CN1368291A - Nano anisodamine-musk medicine and its preparing process - Google Patents
Nano anisodamine-musk medicine and its preparing process Download PDFInfo
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- CN1368291A CN1368291A CN 01102646 CN01102646A CN1368291A CN 1368291 A CN1368291 A CN 1368291A CN 01102646 CN01102646 CN 01102646 CN 01102646 A CN01102646 A CN 01102646A CN 1368291 A CN1368291 A CN 1368291A
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Abstract
A nanometre (0.1-200 nm) medicine "Shanliangtuo Shexiang" is prepared from the nanometre powders of methyl salicylate and 8 Chinese medicinal materials including musk, thymelaeaceae tonguticus, dried ginger, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano anisodamine-musk medicine of a kind of invigorating blood circulation analgesia, expelling wind and removing dampness, the invention still further relates to the method for this medication preparation.
Anisodamine-musk cream is a kind of classical Chinese patent medicine, mainly contains effects such as invigorating blood circulation analgesia, expelling wind and removing dampness, is used for rheumatic arthralgia, arthritis, rheumatoid arthritis, the pain of diseases such as traumatic injury.But traditional anisodamine-musk cream absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano anisodamine-musk medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano anisodamine-musk medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano musk 0.1-2 part nanometer Tang Gute winter daphne 700-1500 part nano anisodamine 70-180 part
Nanometer Rhizoma Zingiberis 30-80 part nanometer Olibanum 15-40 part nanometer Myrrha 15-40 part
Nanometer Borneolum Syntheticum 10-30 part nanometer Camphora 12-30 part nanometer methyl salicylate 120-300 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano musk 0.1-1 part nanometer Tang Gute winter daphne 800-1200 part nano anisodamine 90-150 part
Nanometer Rhizoma Zingiberis 40-60 part nanometer Olibanum 20-30 part nanometer Myrrha 20-30 part
Nanometer Borneolum Syntheticum 15-25 part nanometer Camphora 15-25 part nanometer methyl salicylate 150-250 part
The optimum weight proportioning of medicine of the present invention is:
125 parts of 1000 parts of nano anisodamines of 0.25 part of nanometer Tang Gute of nano musk winter daphne
25 parts of 25 parts of nanometer Myrrhas of 50 parts of nanometer Olibanums of nanometer Rhizoma Zingiberis
170 parts of 20 parts of nanometer methyl salicylate of 20 parts of nanometer Camphoras of nanometer Borneolum Syntheticum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get anisodamine-musk preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano anisodamine-musk medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common anisodamine-musk paste formulation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, medicated wine, syrup, oral solution of nano anisodamine-musk medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the treatment of pain of diseases such as rheumatic arthralgia, arthritis, rheumatoid arthritis and traumatic injury, and clinical efficacy significantly is better than traditional anisodamine-musk cream.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
125 parts of 1000 parts of nano anisodamines of 0.25 part of nanometer Tang Gute of nano musk winter daphne
25 parts of 25 parts of nanometer Myrrhas of 50 parts of nanometer Olibanums of nanometer Rhizoma Zingiberis
170 parts of 20 parts of nanometer methyl salicylate of 20 parts of nanometer Camphoras of nanometer Borneolum Syntheticum
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
125 parts of 1000 parts of nano anisodamines of 0.25 part of nanometer Tang Gute of nano musk winter daphne
25 parts of 25 parts of nanometer Myrrhas of 50 parts of nanometer Olibanums of nanometer Rhizoma Zingiberis
170 parts of 20 parts of nanometer methyl salicylate of 20 parts of nanometer Camphoras of nanometer Borneolum Syntheticum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano anisodamine-musk membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nano anisodamine-musk medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano musk 0.1-2 part nanometer Tang Gute winter daphne 700-1500 part nano anisodamine 70-180 part
Nanometer Rhizoma Zingiberis 30-80 part nanometer Olibanum 15-40 part nanometer Myrrha 15-40 part
Nanometer Borneolum Syntheticum 10-30 part nanometer Camphora 12-30 part nanometer methyl salicylate 120-300 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30-60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano anisodamine-musk medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano musk 0.1-1 part nanometer Tang Gute winter daphne 800-1200 part nano anisodamine 90-150 part
Nanometer Rhizoma Zingiberis 40-60 part nanometer Olibanum 20-30 part nanometer Myrrha 20-30 part
Nanometer Borneolum Syntheticum 15-25 part nanometer Camphora 15-25 part nanometer methyl salicylate 150-250 part
3, nano anisodamine-musk medicine according to claim 1, wherein the weight proportion of each nano raw material is:
125 parts of 1000 parts of nano anisodamines of 0.25 part of nanometer Tang Gute of nano musk winter daphne
25 parts of 25 parts of nanometer Myrrhas of 50 parts of nanometer Olibanums of nanometer Rhizoma Zingiberis
170 parts of 20 parts of nanometer methyl salicylate of 20 parts of nanometer Camphoras of nanometer Borneolum Syntheticum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano anisodamine-musk medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano anisodamine-musk medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30-60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102646 CN1368291A (en) | 2001-02-06 | 2001-02-06 | Nano anisodamine-musk medicine and its preparing process |
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| CN 01102646 CN1368291A (en) | 2001-02-06 | 2001-02-06 | Nano anisodamine-musk medicine and its preparing process |
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| CN 01102646 Pending CN1368291A (en) | 2001-02-06 | 2001-02-06 | Nano anisodamine-musk medicine and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997848A (en) * | 2016-07-02 | 2016-10-12 | 青海民族大学 | Tangut anisodus radix and musk gel and preparation method thereof |
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2001
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997848A (en) * | 2016-07-02 | 2016-10-12 | 青海民族大学 | Tangut anisodus radix and musk gel and preparation method thereof |
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