CN1373678A - Flow control and filtration method and apparatus - Google Patents
Flow control and filtration method and apparatus Download PDFInfo
- Publication number
- CN1373678A CN1373678A CN00812779A CN00812779A CN1373678A CN 1373678 A CN1373678 A CN 1373678A CN 00812779 A CN00812779 A CN 00812779A CN 00812779 A CN00812779 A CN 00812779A CN 1373678 A CN1373678 A CN 1373678A
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- China
- Prior art keywords
- fluid
- porous media
- valve according
- valve
- outlet
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/30—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages
- B05B1/32—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages in which a valve member forms part of the outlet opening
- B05B1/323—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages in which a valve member forms part of the outlet opening the valve member being actuated by the pressure of the fluid to be sprayed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
- B05B15/40—Filters located upstream of the spraying outlets
Abstract
A porous material valve (18) is placed in the fluid conveyance path of a fluid dispensing apparatus (2). By selecting a specific thickness of the porous material, the size of the pores, the pore volume, and the hydrophillic/hydrophobic balance of the material, a predetermined activation/closure pressure and flow rate is achieved.
Description
The U.S. Provisional Application No.60/153 of the application's reference JIUYUE in 2000 submission on the 13rd, 647, proposed claim and also by reference its whole disclosures have been included in herein.
Technical field
The present invention relates to current control and flow through filtering method and equipment, it is applicable to medical treatment device, medicine delivering device, food distributor, aerosol generator etc.
Background technology
Fluid distributing apparatus is applied in the multiple occasion, comprises the distribution etc. of distribution, cleaning agent or hair jelly of conveying, the food of medicine for example.This device can comprise that usually an aerosol produces surface and and is used to transmit fluidic passage, this passage have one be communicated with container maintenance fluid inlet and be positioned the outlet of aerosol generation surface.Fluid to be transmitted is contained in the container.
Yet proper method and device that traditional fluid dispensing apparatus lacks the usefulness cost efficient carry out the control of fluid stream.And traditional fluid distributing apparatus, particularly medicine delivering device will be subjected to lacking efficient mechanism and control the evaporation of fluid container and the puzzlement of pollution problem.Because machinery cost height and reliability low (crash rate height), so machinery is not a feasible selection.
Therefore, just need to develop evaporation and the pollution that a kind of usefulness cost efficient is controlled fluid stream with reliable shut off valve and prevented fluid container.
Summary of the invention
The present invention proposes that new and method and apparatus uniqueness are closed and devices such as control medical devices, drug delivery systems, food distributions, aerosol generation in fluid in the used fuid distribution system flow.
Utilized a kind of porous material at the shut off valve that is used for carrying out the fluid controlled adjuster of fluid distribution and/or depending on pressure among the present invention.This porous material also can be used for preventing fluid from the source of pressurised fluid seepage, and the fluidic evaporation that wherein holds is reduced to minimum, and/or prevent pollution problem.
The present invention proposes a kind of closing and/or flow control valve of fuid distribution system and so on that be used for.Flow measurement of the present invention and distribution system are sent to distribution locations with fluid from a source container by applying pressure drop.
In order to protect source container and evaporation to be reduced to minimum, on fluid delivery path, set up a shut off valve.For example the mechanical closing valve of check-valves, lift valve, flapper valve, duckbill valve and other mechanical valve prices are too expensive, also also unreliable.
Therefore, the invention provides new method and equipment, the porous media that wherein inserts in the fluid delivery path of fuid distribution system plays shut off valve, fluid flow control mechanism and environmental control system.
This porous media need reach predetermined startup pressure drop or critical pressure just can keep fluid flow.Be lower than under the force value of starting pressure, fluid can not flow.Therefore, when pressure drop was lower than certain level, the pressure drop of porous media just played shut off valve.When user carries out air-breathingly at the beginning, in suction-type medicine conveyer device, will produce this pressure drop.
