CN1386735A - Process for condensating salicyladehyde with arylamine - Google Patents

Process for condensating salicyladehyde with arylamine Download PDF

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CN1386735A
CN1386735A CN 01118314 CN01118314A CN1386735A CN 1386735 A CN1386735 A CN 1386735A CN 01118314 CN01118314 CN 01118314 CN 01118314 A CN01118314 A CN 01118314A CN 1386735 A CN1386735 A CN 1386735A
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amino
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methyl
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cdcl
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CN1164568C (en
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孙文华
杨海健
李秀华
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Institute of Chemistry CAS
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Abstract

A condensation process of salicylaldehyde and arylamine includes such steps as feeding salicylaldehyde and arylamine in reactor, putting the reactor in 600-800 W microwave oven, reaction for 2 seconds-6 min to obtain schiff base, cooling and crystallizing. Its advantages are high yield and no environmental pollution.

Description

The method of condensing of a kind of salicylic aldehyde and aromatic perfume amine
The present invention relates to the synthetic method of a series of salicylic alidehyde imine compounds, particularly a kind of method of producing the salicylic alidehyde imine compound by salicylic aldehyde and aromatic perfume amine condensation.
The organic chemistry develop rapidly benefits from the foundation (1874 of carbon tetravalence theory, Holland chemist Jacobus Hendricus van ' t Hoff), and the aldimine condensation reaction western Buddhist alkali of formation (Schiff-base) launches (Ann.Chem.1869 before the theoretical proposition of carbon tetravalence, 150 volumes, 193 pages), be the earliest one of Chemical Problem in the organic chemistry research, thereby with investigator's naming.Although to aldimine condensation reaction having carried out systematic research, yet because the critical role of carbon-to-nitrogen double bon in the heteroato mic organic compound, still be widely used in the synthesizing of medicine, agricultural chemicals and organic chemical industry's product.Thermal chemical reaction is generally adopted in this class reaction, needs solvent to make medium, and environment is being produced certain pollution; Simultaneously, react length often consuming time (several hours to a couple of days), the productive rate height does not wait.In order to improve reaction efficiency and to make full use of the natural resources, realize the synthetic of some unknown compounds, enrich western Buddhist alkali cpd family, enlarge using value and the Application Areas of western Buddhist alkali in people's daily life and industrial and agricultural production, need to inquire into new western Buddhist alkali synthetic method.
The objective of the invention is to overcome in the thermal response of the synthetic western Buddhist alkali of traditional aldimine condensation, need solvent, reaction times is longer, aftertreatment is trouble, the productive rate instability has the shortcoming of pollution to environment, and a kind of method that adopts microwave to promote chemical reaction is provided, make that being reflected at of the synthetic western Buddhist alkali of aldimine condensation is solvent-free, the reaction times short and high yield under efficiently carry out, environmental pollution is little.Be applicable to short run, many kinds, nuisanceless western Buddhist alkali cpd and the derivative thereof produced.
Microwave of the present invention promotes the reaction expression of the synthetic western Buddhist alkali of aldehyde ketone condensation reaction to be:
Figure A0111831400031
Western Buddhist alkali general structure of the present invention is: Ar is respectively: 5-methyl isophthalic acid H-pyrazole-3-yl, 2-anisole-1-base, pyridine-2-base, 6-picoline-2-base; 2,6-dimethyl benzene-1-base, 2; 3-dimethyl benzene-1-base, 4,6-lutidine-2-base; 5-methyl-isoxazole-3-base, 5-picoline-2-base, 4-picoline-2-base; 3-benzyloxy pyridine-2-base, 3-chloro-5-5-flumethiazine-2-base, 5-Shu butyl isoxazole-3-base; 6-ethylpyridine-2-base, 4,6-dimethyl pyrimidine-2-base; 3,5-two bromo-6-picoline-2-bases, 4-ethylpyridine-2-base; 3-acetylbenzene-1-base, different quinone quinoline-1-base, 3; 5-dibromo pyridine-2-base, 5-bromopyridine-2-base, 5-ethylmercapto group-1; 3,4-thiadiazoles-2-base, 5-chloro-2-Benzoylbenzene-1-base; 9-Fluorenone-1-base, different quinone quinoline-5-base, diphenyl-methyl; 5-ethyl-1,3,4-thiadiazoles-2-base; acridine-9-base, 2-hydroxybenzene-1-base, 2; 6-diisopropyl benzene-1-base, 4-methylbenzothiazole-2-base, 2-carboxyl benzene-1-base.
