CN1375291A - Veterinary mixed injection containing levamisole or its salts - Google Patents
Veterinary mixed injection containing levamisole or its salts Download PDFInfo
- Publication number
- CN1375291A CN1375291A CN 02100632 CN02100632A CN1375291A CN 1375291 A CN1375291 A CN 1375291A CN 02100632 CN02100632 CN 02100632 CN 02100632 A CN02100632 A CN 02100632A CN 1375291 A CN1375291 A CN 1375291A
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- levamisole
- oleum
- ivermectin
- oil
- injection
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Abstract
The present invention is an animal compound injection containing levamisole or its salt compound with formula composed of levamisole of 1-25% (W/V) and other vermifuge content of 0.1-20% (W/V). The compound preparation has the characteristics as follows: 1) It has an obvious synergy action at the aspect of dispelling and killing nematode in the body of pig, cattle and sheep and simultaneously it can dispel external parasite to enlarge the insect spetrum and overcome the shortcoming that levamisole can not dispel and kill external parasite; 2). The injection compounds is extremely effective to nematode which has single drug-resistance; 3) The injection oil compound having both actions of fast and long term is a very good injection with good absorption and small irritability.
Description
The present invention is a kind of by levamisole (levamisole) or its esters and the formulated anthelmintic compound injection for animals of Macrolide anthelmintic.
Levamisole is the levo form of tetramisole, it is a kind of wide spectrum antinematodal agent, it all kills effect to parasitizing the intravital multiple nematicide of animal, but the nematicide of different genera is killed active different, kill activity and can reach 95～100% (seeing Table 1) parasitizing several nematicides in animal (pig, cattle, sheep) the harmonization of the stomach lung tissue as it, and active on the low side for parasitizing killing of some nematicide in small intestinal and the large intestine, and levamisole does not have the activity of killing for trematodiasis, cestode and epizoa.
The Macrolide anthelmintic comprises: avilamycin (abamectin), ivermectin (ivermectin), Ai Purui rhzomorph (eprinomectin), moxidectin (moxidectin), road draw rhzomorph (doramectin).They are efficient, the broad-spectrum de-worming medicines of a class, to extensively parasitizing intravital nematicide of animal and epizoa activity are arranged all, but the nematicide of the different genera that parasitizes the body different parts is killed active different (seeing Table 1).Nearest investigation and clinical trial show: ivermectin or the agent of levamisole list are owing to use for many years (nearly 20 years), some nematicide has produced drug resistance in various degree to these two kinds of medicines, is 100% to the deworming rates of haemonchus as ivermectin when bringing into use, and is 78-85% now.When cattle, sheep (contain avilamycin or ivermectin 5mg with per 10 kg body weight injection 0.5ml compound preparation of the present invention, levamisole 50-60mg) time, its deworming rates to haemonchus and other multiple nematicide still can reach 95～100% (seeing Table 1), and after adding avilamycin or ivermectin in the prescription, epizoa is controlled.
Therefore, the characteristics of preparation of the present invention are exactly that Macrolide anthelmintics such as levamisole and avilamycin are formed compound preparation, be used to control the drug resistance nematicide, and compound injection of the present invention promptly has quick-acting, have long-lasting again, promptly reduce medication number of times and drug cost thereby reached, purpose such as anthelmintic is thorough again.
The animal compound injection prescription that contains levamisole or its esters of the present invention consists of:
(a) levamisole or its esters chemical compound 1-25% (W/V);
(b) Macrolide anthelmintic (avilamycin abamectin, ivermectin ivermectin, Ai Purui rhzomorph eprinomectin, moxidectin moxidectin), road draw rhzomorph doramectin) 0.1-10% (W/V);
(c) all the other are disperse medium;
The insecticidal spectrum of table 1 levamisole and ivermectin and compound preparation thereof
| Nematicide | Epizoa | |||||||||||||
| Stomach | Small intestinal | Large intestine | Lung | Torsalo | Botfly | Demodicid mite | Ticks | Louse | Fly larvae | |||||
| Haemonchus | The special line nematicide worm of Ao Maosi circle | The thin Bai Yuan neck of ancient class line line neck worm worm worm | Bunostomum trigonoce phalum | The special line nematicide of food Xia Daobai mouth worm | The first nematicide of hair | Net raw wool tail circle fine rule line lung worm worm worm | Sucking louse | Sting louse | ||||||
| Ivermectin | ????100％ | ????＞80％ | ??100％ | ??＜50％ | ??100％ | ??100％ | ??100％ | ??100％ | ??＞80％ | ??100％ | ??＜50％ | ??100％ | ||
| Levamisole | ????100％ | ????＞80％ | ??????＞80％ | ??100％ | ???- | ???- | ???- | ???- | ???????- | ???- | ||||
| Ivermectin+levamisole | ????100％ | ????100％ | ??100％ | ??＞90％ | ??100％ | ??100％ | ??100％ | ??100％ | ??＞80％ | ??100％ | ??＜50％ | ??100％ | ||
(d) in case of necessity, can add other auxiliary agent (as suspending agent, surfactant and antioxidant).
