CN1377714A - Epilepsy treating instrument - Google Patents
Epilepsy treating instrument Download PDFInfo
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- CN1377714A CN1377714A CN 01112239 CN01112239A CN1377714A CN 1377714 A CN1377714 A CN 1377714A CN 01112239 CN01112239 CN 01112239 CN 01112239 A CN01112239 A CN 01112239A CN 1377714 A CN1377714 A CN 1377714A
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- circuit
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- control circuit
- chaotic signal
- epilepsy
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Abstract
The epilepsy treating instrument as one physiotherapeutic instrument has chaotic signal circuit, output control circuit, timing control circuit, output device and voltage stabilizer. The output control circuit has chaotic signal input connected to the outout of the chaotic signal circuit, timing signal input connected to the output of the timing control circuit and chaotic signal output connected to the output device. Experiment shows that skull chaotic signal irritation is effective to epilepsy attack of rat induced with Bemegride; and clinical application shows that the said instrument can reduce obviously the epilepsy attack frequency and strictness. It has excellent tolerance.
Description
The present invention relates to a kind of physical therapy device.
Studies show that human brain is handled various information by the nonlinear kinetics rule, brain wave presents determines the opinion chaotic characteristic, in order to adapt to Protean environment of moment.Epilepsy is a kind of cranial nerve class disease, and when epilepsy, it is main that absence seizure especially, its dynamic characteristic show as periodically, and the chaos attenuating is clinical in Drug therapy.But the prevalence height of epilepsy (being about 0.5%), intractable also high (being about 20%).The CN2406661Y patent provides a kind of Headwear for acupoint stimulation, can treat the multiple disease relevant with head acupoint, is worn over head and goes up back treatment head and be fixed on relevant acupuncture point, and the oscillatory surge air communication is crossed the treatment head and acted on the human body head acupuncture point.Chinese catalpa, Taiyuan person of outstanding talent's health-oriented products institute discloses a kind of instrument for the treatment of epileptics---the precious flat insane town of universe epilepsy instrument, it is massaged human acupoint by vibration swirl gas and magnetic field and reaches therapeutic purposes, cooperates the atomization medicine iontophoresis to strengthen therapeutic effect clinically.The source oscillation signal of this therapeutic instrument belongs to pulse pattern, and the classical signal type of curing usefulness to routine is similar.
The object of the present invention is to provide a kind of application of chaos ripple to act on the epilepsy treating instrument of brain.
The present invention is provided with chaotic signal circuit, output control circuit, timing control circuit, output device and regulated power supply.The outfan of the chaotic signal input termination chaotic signal circuit of output control circuit, the timing signal input end of output control circuit connects the timing signal output of timing control circuit, the chaotic signal output termination output device of output control circuit.Regulated power supply provides power supply for circuit.
The chaotic signal circuit can produce circuit by chaotic signal, power amplification circuit is formed, and the outfan of chaotic signal generation circuit connects the input of power amplification circuit through impedance matching circuit.Chaotic signal produces on the circuit can establish limit cycle control circuit and manual reset switch, the control termination chaotic signal of limit cycle control circuit produces the oscillation circuit of circuit, oscillator signal is controlled automatically,, promptly do not entered limit cycle to prevent that chaotic signal from producing circuit and entering non-chaos state.When limit cycle control circuit or some other reason cause runaway electric circuit, then can start manual reset switch, to guarantee existing of chaotic signal.
In order to control the output of chaotic signal automatically, between chaotic signal circuit and output control circuit, can establish over-current control circuit, when loop current surpasses certain value, cut off the output of chaotic signal.Timing control circuit is established time preset circuit, intervalometer and time indicating circuit, the outfan of time preset circuit connects the electrical switch input control end and the time indicating circuit of intervalometer respectively, and the timing signal output of intervalometer connects the timing signal input end of output control circuit.Output control circuit can be established electronic switching circuit and trigger, and electronic switching circuit output connects output device, the input termination timing control circuit control signal output ends of trigger, the input control end of the output termination electronic switching circuit of trigger.
