Summary of the invention: purpose foot of the present invention provides fused heterocyclic derivative of a kind of heterocyclic substituted and preparation method thereof.Compound of the present invention is represented with general structure (I):
Wherein: n=0,1; X is carbon, nitrogen; Y, Z are oxygen or sulphur;
R be hydrogen, alkyl, thiazolinyl, alkynyl, alkynyl halide, alkyl carbonyl, carbalkoxy, alkanamine carbonyl,
Alkylsulfonyl, cyano group, amino; Better be alkyl, alkynyl, alkynyl halide, amino;
R
1Be hydrogen, halogen, cyano group, nitro, amino, alkyl, alcoxyl (sulphur) base; Better be halogen
Plain, cyano group;
Het is 2,4-(1H, 3H) during pyrimidine (two) ketone structural formula of compound with general formula (II) expression; For
1,3, structural formula of compound is represented with general formula (III) during 4-thiadiazolidine ketone; Be 1,2, the 4-triazoline
Structural formula of compound is represented with general formula (IV) during ketone; Compound structure during for the phthaloyl cyclic imide
Formula is represented with logical formula V; Structural formula of compound is represented with general formula (VI) during for pyrazoles; For
Structural formula of compound is represented with general formula (VII) during pyridazinone; Chemical combination during Wei Evil (miaow) oxazolidinedione
The thing structural formula is represented with general formula (VIII); Wei during oxane quinoline ketone structural formula of compound with general formula (IX)
Expression; Structural formula of compound is represented with general formula (X) during for the non-annularity phthalimide; Be triazole
The time structural formula of compound with general formula (XI); Better be 2,4-(1H, 3H) pyrimidine dione, 1,3,4-
Thiadiazolidine ketone, 1,2,4-Triazolinones, phthaloyl cyclic imide, non-annularity phthalimide;
In the formula (II): n, X, Y, Z, R, R
1Ditto described.W be singly-bound ,-CH2-,-NH-, O, S; Better be singly-bound ,-NH-; R
2=hydrogen, alkyl, thiazolinyl, alkynyl, alcoxyl (sulphur) base, alkyl carbonyl, carbalkoxy, cyano group,
Amino, cyano group, hydroxyl; Better be alkyl, amino; R
3=hydrogen, halogen, cyano group, amino, carboxyl, hydroxyl, alkyl, alcoxyl (sulphur) base, alcoxyl carbonyl
Base, formyl radical, formamyl, oximido methyl, alkylsulfonyl; Better be alkyl, amino; R
4=hydrogen, amino, halogen, cyano group, nitro, alkyl; Better be hydrogen, halogen; R preferably
3
With R
4Be two keys; R
5The hydroxysalt of=(sulphur) carbonyl, imido grpup, alcoxyl (sulphur) base, alkene oxygen (sulphur) base, alkynes oxygen (sulphur) base or Na, K, Li; Better be (sulphur) carbonyl, R
5With R
2Constitute five yuan or hexa-atomic (mixing) ring.
In the formula (III): n, X, Y, Z, R, R
1Ditto described.
M=3,4; Better be m=4
It can be (replacement) five yuan or hexa-atomic (mixing) ring.
In the formula (IV): n, X, Y, Z, R, R
1Ditto described.
R
6=hydrogen, alkyl, thiazolinyl, alkynyl,, alkyl (sulphur) base, carbalkoxy, alkanamine carbonyl,
Alkyl sulphonyl, triazolyl, triazole methylene radical, triazole alkylsulfonyl; Better be alkyl,
Alkynyl, alkanamine carbonyl;
R
7=hydrogen, alkyl, thiazolinyl, alkynyl, halogen; It better is alkyl;
In the formula V: n, X, Y, Z, R, R
1Ditto described.
I=3,4; Better be i=4
Can be phenyl ring, five yuan or hexa-atomic (mixing) ring.
In the formula (VI): n, X, Y, Z, R, R
1Ditto described.
R
8=hydrogen, halogen, cyano group, amino; Better be halogen, cyano group;
R
9=hydrogen, alkyl, alcoxyl (sulphur) base; It better is alcoxyl (sulphur) base;
R
10=hydrogen, alkyl, thiazolinyl, alkynyl; It better is alkyl;
In the formula (VII): n, X, Y, Z, R, R
1Ditto described.
R
11=hydrogen, alkyl, thiazolinyl, alkynyl, alcoxyl (sulphur) base, alkyl carbonyl, carbalkoxy, cyano group,
Amino; Better be alkyl, cyano group;
R
12=hydrogen, alkyl, cyano group, carboxyl, hydroxyl, carbalkoxy, formyl radical, formamyl, oximido
Methyl; Better be alkyl, formyl radical, formamyl;
In the formula (VIII): n, X, Y, Z, R, R
1Ditto described.
X’=O,N;
When X '=N: R
13=hydrogen, amino, alkyl, thiazolinyl, alkynyl, ester group; Better be amino,
Alkyl;
R
14Be (sulphur) carbonyl, imido grpup; It better is (sulphur) carbonyl;
In the formula (IX): n, X, Y, Z, R, R
1Ditto described.
R
15=hydrogen, alkyl, thiazolinyl, alkynyl; It better is alkyl;
In the formula (X): n, X, Y, Z, R, R
1Ditto described.
R
16=hydrogen, alkyl, alkyl carbonyl, alkene carbonyl, alkynes carbonyl, aryl carbonyl; Better be alkyl carbonyl,
Aryl carbonyl;
R
17=hydroxyl, alcoxyl (sulphur) base, alkylamino radical; Better be alcoxyl (sulphur) base, alkylamino radical;
Can be phenyl ring, cyclohexyl, five yuan or hexa-atomic (mixing) ring; Better be cyclohexyl, five yuan or hexa-atomic (mixing) ring;
In the formula (XI): n, X, Y, Z, R, R
1Ditto described.
Vj is-SO
2-,-OSO
2-,-NRSO
2-;
Uk is singly-bound or CH
2
R
18Be-CONRR ' ,-SO
2NRR '-;
Measure through biological screening, the fused heterocyclic derivative of finding the heterocyclic substituted of general formula of the present invention (I) has extraordinary biological activity, weeding activity is better than the conventional weedicide of use at present, when the low dosage of 18.75ga.i/ha is used, broadleaf weeds there is good preventive effect greater than 95%, to corn, wheat, soybean and rice safety.Formula (IV) compounds also has good fungicidal activity, under 100ppm concentration, to germ has greater than 90% protection and result of treatment such as downy mildew, epidemic disease be mould.The present invention is prepared by the following method.The preparation method of typical compound among 1 the present invention (II) is as follows:
Intermediate (A) adds corresponding substituted-amino chain acid ester in appropriate solvent, be heated to 30 ℃~150 ℃, and stirring reaction 1~12h obtains (D).Wherein solvent is an acetate preferably; Mol ratio is 1: 1 preferably; Preferable temperature is the solvent refluxing temperature; The more excellent reaction times is 3h.
Compound (D) adds acid binding agent in appropriate solvent and halide reaction obtains (E).Wherein solvent is DMF preferably; Acid binding agent is K preferably
2CO
3Mol ratio is (D) preferably: halogenide: K
2CO
3=1: 2: 3; 25 ℃ of preferable temperature; More excellent reaction times 24h.
Compound (D) adds ammoniation agent and obtains (F) in above-mentioned solvent and acid binding agent system.Wherein ammoniation agent is a 1-amino oxygen base-2 preferably, the 4-dinitrobenzene.
Compound (E) to-70 ℃, feeds ammonia with cooled with liquid nitrogen in appropriate solvent, stirring at room obtains compound (II) then.Wherein better solvent is HTF; Logical half an hour ammonia time; Stirring at room time 18h.The preparation method of typical compound among 2 the present invention (III) is as follows:
Intermediate (A) obtains (H) with the thiophosgene processing in appropriate solvent.Better condition is: in toluene with excessive one times thiophosgene reflux 4h.