Microwave of the present invention promotes the novel method of salicylic aldehyde and aromatic perfume amine condensation, and raw material comprises salicylic aldehyde, 3-amino-5-methyl isophthalic acid H-pyrazoles; the 2-anisidine, 2-aminopyridine, 2-amino-6-picoline; 2,6-xylidine, 2; the 3-xylidine, 2-amino-4,6-lutidine; 3-amino-5-methyl-isoxazole, 2-amino-5-picoline, 2-amino-4-picoline; 2-amino-3-benzyloxy pyridine; 2-amino-3-chloro-5-5-flumethiazine, 3-amino-5-Shu butyl isoxazole, 2-amino-6-ethylpyridine; 2-amino-4; the 6-dimethyl pyrimidine, 2-amino-3,5-two bromo-6-picolines; 2-amino-4-ethylpyridine; the 3-aminoacetophenone, the amino different quinone quinoline of 1-, 2-amino-3; the 5-dibromo pyridine; 2-amino-5-bromopyridine, 2-amino-5-ethylmercapto group-1,3; the 4-thiadiazoles; 2-amino-5-chlorobenzene formacyl benzene, 1-amino-9-Fluorenone, the amino different quinone quinoline of 5-; benzhydrylamine; 2-amino-5-ethyl-1,3, the 4-thiadiazoles; 9-amino-acridine; the 2-amino phenol, 2, the 6-diisopropyl aniline; 2-amino-4-methylbenzothiazole, the 2-benzaminic acid.
The method of condensing of a kind of salicylic aldehyde of the present invention and aromatic perfume amine, carry out according to the following steps:
Salicylic aldehyde and aromatic perfume amine are added reaction vessel, be placed in 600-800 watt the microwave device, react 2 seconds to 6 minutes postcooling, products obtained therefrom employing ordinary method is as with ethanol or ethanol-methylene dichloride recrystallization.Productive rate 65%～98%, known compound structure warp 1H NMR confirms, the unknown compound structure is through IR, 1H NMR, 13C NMR and ultimate analysis data confirm.
Product preparation method of the present invention is simple, and purifying is easy, the productive rate height, and compound stability is better, and production cost is lower, is convenient to produce in enormous quantities.
Below in conjunction with embodiment the present invention is done further detailed description.Embodiment 1:2-[[(5-methyl isophthalic acid H-pyrazole-3-yl) imido grpup] methyl]-preparation of phenol: adding waits the salicylic aldehyde and the 2-amino-5-methyl isophthalic acid H-pyrazoles of amount of substance (3mmol) in the 25ml Erlenmeyer flask, put into " beautiful " (Midea PJ21B-A, the 800W type, 21 liters of volumes) in the microwave oven, " middle high fire " (616W) 30 seconds of shelves reaction, get solid after the cooling, use ethyl alcohol recrystallization, productive rate 96%.FT-IR(KBr)：3430.6，3204.7，1614.4，1576.6，1499.3，1470.2。 1H?NMR(CDCl 3，200MHz，TMS)δ：2.33(s，3H)，6.12(s，1H)，6.91-7.39(m，4H)，8.82(s，1H)，11.90(s，1H)，13.00(s，1H)ppm； 13C?NMR(CDCl 3，300MHz，TMS)δ：11.3，95.2，117.0，118.6，118.9，132.2，133.0，141.7，156.4，160.8，162.5?ppm。Ultimate analysis measured value (in the bracket is calculated value, down together), C:66.65% (65.66%), H:5.49% (5.51%), N:20.86% (20.88%).Experimental technique is identical with embodiment 1 among the embodiment 2 to embodiment 29, and institute's column data is in proper order: reaction raw materials, and the reaction times, productive rate, fusing point, the FT-IR data, 1H NMR data, 13C NMR data, the ultimate analysis data.Known compound is only listed 1H NMR data.
