CN1413738A - Soft artificial bone material - Google Patents
Soft artificial bone material Download PDFInfo
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- CN1413738A CN1413738A CN 01134095 CN01134095A CN1413738A CN 1413738 A CN1413738 A CN 1413738A CN 01134095 CN01134095 CN 01134095 CN 01134095 A CN01134095 A CN 01134095A CN 1413738 A CN1413738 A CN 1413738A
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- artificial bone
- bone material
- cuttlebone
- hydroxyapatite
- bone
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Abstract
An artificial soft bone material for repairing the cartrilage and soft tissue is prepared from cuttlefish bone through hydrothermal reaction. Its advantages are low density, high flexibility and biocompatibility, low cost, good bioactivity, and controllable biodegradability.
Description
The technical field is as follows:
the present invention relates to artificial bone material for surgical operation.
Background art:
bioactive artificial bone materials with excellent properties are often required in surgical operations such as orthopedics, dentistry, face-lifting, maxillofacial restoration, and the like. The currently commonly adopted artificial bone materials comprise autogenous bone, allogeneic bone, titanium metal, biological ceramic, bone cement and the like. The titanium metal, the bioceramics, the bone cement and other materials can be implanted with good biocompatibility, and some materials also have good biological activity or absorbability, but the performance is not enough, and the implant is also required to be rich in communicating channels, so that the titanium metal, the bioceramics, the bone cement and other materials play a decisive role in the growth of blood vessels, nerves and muscle tissues and the circulation of body fluid and blood in the implant, and have important significance in the fixation, degradation and new bone growth of the artificial bone. All of the above materials are difficult to do. The allogenic bone (animal bone or human bone) often causes immune reaction during implantation, and the implantation of the autologous bone causes new pain and disability to patients.
Us patent 3,929,971(1975, 12) discloses an artificial bone material formed by hydrothermal reaction of calcium carbonate bone tissue of echinoderm and coral to hydroxyapatite, wherein the obtained product has the same macroscopic structure as coral and has a large number of interconnected pores, which can provide a good pore structure for Haversian system and healthy development of blood supply and new tissue. This patent is therefore used in artificial bone. However, coral is a long-term accumulation of coral skeleton and has a slow rate of formation. The existing coral reefs are all precious natural resources and are seriously damaged. The coral is used as the raw material, and the damage to the coral resource is aggravated. On the other hand, artificialbone materials modified by coral are hard in texture and very suitable for some occasions (such as load-bearing bones and skull bones), but are difficult to be suitable for some occasions (such as jaw faces) needing soft bones.
The invention content is as follows:
the invention aims to provide a soft artificial bone material which has easily obtained raw materials and simple preparation method.
The technical solution of the invention is as follows:
the artificial bone material is obtained by modifying cuttlebone, the component of the artificial bone material is hydroxyapatite, the macroscopic structure of the artificial bone material is the same as that of the cuttlebone, and the artificial bone material has mutually communicated pore passages with the diameter of 0.2-2 mm.
In the scheme, the components of the composite material can also be hydroxyapatite and calcium carbonate, wherein the weight ratio of the hydroxyapatite is more than or equal to 10 percent, the weight ratio of the calcium carbonate is less than or equal to 90 percent, and the composite material has the same macroscopic structure as the cuttlebone and has mutually communicated pore channels with the diameter of 0.2-2 mm.
The invention uses reproducible cuttlebone to replace non-reproducible coral to prepare the soft artificial bone material with a large number of mutually communicated pore structures, which can also provide good pores for the health development of a Haves system, blood supply and new tissues, can meet the required flexibility and can protect the ecological environment.
In order to achieve the purpose, the cuttlebone with calcium carbonate as the component is placed in phosphate aqueous solution with the concentration of more than 6 percent, and hydrothermal reaction is carried out in a high-pressure kettle. The hydrothermal reaction is carried out at a temperature of 100 to 600 ℃, a pressure of 1 to 6000atm, and a pH of 6 to 10.
The chemical reactions that occur in the hydrothermal reaction are as follows:
the chemical molecular formula of the product hydroxyapatite is Ca10(PO4)6(OH)2Has the same components as human skeleton and teeth, and has good biocompatibility. The macroscopic structure of the device is the same as that of cuttlebone, and the device has a developed pore network with the diameter of 0.2-2 mm and communicated with each other. Compared with coral, it has low density and high flexibility, so that it is suitable for treating and repairing soft bone and some special human tissue.
To achieve reaction completion, it is necessary to ensure a sufficient amount of phosphate. According to the chemical reaction formula, the molar ratio of the cuttlebone to the phosphate is 10: 6. The use of an excess of phosphate is very effective in accelerating the reaction and ensuring completion of the reaction. There is no particular limitation on the kind of phosphate used, for example: k3PO4，Na3PO4，(NH4)3PO4，(NH4)2HPO4，(NH4)H2PO4，Li3PO4，LiH2PO4，Na2HPO4，NaH2PO4，Na3H3(PO4)2，Na4H5(PO4)3，NaH5(PO4)2，KH2PO4，KH5(PO4)2，NH4H5(PO4)3，2CaO·P2O5，CaO·P2O5，CaHPO4，Ca4P2O9，Ca(H2PO4)2And the like may be used.