Compound (H) mixes with hexahydro-pyridazine in appropriate solvent, and stirring at room reaction 1~24h in the presence of suitable acid binding agent, adds 20% excessive phosgene toluene or thiophosgene and handles then, and obtaining compound (J) is typical compound (III).Wherein, better solvent is a methylene dichloride; Better mol ratio (H): hexahydro-pyridazine=1: 1; Stirring at room 12h; More excellent acid binding agent is a pyridine.The preparation method of typical compound among 3 the present invention (IV) is as follows:
Intermediate (A) makes hydrazine (K) through diazotization, reduction, and good conditions is: use NaNO under 0 ℃
2Diazotization, SnCl
2/ HCl reduction.
Compound (K) handles with aldehyde, Sodium Thiocyanate 99 and clorox successively that better condition is in the trimethyl carbinol that contains 12% water when obtaining in (L) tool handling with aldehyde in appropriate solvent, use equimolar aldehyde, and stirring at room is reacted 4h; The more excellent condition of handling with Sodium Thiocyanate 99 is in same system, uses equimolar Sodium Thiocyanate 99, stirring at room 4h; The more excellent condition of handling with clorox is to handle stirring at room 18h with 6% aqueous sodium hypochlorite solution of twice.
Compound (L) adds acid binding agent in appropriate solvent, handle obtaining compound (IV) with corresponding halides.Better condition is in acetone, uses K
2CO
3Make acid binding agent, handle reflux 12h with equimolar bromide.
R in compound (IV)
5During for thiazolinyl and alkynyl, in the presence of appropriate solvent and catalyzer, can obtain R with the processing of N-iodo succimide
5(IV) for iodine thiazolinyl and iodine alkynyl.Wherein solvent is an acetone preferably, and catalyzer is AgNO preferably
3The preparation method of typical compound among 4 the present invention (V) is as follows:
Intermediate (A) is in appropriate solvent, and with 3,4,5, the 6-Tetra Hydro Phthalic Anhydride is handled and obtained typical compound (V).Better condition is: in glacial acetic acid, and with equimolar 3,4,5,6-Tetra Hydro Phthalic Anhydride reflux 4h.The preparation method of typical compound among 5 the present invention (X) is as follows:
With 2,3,4, handle and obtain (O) by the 5-Tetra Hydro Phthalic Anhydride in appropriate solvent for intermediate (A), and esterification/amidation obtains (P) then, and last acidylate obtains typical compound (X).Preparation (O) better condition is in acetone, stirring at room 24h; The better condition of esterification is to use H
2SO
4Make catalyzer, reflux, azeotropic dehydration; The better condition of acidylate is in the presence of catalyzer DMAP, reacts with carboxylic acid halides.The preparation side of typical compound among 6 the present invention (XI) is as follows:
Under room temperature and fierce stirring, equimolar triazole SULPHURYL CHLORIDE slowly is added drop-wise among intermediate A or the A ', continue the reaction certain hour, obtain (S) and (T), i.e. typical compound (XI).Other compound can be with reference to similar literature method preparation among 7 the present invention.
According to above-mentioned preparation method, synthesized the fused heterocyclic derivative of a series of heterocyclic substituted of the present invention, specifically see Table 1 to table 10.
Table 1
??No | ??n | ??X | ??Y | ??Z | ????W | ????R | ??R1 | ??R2 | ??R5 | ??R3(R3?R4) | ??R4 |
????1 ????2 ????3 ????4 ????5 ????6 ????7 ????8 ????9 ????10 ????11 ????12 ????13 ????14 ????15 ????16 ????17 ????18 ????19 ????20 ????21 ????22 ????23 ????24 ????25 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2 | ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ???CH
3 | ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H | ??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H
| ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2 | ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
????26 ????27 ????28 ????29 ????30 ????31 ????32 ????33 ????34 ????35 ????36 ????37 ????38 ????39 ????40 ????41 ????42 ????43 ????44 ????45 ????46 ????47 ????48 ????49 ????50 ????51 ????52 ????53 ????54 ????55 ????56 ????57 ????58 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????0 ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CHH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2 | ????CH
3????C1
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2 | ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl | ????H ????H ????H ????H ????H ????H ????H ???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???NH
2???NH
2???NH
2???NH
2???NH
2???NH
2???NH
2???NH
2????H ????H ????H ????H ????H ????H ????H ????H ???CH
3???CH
3 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2 | ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
????59 ????60 ????61 ????62 ????63 ????64 ????65 ????66 ????67 ????68 ????69 ????70 ????71 ????72 ????73 ????74 ????75 ????76 ????77 ????78 ????79 ????80 ????81 ????82 ????83 ????84 ????85 ????86 ????87 ????88 ????89 ????90 ????91 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2 | ????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F | ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2 | ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
????92 ????93 ????94 ????95 ????96 ????97 ????98 ????99 ????100 ????101 ????102 ????103 ????104 ????105 ????106 ????107 ????108 ????109 ????110 ????111 ????112 ????113 ????114 ????115 ????116 ????117 ????118 ????119 ????120 ????121 ????122 ????123 ????124 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CH
2????CH
2????CH
2????CH
2????CH
2????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH
| ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ??????CH
3??????CH
3??????CH
3??????CH
3 | ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN | ?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H
| ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CF
3And NH
2????CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3And NH
2CF3 when key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3And NH
2 | ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H |
??125 ??126 ??127 ??128 ??129 ??130 ??131 ??132 ??133 ??134 ??135 ??136 ??137 ??138 ??139 ??140 ??141 ??142 ??143 ??144 ??145 ??146 ??147 ??148 ??149 ??150 ??151 ??152 ??153 ??154 ??155 ??156 ??157 | ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH | ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2 | ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H | ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two)
| ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
??158 ??159 ??160 ??161 ??162 ??163 ??164 ??165 ??166 ??167 ??168 ??169 ??170 ??171 ??172 ??173 ??174 ??175 ??176 ??177 ??178 ??179 ??180 ??181 ??182 ??183 ??184 ??185 ??186 ??187 ??188 ??189 ??190 | ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH | ????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl | ?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2 | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two)
| ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H |
??191 ??192 ??193 ??194 ??195 ??196 ??197 ??198 ??199 ??200 ??201 ??202 ??203 ??204 ??205 ??206 ??207 ??208 ??209 ??210 ??211 ??212 ??213 ??214 ??215 ??216 ??217 ??218 ??219 ??220 ??221 ??222 | ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 | ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?NH ?NH ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ?CH
2C≡CH ?CH
2C≡CH ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3 | ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl | ?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H
| ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two)
| ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H |
?223 ?224 ?225 ?226 ?227 ?228 ?229 ?230 ?231 ?232 ?233 ?234 ?235 ?236 ?237 ?238 ?239 ?240 ?241 ?242 ?243 ?244 ?245 ?246 ?247 ?248 ?249 ?250 ?251 ?252 ?253 ?254 ?255 | ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 | ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?0 ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2 | ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F | ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3 | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two)
| ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
??256 ??257 ??258 ??259 ??260 ??261 ??262 ??263 ??264 ??265 ??266 ??267 ??268 ??269 ??270 ??271 ??272 ??273 ??274 ??275 ??276 ??277 ??278 ??279 ??280 ??281 ??282 ??283 ??284 ??285 ??286 ??287 ??288 | ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN | ?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two)
| ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
??289 ??290 ??291 ??292 ??293 ??294 ??295 ??296 ??297 ??298 ??299 ??300 ??301 ??302 ??303 ??304 ??305 ??306 ??307 ??308 ??309 ??310 ??311 ??312 ??313 ??314 ??315 ??316 ??317 ??318 ??319 ??320 ??321 | ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 | ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | Singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound | ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3 | ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H | ??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3 | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2 | ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H |
??322 ??323 ??324 ??325 ??326 ??327 ??328 ??329 ??330 ??331 ??332 ??333 ??334 ??335 ??336 ??337 ??338 ??339 ??340 ??341 ??342 ??343 ??344 ??345 ??346 ??347 ??348 ??349 ??350 ??351 ??352 ??353 ??354 | ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | Singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound | ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2 | ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl | ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2 | ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
??355 ??356 ??357 ??358 ??359 ??360 ??361 ??362 ??363 ??364 ??365 ??366 ??367 ??368 ??369 ??370 ??371 ??372 ??373 ??374 ??375 ??376 ??377 ??378 ??379 ??380 ??381 ??382 ??383 ??384 ??385 ??386 ??387 | ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O | Singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound O NH CH2 | ????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ??NH
2?CH
2C≡CH
| ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?F ?F ?F | ?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3When key (two) CF
3And NH
2 | ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
??427 ??428 ??429 ??430 ??431 ??432 ??433 ??434 ??435 ??436 ??437 ??438 ??439 ??440 ??441 ??442 ??443 ??444 ??445 ??446 ??447 ??448 ??449 ??450 ??451 ??452 ??453 ??454 ??455 ??456 ??457 ??458 ??459 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2 | ????H ????H ????H ????H ????H ????H ????H ????H ????H ???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3 | ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN | ?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two)
| ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
??460 ??461 ??462 ??463 ??464 ??465 ??466 ??467 ??468 ??469 ??470 ??471 ??472 ??473 ??474 ??475 ??476 ??477 ??478 ??479 ??480 ??481 ??482 ??483 ??484 ??485 ??486 ??487 ??488 ??489 ??490 ??491 ??492 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2 | ????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H | ??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3 | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2 | ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H |
??493 ??494 ??495 ??496 ??497 ??498 ??499 ??500 ??501 ??502 ??503 ??504 ??505 ??506 ??507 ??508 ??509 ??510 ??511 ??512 ??513 ??514 ??515 ??516 ??517 ??518 ??519 ??520 ??521 ??522 ??523 ??524 ??525 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????CH
2????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH
| ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI
| ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl | ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2 | ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??HI ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
??526 ??527 ??528 ??529 ??530 ??531 ??532 ??533 ??534 ??535 ??536 ??537 ??538 ??539 ??540 ??541 ??542 ??543 ??544 ??545 ??546 ??547 ??548 ??549 ??550 ??551 ??552 ??553 ??554 ??555 ??556 ??557 ??558 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH | ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
2C≡CI ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????NH
2????NH
2????NH
2 | ?F ?CN ?H ?Cl ?F ?CN ?H ?C ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F | ?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H
| ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2 | ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
??559 ??560 ??561 ??562 ??563 ??564 ??565 ??566 ??567 ??568 ??569 ??570 ??571 ??572 ??573 ??574 ??575 ??576 ??577 ??578 ??579 ??580 ??581 ??582 ??583 ??584 ??585 ??586 ??587 ??588 ??589 ??590 ??591 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH ??NH | ????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN | ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3 | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2 | ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H |
??592 ??593 ??594 ??595 ??596 ??597 ??598 ??599 ??600 ??601 ??602 ??603 ??604 ??605 ??606 ??607 ??608 ??609 ??610 ??611 ??612 ??613 ??614 ??615 ??616 ??617 ??618 ??619 ??620 ??621 ??622 ??623 ??624 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??H ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????NH ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H
| ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H | ?CH
3?CH
3?CH
2?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two)
| ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
??625 ??626 ??627 ??628 ??629 ??630 ??631 ??632 ??633 ??634 ??635 ??636 ??637 ??638 ??639 ??640 ??641 ??642 ??643 ??644 ??645 ??646 ??647 ??648 ??649 ??650 ??651 ??652 ??653 ??654 ??655 ??656 ??657 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2 | ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl | ?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H
| ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3And NH
2????CF
3When key (two) CF
3When key (two)
| ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H |
??658 ??659 ??660 ??661 ??662 ??663 ??664 ??665 ??666 ??667 ??668 ??669 ??670 ??671 ??672 ??673 ??674 ??675 ??676 ??677 ??678 ??679 ??680 ??681 ??682 ??683 ??684 ??685 ??686 ??687 ??688 ??689 ??690 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ?F ?CN ?H ?Cl ?H ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F | ???H ???H ??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??NH
2??NH
2??NH
2??NH
2??NH
2??NH
2??NH
2??NH
2???H ???H ???H ???H ???H ???H ???H ???H ??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two)
| ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
??691 ??692 ??693 ??694 ??695 ??696 ??697 ??698 ??699 ??700 ??701 ??702 ??703 ??704 ??705 ??706 ??707 ??708 ??709 ??710 ??711 ??712 ??713 ??714 ??715 ??716 ??717 ??718 ??719 ??720 ??721 ??722 ??723 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | O O O O O O O O O singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound | ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI
| ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN | ?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2 | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two)
| ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H |
??724 ??725 ??726 ??727 ??728 ??729 ??730 ??731 ??732 ??733 ??734 ??735 ??736 ??737 ??738 ??739 ??740 ??741 ??742 ??743 ??744 ??745 ??746 ??747 ??748 ??749 ??750 ??751 ??752 ??753 ??754 ??755 ??756 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | Singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound | ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2 | ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H | ??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3 | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3And NH
2?CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2 | ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H ?H |
