CN1364551A - Nano phlegm removing and cough arresting medicine and its preparing method - Google Patents
Nano phlegm removing and cough arresting medicine and its preparing method Download PDFInfo
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- CN1364551A CN1364551A CN 01100818 CN01100818A CN1364551A CN 1364551 A CN1364551 A CN 1364551A CN 01100818 CN01100818 CN 01100818 CN 01100818 A CN01100818 A CN 01100818A CN 1364551 A CN1364551 A CN 1364551A
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Abstract
The nano phlegm removing and cough arresting medicine is prepared with nano Codonopsis Pilosulae, nano pinellia tuber, nano Scirpus tabernaemontani flower, nano kansui root, nano leaf and twig of mary rhododeneron and nano alum in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to a kind of the spleen strengthening and damp drying, expelling phlegm for arresting cough, cure mainly chronic bronchitis and bronchitis and merge emphysema, the caused abundant expectoration of pulmonary heart disease, cough, the nano phlegm removing and cough arresting medicine of panting the invention still further relates to the method for this medication preparation.
The expelling phlegm for arresting cough electuary is a kind of classical Chinese patent medicine, mainly contains effects such as the spleen strengthening and damp drying, expelling phlegm for arresting cough, is used for chronic bronchitis and bronchitis and merges emphysema, the caused abundant expectoration of pulmonary heart disease, cough, disease such as pant.But traditional expelling phlegm for arresting cough electuary absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano phlegm removing and cough arresting medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano phlegm removing and cough arresting medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Codonopsis 1680-4220 part nanometric Typhonium flagelliforme (Lodd.) Blume 2520-6480 part nanometric Aster flaccidus 560-1440 part
Nanometer Alumen 140-360 part nanometer Folium et Cacumen Rhododendri Mariae 840-2160 part nanometer Radix Kansui 560-1440 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Codonopsis 2400-3600 part nanometric Typhonium flagelliforme (Lodd.) Blume 3600-5400 part nanometric Aster flaccidus 800-1200 part
Nanometer Alumen 200-300 part nanometer Folium et Cacumen Rhododendri Mariae 1200-1800 part nanometer Radix Kansui 800-1200 part
The optimum weight proportioning of medicine of the present invention is:
1000 parts of 4500 parts of nanometric Aster flaccidus of 3000 parts of nanometric Typhonium flagelliforme (Lodd.) Blumes of nanometer Radix Codonopsis
1000 parts of 1500 parts of nanometer Radix Kansuis of 250 parts of nanometer Folium et Cacumen Rhododendri Mariaes of nanometer Alumen
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the phlegm removing and cough arresting nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano phlegm removing and cough arresting medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common expelling phlegm for arresting cough electuary preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano phlegm removing and cough arresting medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for chronic bronchitis and bronchitis and merges emphysema, the caused abundant expectoration of pulmonary heart disease, cough, and treatment of conditions such as pant, clinical efficacy significantly is better than traditional expelling phlegm for arresting cough electuary.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
1000 parts of 4500 parts of nanometric Aster flaccidus of 3000 parts of nanometric Typhonium flagelliforme (Lodd.) Blumes of nanometer Radix Codonopsis
1000 parts of 1500 parts of nanometer Radix Kansuis of 250 parts of nanometer Folium et Cacumen Rhododendri Mariaes of nanometer Alumen
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
1000 parts of 4500 parts of nanometric Aster flaccidus of 3000 parts of nanometric Typhonium flagelliforme (Lodd.) Blumes of nanometer Radix Codonopsis
1000 parts of 1500 parts of nanometer Radix Kansuis of 250 parts of nanometer Folium et Cacumen Rhododendri Mariaes of nanometer Alumen
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano phlegm removing cough-relieving powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
1000 parts of 4500 parts of nanometric Aster flaccidus of 3000 parts of nanometric Typhonium flagelliforme (Lodd.) Blumes of nanometer Radix Codonopsis
1000 parts of 1500 parts of nanometer Radix Kansuis of 250 parts of nanometer Folium et Cacumen Rhododendri Mariaes of nanometer Alumen
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano phlegm removing cough-relieving membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano phlegm removing and cough arresting medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Codonopsis 1680-4220 part nanometric Typhonium flagelliforme (Lodd.) Blume 2520-6480 part nanometric Aster flaccidus 560-1440 part
Nanometer Alumen 140-360 part nanometer Folium et Cacumen Rhododendri Mariae 840-2160 part nanometer Radix Kansui 560-1440 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano phlegm removing and cough arresting medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Codonopsis 2400-3600 part nanometric Typhonium flagelliforme (Lodd.) Blume 3600-5400 part nanometric Aster flaccidus 800-1200 part
Nanometer Alumen 200-300 part nanometer Folium et Cacumen Rhododendri Mariae 1200-1800 part nanometer Radix Kansui 800-1200 part
3, nano phlegm removing and cough arresting medicine according to claim 1, wherein the weight proportion of each nano raw material is:
1000 parts of 4500 parts of nanometric Aster flaccidus of 3000 parts of nanometric Typhonium flagelliforme (Lodd.) Blumes of nanometer Radix Codonopsis
1000 parts of 1500 parts of nanometer Radix Kansuis of 250 parts of nanometer Folium et Cacumen Rhododendri Mariaes of nanometer Alumen
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano phlegm removing and cough arresting medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano phlegm removing and cough arresting medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100818 CN1364551A (en) | 2001-01-11 | 2001-01-11 | Nano phlegm removing and cough arresting medicine and its preparing method |
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| CN 01100818 CN1364551A (en) | 2001-01-11 | 2001-01-11 | Nano phlegm removing and cough arresting medicine and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147080A (en) * | 2013-05-14 | 2014-11-19 | 肇庆星湖制药有限公司 | Traditional Chinese medicine preparation, preparation method and application of traditional Chinese medicine preparation |
| CN108245601A (en) * | 2018-02-28 | 2018-07-06 | 广东力罗定制药有限公司 | A kind of expelling phlegm and arresting coughing capsule and preparation method thereof |
| CN110522786A (en) * | 2018-05-23 | 2019-12-03 | 北京盈科瑞创新药物研究有限公司 | A kind of sucking rhododendron mariae pharmaceutical solutions and preparation method thereof |
-
2001
- 2001-01-11 CN CN 01100818 patent/CN1364551A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147080A (en) * | 2013-05-14 | 2014-11-19 | 肇庆星湖制药有限公司 | Traditional Chinese medicine preparation, preparation method and application of traditional Chinese medicine preparation |
| CN104147080B (en) * | 2013-05-14 | 2018-04-27 | 肇庆星湖制药有限公司 | Chinese medicine preparation, preparation method and applications |
| CN108245601A (en) * | 2018-02-28 | 2018-07-06 | 广东力罗定制药有限公司 | A kind of expelling phlegm and arresting coughing capsule and preparation method thereof |
| CN110522786A (en) * | 2018-05-23 | 2019-12-03 | 北京盈科瑞创新药物研究有限公司 | A kind of sucking rhododendron mariae pharmaceutical solutions and preparation method thereof |
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