The outfan of power amplification circuit also can be established the chaos indicating device.The output control circuit outfan also can be established the output signal indicating device, with the value of indicative function in the chaos output signal of human body, for example magnitude of voltage of chaos output signal and current value.
Regulated power supply through transformator transformation, rectification, filtering, mu balanced circuit, is exported the required voltage of constituent parts circuit by line voltage again.
Modern science has assert that human brain is a chaos system of determining opinion, and chaos can be opened the passage that leads to various behavior and nerves reaction as the state on duty of brain, and therefore, the chaos ripple just may become the supplementary means of the neural class spirit of control class disease.With the epilepsy is example, and epilepsy is the hypersynchronous discharge of neuron colony periodically preponderating, and the electroencephalogram of normal healthy people to present chaos be main.Theoretical and experiment (comprising animal experiment, clinical trial) shows that little chaotic signal acts on big brain-capacity periodicity is induced to chaos, thereby can suppress and the Taking Control of Epilepsy activity.The present invention is just according to above-mentioned principle, and the application of chaos signal acts on brain reaching the purpose of treatment epileptics, and good tolerability is arranged.
The test of pesticide effectiveness of the present invention shows, for rat epilepsy test due to the bemegride, with the dosage treatment of effectively reading electric reading 0.1mA and 0.05mA obvious incubation period of prolong rats epilepsy outbreak, also can prolong simultaneously the incubation period that electroencephalogram epilepsy ripple occurs, the content of bemegride rat epilepsy model Hippocampus glutamic acid, two kinds of neurotransmitteies of γ-An Jidingsuan is not had obvious influence.Table 1 provides the influence of the present invention to the behavior of bemegride epilepsy outbreak, and as shown in Table 1, treating preceding abdominal cavity, to give respectively to organize behind the bemegride average epilepsy outbreak incubation period be 1.78～1.88min, basically identical.Treat after 6 days visible high dose group and obviously prolong incubation period, reach 5.20 ± 2.58min, compare with matched group 1.74 ± 0.85min that there were significant differences (P＜0.05).The degree of outbreak also alleviates, and prompting to the incubation period of the rat epilepsy outbreak due to the bemegride tangible retardation function being arranged, can delay its outbreak, and some rat does not show effect still to 30min late after the present invention treats.
Table 1 epilepsy treating instrument is handled routine number and is caused epilepsy for the first time and cause epilepsy for the second time and cause epilepsy for the third time the group that influences of bemegride epilepsy outbreak behavior
Mode (only) light-duty heavy type incubation period light-duty heavy type light-duty heavy incubation period of incubation period
(min) (%) (%) (min) (%) (%) (min) (%) (%) matched group bemegride 20mg/kg 15 1.80+0.96 100 53 1.94 ± 0.85 100 73 1.70 ± 0.92 100 73 treatment organize beautiful 20mg/kg+0.05mA 15 1.88 ± 0.91 100 60 2.95 ± 1.80 93 60 3.95 ± 2.32
*80 60
Beautiful 20mg/kg+0.1mA 15 1.78 ± 0.98 100 53 5.20 ± 2.58
*80 60 8.75 ± 3.58
*73 60 annotate: compare with matched group,
*P＜0.05;
*P＜0.01
Table 2 provides the preclinical situation of change of treatment front and back epilepsy EEG, can prolong bemegride after the visible treatment and cause the incubation period (P＜0.05, P＜0.01) that rat epilepsy EEG occurs.
Table 2 epilepsy treating instrument is handled routine number incubation period to the group that influences of bemegride epilepsy outbreak EEG
Mode (only) the epilepsy outbreak first time epilepsy outbreak second time is epilepsy outbreak for the third time
(min) (min) beautiful 20mg/kg+0.05mA 8 1.48 ± 0.66 2.01 ± 1.40 3.00 ± 1.85 are organized in (min) matched group bemegride 20mg/kg 8 1.40 ± 0.72 1.35 ± 0.72 1.36 ± 0.75 treatments
*
Beautiful 20mg/kg+0.1mA 8 1.41 ± 0.72 4.10 ± 2.12
*7.05 ± 2.45
*Annotate: compare with matched group,
*P＜0.05;
*P＜0.01
Table 3 provides the influence of treatment back to the rat hippocampus neurotransmitter, as seen each histidine content of model control group is than blank group obviously raise (P＜0.05), each propylhomoserin of Hippocampus increased when epilepsy was described, but treatment group and model group differences are not obvious, and the content of γ-An Jidingsuan is no significant difference also.