Embodiment 22-[[(2-anisole-1-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and adjacent aminoanisole (2-anisidine) reaction, 3 minutes, 98%, 1H NMR (CDCl 3, 200MHz, TMS) δ: 3.89 (s, 3H), 6.91-7.40 (m, 8H), 8.70 (s, 1H), 13.89 (s, 1H) ppm.
Embodiment 32-[(pyridine-2-imido grpup) methyl]-preparation of phenol: salicylic aldehyde and 2-aminopyridine, 2 minutes, 93%, 1H NMR (CDCl 3, 200 MHz, TMS) δ: 6.96-7.87 (m, 7H), 8.50 (d, 1H), 9.44 (s, 1H), 13.47 (s, 1H) ppm.
Embodiment 42-[[(6-picoline-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-6-picoline, 2 minutes, 95%, 1H NMR (CDCl 3, 200 MHz, TMS) δ: 2.57 (s, 3H), 6.92-7.90 (m, 7H), 9.42 (s, 1H), 13.48 (s, 1H) ppm.
Embodiment 52-[[(2,6-dimethyl benzene-1-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2, the 6-xylidine, 3 minutes, 97%, 1H NMR (CDCl 3, 200 MHz, TMS) δ: 2.30 (s, 3H), 2.33 (s, 3H), 6.92-7.40 (m, 7H), 8.50 (s, 1H), 13.44 (s, 1H) ppm.Embodiment 62-[[(2,3-dimethyl benzene-1-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 23 dimethyl aniline, 1 minute, 98%, 1HNMR (CDCl 3, 200 MHz, TMS) δ: 2.31 (s, 3H), 2.34 (s, 3H), 6.94-7.42 (m, 7H), 8.53 (s, 1H), 13.43 (s, 1H) ppm.
Embodiment 72-[[(4,6-lutidine-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-4, the 6-lutidine, 4 minutes, 98%, 1H NMR (CDCl 3, 200 MHz, TMS) δ: 2.34 (s, 3H), 2.53 (s, 3H), 6.91-7.51 (m, 7H), 9.41 (s, 1H), 13.61 (s, 1H) ppm.
Embodiment 82-[[(5-methyl-isoxazole-3-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 3-amino-5-methyl-isoxazole, 4 minutes, 98%, 1H NMR (CDCl 3, 200 MHz, TMS) δ: 2.46 (s, 3H), 6.12 (s, 1H), 6.96-7.43 (m, 4H), 8.84 (s, 1H), 12.44 (s, 1H) ppm.
Embodiment 92-[[(5-picoline-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-5-picoline, 30 seconds, 94%, 1H NMR (CDCl 3, 200 MHz, TMS) δ: 2.36 (s, 3H), 6.94-7.56 (m, 6H), 8.30 (d, 1H), 9.41 (s, 1H), 13.53 (s, 1H) ppm.
Embodiment 102-[[(4-picoline-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-4-picoline, 1 minute, 95%, 1H NMR (CDCl 3, 200 MHz, TMS) δ: 2.40 (s, 3H), 6.94-7.50 (m, 6H), 8.36 (d, 1H), 9.43 (s, 1H), 13.51 (s, 1H) ppm.