??757 ??758 ??759 ??760 ??761 ??762 ??763 ??764 ??765 ??766 ??767 ??768 ??769 ??770 ??771 ??772 ??773 ??774 ??775 ??776 ??777 ??778 ??779 ??780 ??781 ??782 ??783 ??784 ??785 ??786 ??787 ??788 | ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | Singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound singly-bound | ????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H | ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2?NH
2??H ??H ??H ??H ??H ??H ??H ??H ?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?CH
3?NH
2 | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3And NH
2??CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3When key (two) CF
3And NH
2 | ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H ??H |
Table 2
????No. | ????n | ????X | ????Y | ????Z | ????R | ??R1 | ??(CH2)m |
????823 ????824 ????825 ????826 ????827 ????828 ????829 ????830 ????831 ????832 ????833 ????834 ????835 ????836 ????837 ????838 ????839 ????840 ????841 ????842 ????843 ????844 ????845 ????846 ????847 ????848 ????849 ????850 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N ????N | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????S ????S ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????S ????S ????O ????O ????O ????O ????O ????O ????O ????O | ?????H ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ????H ????CH
3??CH
2C≡CI ??CH
2C≡CH ????H ????CH
3??CH
2C≡CI ??CH
2C≡CH ????H ????CH
3??CH
2C≡CI ??CH
2C≡CH
| ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?F ?F ?F ?F ?F ?F ?F ?F ?F ?F ?F ?F | ????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4 |
????851 ????852 ????853 ????854 ????855 ????856 ????857 ????858 ????859 ????860 ????861 ????862 ????863 ????865 ????866 ????867 ????868 ????869 ????870 ????871 ????872 ????873 ????874 ????875 ????876 ????877 ????878 ????879 | ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N ????N | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????S ????S ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????S ????S ????O ????O ????O ????O ????O ????O ????O ????O | ?????H ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ?????H ????CH
3??CH
2C≡CI ??CH
2C≡CH ?????H ????CH
3??CH
2C≡CI ??CH
2C≡CH ?????H ????CH
3??CH
2C≡CI ??CH
2C≡CH
| ???H ???Cl ???F ???CN ???H ???Cl ???F ???CN ???H ???Cl ???F ???CN ???H ???Cl ???F ???CN ???F ???F ???F ???F ???F ???F ???F ???F ???F ???F ???F ???F | ????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4 |
Table 3
????No. | ??N | ??X | ??Y | ??Z | ????R | ??R1 | ????R6 | ????R7 |
????880 ????881 ????882 ????883 ????884 ????885 ????886 ????887 ????888 ????889 ????890 ????891 ????892 ????893 ????894 ????895 ????896 ????897 ????898 ????899 ????900 ????901 ????902 ????903 ????904 ????905 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????CH
3????CH
3 | ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl | ????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C ≡ CI 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl CHF2????CHF
2 | ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3 |
????906 ????907 ????908 ????909 ????910 ????911 ????912 ????913 ????914 ????915 ????916 ????917 ????918 ????919 ????920 ????921 ????922 ????923 ????924 ????925 ????926 ????927 ????928 ????929 ????930 ????931 ????932 ????933 ????934 ????935 ????936 ????937 ????938 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2 | ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F | ????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C ≡ CI 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl CHF2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI
| ??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3 |
????939 ????940 ????941 ????942 ????943 ????944 ????945 ????946 ????947 ????948 ????949 ????950 ????951 ????952 ????953 ????954 ????955 ????956 ????957 ????958 ????959 ????960 ????961 ????962 ????963 ????964 ????965 ????966 ????967 ????968 ????969 ????970 ????971 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN | ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C ≡ CI 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl CHF2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C ≡ CI 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl
| ??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3 |
????972 ????973 ????974 ????975 ????976 ????977 ????978 ????979 ????980 ????981 ????982 ????983 ????984 ????985 ????986 ????987 ????988 ????989 ????990 ????991 ????992 ????993 ????994 ????995 ????996 ????997 ????998 ????999 ????1000 ????1001 ????1002 ????1003 ????1004 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??N ??N ??N ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??S ??S ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??S ??S ??S ??O ??O ??O ??O ??S ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ????NH
2????CH
3?CH
2C≡CH ????NH
2?CH
2C≡CH ????CH
3?CH
2C≡CH ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H
| ??H ??Cl ??F ??CN ??F ??F ??F ??F ??F ??F ??F ??F ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H | 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C ≡ CI 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl
| ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n
|
??1005 ??1006 ??1007 ??1008 ??1009 ??1010 ??1011 ??1012 ??1013 ??1014 ??1015 ??1016 ??1017 ??1018 ??1019 ??1020 ??1021 ??1022 ??1023 ??1024 ??1025 ??1026 ??1027 ??1028 ??1029 ??1030 ??1031 ??1032 ??1033 ??1034 ??1035 ??1036 ??1037 | ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2 | ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl | 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl 1.2.4-triazole alkylsulfonyl CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C ≡ CI 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl CHF2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2 | ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n
|
??1038 ??1039 ??1040 ??1041 ??1042 ??1043 ??1044 ??1045 ??1046 ??1047 ??1048 ??1049 ??1050 ??1051 ??1052 ??1053 ??1054 ??1055 ??1056 ??1057 ??1058 ??1059 ??1060 ??1061 ??1062 ??1063 ??1064 ??1065 ??1066 ??1067 ??1068 ??1069 ??1070 | ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2????NH
2?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI
| ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F | ????CHF
2????CHF
2??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C ≡ CI 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl CHF2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI
| ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n
|
??1071 ??1072 ??1073 ??1074 ??1075 ??1076 ??1077 ??1078 ??1079 ??1080 ??1081 ??1082 ??1083 ??1084 ??1085 ??1086 ??1087 | ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??N ??N ??N | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??S ??S ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??S ??S ??S ??O ??O ??O ??O ??S | ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ????NH
2????CH
3??CH
2C≡CH ????NH
2??CH
2C≡CH ????CH
3??CH
2C≡CH
| ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????F ????F ????F ????F ????F ????F ????F ????F | ????CH
2C ≡ CI 1.2.4-triazole sulfonyl 1.2 4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl 1.2.4-triazole sulfonyl CHF2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2????CHF
2 | ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ?C
3H
7-n ??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3 |
Table 4
?????No. | ????n | ????X | ????Y | ????Z | ?????R | ?R1 | ????(CH2)i |
????1088 ????1089 ????1090 ????1091 ????1092 ????1093 ????1094 ????1095 ????1096 ????1097 ????1098 ????1099 ????1100 ????1101 ????1102 ????1103 ????1104 ????1105 ????1106 ????1107 ????1108 ????1109 ????1110 ????1111 ????1112 ????1113 ????1114 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH
| ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?CI ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F | ????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring (CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring (CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring (CH2)
4????(CH2)
4????(CH2)
4 |
