CN1394531A - Composite nutrient enriching substance with zinc, potassium and glutamic acid coordination compound - Google Patents

Composite nutrient enriching substance with zinc, potassium and glutamic acid coordination compound Download PDF

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Publication number
CN1394531A
CN1394531A CN02123908A CN02123908A CN1394531A CN 1394531 A CN1394531 A CN 1394531A CN 02123908 A CN02123908 A CN 02123908A CN 02123908 A CN02123908 A CN 02123908A CN 1394531 A CN1394531 A CN 1394531A
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Prior art keywords
glutamic acid
zinc
potassium
preparation
reaction
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CN02123908A
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CN1189098C (en
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牛春吉
王增林
杨魁跃
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Changchun Institute of Applied Chemistry of CAS
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Changchun Institute of Applied Chemistry of CAS
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Abstract

The preparation method of the invented compound zinc, potassium and glutamic acid nutrient enriching agent includes the following steps: according to chemical metering weighing zinc carbonate, adding water and stirring to obtain paste material, mixing the obtained zinc carbonate paste material with saturated solutions of sodium carbonate and potassium carbonate, stirring them and adding glutamic acid solution into the above-mentioned mixed solution in three times while stirring, reaction temp. is controlled at 40-55 deg.C, and making reaction until it has no production of bubble, continuously reacting for 0.5-1.0 hr., evaporating and concentrating, filtering, separating out product, drying so as to obtain its object product, its yield is 95.6%-97.3%. The chemical formula of the invented product is also disclosed.

