroxy radical component (tocopherol acetas) | ????1.0 |
| Anti-hydroxy radical component (tocopherol) | ????0.2 |
| Anti-hydroxy radical component (tetrahydrochysene two Resina Ferulae acyl group methane) | ????0.1 |
| Anti-hydroxy radical component (Fructus Vitis viniferae (Fructus Vitis viniferae) seed extract (﹠) phospholipid | ????0.1 |
| Anti-hydroxy radical component (bioflavonoids) | ????0.1 |
| Anti-hydroxy radical component (palmityl hydroxypropyl trimethylammonium amylopectin/glycerol cross linked polymer (with) lecithin (with) tea extract) | ????0.1 |
| Cytoactive component (retinyl acetate) | ????0.16 |
| Cellular energy generates component (ubiquinone) | ????0.05 |
| Collagen synthesizes component (tetrahexydecyl ascorbate) | ????0.1 |
| Emollient | ????26.5 |
| Wetting agent | ????5.3 |
| Emulsifying agent | ????2.3 |
| Skin conditioning agent | ????0.1 |
| Silicon dioxide (12 microns) | ????2.0 |
| Silicon dioxide (3 microns) | ????2.0 |
| Aloe gel | ????1.0 |
| Thickening agent | ????0.3 |
| The pH regulator agent | ????0.3 |
| Antiseptic | ????0.3 |
| Spice | ????0.150 |
| Altogether | ????100.00 |
Embodiment 3
Be topical skin composition below according to an embodiment of the present invention.In this embodiment, compositions provides the protective effect of anti-ROS, and includes the component that helps to repair the infringement that ROS causes.
| Component | ????Wt.％ |
| Distilled water | ????66.68 |
| Anti-superoxides component (superoxide dismutase) | ????0.005 |
| Resistive to hydrogen peroxide component (glutathion) | ????0.2 |
| Anti-hydroxy radical component (tocopherol acetas) | ????1.0 |
| Anti-hydroxy radical component (tocopherol) | ????0.2 |
| Anti-hydroxy radical component (tetrahydrochysene two Resina Ferulae acyl group methane) | ????0.1 |
| Anti-hydroxy radical component (Fructus Vitis viniferae (Fructus Vitis viniferae) seed extract (﹠) phospholipid | ????0.1 |
| Anti-hydroxy radical component (bioflavonoids) | ????0.1 |
| Anti-hydroxy radical component (palmityl hydroxypropyl trimethylammonium amylopectin/glycerol cross linked polymer (with) lecithin (with) tea extract) | ????0.1 |
| Cytoactive component (retinyl acetate) | ????0.16 |
| Cellular energy generates component (ubiquinone) | ????0.05 |
| Collagen synthesizes component (tetrahexydecyl ascorbate) | ????0.1 |
| Emollient | ????1 |
| Wetting agent | ????1.65 |
| Emulsifying agent | |
| Skin conditioning agent | ????0.1 |
| Thickening agent | ????0.2 |
| The pH regulator agent | |
| Antiseptic | ????0.3 |
| Spice | ????0.15 |
| Ring first silicone | ????10.00 |
| The polyisobutylene acid glyceride | ????10.00 |
| The diformazan silicone copolyol | ????2.00 |
| 12 micron silicas | ????2.00 |
| 3 micron silicas | ????2.00 |
| Polyacrylamide (with) C 13-14Isoparaffin (with) Laureth-7 | ????1.00 |
| Polysorbas20 | ????0.50 |
| Altogether | ????100.00 |
Embodiment 4
Carry out following test with relatively complex composition of the present invention and placebo, vitamin E and ascorbic effect.Test is to be undertaken by describe a plurality of 2 inches zones at people's back.Give these zone coatings series preparation down in mode at random.