??1115 ??1116 ??1117 ??1118 ??1119 ??1120 ??1121 ??1122 ??1123 ??1124 ??1125 ??1126 ??1127 ??1128 ??1129 ??1130 ??1131 ??1132 ??1133 ??1134 ??1135 ??1136 ??1137 ??1138 ??1139 ??1140 ??1141 ??1142 ??1143 ??1144 ??1145 ??1146 ??1147 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????S ????S ????S ????O ????O ????O ????O ????S ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ????CH
3??CH
2C≡CI ??CH
2C≡CH ????CH
3??CH
2C≡CH ????CH
3??CH
2C≡CH ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI
| ??CN ??H ??Cl ??F ??CN ??F ??F ??F ??F ??F ??F ??F ??F ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN | ????(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring (CH2)
4????(CH2)
4Phenyl ring (CH2)
4Phenyl ring (CH2)
4Phenyl ring (CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring (CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring (CH2)
4????(CH2)
4????(CH2)
4????(CH2)
4 |
Table 5
??No. | ????n | ????X | ????Y | ????Z | ?????R | ??R1 | ??R8 | ???R9 | ??R10 |
??1160 ??1162 ??1163 ??1164 ??1165 ??1166 ??1167 ??1168 ??1169 ??1170 ??1171 ??1172 ??1173 ??1174 ??1175 ??1176 ??1177 ??1178 ??1179 ??1180 ??1181 ??1182 ??1183 ??1184 ??1185 ??1186 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH
| ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl | ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl ??Cl | ??CF
3??CF
3??CF
3??CF
3?OCHF
2?OCHF
2?OCHF
2?OCHF
2??CF
3??CF
3??CF
3??CF
3?OCHF
2?OCHF
2?OCHF
2?OCHF
2??CF
3??CF
3??CF
3??CF
3?OCHF
2?OCHF
2?OCHF
2?OCHF
2??CF
3??CF
3 | ??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3 |
??1187 ??1188 ??1189 ??1190 ??1191 ??1192 ??1193 ??1194 ??1195 ??1196 ??1197 ??1198 ??1199 ??1200 ??1201 ??1202 ??1203 ??1204 ??1205 ??1206 ??1207 ??1208 ??1209 ??1210 ??1211 ??1212 ??1213 ??1214 ??1215 ??1216 ??1217 ??1218 ??1219 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ??O ??O ??O ??O ??O ??O ??S ??S ??S ??O ??O ??O ??O ??S ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ????CH
3?CH
2C≡CH ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI
| ??F ??CN ??H ??Cl ??F ??CN ??F ??F ??F ??F ??F ??F ??F ??F ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F | ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl ?Cl | ?CF
3?CF
3OCHF
2OCHF
2OCHF
2OCHF
2OCHF
2?CF
3?CF
3OCHF
2?CF
3OCHF
2?CF
3?CF
3?CF
3?CF
3?CF
3?CF
3OCHF
2OCHF
2OCHF
2OCHF
2?CF
3?CF
3?CF
3?CF
3OCHF
2OCHF
2OCHF
2OCHF
2?CF
3?CF
3?CF
3 | ??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3 |
??1220 ??1221 ??1222 ??1223 ??1224 ??1225 ??1226 ??1227 ??1228 ??1229 ??1230 ??1231 ??1232 ??1233 ??1234 ??1235 ??1236 ??1237 ??1238 ??1239 ??1240 | ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????S ????O ????O ????O ????O ????S | ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ????CH
3?CH
2C≡CH ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH
| ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????F ????F ????F ????F ????F ????F ????F ????F | ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl ????Cl | ??CF
3?OCHF
2?OCHF
2?OCHF
2?OCHF
2??CF
3??CF
3??CF
3??CF
3?OCHF
2?OCHF
2?OCHF
2?OCHF
2?OCHF
2??CF
3??CF
3?OCHF
2??CF
3?OCHF
2??CF
3??CF
3 | ??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3 |
Table 6
??No. | ????n | ??X | ???Y | ??Z | ????R | ???R1 | ??R11 | ??R12 |
??1241 ??1242 ??1243 ??1244 ??1245 ??1246 ??1247 ??1248 ??1249 ??1250 ??1251 ??1252 ??1253 ??1254 ??1255 ??1256 ??1257 ??1258 ??1259 ??1260 ??1261 ??1262 ??1263 ??1264 ??1265 ??1266 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????H ????H ????H ????H ????H ????H ????H ????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH
| ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????H ????Cl | ??CH
3??CH
3??CH
3??CH
3??CN ??CN ??CN ??CN ??CH
3??CH
3??CH
3??CH
3??CN ??CN ??CN ??CN ??CH
3??CH
3??CH
3??CH
3??CN ??CN ??CN ??CN ??CH
3??CH
3 | ??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3 |
????1267 ????1268 ????1269 ????1270 ????1271 ????1272 ????1273 ????1274 ????1275 ????1276 ????1277 ????1278 ????1279 ????1280 ????1281 ????1282 ????1283 ????1284 ????1285 ????1286 ????1287 ????1288 ????1289 ????1290 ????1291 ????1292 ????1293 ????1294 ????1295 ????1296 ????1297 ????1298 ????1299 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????S ????S ????S ????O ????O ????O ????O ????S ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CI ??CH
2C≡CH ????CH
3??CH
2C≡CH ????CH
3??CH
2C≡CH ????H ????H ????H ????H ????H ????H ????H ????H ???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3???CH
3?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI
| ????F ????CN ????H ????Cl ????F ????CN ????F ????F ????F ????F ????F ????F ????F ????F ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F | ??CH
3??CH
3??CN ??CN ??CN ??CN ??CN ??CH
3??CH
3??CN ??CH
3??CN ??CH
3??CH
3??CH
3??CH
3??CH
3??CH
3??CN ??CN ??CN ??CN ??CH
3??CH
3??CH
3??CH
3??CN ??CN ??CN ??CN ??CH
3??CH
3??CH
3 | ??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3 |
????1300 ????1301 ????1302 ????1303 ????1304 ????1305 ????1306 ????1307 ????1308 ????1309 ????1310 ????1311 ????1312 ????1313 ????1314 ????1315 ????1316 ????1317 ????1318 ????1319 ????1320 | ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????S ????O ????O ????O ????O ????S | ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CI ?CH
2C≡CH ????CH
3?CH
2C≡CH ????CH
3?CH
2C≡CH
| ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????H ????Cl ????F ????CN ????F ????F ????F ????F ????F ????F ????F ????F | ??CH
3??CN ??CN ??CN ??CN ??CH
3??CH
3??CH
3??CH
3??CN ??CN ??CN ??CN ??CN ??CH
3??CH
3??CN ??CH
3??CN ??CH
3??CH
3 | ??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3??CF
3 |
Table 7
Table 8
????No. | ????n | ????X | ????Y | ????Z | ?????R | ??R1 | ????R15 |
????1393 ????1394 ????1395 ????1396 ????1397 ????1398 ????1399 ????1400 ????1401 ????1402 ????1403 ????1404 ????1405 ????1406 ????1407 ????1408 ????1409 ????1410 ????1411 ????1412 ????1413 ????1414 ????1415 ????1416 ????1417 ????1418 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH
| ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl | ????CF
3????CF
3????CF
3????CF
3??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ????CF
3????CF
3????CF
3????CF
3??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ????CF
3????CF
3????CF
3????CF
3??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ????CF
3????CF
3 |
????1419 ????1420 ????1421 ????1422 ????1423 ????1424 ????1425 ????1426 ????1427 ????1428 ????1429 ????1430 ????1431 ????1432 ????1433 ????1434 ????1435 ????1436 ????1437 ????1438 ????1439 ????1440 ????1441 ????1442 ????1443 ????1444 ????1445 ????1446 ????1447 ????1448 ????1449 ????1450 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????S ????S ????S ????O ????O ????O ????O ????S ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ????H ????H ????H ????H ????H ????H ????H ????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3??CH
2C≡CI ??CH
2C≡CI
| ??F ??CN ??H ??Cl ??F ??CN ??F ??F ??F ??F ??F ??F ??F ??F ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl | ????CF
3????CF
3??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ????CF
3??C
4H
9-t ????CF
3??C
4H
9-t ????CF
3??C
4H
9-t ????CF
3????CF
3????CF
3????CF
3??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ????CF
3????CF
3????CF
3????CF
3??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ????CF
3????CF
3 |
????1451 ????1452 ????1453 ????1454 ????1455 ????1456 ????1457 ????1458 ????1459 ????1460 ????1461 ????1462 ????1463 ????1464 ????1465 ????1466 ????1467 ????1468 ????1469 ????1470 ????1471 ????1472 | ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????S ????O ????O ????O ????O ????S | ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH
| ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??F ??F ??F ??F ??F ??F ??F ??F | ????CF
3????CF
3??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ????CF
3????CF
3????CF
3????CF
3??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ??C
4H
9-t ????CF
3??C
4H
9-t ????CF
3??C
4H
9-t ????CF
3??C
4H
9-t
|
Table 9
?No. | ?n | ?X | ?Y | ?Z | ?????R | ?R1 | ????R16 | ????R17 | (CH2)i |
?1473 ?1474 ?1475 ?1476 ?1477 ?1478 ?1479 ?1480 ?1481 ?1482 ?1483 ?1484 ?1485 ?1486 ?1487 ?1488 ?1489 ?1490 ?1491 ?1492 ?1493 ?1494 ?1495 ?1496 ?1497 ?1498 | ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 | ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ????CH
3????CH
3 | ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl | ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO
| ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3????HNC
3H
7-i ????HNC
3H
7-i ????HNC
3H
7-i ????HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ????OCH
3????OCH
3 | (CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4 |
??1499 ??1500 ??1501 ??1502 ??1503 ??1504 ??1505 ??1506 ??1507 ??1508 ??1509 ??1510 ??1511 ??1512 ??1513 ??1514 ??1515 ??1516 ??1517 ??1518 ??1519 ??1520 ??1521 ??1522 ??1523 ??1524 ??1525 ??1526 ??1527 ??1528 ??1529 ??1530 ??1531 | ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI
| ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F | ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO
| ????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i
| ?CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4 |
??1532 ??1533 ??1534 ??1535 ??1536 ??1537 ??1538 ??1539 ??1540 ??1541 ??1542 ??1543 ??1544 ??1545 ??1546 ??1547 ??1548 ??1549 ??1550 ??1551 ??1552 ??1553 ??1554 ??1555 ??1556 ??1557 ??1558 ??1559 ??1560 ??1561 ??1562 ??1563 ??1564 | ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN | ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO
| ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3 | (CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring |
??1565 ??1566 ??1567 ??1568 ??1569 ??1570 ??1571 ??1572 ??1573 ??1574 ??1575 ??1576 ??1577 ??1578 ??1579 ??1580 ??1581 ??1582 ??1583 ??1584 ??1585 ??1586 ??1587 ??1588 ??1589 ??1590 ??1591 ??1592 ??1593 ??1594 ??1595 ??1596 ??1597 | ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 ??0 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ???CH
3???CH
3???CH
3???CH
3???CH
3 | ?H ?Cl ?H ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H | ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO
| ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3 | Phenyl ring phenyl ring phenyl ring phenyl ring (CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4(CH2)
4(CH2)
4(CH2)
4 |
?1598 ?1599 ?1600 ?1601 ?1602 ?1603 ?1604 ?1605 ?1606 ?1607 ?1608 ?1609 ?1610 ?1611 ?1612 ?1613 ?1614 ?1615 ?1616 ?1617 ?1618 ?1619 ?1620 ?1621 ?1622 ?1623 ?1624 ?1625 ?1626 ?1627 ?1628 ?1629 ?1630 | ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI
| ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl | ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO
| ?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3????HNC
3H
7-i ????HNC
3H
7-i ????HNC
3H
7-i ????HNC
3H
7-i ????OCH
3????OCH
3 | (CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4The phenyl ring phenyl ring
|
?1631 ?1632 ?1633 ?1634 ?1635 ?1636 ?1637 ?1638 ?1639 ?1640 ?1641 ?1642 ?1643 ?1644 ?1645 ?1646 ?1647 ?1648 ?1649 ?1650 ?1651 ?1652 ?1653 ?1654 ?1655 ?1656 ?1657 ?1658 ?1659 ?1660 ?1661 ?1662 ?1663 | ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F | ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO
| ????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-I ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i
| Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring |
?1664 ?1665 ?1666 ?1667 ?1668 ?1669 ?1670 ?1671 ?1672 ?1673 ?1674 ?1675 ?1676 ?1677 ?1678 ?1679 ?1680 ?1681 ?1682 ?1683 ?1684 ?1685 ?1686 ?1687 ?1688 ?1689 ?1690 ?1691 ?1692 ?1693 ?1694 ?1695 ?1696 | ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?0 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 | ?C ?C ?C ?C ?C ?C ?C ?C ?C ?N ?N ?N ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C | ?O ?O ?O ?O ?O ?O ?O ?S ?S ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?O ?S ?S ?S ?S ?O ?O ?O ?O ?O ?O ?S ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ????CH
3?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H ????H
| ?CN ?F ?F ?F ?F ?F ?F ?F ?F ?F ?F ?F ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H | ?3-F-C
6H
4CO ??C
2H
5CO ??C
2H
5CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ??C
2H
5CO ?3-F-C
6H
4CO ??C
2H
5CO ?3-F-C
6H
4CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO
| ??HNC
3H
7-i ????OCH
3??HNC
3H
7-i ????OCH
3??HNC
3H
7-i ??HNC
3H
7-i ?OCH
2CH
2OCH
3????OCH
3?OCH
2CH
2OCH
3????OCH
3???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i
| Phenyl ring (CH2)
4(CH2)
4(CH2)
4Phenyl ring (CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring |
??1697 ??1698 ??1699 ??1700 ??1701 ??1702 ??1703 ??1704 ??17O5 ??1706 ??1707 ??1708 ??1709 ??1710 ??1711 ??1712 ??1713 ??1714 ??1715 ??1716 ??1717 ??1718 ??1719 ??1720 ??1721 ??1722 ??1723 ??1724 ??1725 ??1726 ??1727 ??1728 ??1729 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI
| ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl | ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO
| ??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3 | Phenyl ring phenyl ring phenyl ring (CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4 |
??1730 ??1731 ??1732 ??1733 ??1734 ??1735 ??1736 ??1737 ??1738 ??1739 ??1740 ??1741 ??1742 ??1743 ??1744 ??1745 ??1746 ??1747 ??1748 ??1749 ??1750 ??1751 ??1752 ??1753 ??1754 ??1755 ??1756 ??1757 ??1758 ??1759 ??1760 ??1761 ??1762 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH ?CH
2C≡CH
| ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F | ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO
| ?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3 | (CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring
|
??1763 ??1764 ??1765 ??1766 ??1767 ??1768 ??1769 ??1770 ??1771 ??1772 ??1773 ??1774 ??1775 ??1776 ??1777 ??1778 ??1779 ??1780 ??1781 ??1782 ??1783 ??1784 ??1785 ??1786 ??1787 ??1788 ??1789 ??1790 ??1791 ??1792 ??1793 ??1794 ??1795 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ????CH
2C≡CH ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H ???????H
| ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN | ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ??C
2H
5CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO
| ????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH3 ????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i ??HNC
3H
7-i
| Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring |
?1796 ?1797 ?1798 ?1799 ?1800 ?1801 ?1802 ?1803 ?1804 ?1805 ?1806 ?1807 ?1808 ?1809 ?1810 ?1811 ?1812 ?1813 ?1814 ?1815 ?1816 ?1817 ?1818 ?1819 ?1820 ?1821 ?1822 ?1823 ?1824 ?1825 ?1826 ?1827 ?1828 | ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 | ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C ?C | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O ?O | ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI ?CH
2C≡CI
| ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H | ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO
| ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i
| (CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4 |
??1829 ??1830 ??1831 ??1832 ??1833 ??1834 ??1835 ??1836 ??1837 ??1838 ??1839 ??1840 ??1841 ??1842 ??1843 ??1844 ??1845 ??1846 ??1847 ??1848 ??1849 ??1850 ??1851 ??1852 ??1853 ??1854 ??1855 ??1856 ??1857 ??1858 ??1859 ??1860 ??1861 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH
| ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl | ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO ????3-F-C
6H
4CO
| ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ???HNC
3H
7-i ????OCH
3????OCH
3????OCH
3????OCH
3?OCH
2CH
2OCH
3?OCH
2CH
2OCH
3 | (CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring
|
??1862 ??1863 ??1864 ??1865 ??1866 ??1867 ??1868 ??1869 ??1870 ??1871 ??1872 ??1873 ??1874 ??1875 ??1876 ??1877 ??1878 | ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 ??1 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??N ??N ??N | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??S ??S ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??S ??S ??S ??S ??O ??O ??O ??O ??O ??O ??S | ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ????CH
3??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH
| ????F ????CN ????H ????Cl ????F ????CN ????F ????F ????F ????F ????F ????F ????F ????F ????F ????F ????F | ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ??C
2H
5CO ??C
2H
5CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ?3-F-C
6H
4CO ??C
2H
5CO ?3-F-C
6H
4CO ??C
2H
5CO ?3-F-C
6H
4CO
| ??OCH
2CH
2OCH
3??OCH
2CH
2OCH
3????HNC
3H
7-i ????HNC
3H
7-i ????HNC
3H
7-i ????HNC
3H
7-i ?????OCH
3????HNC
3H
7-i ?????OCH
3????HNC
3H
7-i ????HNC
3H
7-i ??OCH
2CH
2OCH
3?????OCH
3??OCH
2CH
2OCH
3?????OCH
3????HNC
3H
7-i ?????OCH
3 | Phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring phenyl ring (CH2)
4(CH2)
4(CH2)
4Phenyl ring (CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4(CH2)
4 |
Table 10
???No. | ????n | ????X | ????Y | ??Z | ?????R | ?R1 | ????R18 | ??Vj | ??Uk |
??1879 ??1880 ??1881 ??1882 ??1883 ??1884 ??1885 ??1886 ??1887 ??1888 ??1889 ??1890 ??1891 ??1892 ??1893 ??1894 ??1895 ??1896 ??1897 ??1898 ??1899 ??1900 ??1901 ??1902 ??1903 ??1904 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH ??CH
2C≡CI ??CH
2C≡CI
| ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl | ????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2????CON(C
2H
5)
2 | ??SO
2??SO
2??SO
2??SO
2??OSO
2??OSO
2??OSO
2??OSO
2?NHSO
2?NHSO
2?NHSO
2?NHSO
2??SO
2??SO
2??SO
2??SO
2??OSO
2??OSO
2??OSO
2??OSO
2?NHSO
2?NHSO
2?NHSO
2?NHSO
2??SO
2??SO
2 | ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- ??- |
??1905 ??1906 ??1907 ??1908 ??1909 ??1910 ??1911 ??1912 ??1913 ??1914 ??1915 ??1916 ??1917 ??1918 ??1919 ??1920 ??1921 ??1922 ??1923 ??1924 ??1925 ??1926 ??1927 ??1928 ??1929 ??1930 ??1931 ??1932 ??1933 ??1934 ??1935 ??1936 ??1937 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????S ????O ????O ????O ????O ????S ????O ????O ????O | ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ????CH
3??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ????H ????H ????H
| ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??F ??F ??F ??F ??F ??F ??F ??F ??H ??Cl ??F | ??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2??CON(C
2H
5)
2 | ??SO
2??SO
2??OSO
2??OSO
2??OSO
2??OSO
2?NHSO
2?NHSO
2?NHSO
2?NHSO
2??SO
2??SO
2??SO
2??SO
2??OSO
2??OSO
2??OSO
2??OSO
2?NHSO
2?NHSO
2?NHSO
2?NHSO
2?NHSO
2??OSO
2??SO
2?NHSO
2??OSO
2?NHSO
2??SO
2?NHSO
2??SO
2??SO
2??SO
2 | - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - |
?1938 ?1939 ?1940 ?1941 ?1942 ?1943 ?1944 ?1945 ?1946 ?1947 ?1948 ?1949 ?1950 ?1951 ?1952 ?1953 ?1954 ?1955 ?1956 ?1957 ?1958 ?1959 ?1960 ?1961 ?1962 ?1963 ?1964 ?1965 ?1966 ?1967 ?1968 ?1969 ?1970 | ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 ?1 | ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C ??C | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O ??O | ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3????CH
3??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI
| ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN ?H ?Cl ?F ?CN | ?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2 | ??SO
2?OSO
2?OSO
2?OSO
2?OSO
2?NHSO
2?NHSO
2?NHSO
2?NHSO
2??SO
2??SO
2??SO
2??SO
2??OSO
2??OSO
2??OSO
2??OSO
2?NHSO
2?NHSO
2?NHSO
2?NHSO
2??SO
2??SO
2??SO
2??SO
2??OSO
2??OSO
2??OSO
2??OSO
2?NHSO
2?NHSO
2?NHSO
2?NHSO
2 | - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - |
??1971 ??1972 ??1973 ??1974 ??1975 ??1976 ??1977 ??1978 ??1979 ??1980 ??1981 ??1982 ??1983 ??1984 ??1985 ??1986 ??1987 ??1988 ??1989 ??1990 ??1991 ??1992 ??1993 ??1994 ??1995 ??1996 ??1997 ??1998 ??1999 ??2000 ??2001 ??2002 ??2003 | ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????1 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????S ????O ????O ????O ????O ????S ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O | ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ????CH
3??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CH ??CH
2C≡CI ??CH
2C≡CH ??CH
2C≡CH ?????H ?????H ?????H ?????H ?????H ?????H ?????H ?????H ????CH
3????CH
3????CH
3????CH
3????CH
3 | ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??F ??F ??F ??F ??F ??F ??F ??F ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H ??Cl ??F ??CN ??H | ?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2?CON(C
2H
5)
2??????- ??????- ??????- ??????- ??????- ??????- ??????- ??????- ??????- ??????- ??????- ??????- ??????-
| ??SO
2??SO
2??SO
2??SO
2??OSO
2??OSO
2??OSO
2??OSO
2?NHSO
2?NHSO
2?NHSO
2?NHSO
2?NHSO
2??OSO
2??SO
2?NHSO
2??OSO
2?NHSO
2??SO
2?NHSO
2???- ???- ???- ???- ???- ???- ???- ???- ???- ???- ???- ???- ???-
| --------------------singly-bound singly-bound singly-bound singly-bound CH2CH
2CH
2CH
2Singly-bound singly-bound singly-bound singly-bound CH
2 |
?2004 ?2005 ?2006 ?2007 ?2007 ?2009 ?2010 ?2011 ?2012 ?2013 ?2014 ?2015 ?2016 ?2017 ?2018 ?2019 ?2020 ?2021 ?2022 ?2023 ?2024 ?2025 ?2026 ?2027 ?2028 ?2029 ?2030 ?2031 ?2032 ?2033 ?2034 ?2035 ?2036 | ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????0 ????1 ????1 ????1 ????1 ????1 ????1 | ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????C ????N ????N ????N ????C ????C ????C ????C ????C ????C | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????O ????O ????O ????O ????O ????O ????O ????O ????O | ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????O ????S ????S ????S ????O ????O ????O ????O ????S ????O ????O ????O ????O ????O ????O | ????CH
3????CH
3????CH
3??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
2C≡CI ??CH
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Embodiment: below in conjunction with preparation and Application Example, the present invention will be further described: embodiment one: prepare weedicide 3-of the present invention (5-fluoro-3-proyl-1,3-benzoxazolone-6-yl)-6-Trifluoromethyl-1 ,-methyl-2,4 (1H, 3H) pyrimidine diones (NO.375).
Get the amino benzoxazolone 2.06g of 3-proyl-5-fluoro-6-, (N, N dimethylamine carbonyl) amido 4,4,4-trifluoromethyl butenoic acid ethyl 2.54g, glacial acetic acid 20ml is heated to backflow in reaction flask, stirring reaction 2h.Cooling is poured in the 200ml frozen water, separates out solid, filters washing, the dry intermediate that gets.This intermediate is dissolved among the 20mlDMF, adds 2,76gK
2CO
3With 2.13g methyl iodide, stirring at room 12h.Be poured into then in the 20ml frozen water and filter out solid, washing, drying, the post branch obtains (NO.375) 2.53g, yield 66%.NMR:3.02 (m, 1H, pyrimidine ring H) 3.47 (S, 3H, N-CH
3) 4.75 (d, 2H, CH2)
(6.37 S, 1H, C ≡ CH) 7.34 (d, 2H, phenyl ring H)
Can prepare 3-(5-fluoro-3-methyl isophthalic acid, 3-benzoxazolone-6-yl)-6-Trifluoromethyl-1-methyl-2,4 (1H, 3H) pyrimidine dione (NO.327) and similar compound thereof with method.Embodiment two: prepare weedicide 9-of the present invention (5-fluoro-3-proyl-1,3-benzoxazolone-6-yl)-8-sulphur-1,6-diaza-bicyclo [4,3,0] nonanone (NO.837)
Reaction formula:
Get the amino benzoxazolone 2.06g of 3-propenyl-5-fluoro-6-, be dissolved in the 20ml toluene, slowly add the 2.30g thiophosgene, reflux 2h.N is used in cooling
2Catch up with most residual air, precipitation gets the sulphur isocyanic ester.
In another reaction flask, add the 0.86g hexahydro-pyridazine and be dissolved in the 10ml dehydrated alcohol, below 10 degree, slowly slowly add above-mentioned sulphur isocyanic ester and be dissolved in the 15ml methylene dichloride, dropwise stirring at room 4h.With methylene dichloride dilution, washing, drying, precipitation, residual thing are dissolved in the 20ml ethylene dichloride, slowly drip 20% phosgene toluene 10ml under the room temperature.Stirring at room 12h then.Add the ethylene dichloride dilution, washing, drying, precipitation, the post branch obtains NO.837 2.42g, yield 68%.NMR:1.76 (m, 4H) 2.32 (m, 4H) 4.70 (d, 2H) 6.39 (S, and 1H) 7.35 (d, 2H) embodiment three: prepare weedicide N-of the present invention (5-fluoro-3-proyl-1,3-benzoxazolone-6-yl) hexamethylene-1-alkene-1,2-dicarboximide (NO.1114).
Reaction formula:
(NO.1114)
Get the amino benzoxazolone 2.06g of 3-proyl-5-fluoro-6-, be dissolved in the 20ml glacial acetic acid, add 1.67g3,4,5,6-Tetra Hydro Phthalic Anhydride, reflux 4h then.Cooling is poured in the 200ml frozen water, filters out solid, washing, and drying, precipitation gets (NO.1114) 3.00g, yield 88%.