Described disperse medium comprises: water, vegetable oil, mineral oil or other organic liquid medium; Preferred organic media comprises ethanol, 1,2-propylene glycol, glycerol, isobutanol, isopropyl alcohol, Polyethylene Glycol, benzyl alcohol, formal glycerine, dimethyl acetylamide, benzyl benzoate, ethyl oleate, oleic acid, Miglyol 840 (diester of the sad and capric acid of propylene glycol), sorbitan fatty acid esters class, glycerol caprylic/capric diester, tetramethylolmethane dioleate.But two or more forms the complex media use to above liquid dispersion medium in prescription; Described vegetable oil comprises: Semen Maydis oil, Oleum Arachidis hypogaeae semen, soybean oil, Oleum Ricini, Oleum Brassicae campestris, Oleum sesami, Oleum Gossypii semen, almond oil, peach kernel oil, Oleum Cocois, Oleum Camelliae and olive oil, but two or more compound use of the vegetable oil that adds in the prescription also can be formed cosolvent with other disperse medium and use.The described suspending agent that adds in case of necessity is medical available suspending agent; Preferred suspending agent comprises: xanthan gum, carboxymethyl cellulose (sodium), ethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, sodium alginate, aluminium stearate, hydrogenated vegetable oil; The surfactant of Jia Ruing is available surfactant pharmaceutically in case of necessity, comprising: anionic surfactant, cationic surface active agent, nonionic surfactant and amphoteric surfactant; Preferred surfactants is a nonionic surfactant, comprising: polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, alkylphenol polyoxyethylene, Oleum Ricini glymes and by the synthetic ester type compound of glycerol.The surfactant of forming preparation can be a kind of, but also two or more mixes use.
The present invention preferably fills a prescription and consists of:
(a) levamisole or its hydrochlorate 10-20% (W/V);
(b) avilamycin or ivermectin 0.5-2% (W/V);
(c) disperse medium adds to 100% (V/V).
(d) in case of necessity, can add other auxiliary agent.
The further preferred prescription of the present invention consists of:
Prescription one:
(a) levamisole or its hydrochlorate 10% (W/V);
(b) avilamycin or ivermectin 1% (W/V);
(c) 1,2-propylene glycol 50-80% (V/V);
(d) formal glycerine 20-50% (V/V).
Prescription two:
(a) levamisole or its hydrochlorate 12% (W/V);
(b) avilamycin or ivermectin 1% (W/V);
(c) dimethyl acetylamide 10% (V/V);
(d) tween 80 10% (V/V)
(e) 1,2-propylene glycol 20% (V/V)
(f) water for injection adds to 100% (V/V).
Above preparation is used for nematicide and ectozoic control in the animal body, oral or injection, and pig, cattle, the every 20kg body weight of sheep using dosage are 1-2ml.
With example preparation of the present invention is described below, but example do not limit the scope of the invention, scope of the present invention and core content are determined according to claims.
Example 1
This example is that preparation contains avilamycin 1%, the compound injection of levamisole hydrochloride 12%
Levamisole hydrochloride 12% (W/V)
Avilamycin 1.0% (W/V)
Dimethyl acetylamide 10% (W/V)
Tween-80????????????????????10％(W/V)
1,2-propylene glycol 20% (W/V)
Water adds to 100% (W/V)
Usage and dosage: pig, cattle, sheep are used the 2ml/40kg body weight.