Table 3 epilepsy treating instrument is to the influence of rat hippocampus neurotransmitter
Group is handled Glu GABA
Mode (μ mol/g, pro) (μ mol/g, pro) blank group 45.32 ± 12.13 24.10 ± 7.31 model control group bemegride 20mg/kg 60.21 ± 14.58
*20.82 beautiful 20mg/kg+0.05mA 58.43 ± 16.42 22.45 ± 5.83 are organized in ± 6.42 treatments
Beautiful 20mg/kg+0.1mA 61.40 ± 14.86
*19.50 ± 5.34 annotate: compare with the blank group,
*P＜0.05.
Effective in order to confirm to epilepsy through cranium chaos stimulating electrical signal, select 15～60 years old through system antiepileptic treatment 4 times/the epileptic patient more than week that still shows effect, be a cup too low obstacle and mental retardation, neuroimaging do not find that obviously unusual person treats, and the influence of seizure frequency and degree is seen Table 4.The result shows that the seizure frequency of all cases and outbreak severity all have tangible reduction, and toleration is good.
Table 4 auxiliary treatment to the case outbreak course of disease medicining condition basis review phase that influences of seizure frequency and degree treat the 1st～2 treatment the 3rd～4 treatment the 5th～No. 8 type (year) 2 months (inferior/SSS) week (inferior/SSS) week (inferior/it is SSS) all that (inferior/SSS) 001 CP, 9 VPA 0.4, tid 30,/20 8,/16 7,/12 13/16
CZP?2mg，tid?002 CP 12 PB?0.03，id 66/15 24/12 14/8 24/13
PHT?0.1，qn003 A 5 VPA?0.4，tid 40/7 8/7 10/6 17/6
CZP?1mg，tid004 CP、A 21 CBZ
*，VPA?0.4，tid 40/2.75 12/2.75 10/2.75 18/2.75005 GTCS 23 PHT0.1tid，CZPlmg 1/66 0/0 0/0 1/54
A tid，VPA-Mg2#tid 23/11 6/11 7/11 14/11006 GTCS 10 CBZ?PHT?PB
** 7/55 0/0 2/46 5/41
Annotate: CP is a complex partial seizure, A absence seizure, GTCS complete tetanus Myoclonic seizures; The VPA valproic acid is received, PB phenobarbital, CZP clonazepam, PHT phenytoin, CBZ carbamazepine, VPA-Mg magnesium valproate, the scoring of SSS epilepsy;
*,
*In therapeutic process, change
Fig. 1 is a block diagram of the present invention.
Fig. 2 is the chaotic signal circuit theory diagrams of embodiments of the invention.
Fig. 3 is the output control circuit schematic diagram of the embodiment of the invention.
Fig. 4 is the timing control circuit schematic diagram of the embodiment of the invention.
Fig. 5 is the voltage-stabilized power supply circuit schematic diagram of the embodiment of the invention.
The present invention is further illustrated in conjunction with the accompanying drawings for following examples.