The pore-size of porous material, overall pore volume and hydrophilic/hydrophobic reach is determining to begin the required force value (being critical pressure) that flows to a certain degree.These variablees are also determining the flow velocity in the material.For example, some porous media will promote free flow after reaching critical pressure.In case reach critical pressure, flowing of being promoted in other porous medias will increase with the increase of pressure, reaches maximum predetermined value.
Pore-size has also limited the particulate size that enters and leave porous media.Therefore, the particulate size of leaving fluid dispensing apparatus is subjected to the restriction of specific dimensions, has also eliminated the fluid loss that causes owing to evaporating pressure (fluidic evaporation) in the fluid container simultaneously substantially.Therefore, multi-orifice valve also can be regarded a kind of defecator as, and convection cell filters so that only distribute the fluid particle of specific dimensions.
Fluid contamination in all right basic eliminate fluid container of particle size restriction.Because therefore biological pollutant can not can prevent effectively that biological pollutant from passing through porous material by the hole of multi-orifice valve.In order to prevent the biological cell contaminated-fluid container of particular type, pore-size can be made the particular bore size.
For example, can determine that pore-size enters fluid path or container to prevent following organism:
-virus: 0.05 to 0.1 micron;
-antibacterial: 0.5 to 1.5 micron;
-erythrocyte: 5 microns; And
-lymphocyte: 5 to 8 microns.
In addition, it is all very important in many fuid distribution systems to leave the particle size of fluid container.For example, in drug delivery systems, particularly in the inhaler device, distribute to enter the easier absorption when particular particle size of the intravital drug dose of patient.
In order to reduce to minimum from source container, can adjust the hydrophilic/hydrophobic and the porous of porous material by the fluid that the fluid media (medium) valve evaporates.Multi-orifice valve of the present invention can reduce by 60% than mechanical valve with evaporation loss.
Therefore, the parameter of the hydrophilic/hydrophobic of thickness, pore-size, pore volume and material by Change Example such as porous material can reach countless versions startup/closing presure and/or flow velocity.
Therefore, in one aspect of the invention, the pressure valve of outlet that is used for the fluid container of fluid distributing apparatus comprises a porous media.
In another aspect of the present invention, the pressure valve that is used for fluid distributing apparatus comprises that one has fluid communication passageways, an outlet and an inlet of an internal diameter, and they keep fluid to be communicated with fluid container.Valve also comprises near the porous media being positioned to export.
Of the present invention aspect another in, the distributing pipe that is used for fluid distributing apparatus comprises that one has the fluid communication passageways of an internal diameter, wherein this passage comprises that one is positioned an outlet and the inlet that is communicated with fluid container maintenance fluid that aerosol produces the surface.Distributing pipe comprises that also one is positioned near the pressure valve of outlet, and wherein this valve comprises a porous media.
In another aspect of the present invention, the pressure regulator of outlet that is used for the fluid container of fluid distributing apparatus comprises a porous media.
In another aspect of the present invention, the actuator that is used for fluid distributing apparatus comprises that one has the fluid communication passageways of an internal diameter, and this passage has one and is positioned an outlet and the inlet that is communicated with fluid container maintenance fluid that aerosol produces the surface.Actuator comprises that also one is positioned to export near porous media.
In another aspect of the present invention, the porous media that is used for fluid distributing apparatus comprises the aerated plastics of pore-size between about 0.02 to 0.80 micron.
In another aspect of the present invention, the pressure valve system that is used for fluid distributing apparatus comprises that being used for that fluid is sent to aerosol from fluid container produces the device on surface and the Multiple-Aperture Device that keeps fluid to be communicated with this transporter.Multiple-Aperture Device makes fluid can flow to when applying pressure drop on the aerosol generation surface.
In another aspect of the present invention, a kind of method that is used in the fluid distributing apparatus distributing fluids has been proposed, wherein fluid distributing apparatus comprises a fluid container, this fluid container has one and is positioned the outlet that an aerosol produces near surface, one flows through the valve that this surperficial air-flow and one comprises near the porous media being positioned to export.Porous media comprises predetermined starting pressure.This method may further comprise the steps, and predetermined activation pressure is applied to crosses porous media, medicament distribution is produced on the surface to aerosol, and the atomizing particle that the surface produces is brought in the air-flow.
In another aspect of the present invention, a kind of system that is used in the fluid distributing apparatus distributing fluids has been proposed.This fluid distributing apparatus comprises a fluid container, and this fluid container has one and is positioned the outlet that an aerosol produces near surface, and one flows through the valve that this surperficial air-flow and one comprises near the porous media being positioned to export.Porous media comprises predetermined starting pressure.This system comprises predetermined activation pressure is applied to the device of crossing porous media, and described medicament distribution is produced lip-deep device to aerosol, and the atomizing particle that should the surface produces is brought the device in the air-flow into.
In another aspect of the present invention, a kind of method that is used for distributing at medicine delivering device medicine has been proposed.This medicine delivering device comprises a medicament reservoir, and this medicament reservoir has one and is positioned the outlet that an aerosol produces near surface, and one flows through the valve that this surperficial air-flow and one comprises near the porous media being positioned to export.Porous media comprises predetermined starting pressure.This method may further comprise the steps, and predetermined activation pressure is applied to crosses porous media, medicament distribution is produced on the surface to aerosol, and the atomizing particle that the surface produces is brought in the air-flow.
With reference to the following drawings and the description of being write, will have more clearly above-mentioned each side of the present invention and understand.
Description of drawings
Figure 1A-1F shows a plurality of views of the syllogic fuid distribution system that assembles.
Fig. 2 A-2F shows a plurality of views of the end section of the fuid distribution system shown in Figure 1A-1F.
Fig. 3 A-3G shows a plurality of views in the stage casing of the fuid distribution system shown in Figure 1A-1F.
Fig. 4 A-4F shows a plurality of views of the back segment of the fuid distribution system shown in Figure 1A-1F.
Fig. 5 is the side cutaway view with distributing pipe of porous material valve of the present invention.
Fig. 6 shows the view of multi-orifice valve of the present invention.
Fig. 7 shows the chart of the efficient that the fuid distribution system that utilizes multi-orifice valve of the present invention is described.
Fig. 8 shows the chart of the performance of explanation multi-orifice valve of the present invention.
Fig. 9 shows the chart of the performance summary that the medicine delivering device that utilizes multi-orifice valve of the present invention is described.
Figure 10 shows the chart of explanation water flow velocity to the relation of pipe size.
Figure 11 shows the chart of the tube voltage drop of the interior caliber of listing among explanation Figure 10.
Figure 12 shows the calculation of pressure of inhaler device.
The specific embodiment
Figure 1A-1F shows a plurality of views of the syllogic fuid distribution system 2 that assembles, and it has according to multi-orifice valve of the present invention.This system comprises back segment 4, stage casing 6 and spout section 8, and spout section 8 comprises spout 10 and spout tip 12.
Fig. 2 A-2F shows a plurality of views of the end section of the fuid distribution system shown in Figure 1A-1F that comprises a spout, and this spout comprises according to porous material valve of the present invention.
Fig. 3 A-3G shows a plurality of views in the stage casing of the fuid distribution system shown in Figure 1A-1F.
Fig. 4 A-4F shows a plurality of views of the back segment of the fuid distribution system shown in Figure 1A-1F.
Fig. 5 is the side cutaway view of the distributing pipe 14 of fuid distribution system, has a porous material valve 18 that is communicated with fluid container maintenance fluid at 16 places, end of distributing pipe 14.
Fig. 6 shows a plurality of views according to multi-orifice valve of the present invention.
Fig. 7 shows explanation and utilizes the efficient of fuid distribution system of multi-orifice valve of the present invention to the chart of the relation of particle size.The X-axis line represents to pass through the particulate size of porous filter, and the efficient of Y-axis line precentagewise indication device.This figure explanation, along with particle size increases, the efficient of device also increases.About the present invention, by multi-orifice valve of the present invention, efficient is increased to the meansigma methods that surpasses when only utilizing long tube.The average efficiency value added surpasses 7%.