Example 2
This example is that preparation contains ivermectin 0.3%, the compound injection of levamisole hydrochloride 6%
Levamisole hydrochloride 6% (W/V)
Ivermectin 0.3% (W/V)
Dimethyl acetylamide 7% (V/V)
Polyethylene Glycol-200 25% (V/V)
Formal glycerine 40% (V/V)
It is that preparation contains ivermectin 0.5% that benzyl alcohol 1% (V/V) glycerol triacetate adds to 3 examples of 100% (V/V) example, and oil preparation injection levamisole hydrochloride 5% (W/V) ivermectin 0.5% (W/V) benzyl alcohol 10% (V/V) benzyl benzoate 40% (V/V) soybean oil of levamisole hydrochloride 5% adds to 100% (V/V)
Claims (6)
1, a kind of animal compound injection that contains levamisole or its esters is characterized in that prescription consists of:
(a) levamisole or its esters chemical compound 1-25% (W/V);
(b) Macrolide anthelmintic (avilamycin abamectin, ivermectin ivermectin, Ai Purui rhzomorph eprinomectin, moxidectin moxidectin, road draw rhzomorph doramectin) 0.1-10% (W/V);
(c) all the other are disperse medium;
(d) in case of necessity, can add other auxiliary agent (as suspending agent, table and activating agent and antioxidant).
2, by the described compound injection of claim 1, it is characterized in that described disperse medium comprises: water, vegetable oil, mineral oil or other organic liquid medium; Preferred organic media comprises ethanol, 1,2-propylene glycol, glycerol, isobutanol, isopropyl alcohol, Polyethylene Glycol, benzyl alcohol, formal glycerine, dimethyl acetylamide, benzyl benzoate, ethyl oleate, oleic acid, Miglyol 840 (diester of the sad and capric acid of propylene glycol), sorbitan fatty acid esters class, glycerol caprylic/capric diester, tetramethylolmethane dioleate.But two or more forms the complex media use to above liquid dispersion medium in prescription; Described vegetable oil comprises: Semen Maydis oil, Oleum Arachidis hypogaeae semen, soybean oil, Oleum Ricini, Oleum Brassicae campestris, Oleum sesami, Oleum Gossypii semen, almond oil, peach kernel oil, Oleum Cocois, Oleum Camelliae and olive oil, but two or more compound use of the vegetable oil that adds in the prescription also can be formed cosolvent with other disperse medium and use; The described suspending agent that adds in case of necessity is medical available suspending agent; Preferred suspending agent comprises: xanthan gum, carboxymethyl cellulose (sodium), ethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, sodium alginate, aluminium stearate, hydrogenated vegetable oil; The surfactant of Jia Ruing is available surfactant pharmaceutically in case of necessity, comprising: anionic surfactant, cationic surface active agent, nonionic surfactant and amphoteric surfactant; Preferred surfactants is a nonionic surfactant, comprising: polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, alkylphenol polyoxyethylene, Oleum Ricini glymes and by the synthetic ester type compound of glycerol.The surfactant of forming preparation can be a kind of, but also two or more mixes use.
3,, it is characterized in that preferred prescription consists of by the described preparation of claim 1:
(a) levamisole or its hydrochlorate 10-20% (W/V);
(b) avilamycin or ivermectin 0.5-2% (W/V);
(c) disperse medium adds to 100% (V/V).
(d) in case of necessity, can add other auxiliary agent.
4,, it is characterized in that further preferred prescription consists of by the described preparation of claim 3:
(a) levamisole or its hydrochlorate 10% (W/V):
(b) avilamycin or ivermectin 1% (W/V);
(c) 1,2-propylene glycol 50-80% (V/V);
(d) formal glycerine 20-50% (V/V).
5,, it is characterized in that further preferred prescription consists of by the described preparation of claim 3:
(a) levamisole or its hydrochlorate 12% (W/V);
(b) avilamycin or ivermectin 1% (W/V);
(c) dimethyl acetylamide 10% (V/V);
(d) tween 80 10% (V/V)
(e) 1,2-propylene glycol 20% (V/V)
(f) water for injection adds to 100% (V/V).
