CN1421459A - Humanized CD3-resisting monoclonal antibody - Google Patents
Humanized CD3-resisting monoclonal antibody Download PDFInfo
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- CN1421459A CN1421459A CN 01132281 CN01132281A CN1421459A CN 1421459 A CN1421459 A CN 1421459A CN 01132281 CN01132281 CN 01132281 CN 01132281 A CN01132281 A CN 01132281A CN 1421459 A CN1421459 A CN 1421459A
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Abstract
Description
Antibody | Antibody concentration μ g/ml | ||
?0.1 | ?1 | ?10 | |
?Rituxan | ?57MFI | ?88MFI | ?101MFI |
?cGD3 | ?171MFI | ?224MFI | ?320MFI |
?huGD3 | ?55MFI | ?76MFI | ?97MFI |
CD3 modulation (%) | |||||||
[antibody] ng/ml | ?10 -1 | ?10 | ?10 1 | ?10 2 | ?10 3 | ?10 4 | ?10 5 |
mGD3 | ?10.56 | ?15.45 | ?16.78 | ?67.67 | ?78.89 | ?85.86 | ?85.34 |
huGD3 | ?9.52 | ?13.25 | ?13.57 | ?56.87 | ?70.00 | ?85.36 | ?85.64 |
Claims (9)
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CN 01132281 CN1189483C (en) | 2001-11-23 | 2001-11-23 | Humanized CD3-resisting monoclonal antibody |
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CN 01132281 CN1189483C (en) | 2001-11-23 | 2001-11-23 | Humanized CD3-resisting monoclonal antibody |
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CN1421459A true CN1421459A (en) | 2003-06-04 |
CN1189483C CN1189483C (en) | 2005-02-16 |
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CN 01132281 Expired - Lifetime CN1189483C (en) | 2001-11-23 | 2001-11-23 | Humanized CD3-resisting monoclonal antibody |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7777017B2 (en) | 1998-06-15 | 2010-08-17 | Biosynexus Incorporated | Nucleic acids encoding opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
CN1984931B (en) * | 2004-06-03 | 2012-11-28 | 诺维莫尼公司 | Anti-CD3 antibodies and methods of use thereof |
CN104098698A (en) * | 2013-04-08 | 2014-10-15 | 中国人民解放军第二军医大学 | Antibody against CD3, and preparation method and application thereof |
US9782478B1 (en) | 2011-04-22 | 2017-10-10 | Aptevo Research And Development Llc | Prostate-specific membrane antigen binding proteins and related compositions and methods |
CN109913493A (en) * | 2017-12-12 | 2019-06-21 | 百奥赛图江苏基因生物技术有限公司 | The preparation method and application of humanization CD3 genetic modification animal model |
US11352426B2 (en) | 2015-09-21 | 2022-06-07 | Aptevo Research And Development Llc | CD3 binding polypeptides |
WO2024152963A1 (en) * | 2023-01-18 | 2024-07-25 | 贝达药业股份有限公司 | Humanized anti-cd3 antibody and use thereof |
US12122850B2 (en) | 2023-03-14 | 2024-10-22 | LamKap Bio gamma AG | Bispecific GPC3xCD28 and GPC3xCD3 antibodies and their combination for targeted killing of GPC3 positive malignant cells |
-
2001
- 2001-11-23 CN CN 01132281 patent/CN1189483C/en not_active Expired - Lifetime
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7777017B2 (en) | 1998-06-15 | 2010-08-17 | Biosynexus Incorporated | Nucleic acids encoding opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
CN1984931B (en) * | 2004-06-03 | 2012-11-28 | 诺维莫尼公司 | Anti-CD3 antibodies and methods of use thereof |
US9782478B1 (en) | 2011-04-22 | 2017-10-10 | Aptevo Research And Development Llc | Prostate-specific membrane antigen binding proteins and related compositions and methods |
CN104098698A (en) * | 2013-04-08 | 2014-10-15 | 中国人民解放军第二军医大学 | Antibody against CD3, and preparation method and application thereof |
CN104098698B (en) * | 2013-04-08 | 2019-04-05 | 中国人民解放军第二军医大学 | A kind of anti-cd 3 antibodies and its preparation method and application |
US11352426B2 (en) | 2015-09-21 | 2022-06-07 | Aptevo Research And Development Llc | CD3 binding polypeptides |
CN109913493A (en) * | 2017-12-12 | 2019-06-21 | 百奥赛图江苏基因生物技术有限公司 | The preparation method and application of humanization CD3 genetic modification animal model |
US10945420B2 (en) | 2017-12-12 | 2021-03-16 | BiocytogenPharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric CD3e |
US12016315B2 (en) | 2017-12-12 | 2024-06-25 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric CD3e |
WO2024152963A1 (en) * | 2023-01-18 | 2024-07-25 | 贝达药业股份有限公司 | Humanized anti-cd3 antibody and use thereof |
US12122850B2 (en) | 2023-03-14 | 2024-10-22 | LamKap Bio gamma AG | Bispecific GPC3xCD28 and GPC3xCD3 antibodies and their combination for targeted killing of GPC3 positive malignant cells |
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