NMR:3.68 (m, 4H) 3.79 (m, 4H) 4.72 (d, 2H) 6.31 (S, 1H) 7.30 (d, 2H) embodiment four: prepare sterilant 1-of the present invention (5-fluoro-3-iodine proyl-1,3-benzoxazolone-6-yl)-3-n-propyl-4-iodine proyl Triazolinones (NO.966).Reaction formula:
Get 3-proyl-5-Fu benzoxazolone hydrazine 2.21g, be dissolved in the 40ml trimethyl carbinol: in the mixed solvent of water=88: 12, slowly drip the 0.72g butyraldehyde-n below 10 degree, then stirring at room 2h.Then in reaction flask, slowly add the soup compound that 0.97gNaCNO is dissolved in 2ml water, after adding, stirring at room 4h.Then in reaction, slowly drip the 20ml 6%NaClO aqueous solution, dropwise, stirring at room reaction 12h.Be poured in the 500ml frozen water, separate out solid, filter, washing, drying, precipitation, residual thing are dissolved in the 20ml acetone, add 4.5gN-iodo succimide, 0.2g AgNO
3, stirring at room 24h.Filter, precipitation, the post branch obtains (NO.966) 2.18g, yield 34%.
(m, 3H) 1.21 (m, 2H) 2.06 (m, 2H) 4.70 (d, 2H) 7.32 (d, 2H) the Application Example example one: potted plant weeding test (1) reagent for NMR:0.98
Accurately take by weighing sample, after the The suitable solvent dissolving, add small amounts of emulsifiers, adding distil water is settled to 10ml and adopts suitable spraying machine sprinkling again, and reduced unit's area dose is 18.75ga.i/ha.(2) examination material
Dicotyledonously select lamb's-quarters (Chenopodium album), piemarker (Abutilon theophrast) i, recessed amaranth (Amaranthus ascedense) for use, unifacial leaf is selected lady's-grass (Digitaria sanguinalis), barnyard grass grass (Echinochloa crus-galli), Herba Setariae Viridis (Setaria viridis) for use.(3) cultivation of examination material plant
At sectional area 64cm
2The plastic tub alms bowl in quantitative dress soil, flatten, water permeable, choose full seed, lady's-grass of the same size, barnyard grass grass, Herba Setariae Viridis, piemarker, lamb's-quarters, recessed amaranth seed, divide single, double cotyledon plant to divide the pot culture kind, respectively account for 1/3 of alms bowl area, cover thick fine earth of 1cm and trickle, place hot-house culture.Treat that unifacial leaf examination material grows to 1 heart stage of 1 leaf, dicotyledonous examination material grows to 2 leaf periods, carry out seedling with soup after the cauline leaf spraying handle, soil treatment before the seedling is carried out in the sowing of examination material next day.Put back to the greenhouse subsequently.(4) test
15 back range estimation overground part growing states calculate growth inhibition ratio, growth inhibition ratio (%)=100 (contrast plant height-processing plant height)/contrast plant height.Carry out the weeding activity classification according to growth inhibition ratio: A level growth inhibition ratio>90% B level growth inhibition ratio, 75~90% C level growth inhibition ratios, 50~75% D level growth inhibition ratios are less than 50%.
Part of compounds of the present invention such as compound N O.375 327 837 1114 etc. respectively with amount of application to potted plant examination material plant bud after cauline leaf handle, suppress the virulence effect and see Table 11.
Table 11: recessed amaranth NO.375 of potted plant weeding test sample lady's-grass barnyard grass grass Herba Setariae Viridis lamb's-quarters piemarker D D D C B A 327 D D D A A A 837 D D D B B A 1114 D D D C B B
As table 11 as can be known: four compounds of test all have certain preventive effect to broadleaf weeds under the low dosage of 18.75ga.i/ha, wherein O.327 compound N has good preventive effect to broadleaf weeds under the low dosage of 18.75ga.i/ha.But it is invalid to gramineous weeds under the low dosage of 18.75ga.i/ha.Example two: crop safety test.
Choose full seed, paddy rice Oryza sativa of the same size, wheat Triticum aestivum, corn Zea mays, Chinese sorghum sorghum vulgare, soybean Glycine max and rape Brassicacampestris seed, use 0.1%HgCl
2Sterilization 5min, the back leaches and puts into little porcelain dish (putting wetting thieving paper) at 25 ℃ of growth chamber vernalization 24h with the distilled water 12h that soaks seed, and gets 10 in the consistent seed of size and bud length, is sowed at 64cm
2Quantitatively in the plastic tub alms bowl of dress soil, cover thick fine earth of 1cm and trickle, place hot-house culture.Treat that unifacial leaf examination material grows to 1 heart stage of 1 leaf, dicotyledonous examination material grows to 2 leaf periods, with 150,75,37.5,18.75,9.375, the 4.6875ga.i./ha soup carry out seedling after the cauline leaf spraying handle, the examination material is sowed and is carried out the preceding soil treatment of seedling next day, be contrast with spraying solvent and clear water respectively, twice repetition, handle the examination material and place hot-house culture, observe the crop symptom of being injured behind the 15d, range estimation overground part growth inhibition ratio.Growth inhibition ratio (%)=100 (contrast plant height-processing plant height)/contrast plant height is according to growth inhibition ratio estimation crop IC '
10Value, and in conjunction with weeds IC
90Value is pressed IC '
10/ IC
90Calculate selectivity index (Z), safety grades standard: A:Z>4 B, 2<Z<4 C Z<2 can be considered safety more than the B level.
Compound of the present invention (NO.327) the results are shown in Table 12 to the safety experiment of crop
Table 12: safety experiment sample dose ga.i/ha rice and wheat rape corn and Chinese sorghum soybean
150??????????C???????A??????C??????A???????C??????C
75???????????C???????A??????C??????A???????C??????CNO.327??????37.5?????????B???????A??????C??????A???????C??????B
18.75????????A???????A??????C??????A???????C??????A
9.375????????A???????A??????C??????A???????C??????A
4.6875???????A???????A??????B??????A???????C??????A
As table 12 as seen: compound N O.327 under the high dosage of 150ga.i/ha to wheat and corn safety.18.75ga.i/ha than under the low dosage to paddy rice and soybean safety.But to rape and Chinese sorghum even also dangerous under the low dosage of 4.6875ga.i/ha.Example three: bactericidal assay.
At greenhouse pot culture plant examination material, it is standby to grow to the certain period.The former medicinal a certain amount of DMF dissolving of testing compound is diluted with water to finite concentration.Spray pesticide is contrast with the examination material that sprays clear water to plant examination material, and after the spray medicine finished, it is In Shade air-dry that plant is tried material, carries out the disease inoculation after 24 hours.After the inoculation, plant is tried in the incubator that material is placed on fixed temperature and humidity, made infecting continuing of pathogenic bacteria.After inoculating a couple of days, when contrast is fully fallen ill, carry out the incidence survey of disease.The fungicidal activity grade is as follows: the A level: bacteriostasis rate>90%; B level: bacteriostasis rate 75~90%; C level: bacteriostasis rate 50~75%; The D level: bacteriostasis rate is less than 50%.
Part of compounds of the present invention such as compound N O.966 with 100ppm concentration to potted plant examination material plant bud after cauline leaf handle, fungistatic effect sees Table 13.
Table 13: the mould tomato late blight of bacteriostatic experiment sample Phytophthora nicotianae Phytophthora capsici cucumber epidemic disease potato late blight grape downy mildew NO.966 A A A A A A
As shown in Table 13: new compound NO.966 has a bacteriostatic action preferably to various fungal diseases such as Yimeishuang cream against mould are mould.