As shown in Figure 1, the present invention is made up of chaotic signal circuit 1, output control circuit 2, timing control circuit 3, output device 4 and regulated power supply 5.Referring to Fig. 2～4, form chaotic signal by operational amplifier U1 and auxiliary circuit (resistance R 37～R41, diode D8, D9, capacitor C 7, C8, inductance L 1, potentiometer W1, W4 etc.) and produce circuit, produce chaotic signal, S1 is a manual reset switch.Operational amplifier U2, U3 and auxiliary circuit (potentiometer W6, W7, resistance R 34, R35, diode D18, D19 etc.) amplitude limiter formed inserts oscillation circuit L1, the C7 that chaotic signal produces circuit as the limit cycle control circuit, is used to prevent that oscillator signal from being that non-chaotic signal enters limit cycle.Chaotic signal produces the chaotic signal of circuit and sends into power amplification circuit through the impedance matching circuit that resistance R 32, R33 form, power amplification circuit is made up of operational amplifier U4 and auxiliary circuit, potentiometer W3 is used to regulate the amplitude of output, and be provided with the chaotic signal state indicating device, adopt light emitting diode D10 in this circuit.The output of power amplification circuit is connected to output control circuit, output control circuit can be made up of electronic switching circuit (by audion N1, relay P1 and auxiliary element: resistance R 44, diode D12 etc. is formed) and trigger (being made up of U12 and auxiliary circuit) etc., and triggering signal is that trigger impulse provides by the output of timing control circuit.The outfan of output control circuit is connected to electrode and output signal indicating device through relay switch and R46, and the output signal indicating device can adopt voltage indication V1 and electric current indication A1, and V1 and A1 difference indicative function are in the voltage and current value of the output signal of human body.The scalp electrode that electrode can adopt electroencephalogram/brain electrical activity mapping instrument to use, electroencephalogram medicated cap, or headgear, for example Ag-AgCl scalp plane electrode etc.Over-current control circuit is made up of sample resistance R46, operational amplifier U5, diode D14～D17, photoelectrical coupler U6 and potentiometer W5 etc., and when loop current surpassed certain certain value (for example 3mA), the output of chaotic signal was cut off in photoelectrical coupler U6 conducting.
Timing control circuit is established time preset circuit, intervalometer and time indicating circuit.The time preset circuit is made up of octal addition enumerator and time preset switch S 2 that decade computer U9 forms.Whenever just add 1 by start-stop counter, the binary-coded decimal of U9 output divides two-way: the one tunnel connects the time indicating circuit, through decoder U7 rear drive LED-5,10,15,20,25,30,35,40, is used to indicate corresponding time value; The electrical switch U8 (4051) of another road control timer selects the corresponding charging resistor of intervalometer.Intervalometer can be established electrical switch (U8), resistor network (R6～R19, R27, R28), agitator (U10), frequency divider (U11) and amplifying circuit (audion N2) etc., intervalometer is formed multivibrator by U10 (NE555), U11 (4510) constitutes 16 system subtractors, is used for frequency division is carried out in the pulse of U10 output.During start, the Q of U9
3Q
2Q
1Q
0=0000, Q after U7 decoding
0=' 1 ', LED-5 is bright.Make X and the X0 of electrical switch U8 connect on the other hand, then the charging resistor of U10 is R28, R27.Because the Q of trigger U12 is ' 1 ', then not conducting of audion N1, relay P1 dead electricity, output disconnects.Make U11 be in preset condition simultaneously and the U10 that resets, at this moment,, do not have commutator pulse output by the not starting of oscillation of multivibrator that U10 forms.When pressing chaos output time switch S3, the Q=0 of U12 then, relay P1 gets electric, connects output, U10 starting of oscillation this moment, U11 begins counting.When U11 had count down to borrow, the positive triggering pulse of its CO end output one pulse (trailing edge) after audion N2 conversion delivered to the CLK end of U12, makes its upset, and promptly Q becomes ' 1 ' by ' 0 ', and then relay P1 dead electricity disconnects output.
Line voltage～220V is output～16.5V after transformator T1 transformation, delivers to the input of circuit of three-terminal voltage-stabilizing integrated 7818,7918 behind diode D4～D7 and capacitor C 3～C6 rectifying and wave-filtering, output+18V ,-18V, use for each element circuit.
Claims (9)
1, epilepsy treating instrument, it is characterized in that being provided with chaotic signal circuit, output control circuit, timing control circuit, output device and regulated power supply, the outfan of the chaotic signal input termination chaotic signal circuit of output control circuit, the timing signal input end of output control circuit connects the timing signal output of timing control circuit, the chaotic signal output termination output device of output control circuit, mu balanced circuit provides power supply for each element circuit.
2, epilepsy treating instrument as claimed in claim 1, it is characterized in that said chaotic signal circuit is provided with chaotic signal and produces circuit, impedance matching circuit and power amplification circuit, chaotic signal produces the output termination impedance matching circuit input of circuit, the output termination power amplification circuit input of impedance matching circuit.