Embodiment 112-[[(3-benzyloxy pyridine-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-3-benzyloxy pyridine, 4 minutes, 88%, 106-107 ℃, FT-IR (KBr): 3436.8,1605.3,1580.3,1555.6,1453.9,1021.8; 1H NMR (CDCl 3, 200 MHz, TMS) δ: 5.21 (s, 2H), 6.79-7.48 (m, 11H), 8.10 (d, 1H), 9.44 (s, 1H), 14.17 (s, 1H) ppm; 13C NMR (CDCl 3, 300 MHz, TMS) δ: 70.3,117.4,118.3,118.7,119.1,121.1,126.7,127.9,128.5,133.0,133.6,135.9,139.9,147.4,148.5,162.4,162.9ppm.Towering plain analytical data: C:74.97% (74.98%), H:5.33% (5.30%), N:9.17% (9.20%).
Embodiment 122-[[(3-chloro-5-(trifluoromethyl) pyridine-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-3-chloro-5-5-flumethiazine, 4 minutes, 76%, 146.5-148 ℃, FT-IR (KBr): 3447.9,1614.7,1599.1,1559.8,1451.9. 1H NMR (CDCl 3, 200MHz, TMS) δ: 6.99-7.58 (m, 4H), 8.05 (s, 1H), 8.64 (s, 1H), 9.51 (s, 1H), 13.31 (s, 1H) ppm; 13C NMR (CDCl 3, 300MHz, TMS) δ: 117.6,118.6,119.5,120.8,124.4,127.5,134.1,135.3,135.9,143.7,156.5,162.5,167.3ppm; Ultimate analysis data: C:51.91% (51.93%), H:2.65% (2.68%), N:9.28% (9.32%).
Embodiment 132-[[(5-Shu butyl isoxazole-3-base) imido grpup] methyl]-preparation of phenol:, salicylic aldehyde and 3-amino-5-Shu butyl isoxazole, 4 minutes, 96%, 69.5-71 ℃, FT-IR (KBr): 3445.4,1620.6,1598.8,1577.1,1457.3; 1H NMR (CDCl 3, 200MHz, TMS) δ: 1.38 (s, 9H), 6.08 (s, 1H), 6.94-7.42 (m, 4H), 8.88 (s, 1H), 12.45 (s, 1H) ppm; 13C NMR (CDCl 3, 300MHz, TMS) δ: 28.6,33.0,93.2,117.4,118.3,119.3,133.2,134.5,61.5,166.9,167.4,182.9ppm.Ultimate analysis data: C:68.80% (68.83%), H:6.61% (6.60%), N:11.47% (11.47%).
Embodiment 142-[[(6-ethylpyridine-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-6-ethylpyridine, 2 minutes, 87%, 38.5-40 ℃, FT-IR (KBr): 3436.9,1612.8,1554.8,1496.5,1458.8. 1H?NMR(CDCl 3，200?MHz，TMS)δ：1.31-1.38(t，3H)，2.79-2.90(q，2H)，6.86-7.71(m，7H)，9.46(s，1H)，13.62(s，1H)ppm； 13C?NMR(CDCl 3，300MHz，TMS)δ：13.6，31.1，117.0，117.3，118.9，120.8，133.2，133.4，138.4，156.6，161.7，163.0，164.1，172.2ppm。Ultimate analysis data: C:74.36% (74.31%), H:6.22% (6.24%), N:12.34% (12.38%).
Embodiment 152-[[(4,6-dimethyl pyrimidine-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-4,6-dimethyl pyrimidine, 4 minutes, 67%, 75-78 ℃, FT-IR (KBr): 3423.6,1627.5,1598.5,1570.0,1466.4. 1H?NMR(CDCl 3，200MHz，TMS)δ：2.29(s，3H)，6.37(s，1H)，6.97-7.58(m，4H)，9.90(s，1H)，11.05(s，1H)ppm； 13C?NMR(CDCl 3，300MHz，TMS)δ：23.7，110.5，117.6，119.8，121.1，133.7，136.9，161.6，162.8，167.7，196.5ppm。Ultimate analysis data: C:68.62% (68.70%), H:5.79% (5.77%), N:18.54% (18.49%).