The artificial bone material with the components of hydroxyapatite or hydroxyapatite and calcium carbonate can be prepared after a proper period of time (namely the modified cuttlebone can be completely hydroxyapatite or partially hydroxyapatite and partially calcium carbonate). The reaction time can be 0.2 hour to 12 days under different conditions. The specific time depends on the temperature, pressure, material properties, phosphate type and concentration, pH value of the reaction and the content of hydroxyapatite in the required product. The content of hydroxyapatite may be in the range of 100 to 10% by weight, that is, the content of calcium carbonate may be in the range of 0 to 90% by weight, selected according to the functional requirements (flexibility, bioactivity, degradability, etc.) of the artificial bone in use. The higher the content of hydroxyapatite, the better the flexibility thereof, and the stronger the direct bonding with human bone, but the poorer the degradability.
Animal experiments also show that the material has good biocompatibility.
In conclusion, the artificial bone material modified by the cuttlebone provided by the invention has good flexibility, biocompatibility, bioactivity, controllable biodegradability and the like. The raw materials are renewable resources, the sources are rich, the preparation process is simple, and the cost is low, so the method has good application prospect.
The specific implementation mode is as follows:
example 1 cuttlebone was washed and treated at a concentration of 25% (NH) at 180 c, 10 atm, pH 84)2HPO4Reacting in water solution for 2 days to obtain the cuttlebone artificial bone material. The ingredients are hydroxyapatite, macrostructure and cuttleboneThe original structure is the same.
Example 2 cuttlebone was treated at a concentration of 25% (NH) at 120 c, 2 atmospheres, pH 74)H2PO4Reacting in water solution for 1 day to obtain Os Sepiae artificial bone material partially converted into hydroxyapatite. The calcium carbonate powder contains 65 percent of hydroxyapatite and the balance of calcium carbonate. The macroscopic structure of the cuttlebone is the same as the original structure of the cuttlebone.
Example 3 cuttlebone was washed and treated at a concentration of 6% (NH) at 100 c, 1 atm, pH 7.54)2HPO4Reacting in the water solution for 3 hours to obtain the cuttlebone artificial bone material partially converted into hydroxyapatite. Wherein the content of hydroxyapatite is 10 percent, and the rest is calcium carbonate. The macroscopic structure of the cuttlebone is the same as the original structure of the cuttlebone.
Claims (2)
1. A soft artificial bone material is characterized in that the artificial bone material is obtained by modifying cuttlebone, the component of the artificial bone material is hydroxyapatite, the macroscopic structure of the artificial bone material is the same as that of the cuttlebone, and the artificial bone material is provided with mutually communicated pore channels with the diameter of 0.2-2 mm.
2. The soft artificial bone material is characterized in that the artificial bone material is obtained by modifying cuttlebone, and comprises hydroxyapatite and calcium carbonate, wherein the weight ratio of the hydroxyapatite is more than or equal to 10%, the weight ratio of the calcium carbonate is less than or equal to 90%, the macroscopic structure of the artificial bone material is the same as that of the cuttlebone, and the artificial bone material has mutually communicated pore canals with the diameter of 0.2-2 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01134095 CN1413738A (en) | 2001-10-24 | 2001-10-24 | Soft artificial bone material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01134095 CN1413738A (en) | 2001-10-24 | 2001-10-24 | Soft artificial bone material |
Publications (1)
| Publication Number | Publication Date |
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| CN1413738A true CN1413738A (en) | 2003-04-30 |
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| CN 01134095 Pending CN1413738A (en) | 2001-10-24 | 2001-10-24 | Soft artificial bone material |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934087A (en) * | 2009-09-21 | 2011-01-05 | 上海交通大学医学院附属第九人民医院 | Application of carbonized cuttlebones in orthopaedics |
| CN102274737A (en) * | 2010-06-13 | 2011-12-14 | 宁波大学 | Method for preparing macroporous material loaded with silver nanometer particles |
| CN102764450A (en) * | 2011-07-19 | 2012-11-07 | 李亚屏 | Cuttlebone transformation series porous composite bio-ceramic, its preparation method and application |
| CN106693062A (en) * | 2017-02-20 | 2017-05-24 | 福州市大福瑞生物科技有限公司 | Composite bone tissue repair material and preparation method thereof |
| CN107823712A (en) * | 2017-12-13 | 2018-03-23 | 华中科技大学 | A kind of method for preparing imitative artificial bone of coral with cuttlebone and products thereof |
| CN110025406A (en) * | 2019-04-17 | 2019-07-19 | 上海黑焰医疗科技有限公司 | A kind of preparation method of 3D printing bone defect filler |
-
2001
- 2001-10-24 CN CN 01134095 patent/CN1413738A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934087A (en) * | 2009-09-21 | 2011-01-05 | 上海交通大学医学院附属第九人民医院 | Application of carbonized cuttlebones in orthopaedics |
| CN102274737A (en) * | 2010-06-13 | 2011-12-14 | 宁波大学 | Method for preparing macroporous material loaded with silver nanometer particles |
| CN102764450A (en) * | 2011-07-19 | 2012-11-07 | 李亚屏 | Cuttlebone transformation series porous composite bio-ceramic, its preparation method and application |
| CN102764450B (en) * | 2011-07-19 | 2013-12-04 | 李亚屏 | Cuttlebone transformation series porous composite bio-ceramic, its preparation method and application |
| CN106693062A (en) * | 2017-02-20 | 2017-05-24 | 福州市大福瑞生物科技有限公司 | Composite bone tissue repair material and preparation method thereof |
| CN107823712A (en) * | 2017-12-13 | 2018-03-23 | 华中科技大学 | A kind of method for preparing imitative artificial bone of coral with cuttlebone and products thereof |
| CN110025406A (en) * | 2019-04-17 | 2019-07-19 | 上海黑焰医疗科技有限公司 | A kind of preparation method of 3D printing bone defect filler |
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