CN1410060A - Matrine vaginal gel - Google Patents
Matrine vaginal gel Download PDFInfo
- Publication number
- CN1410060A CN1410060A CN 02135793 CN02135793A CN1410060A CN 1410060 A CN1410060 A CN 1410060A CN 02135793 CN02135793 CN 02135793 CN 02135793 A CN02135793 A CN 02135793A CN 1410060 A CN1410060 A CN 1410060A
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- CN
- China
- Prior art keywords
- matrine
- distilled water
- glycerol
- vaginal gel
- card pool
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
A matrine vagina gel is prepared from matrine (5-50 wt. portions) Kapomu (5-50), glycerine (25-500) and distilled water (400-4500). Its advantages are high curative effect, long stay time, no damage to vagina and no pollution to clothes.
Description
Technical field
The present invention relates to the Amino-Cerv technical field.
Background technology
Matrine (Matrine) is an isolated monosomic alkali from the Chinese medicine Radix Sophorae Flavescentis; has the immunity of raising leukocyte increasing number; strengthen immunity of organisms, the remarkable effect of performance anti-inflammation, and have various pharmacological activities such as antiviral, antiinflammatory, antitumor, the liver protecting function.Because matrine all has good anti-infectious function to dysentery liver bacterium, dermatophytes, infusorian, ameba etc., the clinical diseases such as chronic cervicitis, cervical erosion, infusorian property and colpitis mycotica, senile vaginitis, adnexitis, pruritus vulvae vulval eczema that are used for the treatment of more.
Cervicitis is the women of child-bearing age's a commonly encountered diseases, and pathogen is mainly staphylococcus, streptococcus, colibacillus and anaerobe, secondly is gonorrhea diplococcus, tubercule bacillus, has infusorian and ameba to cause in the protozoon.At present, the medicine of widely used clinically this disease of treatment mostly is an external suppository, be vaginal suppository and vagina type of effervescent suppository, there is administration inconvenience in it when reality is used, the intravaginal anelasticity is poor, and drug treating time is short, medicine is difficult to whole releases, intravaginal has foreign body sensation, easy damaged vagina and the not fairly obvious shortcoming of curative effect.And suppository easily pollution clothes of back.
Summary of the invention
The purpose of this invention is to provide a kind of matrine vaginal gel, its curative effect is obvious, convenient drug administration, intravaginal anelasticity are good, drug treating time long, medicine can all discharge, intravaginal does not have foreign body sensation, can not damage vagina, and its not yielding, easy preservation, with after pollution clothes not.
The objective of the invention is to be achieved through the following technical solutions: matrine vaginal gel, it comprises following component (in weight portion):
Matrine 5-50 card pool nurse 5-50
Glycerol 25-500 distilled water 400-4500
For further realizing also being achieved through the following technical solutions purpose of the present invention: described matrine vaginal gel, it comprises following component (in weight portion):
Matrine 5-30 card pool nurse 5-30
Glycerol 25-300 distilled water 400-3000
Described matrine vaginal gel, it comprises following component (in weight portion):
Matrine 5-20 card pool nurse 5-20
Glycerol 25-200 distilled water 500-2000
Described matrine vaginal gel, it comprises following component (in weight portion):
Matrine 8-15 card pool nurse 8-15
Glycerol 30--100 distilled water 600-1200
Described matrine vaginal gel, it comprises following component (in weight portion):
Matrine 8-12 card pool nurse 8-12
Glycerol 40-60 distilled water 800-1100
Described matrine vaginal gel, it comprises following component (in weight portion):
Matrine 9-11 card pool nurse 9-11
Glycerol 45-55 distilled water 850-1050
Described matrine vaginal gel, it comprises following component (in weight portion):
Matrine 10 card pool nurses 10
Glycerol 50 distilled water 930
The beneficial effect that the present invention can produce: because of matrine has heat-clearing and toxic substances removing, dispeiling pathogenic wind and removing dampness, anti-inflammatory analgetic, antipruritic effect and promoting granulation effect by the clinical research proof; various pathogens, fungus, infusorian, ameba there be strong the inhibition or killing action; and can improve local immunity function, the diffusion of restriction pro-inflammatory cytokine, improve the many-sided pharmacological action and the clinical function of mucosa hyperemia, protection mucosa, growth epithelium.
The effect that the present invention utilizes matrine to have and regulates ph balancing, corrects dysbacteriosis, wind dispelling insecticide, and adopt vagina gel for belonging to biologic adhesion preparation, behind scientific formula, have convenient drug administration, the intravaginal anelasticity is good, drug treating time long, medicine is all discharged easily or by all absorption, non-stimulated, no foreign body sensations, do not damage the advantage of vagina.The present invention adopts water-soluable gel substrate, can make medicine be the molecular level diffusion, has improved bioavailability of medicament greatly, to modal bacterial vaginosis in gynecological's reproductive tract infection, has excellent curative, not pollution clothes.
The specific embodiment
Embodiment 1
Get: matrine 50Kg card pool nurse 50Kg
The above-mentioned prescription of glycerol 500Kg distilled water 4500Kg is inserted in the vaginal administration device after preparing by known technology, and sealing gets final product.
Embodiment 2
Get: matrine 5Kg card pool nurse 5Kg
The above-mentioned prescription of glycerol 25Kg distilled water 400Kg is inserted in the vaginal administration device after preparing by known technology, and sealing gets final product.
Embodiment 3
Get: matrine 20Kg card pool nurse 20Kg
The above-mentioned prescription of glycerol 200Kg distilled water 2000Kg is inserted in the vaginal administration device after preparing by known technology, and sealing gets final product.Embodiment 4
Get: matrine 8Kg card pool nurse 8Kg
The above-mentioned prescription of glycerol 30Kg distilled water 600Kg is inserted in the vaginal administration device after preparing by known technology, and sealing gets final product.
Embodiment 5
Get: matrine 12Kg card pool nurse 12Kg
The above-mentioned prescription of glycerol 60Kg distilled water 1100Kg is inserted in the vaginal administration device after preparing by known technology, and sealing gets final product.
Embodiment 6
Get: matrine 9Kg card pool nurse 9Kg
The above-mentioned prescription of glycerol 45Kg distilled water 850Kg is inserted in the vaginal administration device after preparing by known technology, and sealing gets final product.Embodiment 7
Get: matrine 10Kg card pool nurse 10Kg
The above-mentioned prescription of glycerol 50Kg distilled water 930Kg is inserted in the vaginal administration device after preparing by known technology, and sealing gets final product.
The technology that the present invention does not describe in detail partly is known technology.
Claims (7)
1, matrine vaginal gel is characterized in that: it comprises following component (in weight portion):
Matrine 5-50 card pool nurse 5-50
Glycerol 25-500 distilled water 400-4500
2, matrine vaginal gel according to claim 1 is characterized in that: it comprises following component (in weight portion):
Matrine 5-30 card pool nurse 5-30
Glycerol 25-300 distilled water 400-3000
3, matrine vaginal gel according to claim 1 is characterized in that: it comprises following component (in weight portion):
Matrine 5-20 card pool nurse 5-20
Glycerol 25-200 distilled water 500-2000
4, matrine vaginal gel according to claim 1 is characterized in that: it comprises following component (in weight portion):
Matrine 8-15 card pool nurse 8-15
Glycerol 30--100 distilled water 600-1200
5, matrine vaginal gel according to claim 1 is characterized in that: it comprises following component (in weight portion):
Matrine 8-12 card pool nurse 8-12
Glycerol 40-60 distilled water 800-1100
6, matrine vaginal gel according to claim 1 is characterized in that: it comprises following component (in weight portion):
Matrine 9-11 card pool nurse 9-11
Glycerol 45-55 distilled water 850-1050
7, matrine vaginal gel according to claim 1 is characterized in that: it comprises following component (in weight portion):
Matrine 10 card pool nurses 10
Glycerol 50 distilled water 930
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021357935A CN1159011C (en) | 2002-11-15 | 2002-11-15 | Matrine vaginal gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021357935A CN1159011C (en) | 2002-11-15 | 2002-11-15 | Matrine vaginal gel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1410060A true CN1410060A (en) | 2003-04-16 |
| CN1159011C CN1159011C (en) | 2004-07-28 |
Family
ID=4748362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021357935A Expired - Fee Related CN1159011C (en) | 2002-11-15 | 2002-11-15 | Matrine vaginal gel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1159011C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101237851A (en) * | 2005-06-16 | 2008-08-06 | 沃纳奇尔科特公司 | Estrogen compositions for vaginal administration |
| CN100418528C (en) * | 2006-02-28 | 2008-09-17 | 上海华拓医药科技发展有限公司 | Heat-sensitive gel containing matrine alkaloid and its preparing method |
| CN102973560A (en) * | 2012-12-03 | 2013-03-20 | 施惠娟 | Novel method of applying matrine to treating eczematous dermatitis |
| CN103271984A (en) * | 2013-05-30 | 2013-09-04 | 兰州大学第一医院 | Preparation method and application of sophora alopecuroides total alkaloid temperature-sensitive gel for treating ulcerative colitis and gynecological inflammation |
| CN105250280A (en) * | 2014-07-14 | 2016-01-20 | 诺维科国际控股股份有限公司 | Microbicidal composition comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof |
| CN105663029A (en) * | 2016-01-13 | 2016-06-15 | 杭州市儿童医院 | Bioadhesion slow-release gel preparation for oral administration and preparation method thereof |
| CN106466355A (en) * | 2015-08-14 | 2017-03-01 | 佛山手心制药有限公司 | A kind of Chinese traditional effective part compound preparation treating V＆V prurituss and preparation method thereof |
| CN111514191A (en) * | 2020-05-08 | 2020-08-11 | 湖南奥朗特医疗器械有限公司 | Vagina care solution gel and preparation method thereof |
-
2002
- 2002-11-15 CN CNB021357935A patent/CN1159011C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101237851A (en) * | 2005-06-16 | 2008-08-06 | 沃纳奇尔科特公司 | Estrogen compositions for vaginal administration |
| CN100418528C (en) * | 2006-02-28 | 2008-09-17 | 上海华拓医药科技发展有限公司 | Heat-sensitive gel containing matrine alkaloid and its preparing method |
| CN102973560A (en) * | 2012-12-03 | 2013-03-20 | 施惠娟 | Novel method of applying matrine to treating eczematous dermatitis |
| CN103271984A (en) * | 2013-05-30 | 2013-09-04 | 兰州大学第一医院 | Preparation method and application of sophora alopecuroides total alkaloid temperature-sensitive gel for treating ulcerative colitis and gynecological inflammation |
| CN105250280A (en) * | 2014-07-14 | 2016-01-20 | 诺维科国际控股股份有限公司 | Microbicidal composition comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof |
| US9884049B2 (en) | 2014-07-14 | 2018-02-06 | Orion Biotechnology Canada Ltd. | Microbicidal composition comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof |
| EP3169324A4 (en) * | 2014-07-14 | 2018-02-21 | Novicol International Holding Inc. | Microbicidal composition comprising an octoxynol and a quinolizidine alkaloid compound or a source thereof |
| CN105250280B (en) * | 2014-07-14 | 2020-03-10 | 诺维科国际控股股份有限公司 | Microbicidal composition comprising octoxynol and a quinolizidine alkaloid compound or source thereof |
| CN106466355A (en) * | 2015-08-14 | 2017-03-01 | 佛山手心制药有限公司 | A kind of Chinese traditional effective part compound preparation treating V＆V prurituss and preparation method thereof |
| CN105663029A (en) * | 2016-01-13 | 2016-06-15 | 杭州市儿童医院 | Bioadhesion slow-release gel preparation for oral administration and preparation method thereof |
| CN111514191A (en) * | 2020-05-08 | 2020-08-11 | 湖南奥朗特医疗器械有限公司 | Vagina care solution gel and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1159011C (en) | 2004-07-28 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040728 |