| Component | ???Wt.％ | ???Wt.％ | ????Wt.％ | ????Wt.％ |
| ????A | ????B | ????C | ????D | |
| Emollient | ????21.5 | ????21.5 | ????21.5 | ????21.5 |
| Wetting agent | ????6.205 | ????6.205 | ????6.205 | ????6.205 |
| Emulsifying agent | ????1.3 | ????1.3 | ????1.3 | ????1.3 |
| Skin conditioning agent | ????0.1 | ????0.1 | ????0.1 | ????0.1 |
| Thickening agent | ????0.3 | ????0.3 | ????0.3 | ????0.3 |
| The pH regulator agent | ????0.3 | ????0.3 | ????0.3 | ????0.3 |
| Antiseptic | ????1.25 | ????1.25 | ????1.25 | ????1.25 |
| Spice | ????0.15 | ????0.15 | ????0.15 | ????0.15 |
| Tocopherol | ????1.2000 | ????0.2000 | ||
| Glutathion | ????0.2000 | |||
| Tetrahydrochysene two Resina Ferulae acyl group methane | ????0.1000 | |||
| Fructus Vitis viniferae (Fructus Vitis viniferae) seed extract (﹠) phospholipid | ????0.1000 | |||
| Bioflavonoids | ????0.1000 | |||
| Palmityl hydroxypropyl trimethylammonium amylopectin/glycerol cross linked polymer (with) lecithin (with) tea extract | ????0.1000 | |||
| Superoxide dismutase | ????0.0050 | |||
| Hyaluronate sodium | ????0.0005 | ????0.0005 | ????0.0005 | ????0.0005 |
| Ascorbic acid | ????10.000 | |||
| Water | ????QS | ????QS | ????QS | ????QS |
Apply after the above-mentioned preparation, the UV radiation is carried out at the back, and measure skin erythema.
Attached Fig. 1 and 2 has represented measurement result.
Should be appreciated that and to carry out multiple changes and improvements to above-mentioned embodiment.The description of front just illustrates rather than limits the present invention, and the scope of the invention comprises that by claims all coordinates limit.
Claims (18)
1. topical skin composition wherein comprises:
A. at least a anti-superoxides component;
B. at least a component that is selected from resistive to hydrogen peroxide component and anti-peroxy component;
C. at least a anti-hydroxy radical component; With
D. choose wantonly and contain at least a chain terminating agent.
2. the skin composition of claim 1 wherein also includes the component that helps the cellular energy generation.
3. the skin composition of claim 1 wherein also includes and helps the synthetic component of collagen.
4. the skin composition of claim 1 wherein also includes the component that helps cytoactive.
5. the skin composition of claim 1, but the used for cosmetic carrier wherein also comprised.
6. the skin composition of claim 1, wherein said anti-superoxides component is selected from superoxide dismutase, sod derivative, porphorins and their mixture.
7. the skin composition of claim 1; wherein at least a component is to be selected from following sulphur compound: captopril; cysteamine; ergothioneine; mercapto-propionyl-glycin; penicillamine; the N-acetylcysteine; the S-acetylcysteine; N; S-diacetyl cysteine; N; S-diacetyl cysteine amide; ethycysteine; N-acetylcysteine ethyl ester; S-acetylcysteine ethyl ester; N, S-diacetyl ethycysteine; thioglycolic acid; cysteine; homocysteine; glutathion; thioglycerol; thiomalic acid; 2 mercaptopropionic acid; the 3-mercaptopropionic acid; thiodiglycol; 2 mercapto ethanol; dithiothreitol, DTT; thioxanthene; thiosalicylic acid; thiolactic acid; propane thioic acid; thiodiglycolic acid; thioctic acid; but with their used for cosmetic salt.
8. the skin composition of claim 1, wherein said anti-hydroxy radical component is selected from tocopherol, Renascin, tocopherol acid, fertility phenates, tetrahydrochysene Resina Ferulae acyl group methane, Semen Vitis viniferae extract, green tea extract, flavonoid and their mixture.
9. the skin composition of claim 2, the wherein said component that helps cellular energy to generate is selected from ubiquinone, pantothenylol and their mixture.
10. the skin composition of claim 3, the wherein said synthetic component of collagen that helps is selected from ascorbic acid and derivant thereof.
11. the skin composition of claim 10, wherein said ascorbic acid be selected from water solublity ascorbic acid, fat-soluble ascorbic acid, its separately derivant and their mixture.