6, by claim 4 and 5 described preparations, it is characterized in that they are used for nematicide and ectozoic control in the animal body, oral or injection, pig, cattle, the every 20kg body weight of sheep using dosage are 1-2ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02100632 CN1375291A (en) | 2001-03-16 | 2002-01-29 | Veterinary mixed injection containing levamisole or its salts |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN01109662.4 | 2001-03-16 | ||
| CN01109662 | 2001-03-16 | ||
| CN 02100632 CN1375291A (en) | 2001-03-16 | 2002-01-29 | Veterinary mixed injection containing levamisole or its salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1375291A true CN1375291A (en) | 2002-10-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02100632 Pending CN1375291A (en) | 2001-03-16 | 2002-01-29 | Veterinary mixed injection containing levamisole or its salts |
Country Status (1)
| Country | Link |
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| CN (1) | CN1375291A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005084688A1 (en) * | 2004-03-04 | 2005-09-15 | Yuwan Wang | An injection power containing vermifuge |
| CN100364530C (en) * | 2003-10-14 | 2008-01-30 | 江苏先声药物研究有限公司 | Novel levamisole formulation for chronic rhinitis |
| AU2011268899A1 (en) * | 2010-06-24 | 2012-12-13 | Intervet International B.V. | Injectable formulation of a macrocyclic lactone and levamisole |
| CN103550149A (en) * | 2013-10-30 | 2014-02-05 | 游锡火 | Technology for preparing long-acting injection containing antiparasitic drugs |
| CN104306388A (en) * | 2014-09-23 | 2015-01-28 | 江西新天地药业有限公司 | Compound ivermectin injection and preparation method thereof |
| CN105769881A (en) * | 2014-12-20 | 2016-07-20 | 重庆布尔动物药业有限公司 | Veterinary compound levamisole hydrochloride suspension oral liquid and preparation method thereof |
| WO2017108954A1 (en) * | 2015-12-22 | 2017-06-29 | Intervet International B.V. | Injectable formulation of a macrocyclic lactone and levamisole |
| CN106974920A (en) * | 2017-01-02 | 2017-07-25 | 胡友忠 | Whole process is without vaccine livestock and poultry medicine |
| CN109223857A (en) * | 2018-11-23 | 2019-01-18 | 句容市茅山风景区鼎源畜禽养殖场 | A kind of knob raising goat preventing and treating verminosis medicament and preparation method thereof |
-
2002
- 2002-01-29 CN CN 02100632 patent/CN1375291A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100364530C (en) * | 2003-10-14 | 2008-01-30 | 江苏先声药物研究有限公司 | Novel levamisole formulation for chronic rhinitis |
| WO2005084688A1 (en) * | 2004-03-04 | 2005-09-15 | Yuwan Wang | An injection power containing vermifuge |
| AU2011268899A1 (en) * | 2010-06-24 | 2012-12-13 | Intervet International B.V. | Injectable formulation of a macrocyclic lactone and levamisole |
| AU2011268899C1 (en) * | 2010-06-24 | 2020-03-05 | Intervet International B.V. | Injectable formulation of a macrocyclic lactone and levamisole |
| CN103550149A (en) * | 2013-10-30 | 2014-02-05 | 游锡火 | Technology for preparing long-acting injection containing antiparasitic drugs |
| CN104306388A (en) * | 2014-09-23 | 2015-01-28 | 江西新天地药业有限公司 | Compound ivermectin injection and preparation method thereof |
| CN105769881A (en) * | 2014-12-20 | 2016-07-20 | 重庆布尔动物药业有限公司 | Veterinary compound levamisole hydrochloride suspension oral liquid and preparation method thereof |
| CN105769881B (en) * | 2014-12-20 | 2018-04-13 | 重庆布尔动物药业有限公司 | Animal compound levamisole hydrochloride suspension oral liquid and preparation method thereof |
| WO2017108954A1 (en) * | 2015-12-22 | 2017-06-29 | Intervet International B.V. | Injectable formulation of a macrocyclic lactone and levamisole |
| AU2016377165B2 (en) * | 2015-12-22 | 2022-08-11 | Intervet International B.V. | Injectable formulation of a macrocyclic lactone and levamisole |
| CN106974920A (en) * | 2017-01-02 | 2017-07-25 | 胡友忠 | Whole process is without vaccine livestock and poultry medicine |
| CN109223857A (en) * | 2018-11-23 | 2019-01-18 | 句容市茅山风景区鼎源畜禽养殖场 | A kind of knob raising goat preventing and treating verminosis medicament and preparation method thereof |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |