CN1408708A - Process for synthesizing 2-pyridine chromium formate of fodder additive - Google Patents
Process for synthesizing 2-pyridine chromium formate of fodder additive Download PDFInfo
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- CN1408708A CN1408708A CN01141486A CN01141486A CN1408708A CN 1408708 A CN1408708 A CN 1408708A CN 01141486 A CN01141486 A CN 01141486A CN 01141486 A CN01141486 A CN 01141486A CN 1408708 A CN1408708 A CN 1408708A
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- pyridine carboxylic
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Abstract
The present invention relates to fodder additive. The synthesis of 2-pyridine chromium formate includes two steps and the process has low material cost, mild reaction condition and less pollution. The fodder additive can raise the production performance of farm animal, reduces fat deposition and strengthen animal's propagation capacity.
Description
Invention field
The present invention relates to feed additive field.
Background of invention
Livestock and poultry stress be one of important research field of modern herding science.In the aquaculture of China, high temperature stress, early weaning stress, the high yield physiological stress ubiquity.Domestic scholars studies show that heat stress is the principal element that constitutes China's animal in summer underproduction." 95 " national science and technology brainstorm subject " research and development of anti-stress additive " and national natural science fund subsidy project " metabolism of pig chromium when heat stress and the research of safety allowance " that Institute of Animal Husbandry, China Academy of Agriculture Scinces is presided over, ubiquitous high temperature stress stress with the high yield physiological in producing at China intensive culture, research high temperature resistance mechanism of action of chromium and chromium picolinate to pig, chicken, milk cow high temperature resistance, high yield physiological stress effect, develop the synthesis technique of the highest active 2-chromium picolinate in the chromium picolinate simultaneously.This technology has been applied to aquaculture and fodder industry.
Detailed description of the invention
The process sequence that the present invention prepares the 2-chromium picolinate is: the 2-vinylpyridine is oxidized to the 2-pyridine carboxylic acid, and recrystallization again with chromium trichloride generation complex reaction, generates the 2-chromium picolinate with purified product.1, the 2-pyridine carboxylic acid is synthetic
Main raw material: 2-vinylpyridine, potassium permanganate
Liquid 2-vinylpyridine and potassium permanganate solution are mixed, be heated to 90 ℃, reacted 4-6 hour.The product deionized water dissolving through recrystallization repeatedly, obtains white crystal 2-pyridine carboxylic acid.2, the reaction of chromium trichloride and 2-pyridine carboxylic acid generates the 2-chromium picolinate
Main raw material: 2-pyridine carboxylic acid, chromium trichloride, sodium hydroxide
Chromium trichloride is dissolved in deionized water, and solid-liquid ratio 2: 3 constantly under the agitation condition, adds the 2-pyridine carboxylic acid, and (2-pyridine carboxylic acid and chromium trichloride mol ratio are 3: 1), 37 ℃ of temperature of reaction, 40% sodium hydroxide solution is regulated pH value, generates until red precipitate.Reaction times is about 1 hour.Filter, and use deionized water wash, obtain the 2-chromium picolinate.
Fodder additives 2-chromium picolinate synthesis technique
The synthesis technique characteristics of 2-chromium picolinate of the present invention:
1, raw material is domestic can synthesize voluntarily, need not import, reduce production costs;
2, reaction conditions gentleness;
3, the production pollution is little, environmental influence is reduced to minimum.
2-chromium picolinate of the present invention to the high temperature resistance of pig, fryer, laying hen and milk cow, high yield physiological stress effect obvious: under hot environment, give and to replenish chromium picolinate 300ppb, 600ppb, 300ppb in growing and fattening pigs, fryer, the dairy cow diet respectively, production performance improves 9.3-16.7%, 10.7% and 16.1-17.0% respectively; Replenish 2-chromium picolinate 300ppb for the egg-laying peak laying hen, egg productivity improves 5.1%; Replenish chromium picolinate 600ppb for the early stage milk cow of lactation, milk yield improves 11.1%.(details are seen appendix)
Claims (4)
1, the 2-chromium picolinate is as fodder additives.
2, synthesize two-step reaction, the first step is a raw material with the 2-vinylpyridine, and potassium permanganate oxidation generates the 2-pyridine carboxylic acid; Second step generated the 2-chromium picolinate with the first step reaction product and chromium trichloride generation complex reaction.
3, according to the said the first step reaction of claim 2, oxidation reaction condition is: oxygenant-potassium permanganate, and 90 ℃ of temperature, reaction times 4-6 hour, process stirred all the time.The recrystallization purifying product.Product 2-pyridine carboxylic acid is a white crystal.
4, according to said second step reaction of claim 2, the complex reaction condition: 2-pyridine carboxylic acid and chromium trichloride mol ratio are 3: 1,37 ℃ of temperature, and process stirs all the time, 40% sodium hydroxide solution conditioned reaction liquid pH value generates until red precipitate, and the reaction times is about 1 hour.Product 2-chromium picolinate is a red-purple fine crystals powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01141486A CN1408708A (en) | 2001-09-27 | 2001-09-27 | Process for synthesizing 2-pyridine chromium formate of fodder additive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01141486A CN1408708A (en) | 2001-09-27 | 2001-09-27 | Process for synthesizing 2-pyridine chromium formate of fodder additive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1408708A true CN1408708A (en) | 2003-04-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN01141486A Pending CN1408708A (en) | 2001-09-27 | 2001-09-27 | Process for synthesizing 2-pyridine chromium formate of fodder additive |
Country Status (1)
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| CN (1) | CN1408708A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101318929B (en) * | 2008-07-04 | 2010-08-18 | 温州大学 | Synthesis process for chromium picolinate |
| CN101602716B (en) * | 2009-04-29 | 2011-05-25 | 南通醋酸化工股份有限公司 | Synthesis method of 2-chromium picolinate |
| CN102875458A (en) * | 2012-10-24 | 2013-01-16 | 北京桑普生物化学技术有限公司 | Synthesis method of chromium 2-pyridylformate |
| CN107337637A (en) * | 2017-08-14 | 2017-11-10 | 毛阿龙 | A kind of synthetic method of novel fodder additive |
| CN113016944A (en) * | 2021-04-29 | 2021-06-25 | 正百生物科技(江门)有限公司 | Feed additive containing composite organic trace elements and preparation method thereof |
-
2001
- 2001-09-27 CN CN01141486A patent/CN1408708A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101318929B (en) * | 2008-07-04 | 2010-08-18 | 温州大学 | Synthesis process for chromium picolinate |
| CN101602716B (en) * | 2009-04-29 | 2011-05-25 | 南通醋酸化工股份有限公司 | Synthesis method of 2-chromium picolinate |
| CN102875458A (en) * | 2012-10-24 | 2013-01-16 | 北京桑普生物化学技术有限公司 | Synthesis method of chromium 2-pyridylformate |
| CN107337637A (en) * | 2017-08-14 | 2017-11-10 | 毛阿龙 | A kind of synthetic method of novel fodder additive |
| CN113016944A (en) * | 2021-04-29 | 2021-06-25 | 正百生物科技(江门)有限公司 | Feed additive containing composite organic trace elements and preparation method thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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