12. the skin composition of claim 11, wherein said fat-soluble ascorbic acid are four esters of ascorbic acid.
13. the skin composition of claim 4, wherein said to help the component of cytoactive be biostearin.
14. the skin composition of claim 1 wherein also comprises the skin growth promoter that is selected from hydroxy acid.
15. the skin composition of claim 14, wherein said skin growth promoter is 'alpha '-hydroxy acids.
16. the skin composition of claim 14, wherein said skin growth promoter is beta-hydroxy acid.
17. the skin composition of claim 1 wherein also comprises UV infringement preventive.
18. the skin composition of claim 1 wherein also comprises antiinflammatory.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16753999P | 1999-11-24 | 1999-11-24 | |
| US60/167,539 | 1999-11-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1424900A true CN1424900A (en) | 2003-06-18 |
Family
ID=22607783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00818601A Pending CN1424900A (en) | 1999-11-24 | 2000-11-21 | Topical skin composition |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1231886A4 (en) |
| KR (1) | KR20030016202A (en) |
| CN (1) | CN1424900A (en) |
| AU (1) | AU1784301A (en) |
| HK (1) | HK1050840A1 (en) |
| WO (1) | WO2001037788A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102781461A (en) * | 2009-12-28 | 2012-11-14 | N.V.佩里科恩有限责任公司 | Topical acyl glutathione formulations |
| CN103327958A (en) * | 2011-03-25 | 2013-09-25 | N.V.佩里科恩有限责任公司 | Topical palmitoyl glutathione formulations |
| US9029317B2 (en) | 2009-12-28 | 2015-05-12 | N.V. Perricone Llc | Methods of improving the appearance of aging skin |
| CN105982890A (en) * | 2014-09-05 | 2016-10-05 | 中国医药大学 | Use of ergothioneine for activating the Nrf2 signaling pathway of cells |
| US9629788B2 (en) | 2010-03-05 | 2017-04-25 | N.V. Perricone Llc | Topical glutathione formulations for menopausal skin |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070003536A1 (en) * | 2000-11-21 | 2007-01-04 | Zimmerman Amy C | Topical skin compositions, their preparation, and their use |
| DE10111053A1 (en) * | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Active ingredient combinations of alpha-lipoic acid and biochinones |
| DE10111046A1 (en) * | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Cosmetic or dermatological preparations for treating or preventing pigmentation disorders, e.g. freckles or liver spots, containing active agent combination of alpha-lipoic acid and UV-A or UV-B absorber |
| US20030105027A1 (en) * | 2001-11-06 | 2003-06-05 | Rosenbloom Richard A. | Nutritional supplements and methods for prevention, reduction and treatment of radiation injury |
| US7435725B2 (en) | 2001-11-06 | 2008-10-14 | The Quigly Corporation | Oral compositions and methods for prevention, reduction and treatment of radiation injury |
| US7407986B2 (en) | 2001-12-18 | 2008-08-05 | Brassica Foundation For Chemoprotection Research, Inc. | Prevention and treatment of oxidative stress disorders by glutathione and phase II detoxification enzymes |
| DE10257949A1 (en) * | 2002-12-12 | 2004-07-01 | Beiersdorf Ag | Cosmetic or dermatological preparation for use on sensitive skin in treating e.g. inflammations or wounds contains thiodiglycol |
| TWI322008B (en) | 2003-01-31 | 2010-03-21 | Kaneka Corp | Fatigue improving agent including reduced coenzyme q10 |
| SI1591105T1 (en) | 2004-03-17 | 2020-09-30 | Stada Arzneimittel Ag | Use of antioxidants for the preparation of pharmaceutical or cosmetic compositions for protecting the skin from damages by infrared-radiations |
| KR100883757B1 (en) * | 2007-03-12 | 2009-02-12 | 성균관대학교산학협력단 | Polyphenol compounds with modulating neurotransmitter release |
| US7829709B1 (en) | 2007-08-10 | 2010-11-09 | Marquette University | Cysteine prodrugs to treat schizophrenia and drug addiction |
| JP2011511770A (en) | 2008-01-25 | 2011-04-14 | シェーリング−プラウ ヘルスケア プロダクツ，インコーポレイテッド | Method for selecting antioxidants for use in topically applied compositions |
| US8173809B2 (en) | 2008-02-07 | 2012-05-08 | Marquette University | Cysteine and cystine prodrugs to treat schizophrenia and reduce drug cravings |
| US20110160143A1 (en) * | 2009-12-28 | 2011-06-30 | Perricone Nicholas V | Topical Acyl Glutathione Psoriasis Compositions |
| US10063312B2 (en) * | 2016-06-21 | 2018-08-28 | Futurewei Technologies, Inc. | Optical network unit reset message |
| US20230157939A1 (en) * | 2020-04-28 | 2023-05-25 | Conopco, Inc., D/B/A Unilever | Personal care compositions with enhanced solubility actives |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378461A (en) * | 1991-07-12 | 1995-01-03 | Neigut; Stanley J. | Composition for the topical treatment of skin damage |
| FR2728790B1 (en) * | 1994-12-29 | 1997-01-24 | Cird Galderma | COMPOSITION MODULATING APOPTOSIS COMPRISING METHONIAL OR ANY FACTOR INFLUENCING THE INTRACELLULAR METHONIAL RATE |
| US5866142A (en) * | 1995-07-20 | 1999-02-02 | Riordan; Neil H. | Skin treatment system |
| US5667791A (en) * | 1996-05-31 | 1997-09-16 | Thione International, Inc. | X-ray induced skin damage protective composition |
| US5935596A (en) * | 1997-03-20 | 1999-08-10 | Chesebrough-Pond's Usa Co. | Delivery of skin benefit agents via adhesive strips |
| US5906811A (en) * | 1997-06-27 | 1999-05-25 | Thione International, Inc. | Intra-oral antioxidant preparations |
| US6011067A (en) * | 1999-06-11 | 2000-01-04 | Thione International, Inc. | Antioxidant composition for the treatment of psoriasis and related diseases |
| JP4198357B2 (en) * | 1999-10-08 | 2008-12-17 | コティ ビー．ヴィ． | A cosmetic active substance formulation containing a synergistically increased radical protection factor |
-
2000
- 2000-11-21 AU AU17843/01A patent/AU1784301A/en not_active Abandoned
- 2000-11-21 KR KR1020027006507A patent/KR20030016202A/en not_active Application Discontinuation
- 2000-11-21 EP EP00980601A patent/EP1231886A4/en not_active Withdrawn
- 2000-11-21 CN CN00818601A patent/CN1424900A/en active Pending
- 2000-11-21 WO PCT/US2000/031933 patent/WO2001037788A1/en not_active Application Discontinuation
-
2003
- 2003-02-18 HK HK03101244.9A patent/HK1050840A1/en unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102781461A (en) * | 2009-12-28 | 2012-11-14 | N.V.佩里科恩有限责任公司 | Topical acyl glutathione formulations |
| US9029317B2 (en) | 2009-12-28 | 2015-05-12 | N.V. Perricone Llc | Methods of improving the appearance of aging skin |
| US9629788B2 (en) | 2010-03-05 | 2017-04-25 | N.V. Perricone Llc | Topical glutathione formulations for menopausal skin |
| CN103327958A (en) * | 2011-03-25 | 2013-09-25 | N.V.佩里科恩有限责任公司 | Topical palmitoyl glutathione formulations |
| US9023801B2 (en) | 2011-03-25 | 2015-05-05 | N.V. Perricone Llc | Topical palmitoyl glutathione formulations |
| CN105982890A (en) * | 2014-09-05 | 2016-10-05 | 中国医药大学 | Use of ergothioneine for activating the Nrf2 signaling pathway of cells |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1784301A (en) | 2001-06-04 |
| EP1231886A1 (en) | 2002-08-21 |
| KR20030016202A (en) | 2003-02-26 |
| EP1231886A4 (en) | 2005-10-12 |
| WO2001037788A1 (en) | 2001-05-31 |
| HK1050840A1 (en) | 2003-07-11 |
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