Embodiment 162-[[(3,5-two bromo-6-picoline-2-yls) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-3,5-two bromo-6-picolines, 4 minutes, 88%, 149-150.5 ℃, FT-IR (KBr): 3442.8,1607.1,1574.8,1533.7,1448.9; 1H NMR (CDCl 3, 200MHz, TMS) δ: 2.63 (s, 3H), 6.93-7.56 (m, 4H), 8.09 (s, 1H), 9.43 (s, 1H), 13.43 (s, 1H) ppm; 13C NMR (CDCl 3, 300MHz, TMS) δ: 24.3,114.8,117.5,118.7,118.9,119.2,133.7,134.4,144.1,152.5,155.5,162.1,165.2ppm.Ultimate analysis data: C:42.17% (42.20%), H:2.72% (2.72%), N:7.55% (7.57%).
Embodiment 172-[[(4-ethylpyridine-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-4-ethylpyridine, 2 minutes, 89%, 46-48 ℃, FT-IR (KBr): 3433.1,1601.9,1575.9,1545.9,1455.6. 1H?NMR(CDCl 3，200MHz，TMS)δ：1.25-1.32(t，3H)，2.64-2.72(q，2H)，6.93-7.51(m，6H)，8.37-8.39(d，1H)，9.43(s，1H)，13.52(s，1H)ppm； 13C?NMR(CDCl 3，300MHz，TMS)δ：14.1，28.0，117.4，119.0，119.8，121.9，122.3，133.2，133.5，148.5，155.7，157.5，161.7，164.3ppm。Ultimate analysis data: C:74.35% (74.31%), H:6.21% (6.24%), N:12.39% (12.38%).
Embodiment 182-[[(3-acetylbenzene-1-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 3-aminoacetophenone, 3.5 minutes, 97%, 90-92 ℃, FT-IR (KBr): 3436.4,1676.4,1618.0,1572.4,1498.9. 1H?NMR(CDCl 3，200MHz，TMS)δ：2.65(s，3H)，6.90-7.85(m，8H)，8.66(s，1H)，13.01(s，1H)ppm； 13C?NMR(CDCl 3，300MHz，TMS)δ：26.6，117.1，118.8，119.1，120.2，126.0，126.5，129.5，132.4，133.4，138.1，148.7，160.9，163.6，197.5ppm。Ultimate analysis data: C:75.31% (75.30%), H:5.42% (5.48%), N:5.83% (5.85%).
The different quinone quinoline of embodiment 192-[[(-1-yl) imido grpup] methyl]-preparation of phenol: the amino different quinone quinoline of salicylic aldehyde and 1-, 4 minutes, 90%, 117-118.5 ℃, FT-IR (KBr): 3451.9,1614.0,1579.2,1551.4,1494.7. 1H?NMR(CDCl 3，200MHz，TMS)δ：6.87-8.84(m，10H)，9.51(s，1H)，13.64(s，1H)ppm； 13C?NMR(CDCl 3，300?MHz，TMS)δ：117.1，119.0，119.2，120.3，123.7，124.8，126.3，127.6，130.5，133.6，134.1，137.6?141.3，156.0，161.9，165.8ppm。Ultimate analysis data: C:77.35% (77.40%), H:4.84% (4.87%), N:11.25% (11.27%).
Embodiment 202-[[(3,5-dibromo pyridine-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-3, the 5-dibromo pyridine, 3 minutes, 92%, 1H NMR (CDCl 3, 200MHz, TMS) δ: 6.96-7.55 (m, 4H), 8.15 (s, 1H), 8.48 (s, 1H), 9.43 (s, 1H), 13.33 (s, 1H) ppm.
Embodiment 212-[[(5-bromopyridine-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-5-bromopyridine, 4 minutes, 92%, 1HNMR (CDCl 3, 200MHz, TMS) δ: 6.86-7.95 (m, 6H), 8.45 (s, 1H), 9.38 (s, 1H), 13.20 (s, 1H) ppm.
Embodiment 222-[[(5-ethylmercapto group-1,3,4-thiadiazoles-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-5-ethylmercapto group-1,3, the 4-thiadiazoles, 4 minutes, 84%, 1H NMR (CDCl 3, 200MHz, TMS) δ: 1.42-1.58 (t, 3H), 3.44-3.58 (q, 2H), 6.90-7.28 (m, 4H), 8.98 (s, 1H), 11.80 (s, 1H) ppm.
Embodiment 232-[[(5-chloro-Benzoylbenzene-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-5-chlorobenzene formacyl benzene, 3 minutes, 89%, 141-143 ℃, FT-IR (KBr): 3439.5,1666.4,1614.1,1579.4,1453.2. 1H?NMR(CDCl 3，200MHz，TMS)δ：6.81-7.82(m，12H)，8.49(s，1H)，11.61(s，1H)ppm； 13C?NMR(CDCl 3，300MHz，TMS)δ：117.1，118.6，119.0，120.0，128.2，128.6，128.7，129.8，131.3，132.2，132.5，133.7，135.6，136.4，145.5，160.6，164.0，195.3ppm。Ultimate analysis data: C:71.56% (71.54%), H:4.11% (4.20%), N:4.00% (4.17%).
Embodiment 242-[[(9-Fluorenone-1-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 1-amino-9-Fluorenone, 4 minutes, 77%, 89.5-92 ℃, FT-IR (KBr): 3435.1,1682.2,1620.2,1489.0,1457.5. 1H?NMR(CDCl 3，200MHz，TMS)δ：6.80-7.62(m，11H)，8.78(s，1H)，13.24(s，1H)ppm； 13C?NMR(CDCl 3，300MHz，TMS)δ：109.5，117.1，117.6，118.1，118.8，119.6，120.2，123.0，124.1，127.4，129.2，132.5，133.3，133.7，134.2，135.3，136.0，161.5，164.2，186.3ppm。Ultimate analysis data: C:80.17% (80.25%), H:4.35% (4.38%), N:4.85% (4.68%).
The different quinone quinoline of embodiment 252-[[(-5-yl) imido grpup] methyl]-preparation of phenol: the amino different quinone quinoline of salicylic aldehyde and 5-, 2 minutes, 65%, 88-89 ℃, FT-IR (KBr): 3436.9,1616.0,1577.3,1485.7,1459.56. 1H?NMR(CDCl 3，200MHz，TMS)δ：6.98-8.01(m，8H)，8.57-8.60(d，1H)，8.68(s，1H)，9.27(s，1H)，13.10(s，1H)ppm； 13CNMR(CDCl 3，300MHz，TMS)δ：116.0，117.4，117.9，119.2，119.4，126.2，127.4，129.0，131.0，132.6，133.9，143.7，145.1，152.3，161.2，164.5ppm。Ultimate analysis data: C:77.17% (77.40%), H:4.94% (4.94%), N:11.40% (11.28%).
Embodiment 262-[(diphenyl-methyl imido grpup) methyl]-preparation of phenol: salicylic aldehyde and benzhydrylamine, 2 seconds, 98%, 1H NMR (CDCl 3, 200MHz, TMS) δ: 5.60 (s, 1H), 6.82-7.40 (m, 14H), 8.42 (s, 1H), 13.45 (s, 1H) ppm.
Embodiment 272-[[(5-ethyl-1,3,4-thiadiazoles-2-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino-5-ethyl-1,3, the 4-thiadiazoles, 2 minutes, 71%, 1H NMR (CDCl 3, 200Hz, TMS) δ: 1.41-1.48 (t, 3H), 3.09-3.18 (q, 2H), 6.97-7.49 (m, 4H), 9.09 (s, 1H), 11.93 (s, 1H) ppm.
Embodiment 282-[[(acridine-9-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 9-aminoacridine, 4 minutes, 68%, 231-233 ℃, FT-IR (KBr): 3442.7,1622.3,1554.0,1516.6,1462.1. 1HNMR(CDCl 3，200MHz，TMS)δ：7.05-8.26(m，12H)，8.64(s，1H)，12.43(s，1H)ppm； 13C?NMR(CDCl 3，300MHz，TMS)δ：116.4，116.7，117.2，118.4，122.2，124.5，128.3，129.2，131.9，133.4，148.0，150.4，160.0，167.9ppm。Ultimate analysis data: C:80.46% (80.52%), H:4.69% (4.73%), N:9.42% (9.39%).
Embodiment 292-[[(2-hydroxybenzene-1-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2-amino phenol, 4 minutes, 94%, 1H NMR (d 6-DMSO, 200MHz, TMS) δ: 6.88-7.59 (m, 8H), 8.95 (s, 1H), 9.72 (s, 1H), 13.80 (s, 1H) ppm.
Embodiment 302-[[(2,6-diisopropyl benzene-1-yl) imido grpup] methyl]-preparation of phenol: salicylic aldehyde and 2, the 6-diisopropyl aniline, 2 minutes, 93%, 1H NMR (CDCl 3, 200MHz, TMS) δ: 1.02-1.38 (d, 12H), 2.82-3.04 (q, 2H), 6.83-7.40 (m, 7H), 8.24 (s, 1H), 13.10 (s, 1H) ppm.
Embodiment 312-[[(4-methyl-benzothiazole-2-yl) imido grpup] methyl]-preparation of phenol: adding waits the salicylic aldehyde and the 2-amino-4-methylbenzothiazole of amount of substance (3mmol) in the 25ml Erlenmeyer flask, put into microwave oven, in " high fire " (800W) shelves reaction 6 minutes, get solid after the cooling, use ethyl alcohol recrystallization, productive rate 82%.Fusing point 99.5-102 ℃, FT-IR (KBr): 3440.2,1617.5,1597.9,1566.5,1473.1,752.2; 1H NMR (CDCl 3, 200MHz, TMS) δ: 2.75 (s, 3H), 7.04-7.70 (m, 7H), 9.27 (s, 1H), 12.29 (s, 1H) ppm; 13C NMR (CDCl 3, 300MHz, TMS) δ: 18.4,117.6,118.3,119.0,119.6,125.1,127.1,133.2,133.9,134.4,135.1,150.8,161.8,167.1,167.7ppm.Ultimate analysis data: C:67.16% (67.14%), H:4.50% (4.51%), N:10.39% (10.44%).
Embodiment 322-[[(2-carboxyl benzene-1-yl) imido grpup] methyl]-preparation of phenol: method is with embodiment 31.Salicylic aldehyde and 2-benzaminic acid, 4 minutes, 77%, 199.5-201.5 ℃, FT-IR (KBr): 3439.7,3070.6,1683.3,1620.0,1488.6,1457.5. 1H?NMR(d 6-DMSO，200MHz，TMS)δ：6.41-7.68(m，8H)，8.84(s，1H)，10.25(s，1H)，10.70(s，1H)ppm； 13C?NMR(d 6-DMSO，300MHz，TMS)δ：116.5，119.3，119.7，122.5，129.4，129.5，130.7，131.4，134.0，136.7，151.7，160.8，169.8，191.9ppm。Ultimate analysis data: C:69.62% (69.70%), H:4.67% (4.60%), N:5.80% (5.81%).

Claims (1)

1. the method for condensing of salicylic aldehyde and aromatic perfume amine, carry out according to the following steps:
Salicylic aldehyde and aromatic perfume amine are added reaction vessel, be placed in 600-800 watt the microwave device, react 2 seconds to 6 minutes postcooling, crystallization;
Described aromatic perfume amine is 3-amino-5-methyl isophthalic acid H-pyrazoles; the 2-anisidine; the 2-aminopyridine; 2-amino-6-picoline; 2; the 6-xylidine; 2; the 3-xylidine; 2-amino-4; the 6-lutidine; 3-amino-5-methyl-isoxazole; 2-amino-5-picoline; 2-amino-4-picoline; 2-amino-3-benzyloxy pyridine; 2-amino-3-chloro-5-5-flumethiazine; 3-amino-5-Shu butyl isoxazole; 2-amino-6-ethylpyridine; 2-amino-4; the 6-dimethyl pyrimidine; 2-amino-3; 5-two bromo-6-picolines; 2-amino-4-ethylpyridine; the 3-aminoacetophenone; the amino different quinone quinoline of 1-; 2-amino-3; the 5-dibromo pyridine; 2-amino-5-bromopyridine; 2-amino-5-ethylmercapto group-1; 3; the 4-thiadiazoles; 2-amino-5-chlorobenzene formacyl benzene; 1-amino-9-Fluorenone; the amino different quinone quinoline of 5-; benzhydrylamine; 2-amino-5-ethyl-1; 3; the 4-thiadiazoles; 9-amino-acridine; the 2-amino phenol, 2; the 6-diisopropyl aniline; 2-amino-4-methylbenzothiazole; the 2-benzaminic acid.
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CN100371417C (en) * 2004-06-09 2008-02-27 太原理工大学 Organic electroluminescent material, preparation and application thereof
CN101811919A (en) * 2010-04-27 2010-08-25 哈尔滨理工大学 Method for preparing amino acid schiff base metal complexes without solvent
CN102070487A (en) * 2011-01-23 2011-05-25 浙江大学 Preparation method for fluorine and styryl-containing salicylaldimine compounds
CN102391293A (en) * 2011-08-16 2012-03-28 周口师范学院 Method for quickly synthesizing Schiff base composition under assistance of microwaves and fluorescence property of Schiff base composition
CN104098610A (en) * 2014-07-29 2014-10-15 陕西科技大学 Method for preparing hydrazine Schiff alkali substituted by 1-phenyl-5-diferrocenyl-1,3-pentadiene-5-ketal
CN106543030A (en) * 2016-10-26 2017-03-29 桂林理工大学 N,N′（2 aminofluorenes）The preparation method of contracting terephthalaldehyde Schiff's base iron complex
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100371417C (en) * 2004-06-09 2008-02-27 太原理工大学 Organic electroluminescent material, preparation and application thereof
CN101811919A (en) * 2010-04-27 2010-08-25 哈尔滨理工大学 Method for preparing amino acid schiff base metal complexes without solvent
CN101811919B (en) * 2010-04-27 2012-07-25 哈尔滨理工大学 Method for preparing amino acid schiff base metal complexes without solvent
CN102070487A (en) * 2011-01-23 2011-05-25 浙江大学 Preparation method for fluorine and styryl-containing salicylaldimine compounds
CN102391293A (en) * 2011-08-16 2012-03-28 周口师范学院 Method for quickly synthesizing Schiff base composition under assistance of microwaves and fluorescence property of Schiff base composition
CN104098610A (en) * 2014-07-29 2014-10-15 陕西科技大学 Method for preparing hydrazine Schiff alkali substituted by 1-phenyl-5-diferrocenyl-1,3-pentadiene-5-ketal
CN106543030A (en) * 2016-10-26 2017-03-29 桂林理工大学 N,N′（2 aminofluorenes）The preparation method of contracting terephthalaldehyde Schiff's base iron complex
CN106543030B (en) * 2016-10-26 2018-09-11 桂林理工大学 N,N′（2- aminofluorenes）The preparation method of contracting terephthalaldehyde schiff bases iron complex
CN106565501A (en) * 2016-11-08 2017-04-19 南安创友日化有限公司 Method for preparing neral amine compound

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