Description

A kind of compound zinc, potassium and glutamic acid coordination compound nutrition fortifier
Technical field:
The invention belongs to the nutrition fortifier class, relate in particular to a kind of compound zinc, potassium and glutamic acid coordination compound nutrition fortifier.
The invention still further relates to a kind of preparation method of above-mentioned nutrition fortifier.
Background technology:
Zinc enzyme is about kind more than 100 in the human body.Zinc mainly participates in the formation in the activated centre of these enzymes, with the Stability Analysis of Structures of maintenance enzyme and the normal performance of function.The growing of zinc and human body, immune defence, wound healing, reproduction fertility relation are very close.China's nutrition survey and total dietary study result show that by present China people's recipe, the daily intaking amount of zinc reaches standard far away, so the scarce zinc of China people is rather serious.The shortage of zinc causes symptoms such as delayed growth, dermatitis and immunologic hypofunction.Potassium is the element of needed by human, plays an important role in keeping normal vital movement.Its shortage causes muscle weakness and paralysis, arrhythmia cordis, renal dysfunction etc.Result of study proves owing to fearing into amount of the reason potassium of Chinese people foodstuff for the people spectrum is also low excessively.Want the low excessively national condition of intake of indispensable element zinc, potassium in view of above-mentioned China people counterweight, develop multi-functional compound zinc, the potassium and glutamic acid coordination compound nutrition fortifier is very necessary, this for replenish China people zinc, potassium element be not enough to improve health, and then reach that The nation is prosperous and the people are strong and powerful has strategic, far reaching significance.
Indispensable element and amino acid are two class nutrition fortifiers of extensive use, and they play crucial effect in metabolism, the energy transmission of human body and process such as grow.The indispensable element nutrition fortifier mainly contains the first generation mineral nutrition hardening agent based on the sulfate of iron, calcium, zinc, phosphate, based on the second generation acylate nutrition fortifier of its lactic acid, gluconate.Amino acid nutrition intensifying agent is based on single amino acid, as lysine, valine etc.The mineral nutrition hardening agent has its obvious weakness: hydrolysis easily takes place in (1) in human body; (2) inorganic anion has spread effect as sulfate ion to enteron aisle, not only influences enteron aisle to trace elements absorbed, and cause nausea, diarrhoea etc.; (3) inorganic salts also influence vitamins stability.The acylate nutrition fortifier of indispensable element also has its weakness, makes nutrition fortifier (Chinese patent application number 98100374) as EDTA iron, because of its stable especially absorption difference; Saccharin zinc hardening agent (Chinese patent application number 95104822), effect remains arguement and should not use to human body because of asccharin.
Summary of the invention:
The object of the present invention is to provide a kind of compound zinc, potassium and glutamic acid coordination compound nutrition fortifier;
Another purpose of the present invention is to provide a kind of preparation method of above-mentioned nutrition fortifier.
The present invention is based on following principle: the rational allocation of (1) nutritional labeling.Human body needs varied nutrition, and the reasonably combined of multiple nutritional components can be received ideal effect.Proportioning between the indispensable element for example, the rational allocation of nutritional labelings such as indispensable element and amino acid.(2) improve the human body utilizability of indispensable element with the generation of complex.The easy oxidation of the inorganic salts of indispensable element, deliquescence and hydrolysis, especially enter enteron aisle after because the pH value of enteron aisle is higher, the easier generation of hydrolysis, this causes its absorption difference and difficulty is utilized by human body.After indispensable element formed complex, then its stability improved, and its human body utilizability is obviously improved.(3), improve the absorptivity of indispensable element with the carrier of biomolecule as indispensable element.Glutamic acid is important biomolecule molecule in the human body, and the biomolecular complex of human essential elements is present in the human body, participates in the internal metabolism process directly.So with the biomolecule is carrier, indispensable element is easy to absorb, and saves physical efficiency.The present invention proposes multi-functional compound zinc, potassium and glutamic acid coordination compound nutrition fortifier based on above-mentioned principle.
The chemical formula of compound zinc provided by the invention, potassium and glutamic acid (with the HL representative) complex nutrition fortifier is:
Na XK YZn (1-X-Y)L (2-X-Y)In the formula: 0≤X≤1; 0≤Y≤1; X+Y≤1; L= -OOC-CH 2-CH 2-CH (NH 3) +COO -
Raw materials usedly be:
Na 2CO 3(chemical pure), K 2CO 3(chemical pure), ZnCO 3(chemical pure), glutamic acid
(biochemical reagents);
Compound zinc of the present invention, potassium and glutamic acid coordination compound nutrition fortifier can replenish human essential elements zinc, potassium and important nutritional labeling glutamic acid simultaneously.The content that also can adjust sodium as required both can make this nutrition fortifier play the function of monosodium glutamate, and (sodium of taking in because of China people is above standard can to limit the absorption of sodium again.Sodium is mainly by absorptions such as salted vegetables, soy sauce, monosodium glutamate and salt).
Preparation method of the present invention is: according to needed nutrition fortifier chemical composition (Na XK YZn (1-X-Y)L (2-X-Y)) respectively weighing sodium carbonate, potash and glutamic acid exactly.It is dissolved in water respectively, is made into the corresponding aqueous solution.Solution concentration is advisable with saturated solution at room temperature, and is rarer as solution, and it is long that then the product time is separated out in evaporation.Add low amounts of water in the zinc carbonate with accurate weighing, stir pulpous state.Sodium carbonate, solution of potassium carbonate are mixed with the pulpous state zinc carbonate, under continuous condition of stirring, divide 3 times glutamic acid solution to be added in the said mixture.Reaction temperature is controlled at 40～55 ℃.Reaction is undertaken by following formula:
X/2Na 2CO 3+Y/2K 2CO 3+(1-X-Y)ZnCO 3+(2-X-Y)HL