The chart that property comparison when the performance of multi-orifice valve of the present invention was not used any valve with utilizing identical device when Fig. 8 showed explanation and utilizes the interface open, inhaler type medicine delivering device concerns.Breathed part shown in the chart is represented with percentage ratio, can breathe dosage and represent that with ug unit efficiency is then represented with percentage ratio.When using multi-orifice valve, each classification all has improvement.
Fig. 9 shows the chart of the performance summary that the medicine delivering device that utilizes multi-orifice valve of the present invention is described.The original value of having listed special instruction, desired value, fuid distribution system to use long metal pipe in the chart and having obtained, the measured value when using porous filter of the present invention and by datum mark that highest level-immediate commercially produced product obtains.
From the chart of Fig. 9, can know and find out, in fluid delivery path, lay multi-orifice valve and can produce following advantage:
-efficient of fuid distribution system is increased;
-even-fluid that causes is sent to the nebulizer mechanism of inhaler device (piezoelectricity horn shape spare) more;
-evaporation loss is reduced about 60%;
-accuracy of measurement is improved about 4%; And
-cost is lower.
Figure 10 shows the chart of explanation water flow velocity to the relation of the size of the pipe of distributing fluids from fluid container.The column that comprises in the chart has bore (representing with inch and cm), and pipe flow speed (is used cm
3/ s and μ l/s represent), diameter of droplets (representing), quality of microdropletes (representing) and make microdroplet pass through the required power of porous material (representing) with restraining with gram with cm.
Figure 11 shows the chart of the tube voltage drop of the interior caliber of listing among explanation Figure 10.For given interior caliber, listed propelling fluid by porous material required pressure drop or pressure (representing) with millibar and psi.
The maximum pressure that Figure 12 shows by the stream of porous media calculates.As shown in the figure, the maximum, force of generation is 20N, and the maximum pressure that produces at telescopic tip is 2571lb.
f/ in
2
The example of porous material comprises polysulfones, polyether sulfone, cellulose acetate, nylon, Kynoar, politef and polyolefin.The special example of operable porous material is Sartorious 0.2 or 0.20 micron GVPH 2935 of 0.45 micron cellulose acetate CA 12587, Millipore, 0.22 micron GSW PO96 of Millipore or Pall 0.22 micrometer nylon medium.
Pore-size can be between about 0.05 to 1.0 micron, more preferably between about 0.15 to 0.90 micron, most preferably between about 0.20-0.80 micron.
The preferred multi-orifice valve structure of medicine delivering device of the present invention comprises a fluid communication passageways, and its internal diameter is 0.5mm, and the gap is 0.5mm, also has 2mm in piezoelectric atomizer device (being used for being produced by fluid the device of atomizing particle) top.
By a pressure drop is applied to the porous media of crossing the medicament distribution pipe, just can in medicine delivering device of the present invention, distribute medicine.This pressure drop can suck by the user of medicine delivering device the effect and apply, so also can in device, produce air-flow.When applying pressure drop or after a while, the medicine aerosol that is assigned to medicine delivering device produces on the surface.Medicine is atomized and is inhaled into subsequently the air-flow of effect generation and takes away.
Following example is that illustrative of the present invention is described:
One commercialization porous filter material is inserted in the minor diameter sleeve pipe of medicine delivering device.Material comprises 0.45 micron of the diameter fluid dynamic hole of (preferably being no less than 0.2 micron), and full depth is less than 0.010 ".This material comprise a suitable surface area and Pressure Drop Characteristics so that drug delivery equipment can be under the 10psi pressure drop with the flow velocity distributing fluids stream of 300 microlitre/seconds.Granule and fluid that porous material allows average diameter to be lower than 200 millimicrons pass through.
Claims (29)
1. the pressure-activated valve of the outlet of a fluid container that is used for fluid distributing apparatus, it comprises a porous media.
2. valve according to claim 1 is characterized in that, described valve is provided to an aerosol with fluid and produces the surface.
3. valve according to claim 1 is characterized in that described porous media comprises an aerated plastics.
4. valve according to claim 3 is characterized in that described aerated plastics comprises polysulfones or polyether sulfone materials.
5. valve according to claim 3 is characterized in that described aerated plastics comprises the acetate fiber cellulosic material.
6. valve according to claim 3 is characterized in that described aerated plastics comprises nylon material.
7. valve according to claim 3 is characterized in that described aerated plastics comprises polytetrafluoroethylmaterial material.
8. valve according to claim 3 is characterized in that described aerated plastics comprises polyolefine material.
9. valve according to claim 3 is characterized in that described aerated plastics comprises the nylon medium.
10. valve according to claim 3 is characterized in that, the pore-size of described aerated plastics is between about 0.15 micron to 0.80 micron.
11. valve according to claim 1 is characterized in that, the pressure drop that puts in the described outlet makes fluid flow out from described container, and by described porous media.
12. valve according to claim 11 is characterized in that, described pressure drop is a predetermined value.
13. valve according to claim 1 is characterized in that, described porous media plays filter element.
14. valve according to claim 11 is characterized in that, the amount of the described pressure drop of permission fluid flow is by the pore-size decision of described porous media.
15. valve according to claim 11 is characterized in that, the amount of the described pressure drop of permission fluid flow is by the pore volume decision of described porous media.
16. valve according to claim 11 is characterized in that, the amount of the described pressure drop of permission fluid flow is by the hydrophilic/hydrophobic decision of described porous media.
17. valve according to claim 1 is characterized in that, described porous media has suppressed fluid seepage from described container.
18. valve according to claim 1 is characterized in that, described porous media reduces to minimum with the evaporation of fluid from described container.
19. valve according to claim 1 is characterized in that, described porous media has prevented the pollution to described fluid container.
20. valve according to claim 1 is characterized in that, described fluid is a medicine, but and wherein said fluid distributing apparatus be a suction-type medicine conveyer device.
21. a pressure valve that is used for fluid distributing apparatus, it comprises:
One has the fluid communication passageways of an internal diameter, and described passage has one and is positioned an outlet and the inlet that is communicated with fluid container maintenance fluid that aerosol produces the surface; And
One is positioned near the porous media the described outlet.
22. a distributing pipe that is used for fluid distributing apparatus, it comprises:
One has the fluid communication passageways of an internal diameter, and described passage has one and is positioned an outlet and the inlet that is communicated with fluid container maintenance fluid that aerosol produces the surface; And
One is positioned near the pressure valve the described outlet, and described pressure valve comprises a porous media.
23. the pressure regulator of the outlet of a fluid container that is used for fluid distributing apparatus, it comprises a porous media.
24. an actuator that is used for fluid distributing apparatus, it comprises:
One has the fluid communication passageways of an internal diameter, and described passage has one and is positioned an outlet and the inlet that is communicated with fluid container maintenance fluid that aerosol produces the surface; And
One is positioned near the porous media the described outlet.
25. a porous media that is used for fluid distributing apparatus, described porous media comprise the aerated plastics of pore-size between about 0.15 micron to 0.80 micron.
26. a pressure valve system that is used for fluid distributing apparatus, it comprises:
Be used for fluid is sent to the device that aerosol produces the surface from fluid container; And
With the Multiple-Aperture Device that the described device that is used to transmit keeps fluid to be communicated with, wherein said Multiple-Aperture Device makes fluid can flow to when applying pressure drop on the described aerosol generation surface.
27. the method for a distributing fluids in fluid distributing apparatus, described fluid distributing apparatus comprises a fluid container, this fluid container has one and is positioned the outlet that an aerosol produces near surface, one flows through the air-flow on described surface, and one comprise the valve that is positioned near the porous media the described outlet, wherein said porous media comprises predetermined starting pressure, said method comprising the steps of:
Described predetermined activation pressure is applied to crosses described porous media;
Described medicament distribution is produced on the surface to described aerosol; And
The atomizing particle that described surface produces is brought in the described air-flow.
28. system that is used in the fluid distributing apparatus distributing fluids, described fluid distributing apparatus comprises a fluid container, this fluid container has one and is positioned the outlet that an aerosol produces near surface, one flows through the air-flow on described surface, and one comprise the valve that is positioned near the porous media the described outlet, wherein said porous media comprises predetermined starting pressure, and described system comprises:
Be used for described predetermined activation pressure is applied to the device of crossing described porous media;
Be used for described medicament distribution is produced lip-deep device to described aerosol; And
Be used for the atomizing particle that described surface produces is brought into the device of described air-flow.
29. method of in medicine delivering device, distributing medicine, described medicine delivering device comprises a medicament reservoir, this medicament reservoir has one and is positioned the outlet that an aerosol produces near surface, one flows through the air-flow on described surface, and one comprise the valve that is positioned near the porous media the described outlet, wherein said porous media comprises predetermined starting pressure, said method comprising the steps of:
Described predetermined activation pressure is applied to crosses described porous media; With
Described medicament distribution is produced on the surface to described aerosol; And
The atomizing particle that described surface produces is brought in the described air-flow.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15364799P | 1999-09-13 | 1999-09-13 | |
| US60/153,647 | 1999-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1373678A true CN1373678A (en) | 2002-10-09 |
Family
ID=22548110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00812779A Pending CN1373678A (en) | 1999-09-13 | 2000-09-13 | Flow control and filtration method and apparatus |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1212112A1 (en) |
| JP (1) | JP2003509629A (en) |
| KR (1) | KR20020059396A (en) |
| CN (1) | CN1373678A (en) |
| AU (1) | AU7484200A (en) |
| CA (1) | CA2383226A1 (en) |
| MX (1) | MXPA02002713A (en) |
| NO (1) | NO20021194D0 (en) |
| TR (1) | TR200200645T2 (en) |
| WO (1) | WO2001019438A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102014003314A1 (en) | 2014-03-08 | 2015-09-10 | Hydac Fluidcarecenter Gmbh | Method for adapting a filter medium to specifiable parameters and preferably a filter medium produced by this method |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3498294A (en) * | 1964-01-22 | 1970-03-03 | Gen Am Transport | Inhalation aerosol dosimeter and method of measuring dosage |
| US5404871A (en) * | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
| PL173090B1 (en) * | 1992-12-18 | 1998-01-30 | Schering Corp | Powdered drug inhaler |
| US5497763A (en) * | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
| US6089857A (en) * | 1996-06-21 | 2000-07-18 | Japan Tobacco, Inc. | Heater for generating flavor and flavor generation appliance |
-
2000
- 2000-09-13 AU AU74842/00A patent/AU7484200A/en not_active Abandoned
- 2000-09-13 TR TR2002/00645T patent/TR200200645T2/en unknown
- 2000-09-13 CA CA002383226A patent/CA2383226A1/en not_active Abandoned
- 2000-09-13 EP EP00963427A patent/EP1212112A1/en not_active Withdrawn
- 2000-09-13 KR KR1020027003203A patent/KR20020059396A/en not_active Application Discontinuation
- 2000-09-13 WO PCT/US2000/025145 patent/WO2001019438A1/en not_active Application Discontinuation
- 2000-09-13 MX MXPA02002713A patent/MXPA02002713A/en unknown
- 2000-09-13 CN CN00812779A patent/CN1373678A/en active Pending
- 2000-09-13 JP JP2001523065A patent/JP2003509629A/en not_active Withdrawn
-
2002
- 2002-03-11 NO NO20021194A patent/NO20021194D0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02002713A (en) | 2003-10-14 |
| AU7484200A (en) | 2001-04-17 |
| WO2001019438A1 (en) | 2001-03-22 |
| EP1212112A1 (en) | 2002-06-12 |
| WO2001019438A9 (en) | 2002-09-26 |
| KR20020059396A (en) | 2002-07-12 |
| JP2003509629A (en) | 2003-03-11 |
| TR200200645T2 (en) | 2002-07-22 |
| CA2383226A1 (en) | 2001-03-22 |
| NO20021194L (en) | 2002-03-11 |
| NO20021194D0 (en) | 2002-03-11 |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |