CN1389447A - Prepn. and product of colorless transparent needle crystal inositol - Google Patents
Prepn. and product of colorless transparent needle crystal inositol Download PDFInfo
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- CN1389447A CN1389447A CN 02137933 CN02137933A CN1389447A CN 1389447 A CN1389447 A CN 1389447A CN 02137933 CN02137933 CN 02137933 CN 02137933 A CN02137933 A CN 02137933A CN 1389447 A CN1389447 A CN 1389447A
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- inositol
- water
- colorless transparent
- crystallization
- needle crystal
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Abstract
The present invention discloses a method for preparing colourless transparent needle crystal inositol and its product. It is characterized by that it uses wet refined inositol as raw material, and adopts the following steps: adding water and dissolving in crystallizing bed; under the the action of crystallization catalyst making catalyst crystallization; cooling and dewatering, separating and drying to obtain the needle crystal inositol whose grain size is greater than or equal to 0.20 mm, and inositol content is greater than or equal to 99%.
Description
Technical field
The present invention relates to the preparation method and products thereof of the additive colorless transparent needle crystal inositol of medicine material, protective foods, feed and household chemicals.
Background technology
The preparation technique of existing inositol, the person is in the majority to produce the powdered inositol, number is 99124661.6 as Chinese patent application, and name is called " a kind of production method of powdered inositol ".Technology is easy, to produce cost lower although it has, advantage such as pollution-free substantially, but just because it produces is powdered inositol, and exist inositol content low (being generally 95%), in transporting procedures, harden easily or the obvolvent granulating, and mobile poor, particularly taked the can of capsule figuration and cooperated the operating process of mixing and stirring with other material, added many troubles.In recent years,, produce the high-purity crystals inositol, caused attention both domestic and external along with the deep development of inositol research for application and development.This is because the good physical property that the crystal inositol not only has powdered inositol and do not had, and its international market price, exceeds 2/3 at least than powdered inositol.Thereby produce the crystal inositol, just become the deep development of high added value.Japan's number of patent application is special 8-215987, and name is called " manufacture method of anhydrous crystal body ", discloses a kind ofly to maintain under the state of temperature more than 40 ℃ with the inositol aqueous solution, extracts the manufacture method of crystal inositol.Its major advantage is to save energy consumption, but exists the low and too small main deficiency of crystal of inositol recovery rate, and its manufacturing cost is higher undoubtedly for this.
Summary of the invention
The object of the present invention is to provide that a kind of to produce cost relatively low, reparation technology is comparatively simple and easy, the inositol content height, and preparation method of the colorless transparent needle crystal inositol that the wet refining inositol of producing in the employing prior art powdered inositol manufacturing approach craft flow process is a raw material and products thereof is to overcome the deficiency of prior art.
The object of the present invention is achieved like this.It is a raw material with wet refining inositol, and carries out according to following steps successively:
(1) wet refining inositol enters crystallizing bedly, is dissolve medium with water, and dissolves under the certain temperature condition, is urging crystallization under the crystallizing agent existence;
(2) crystallization inositol and water-soluble inositol, water and urge the mixture cooling cooling of crystallizing agent, water-soluble inositol two degree crystallizations are separated out.And the cooling of said mixture cooling, can random rotation cooling in crystallizing bed.Also said mixture can be imported another crystallizing bed interior random rotation cooling.Two kinds of ways respectively have its pros and cons.
(3) inositol crystal and water and urge the mixture of crystallizing agent to carry out dewatering unit make the solid-liquid separation crystallization inositol that must dewater.Water after the solid-liquid separation and alcohol mixture import the used crystallizing bed reuse of the 1st step.
(4) dehydration crystallization inositol enters the drying plant oven dry, removes the moisture content attached to crystallization inositol surface.
The crystallization inositol of moisture content is removed in oven dry, through the test package supply that can appear on the market.
The present invention is the added crystallizing agent of urging in the 1st step, is glycerine, or glyceryl ester, or ethanol.The present invention is ethanol preferably.And according to wet refining inositol: water: content is that the weight ratio metering of 95% ethanol=1: 1.5: 0.5 adds.Add and urge the purpose of crystallizing agent to be, in accelerating crystallization, dissolve water-insoluble organic or inorganic impurity,, and help the crystalline growth in the hope of raising inositol purity.
Inositol is dissolved in water.The dissolution rate of inositol in water is along with the temperature of water improves and accelerates.For dissolving and the oven dry of accelerating inositol, and the solvent temperature in the present invention's the 1st step is 45 ℃～80 ℃; And the bake out temperature in the 4th step is 95 ℃～105 ℃.Certain described solvent temperature and bake out temperature are inversely proportional to dissolution time and drying time.And the effect of dissolved effect and oven dry then is directly proportional with solvent temperature and bake out temperature.For this reason, the solvent temperature of the best of the present invention is 60 ℃, and bake out temperature then is 100 ℃, in the hope of guaranteeing that effectively energy efficient reduces production costs, and enhances productivity under the prerequisite of goods inositol quality of the present invention.
And the crystal inositol that adopts above-described preparation method to produce, its shape is the water white transparency acicular crystals, its particle diameter 〉=0.20
MmAnd its weight percentage is: inositol 〉=99%, other is a unavoidable impurities.
In sum, it is simple that method of the present invention has technology, and production cost is low, characteristics such as inositol yield height; And, having the inositol content height with the product that method of the present invention is produced, its shape is water white acicular crystals, and crystal is bigger, and uniform crystal particles is difficult for hardening in transporting procedures, and good fluidity is convenient to the figuration can and is admixed characteristics such as convenient, all is conspicuous.Compared with the prior art, the present invention has substantial characteristics and obvious improvement.
Description of drawings
Fig. 1 is a kind of process flow sheet of the present invention;
Fig. 2 is an another kind of process flow sheet of the present invention;
Fig. 3 is the micro-photograph enlarged view of product colorless transparent needle crystal inositol of the present invention.
Embodiment
One of embodiment: please join and read accompanying drawing 1.Preparation method of the present invention is a raw material with wet refining inositol, carries out according to the following steps:
(1) be raw material with wet refining inositol, weigh and drop into the crystallization case that Jiangyin chemical produces, and by wet refining inositol: water: the weight percent of ethanol=1: 1.5: 0.5, weighing adds entry and ethanol; Adopt steam to heat to 60 ℃, insulated and stirred is dissolved fully until wet refining inositol, stops then stirring.Urging under the effect of crystallizing agent alcoholic acid, the inositol crystallization is separated out.
(2) crystallization inositol and uncrystallized water-soluble inositol, water and the alcoholic acid mixture that the 1st step was produced, cooling is cooled to normal temperature at random in the crystallization case, and water-soluble inositol crystallization is separated out.
(3) inositol crystal and water and the alcoholic acid mixture that the 2nd step was produced imports centrifugal dehumidifier, makes solid-liquid separation and the inositol that must dewater.And water after will separating and alcoholic acid mixture import the used crystallization case reuse of the 1st step.
(4) the dehydration inositol that the 3rd step was produced drops into the oven dry of electrically heated drying plant, and bake out temperature is controlled at 100 ℃ ± 2 ℃.Removing moisture content, and make product of the present invention attached to the inositol plane of crystal.
Two of embodiment please be joined and be read accompanying drawing 1.The present invention is raw material with the city for powdered inositol, adds to make wet refining inositol behind the water in advance, and thereafter according to as one of embodiment, described 4 steps are produced colorless transparent needle crystal inositol.
Three of embodiment please be joined and be read accompanying drawing 2.It is a raw material with rough inositol, through being dissolved in water and activated carbon decolorizing; After suction filtration or press filtration; Separate out inositol through cooling again; Separate and the refining inositol that must wet through dehydration then.Wet refining inositol passes through as described 4 steps of one of embodiment again, and produces colorless transparent needle crystal inositol.
Through as one of embodiment, two and three, the product colorless transparent needle crystal inositol of being produced of the present invention, its every quality index value is as follows after testing:
Outward appearance: water white transparency needle-like crystal, particle diameter 〉=0.2
Mm(please join and read accompanying drawing 3);
Inositol content: 〉=99%
Moisture content :≤0.20%;
Total impurities≤0.02% such as other inevitable muriate, iron and heavy metal;
Residue :≤0.10%;
The detection desired value shows that product colorless transparent needle crystal inositol of the present invention is compared with existing powdery inositol, has outstanding marked improvement.
Claims (6)
1, a kind of preparation method of colorless transparent needle crystal inositol, it is a raw material with wet refining inositol, it is characterized in that, carries out as follows successively:
(1) wet refining inositol enters crystallizing bedly, is dissolve medium with water, and dissolving at a certain temperature, is urging crystallization under the crystallizing agent existence;
(2) crystallization inositol and water-soluble inositol, water and urge the mixture cooling cooling of crystallizing agent, water-soluble inositol crystallization is separated out;
(3) inositol crystal and water and urge the mixture of crystallizing agent to enter dewatering unit make the solid-liquid separation crystallization inositol that must dewater;
(4) dehydration crystallization inositol enters the drying plant oven dry, removes the moisture content attached to crystallization inositol surface, and gets the product colorless transparent needle crystal inositol.
2, the preparation method of colorless transparent needle crystal inositol according to claim 1, it is characterized in that, the added crystallizing agent of urging is an ethanol in the 1st step, and according to wet refining inositol: water: the weight ratio metering of ethanol (95%)=1: 1.5: 0.5 adds.
3, the preparation method of colorless transparent needle crystal inositol according to claim 1 is characterized in that, the solvent temperature in the 1st step is 45 ℃～80 ℃.
4, the preparation method of colorless transparent needle crystal inositol according to claim 1 is characterized in that, the bake out temperature in the 4th step is 95 ℃～105 ℃.
5, the crystal inositol produced of the preparation method of colorless transparent needle crystal inositol as claimed in claim 1 is characterized in that its shape is the water white transparency acicular crystals, its particle diameter 〉=0.20
Mm
6, colorless transparent needle crystal inositol according to claim 5 is characterized in that, its weight percentage is: inositol 〉=99%, other is unavoidable impurities and water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02137933 CN1211334C (en) | 2002-07-09 | 2002-07-09 | Prepn. and product of colorless transparent needle crystal inositol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02137933 CN1211334C (en) | 2002-07-09 | 2002-07-09 | Prepn. and product of colorless transparent needle crystal inositol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1389447A true CN1389447A (en) | 2003-01-08 |
| CN1211334C CN1211334C (en) | 2005-07-20 |
Family
ID=4749186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02137933 Expired - Fee Related CN1211334C (en) | 2002-07-09 | 2002-07-09 | Prepn. and product of colorless transparent needle crystal inositol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1211334C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015035817A1 (en) * | 2013-09-10 | 2015-03-19 | 诸城市浩天药业有限公司 | An inositol crystal as well as preparation method and use thereof |
| CN105669376A (en) * | 2016-02-27 | 2016-06-15 | 诸城市浩天药业有限公司 | Crystallization process for preparing high-crystallinity myo-inositol with large particle size and application |
-
2002
- 2002-07-09 CN CN 02137933 patent/CN1211334C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015035817A1 (en) * | 2013-09-10 | 2015-03-19 | 诸城市浩天药业有限公司 | An inositol crystal as well as preparation method and use thereof |
| CN105669376A (en) * | 2016-02-27 | 2016-06-15 | 诸城市浩天药业有限公司 | Crystallization process for preparing high-crystallinity myo-inositol with large particle size and application |
| CN105669376B (en) * | 2016-02-27 | 2019-03-12 | 诸城市浩天药业有限公司 | Prepare crystallization processes and the application of the big inositol of high-crystallinity, partial size |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1211334C (en) | 2005-07-20 |
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