=Na xK yZn (1-X-Y)L (2-X-Y)+ (1-X/2-Y/2) H 2O+ (1-X/2-Y/2) CO 2Constantly there is the carbon dioxide bubble to emit in the course of reaction, constantly dissolving of zinc carbonate precipitation simultaneously.After the carbon dioxide bubble stops to emit, show that above-mentioned reaction finishes substantially, after this continue reaction 0.5～1.0 hour to guarantee that target product quantitatively generates.Target product is separated out the product evaporation and concentration, filter, drying obtains multi-functional compound zinc of the present invention, potassium and glutamic acid coordination compound nutrition fortifier, and chemical formula is: Na xK yZn (1-X-Y)L (2-X-Y), wherein L represents glutamate, and its yield is 95.6～97.3%.
The present invention has following distinguishing feature: (1) this nutrition fortifier can replenish human essential elements potassium and zinc simultaneously, also can replenish the nutritional labeling glutamic acid that human body needs simultaneously.Especially can change above-mentioned nutrient composition content as required, make the multiple nutrients hardening agent.(2) make complex form, thereby improved the human body utilizability of this nutrition fortifier significantly.(3) important biomolecule glutamic acid easily is absorbed indispensable element potassium, zinc as the carrier of indispensable element in the body.(4) eliminated the side effect of indispensable element mineral nutrition hardening agent.(5) keep a certain proportion of sodium, then this nutrition fortifier can play the effect of monosodium glutamate, has overcome the edible ubiquitous problem of too high this China of sodium intake people that makes because of monosodium glutamate simultaneously again.(6) preparation method of this nutrition fortifier has many advantages: simple as the preparation method; Do not need complex device, raw material is cheap and be easy to get; Except that target product, water and carbon dioxide are only arranged, so product does not need to separate; Can control the carrying out of reaction easily by the effusion of carbon dioxide bubble.
The specific embodiment:
The present invention will be further described with the following examples.
Embodiment 1
Accurately take by weighing 0.15 mole of Na 2CO 3, 0.1 mole of K 2CO 3With 1.5 mole of glutamic acid.With its nearly saturated aqueous solution, 0.5 mole of ZnCO that accurately takes by weighing of making soluble in water respectively 3The middle low amounts of water that adds is stirred pulp with it.Under constantly stirring, divide and 3 times glutamic acid solution is joined Na 2CO 3, K 2CO 3And ZnCO 3In the suspension.Reaction temperature is controlled at about 40 ℃.CO is constantly arranged in the course of reaction 2Bubble is emitted, and glutamic acid coordination compound constantly generates simultaneously.Work as CO 2After bubble stops to emit, show that above-mentioned reaction finishes substantially, after this continue reaction 0.5 hour to guarantee that target product quantitatively generates.The product evaporation and concentration so that target product is separated out, is filtered, and drying obtains multi-functional composite nourishing energizing agent of the present invention, product chemical formula Na 0.3K 0.2Zn 0.5L 1.5, its yield is 96.5%.
Embodiment 2
Accurately take by weighing 0.15 mole of Na 2CO 3, 0.1 mole of K 2CO 3With 1.5 mole of glutamic acid.It is soluble in waterly respectively made nearly saturated aqueous solution.The 0.5 mole of ZnCO that accurately takes by weighing 3The middle low amounts of water that adds is stirred pulp with it.Under constantly stirring, divide and 3 times glutamic acid solution is joined Na 2CO 3, K 2CO 3And ZnCO 3In the suspension.Reaction temperature is controlled at about 48 ℃.CO is constantly arranged in the course of reaction 2Bubble is emitted, and glutamic acid coordination compound constantly generates simultaneously.Work as CO 2After bubble stops to emit, show that above-mentioned reaction finishes substantially, after this continue reaction 1.0 hours to guarantee that target product quantitatively generates.The product evaporation and concentration so that target product is separated out, is filtered, and drying obtains multi-functional composite nourishing energizing agent of the present invention, product chemical formula Na 0.3K 0.2Zn 0.6L 1.5, its yield is 95.6%.
Embodiment 3
Accurately take by weighing 0.15 mole of Na 2CO 3, 0.1 mole of K 2CO 3With 1.5 mole of glutamic acid.It is soluble in waterly respectively made nearly saturated aqueous solution.The 0.5 mole of ZnCO that accurately takes by weighing 3The middle low amounts of water that adds is stirred pulp with it.Under constantly stirring, divide and 3 times glutamic acid solution is joined Na 2CO 3, K 2CO 3And ZnCO 3In the suspension.Reaction temperature is controlled at about 55 ℃.CO is constantly arranged in the course of reaction 2Bubble is emitted, and glutamic acid coordination compound constantly generates simultaneously.Work as CO 2After bubble stops to emit, show that above-mentioned reaction finishes substantially, after this continue reaction 1 hour to guarantee that target product quantitatively generates.The product evaporation and concentration so that target product is separated out, is filtered, and drying obtains multi-functional composite nourishing energizing agent of the present invention, product chemical formula Na 0.3K 0.2Zn 0.5L 1.5, its yield is 96.1%.
Embodiment 4
Accurately take by weighing 0.1 mole of Na 2CO 3, 0.35 mole of K 2CO 3, 0.1 mole of ZnCO 3With 1.1 mole of glutamic acid.All the other operations are with embodiment 1.The nutrition fortifier chemical formula of preparation is Na 0.2K 0.7Zn 0.1L 1.1Its yield is 96.4%.
Embodiment 5
Accurately take by weighing 0.4 mole of K 2CO 3, 0.2 mole of ZnCO 3With 1.2 mole of glutamic acid.All the other operations are with embodiment 1.The nutrition fortifier chemical formula of preparation is K 0.8Zn 0.2L 1.2, its yield is 97.0%.
Embodiment 6
Accurately take by weighing 0.35 mole of K 2CO 3, 0.3 mole of ZnCO 3With 1.3 mole of glutamic acid.All the other operations are with embodiment 1.The nutrition fortifier chemical formula of preparation is K 0.7Zn 0.3L 1.3, its yield is 96.8%.
Embodiment 7
Accurately take by weighing 0.25 mole of Na 2CO 3, 0.25 mole of K 2CO 3With 1.0 mole of glutamic acid.It is soluble in water respectively, make near saturated solution.Divide and 3 times glutamic acid solution to be added to Na in the stirring 2CO 3And K 2CO 3Mixed solution.All the other operations are with embodiment 1.The nutrition fortifier chemical formula of preparation is Na 0.5K 0.5L, its yield are 97.3%.
Embodiment 8
Accurately take by weighing 1.0 moles of ZnCO 3With 2.0 mole of glutamic acid.Glutamic acid aqueous solution divided join ZnCO 3 times 3In the slurry, and constantly stir.All the other operations are with embodiment 1.The nutrition fortifier chemical formula of preparation is ZnL 2, its yield is 95.9%.
Embodiment 9
Accurately take by weighing 0.5 mole of K 2CO 3With 1.0 mole of glutamic acid.All the other operations are with embodiment 7.The nutrition fortifier chemical formula of preparation is KL, and its yield is 96.9%.

