CN1387824A - Alternating T-wave measuring method and device for sports electrocardiogram - Google Patents
Alternating T-wave measuring method and device for sports electrocardiogram Download PDFInfo
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- CN1387824A CN1387824A CN 02125642 CN02125642A CN1387824A CN 1387824 A CN1387824 A CN 1387824A CN 02125642 CN02125642 CN 02125642 CN 02125642 A CN02125642 A CN 02125642A CN 1387824 A CN1387824 A CN 1387824A
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Abstract
The present invention belongs to the field of medical detection technology, and is the T-wave alternation detecting method and device for sports electrocardiogram. The method includes dividing into four stages of regulating one, first heart rate one, second heart rate one and restoring one; setting the sustaining period of each stage and controlling the moving speed and slope of the plate to make the heart rate enter into the four stages successively and recording the electrocardiogram signal of both first heart rate stage and the second heart rate. The device includes connecting unit, input protector circuit, amplifier system, A/D converter, microcomputer and plate and plate control interface circuit. The present invention is used to detect T-wave alternation in microvolt level in T-wave alternation research and relevant clinical research.
Description
Technical field
The invention belongs to technical field of medical detection, the particularly design of the alternative checkout gear of T ripple in the exercise electrocardiogram.
Background technology
Malignant ventricular arrhythmia is the heart disease that brings very big threat to human life's safety, and it is the big factor that developed country such as America and Europe captures life, thereby is the investigation problem in comparison forward position in predictions of these relevant malignant ventricular arrhythmias of country always.The Forecasting Methodology of relatively generally acknowledging is the cardiac catheter electrophysiologic study at present, it utilizes programmable stimulato, pass through cardiac catheter electrode, provide programme controlled 2 or 3 electricity irritation to right atrium, if can induce chamber speed (VT), just expression has the quiver material base of (Vf) of generation chamber speed and chamber, and the method is called Programed Electro-Stimulation (PES).This method has certain danger, may damage the patient.Thereby much research attempts to find a kind of effective no wound Forecasting Methodology, develops thus based on the cardiac electrical T ripple of digitized to replace detection technique, to predict pernicious chamber arrhythmia.
The electrocardiosignal of a typical cardiac cycle is by the P ripple, and compositions such as QRS ripple and T ripple form electrocardiographic wave as shown in Figure 1, and wherein the P wave table shows the atrium process of depolarization, and the QRS wave table shows the process of depolarization of ventricle, and the T wave table shows the process of repolarization of ventricle.
The T ripple alternately is meant on the surface electrocardiogram, the shape of T ripple or amplitude every clap change by shooting on the multiple basis be the shape of T ripple or amplitude between the heart is clapped continuously with ABABAB ... form occur regularly.Fig. 2 is an example and the alternative surface electrocardiogram of the visible T ripple of naked eyes occurs.
The research of some countries shows that at higher heart rate range 90bpm～110bpm, the alternative appearance of T ripple can be predicted the generation of malignant ventricular arrhythmia.But macroscopic T ripple is alternately rarer, and therefore the generation of alternately predicting malignant ventricular arrhythmia by observation T ripple also fails to use in practice.
Summary of the invention
The objective of the invention is for overcoming the weak point of prior art, alternative detection method of T ripple and device thereof in a kind of exercise electrocardiogram are proposed, can be used for detecting naked eyes invisible also be the microvolt magnitude the T ripple alternately, can be used for the alternative detection of T ripple, handle research, also provide reliable instrument for relevant clinical research.
The present invention proposes the alternative detection method of T ripple in a kind of exercise electrocardiogram, may further comprise the steps:
1) scope according to heart rate value is divided into four-stage, is respectively: the phase of adjustment its heart rate below 90bpm, the one-level heart rate phase, its heart rate is at 90-105bpm, the secondary heart rate phase, its heart rate is more than 105bpm, convalescent period, its heart rate was below 90bpm;
2) persistent period of setting one-level heart rate phase and secondary heart rate phase was respectively 3-6 minute;
3) the dull and stereotyped movement velocity of control and the gradient heart rate that makes the tester enters the four-stage of said heart rate value successively, and keeps the persistent period of this one-level heart rate phase and the setting of secondary heart rate phase;
4) write down the electrocardiosignal in this one-level heart rate phase and secondary heart rate stage phase respectively.
The said method that electrocardiosignal is handled can be successively amplify, step such as filtering, analog digital conversion.
The alternative checkout gear of exercise electrocardiogram T ripple that is used for said method that the present invention proposes, comprise with the lower part: the device that leads that links to each other with the testee, the input protection circuit that links to each other with this device output signal of leading, the amplifier system that links to each other with this holding circuit, and the analog to digital conversion circuit that is connected in this amplifier system outfan, this analog to digital conversion circuit links to each other with a microcomputer, the dull and stereotyped control interface circuit that links to each other with this computer, and link to each other with this control interface circuit and to be used for the flat board that the testee moves; Said amplifier system is made of the pre-amplification circuit, block isolating circuit, main amplifier, 50Hz trap, optical isolation amplifier and the low-pass filter circuit that link to each other successively.
Operation principle of the present invention is described as follows:
According to present clinical research achievement, it is generally acknowledged in 90 to 110bpm the heart rate range, T ripple alternative appearance has diagnostic value, wherein 90 to 105bpm occur remarkable T ripple alternately be occur positive, it is alternately then negative still not occur remarkable T ripple more than 105, according to this standard heart rate range, the present invention has newly created the alternative detection method of T ripple in the exercise electrocardiogram.
The testee is on flat board, and computer is exported control command, the motion of controlled motion flat board by the interface circuit of dull and stereotyped control.The described detection method of program setting; program is according to the dull and stereotyped motion of described method control; the measured is along with treadmill exercise is forced to motion; human motion electrocardiosignal (voltage) from the Mason-Likar lead system after holding circuit (for the reliably working of patient's safety and system); enter amplification system, every straight, filtering, amplification, pass through analog digital conversion by hardware circuit; become digital signal, enter computer.In computer, electrocardiosignal is through digital filtering, the inhibition base floats, power frequency is disturbed and myoelectricity disturbs, subdue the cardiac electrical noise of motion, determine the QRS complex wave then, thereby choose the T ripple, again the T ripple is carried out power spectrumanalysis, adopt moving window to the omnidistance 12 T ripple analyses that hocket of leading, obtain the T ripple and replace testing result.
Characteristics of the present invention and effect:
The present invention is according to the alternative characteristics of T ripple, designed a cover detection method and a device thereof, gathered the motion electrocardiosignal, detection can hocket to the T ripple of microvolt magnitude, can be used for the alternative detection of T ripple, handle research, also provide reliable instrument for relevant clinical research.
Description of drawings
Fig. 1 is an electrocardiogram basic waveform.
Fig. 2 is for being that the alternative surface electrocardiogram of the visible T ripple of naked eyes appears in an example.
Fig. 3 replaces the checkout gear structural representation for the T ripple.
The flow chart of Fig. 4 for alternately detecting for the dull and stereotyped operation of control, T ripple.
Fig. 5 is a preamplifier.
Fig. 6 is a main amplifier.
Fig. 7 is the 50Hz trap circuit.
Fig. 8 is an optical isolation amplifier.
Fig. 9 is a low-pass filter circuit.
Figure 10 is dull and stereotyped control interface circuit.
Figure 11 replaces the changes in heart rate trend curve among the result who detects for the T ripple.
Figure 12 replaces trend for the T ripple in the testing result.
The specific embodiment
Alternative detection method of a kind of ECG T wave that the present invention proposes and device embodiment thereof are described in detail as follows in conjunction with each accompanying drawing:
The alternative checkout gear embodiment of T ripple of a kind of exercise electrocardiogram that the present invention proposes as shown in Figure 3, comprises following essential part: the Mason-Likar device that leads; input protection circuit, amplifier system, and analog to digital conversion circuit; microcomputer, flat board and control interface circuit thereof.Amplifier system is made up of preposition amplification, block isolating circuit, main amplifier stage, 50Hz trap, optical isolation amplifier, low-pass filtering six parts.The specific implementation structure and the operation principle of each several part are described in detail as follows:
The device that leads of present embodiment improves limb lead by Mason-Likar and the Wilson resistor network is formed, and accepts the electrocardiosignal from crosslinking electrode.
The block isolating circuit of present embodiment is the polarizing voltage that produces when being used to eliminate electrode and contacting with human body.
The microcomputer Pentium III of present embodiment is exported control command, the motion of controlled motion flat board by the interface circuit of dull and stereotyped control.Program setting detects the alternative motion scheme of T ripple, and program is according to the dull and stereotyped motion of motion scheme control, and the measured is along with treadmill exercise is forced to motion, and the electrocardiosignal in his motion enters amplification system, computer by electrode through leading.Computer control exercise stress, the alternative flow process of detection T ripple are as shown in Figure 4.
At first, system initialization is set preparations such as electronic health record, amplifier magnification ratio, startup analog digital conversion.Computer passes through dull and stereotyped control interface, the dull and stereotyped original state that resets, and flat board is in level, resting state, gathers 2 minutes quiescent stage electrocardiogram (ECG) data.Then, control dull and stereotyped setting in motion, the phase of adjustment of entering, gather this section electrocardiogram (ECG) data, till heart rate reaches 90bpm.The control treadmill exercise speed and the gradient enter the one-level heart rate phase, gather 5 minutes electrocardiogram (ECG) data.Continue the control treadmill exercise speed and the gradient, when heart rate reaches more than the 105bpm, enter the secondary heart rate phase, gather 5 minutes electrocardiogram (ECG) data, thereafter, the stop motion flat board enters convalescent period, continues the record electrocardiogram (ECG) data, reduces to below the 90bpm up to heart rate.At last, the electrocardiogram (ECG) data that is obtained is analyzed, handled, obtain the alternative analysis result of T ripple.
The input protection circuit of present embodiment is made up of the two-stage limiter protection circuit, and the first order is limited in voltage in 60～70V with neon bulb, and the second level is with the two-way series diode and then make input terminal voltage be no more than 7V.
The preamplifier of present embodiment such as Fig. 5 are made up of instrumentation amplifier INA118 and resistance R 2, R3, Rg capacitor C N1, CN2.This preamplifier has high cmrr, high input impedance, and noise is little, the characteristics that capacity of resisting disturbance is strong.
In order to adapt to different electrocardiosignal amplitudes, the main amplifier of present embodiment has adopted programme controlled variable-gain amplification circuit shown in Figure 6, the motion electrocardiosignal that varies in size with amplitude of adaptation.This main amplifier is made up of 7650 operational amplifiers, analog multichannel switch 4051 and a plurality of resistance R 8-R14, R22 and a plurality of capacitor C 12-C14, CN3, CN4.Analog multichannel switch 4051 is selected different resistance, to select different amplifications.
The 50Hz trap circuit of present embodiment is a band elimination filter, is mainly used in the filtering power frequency and disturbs.Adopted by two operational amplifier A 1, A2 and three resistance R 1 R2, R3 and three typical twin-T networks that capacitor C 1, C2, C3 form, as shown in Figure 7, its amplitude-frequency characteristic is:
K in the formula is the intrinsic standoff ratio of potentiometer W.
The optical isolation amplifier of present embodiment is the safety in order to ensure patient, adopts floating ground technology, realize human body and electric on isolation fully.Utilize the photoelectric coupled device TLP-521 of complementary type to constitute this circuit, as shown in Figure 8, adopt two-stage calculation amplifier A1, A2, realize coupling by photoelectrical coupler PH1, the PH2 that is operated in linear zone, wherein W1, W2 are potentiometer, are used to adjust amplifier operating point and gain.
The low-pass filter circuit of present embodiment is used to suppress the High-frequency Interference that produced by circuit, comprises by operational amplifier A 1, resistance R 1, R2, R4, second order voltage controlled voltage source low pass filter and a passive RC low-pass filter circuit of forming by R3, C3 that capacitor C 1, C2 form, as shown in Figure 9.
The analog to digital conversion circuit of present embodiment uses modulus conversion chip to be MAX122, and sample rate is 12 * 500Hz, and sampling precision is 12.
The flat board of present embodiment adopts known commercially available prod.
The dull and stereotyped control interface circuit of present embodiment as shown in figure 10, is made up of analog multichannel switch 4051, enumerator 74LS169, and analog multichannel switch is switched on or switched off each control button of exercise stress, and the count value of enumerator is determined concrete button.For example, the operation of DOWN switch, the beginning analog switch disconnects, and gives pulse of enumerator then, make its zero clearing, then count 3, the analog switch closure of corresponding DOWN keeps 50 milliseconds, be equivalent to the DOWN switch closure once, disconnect analog switch, counter O reset again.
The method that the T ripple of present embodiment alternately detects is described as follows:
(containing buffer time), one-level heart rate phase phase of adjustment that the design motion scheme being divided into, four-stages such as secondary heart rate phase and convalescent period.
2 minutes quiescent stage electrocardiogram (ECG) data of record then writes down 3 minutes convalescent period electrocardiogram (ECG) data after the motion before the motion.Because experimenter's individual variation is bigger, if any the experimenter early stage have the phenomenon that heart rate is accelerated in motion, for avoiding influencing follow-up classification feedback, so arranged one minute buffer time, treadmill moves with lowest speed during this period of time, and the operator is according to whether experimenter's concrete condition such as motion posture be correct or whether heart rate recovers steadily to regulate this time and give the experimenter with concrete guidance.Afterwards, program begins to adjust according to experimenter's heart rate the kinematic parameter of treadmill because the individual variation of basal heart rate and changes in heart rate rate is bigger, thereby the phase of adjustment time bigger fluctuation will be arranged between individuality.After heart rate surpassed 90bpm, phase of adjustment, finished.
The positive heart rate of external approval is 110bpm at present, promptly below 110bpm, if the T ripple alternately, be symptom then, and more than 110bpm, the T ripple of appearance does not alternately have diagnostic value, because at this more than heart rate, even normal population has the T ripple alternately to occur also the time.Negative heart rate is 105bpm, does not promptly occur the T ripple more than the heart rate yet alternately at this, and it is alternately negative to may be thought of as the T ripple.According to above-mentioned standard, the present invention has adopted the control strategy of two-stage heart rate, and the one-level heart rate is 90-105bpm, and the secondary heart rate is more than the 105bpm.The one-level heart rate is thought of as and detects the alternately positive of T ripple, and it is alternately negative that the secondary heart rate then is thought of as detection T ripple.The phase of adjustment finish after, heart rate was controlled in the one-level heart rate range 5 minutes, if heart rate is crossed low then increased quantity of motion.If it is too high then reduce exercise.The one-level heart rate phase directly enters the secondary heart rate phase after finishing, and in the phase, makes heart rate reach the secondary heart rate by increasing quantity of motion, and the persistent period also is 5 minutes.After the secondary heart rate phase finishes, stop treadmill, finish kinestate.
After replacing check and analysis via the T ripple, judging, the result is presented on the display screen, replaces amplitude curve and corresponding noise level estimation curve is formed by the T ripple of changes in heart rate trend curve in the experimentation and 12 lead.
Clapping with 16 is basic time unit, each constantly is drawn as curve with corresponding average heart rate, to understand the roughly change trend curve of heart rate in the whole experiment, as shown in figure 11, wherein vertical coordinate is a heart rate value, and unit is bpm (inferior/minute), and abscissa is the time, 2 little lattice are 1 minute, and perpendicular dotted line is cut apart different motion stages.
Each analysis result that leads all has two curves, and a curve has reflected in the exercise test process variation of noise level; Another curve then replaces the change curve of amplitude for the T ripple.Figure 12 is that the T ripple that a certain tester's V5 leads replaces trendgram, and among the figure, perpendicular dotted line is cut apart different motion stages, abscissa is the time, 2 little lattice are 1 minute, and the first half is a noise, and vertical coordinate is a noise level, unit is a microvolt, the latter half replaces trend for the T ripple, and black part divides expression T ripple to replace testing result for remarkable, and grey colour specification T ripple alternately detects to unsettled, blank expression T ripple alternately detects negative, and vertical coordinate unit is a microvolt.
Claims (3)
1, the alternative detection method of T ripple in a kind of exercise electrocardiogram may further comprise the steps:
1) scope according to heart rate value is divided into four-stage, is respectively: the phase of adjustment its heart rate below 9bpm, the one-level heart rate phase, its heart rate is at 90-105bpm, the secondary heart rate phase, its heart rate is more than 105bpm, convalescent period, its heart rate was below 90bpm;
2) persistent period of setting one-level heart rate phase and secondary heart rate phase was respectively 3-6 minute;
3) the dull and stereotyped movement velocity of control and the gradient heart rate that makes the tester enters the four-stage of said heart rate value successively, and keeps the persistent period of this one-level heart rate phase and the setting of secondary heart rate phase;
4) respectively the electrocardiosignal in this heart rate phase and secondary heart rate stage phase is handled and record.
2, detection method as claimed in claim 1 is characterized in that, the said method that electrocardiosignal is handled for amplify successively, filtering, analog digital conversion.
3, the alternative checkout gear of T ripple in a kind of exercise electrocardiogram, it is characterized in that, comprise with the lower part: the device that leads that links to each other with the testee, the input protection circuit that links to each other with this device output signal of leading, the amplifier system that links to each other with this holding circuit, and the analog to digital conversion circuit that is connected in this amplifier system outfan, this analog to digital conversion circuit links to each other with a microcomputer, the dull and stereotyped control interface circuit that links to each other with this computer, and link to each other with this control interface circuit and to be used for the flat board that the testee moves; Said amplifier system is made of the pre-amplification circuit, block isolating circuit, main amplifier, 50Hz trap, optical isolation amplifier and the low-pass filter circuit that link to each other successively.
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| CNB02125642XA CN1172630C (en) | 2002-07-26 | 2002-07-26 | Alternating T-wave measuring method and device for sports electrocardiogram |
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| WO2006128325A1 (en) * | 2005-06-03 | 2006-12-07 | Capitalbio Corporation | Optical systems for microarray scanning |
| US7615758B2 (en) | 2005-06-02 | 2009-11-10 | Capitalbio Corporation | Laser confocal microarray scanner |
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| CN104224158A (en) * | 2014-07-21 | 2014-12-24 | 广州碧德电子科技有限公司 | Method and device for detecting heart rate signal |
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| US7615758B2 (en) | 2005-06-02 | 2009-11-10 | Capitalbio Corporation | Laser confocal microarray scanner |
| US7928357B2 (en) | 2005-06-02 | 2011-04-19 | Capitalbio Corporation | High speed scanning platform for microarray scanner |
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| US7706419B2 (en) | 2005-06-03 | 2010-04-27 | Capitalbio Corporation | Optical systems for microarray scanning |
| CN103654742A (en) * | 2013-12-04 | 2014-03-26 | 江南大学 | Multi-parameter identification system for monitoring human health conditions |
| CN104224158B (en) * | 2014-07-21 | 2017-03-08 | 广州碧德电子科技有限公司 | A kind of heart rate signal detection method and device |
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| CN110568304A (en) * | 2019-09-27 | 2019-12-13 | 上海锐开电气有限公司 | Filter circuit of iron core grounding power frequency current |
| CN114469123A (en) * | 2022-01-30 | 2022-05-13 | 北京理工大学 | Electrocardio data classification and health feature identification method in exercise process |
| CN114469123B (en) * | 2022-01-30 | 2024-04-09 | 北京理工大学 | Electrocardiogram data classification and health feature recognition method in exercise process |
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