3, epilepsy treating instrument as claimed in claim 1 is characterized in that said chaotic signal circuit is provided with limit cycle control circuit and manual reset switch.
4, epilepsy treating instrument as claimed in claim 3 is characterized in that adopting amplitude limiter to connect the oscillation circuit that chaotic signal produces circuit as the limit cycle control circuit.
5, epilepsy treating instrument as claimed in claim 1 is characterized in that establishing over-current control circuit between chaotic signal circuit and output control circuit.
6, epilepsy treating instrument as claimed in claim 1, it is characterized in that timing control circuit establishes time preset circuit, intervalometer and time indicating circuit, the outfan of time preset circuit connects the electrical switch input control end and the time indicating circuit of intervalometer respectively, and the timing signal output of intervalometer connects the timing signal input end of output control circuit.
7, epilepsy treating instrument as claimed in claim 1, it is characterized in that output control circuit establishes electronic switching circuit and trigger, electronic switching circuit output termination output device, the control signal output ends of the input termination timing control circuit of trigger, the input control end of trigger output termination electronic switching circuit.
8, epilepsy treating instrument as claimed in claim 1 is characterized in that the outfan of output control circuit is established the output signal indicating device.
9, epilepsy treating instrument as claimed in claim 1 is characterized in that said output device is an electrode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011122390A CN1157238C (en) | 2001-03-30 | 2001-03-30 | Epilepsy treating instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011122390A CN1157238C (en) | 2001-03-30 | 2001-03-30 | Epilepsy treating instrument |
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| Publication Number | Publication Date |
|---|---|
| CN1377714A true CN1377714A (en) | 2002-11-06 |
| CN1157238C CN1157238C (en) | 2004-07-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011122390A Expired - Fee Related CN1157238C (en) | 2001-03-30 | 2001-03-30 | Epilepsy treating instrument |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101947357A (en) * | 2010-10-18 | 2011-01-19 | 刘辉 | Device for treating epilepsia |
| CN102335482A (en) * | 2011-07-18 | 2012-02-01 | 上海交通大学 | Chaos multi-dimensional electrical stimulation system |
| CN101537228B (en) * | 2009-04-23 | 2012-08-22 | 哈尔滨奥博医疗器械有限公司 | Transcranial magnetic therapeutic instrument for computer diseases |
| CN102671298A (en) * | 2012-06-07 | 2012-09-19 | 浙江大学 | Chaos pacemaker control method based on electrocardiograph (ECG) chaos model |
| CN110575377A (en) * | 2019-08-23 | 2019-12-17 | 重庆大学 | simple and easy portable air pulse stimulation device of cerebral apoplexy recovery physiotherapy |
-
2001
- 2001-03-30 CN CNB011122390A patent/CN1157238C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537228B (en) * | 2009-04-23 | 2012-08-22 | 哈尔滨奥博医疗器械有限公司 | Transcranial magnetic therapeutic instrument for computer diseases |
| CN101947357A (en) * | 2010-10-18 | 2011-01-19 | 刘辉 | Device for treating epilepsia |
| CN101947357B (en) * | 2010-10-18 | 2013-01-02 | 刘辉 | Device for treating epilepsia |
| CN102335482A (en) * | 2011-07-18 | 2012-02-01 | 上海交通大学 | Chaos multi-dimensional electrical stimulation system |
| CN102671298A (en) * | 2012-06-07 | 2012-09-19 | 浙江大学 | Chaos pacemaker control method based on electrocardiograph (ECG) chaos model |
| CN102671298B (en) * | 2012-06-07 | 2015-02-25 | 浙江大学 | Chaos pacemaker control method based on electrocardiograph (ECG) chaos model |
| CN110575377A (en) * | 2019-08-23 | 2019-12-17 | 重庆大学 | simple and easy portable air pulse stimulation device of cerebral apoplexy recovery physiotherapy |
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| Publication number | Publication date |
|---|---|
| CN1157238C (en) | 2004-07-14 |
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