Claims (4)

1, a kind of compound zinc, potassium and glutamic acid coordination compound nutrition fortifier, its chemical formula is:
Na XK YZn (1-X-Y)L (2-X-Y)
In the formula: L is a glutamate, and its chemical formula is -OOC-CH 2-CH 2-CH (NH 3) +COO -0≤X≤1; 0≤Y≤1; X+Y≤1.
2, a kind of preparation method who prepares the described nutrition fortifier of claim 1, reaction is undertaken by following formula:
X/2Na 2CO 3+Y/2K 2CO 3+(1-X-Y)ZnCO 3+(2-X-Y)HL
＝Na xK yZn (1-X-Y)L (2-X-Y)+(1-X/2-Y/2)H 2O+(1-X/2-Y/2)CO 2
Concrete preparation process is:
Take by weighing zinc carbonate by stoichiometry, add entry and stir pulp, sodium carbonate, wet chemical are mixed with the pulpous state zinc carbonate, stir and for several times glutamic acid solution was added in the said mixture in following minute, reaction temperature is controlled at 40～55 ℃, after reaction proceeds to bubble and stops to emit, continue reaction 0.5～1.0 hour; Evaporation and concentration is filtered precipitate and dry, and the target product yield that obtains is 95.6%～97.3%.
3, preparation method as claimed in claim 2 is characterized in that described sodium carbonate, potash and glutamic acid aqueous solution at room temperature are saturated solution.
4, preparation method as claimed in claim 2 is characterized in that described glutamic acid divides 3 addings.
CNB021239088A 2002-07-09 2002-07-09 Composite nutrient enriching substance with zinc, potassium and glutamic acid coordination compound Expired - Fee Related CN1189098C (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100445263C (en) * 2003-04-24 2008-12-24 四川大学 Microwave method for synthesizing carbonate of natrium glycine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100445263C (en) * 2003-04-24 2008-12-24 四川大学 Microwave method for synthesizing carbonate of natrium glycine

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