CN1362066A - Nano Bingpeng medicine and its prepn - Google Patents
Nano Bingpeng medicine and its prepn Download PDFInfo
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- CN1362066A CN1362066A CN 01100156 CN01100156A CN1362066A CN 1362066 A CN1362066 A CN 1362066A CN 01100156 CN01100156 CN 01100156 CN 01100156 A CN01100156 A CN 01100156A CN 1362066 A CN1362066 A CN 1362066A
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Abstract
The present invention discloses a medicine made of nano borneol and borax preparations to the public, which uses nano borneol, borax, raw gypsum and glauber salt as a raw material to prepare according to a proportion to make a new medicinal preparation that its granule fineness is up to 1200-1500 mesh number, granule diameter is 0.1-200 nm with absolute majority of them under 100 nm and its has anew substance performance. The invented medicine is prepared by the process of microwave extraction, depressured concentration and ultrasonic jet spray drying, and has high biological utilization rate and obviously curing effect.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, erosion prevention and muscle growing, cure mainly laryngopharynx swelling and pain, gingiva pain, the nanometer of aphtha of the mouth and tongue is iced the boron preparation medicine, the invention still further relates to the method for this medication preparation.
BINGPENG SAN is a kind of classical Chinese patent medicine, mainly contains effects such as antibacterial, detoxifcation, antiinflammatory, analgesia, function of gallbladder promoting, diuresis, is used for laryngopharynx swelling and pain, gingiva pain, aphtha of the mouth and tongue etc.But traditional BINGPENG SAN absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer of increase evident in efficacy ice boron preparation medicine.
Another object of the present invention provides the preparation method of this nanometer ice boron preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Borneolum Syntheticum 10-40 part nanometer Borax 10-40 part
Nanometer Gypsum Fibrosum 32-92 part nanometer Matrii Sulfas Exsiccatus 32-72 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Borneolum Syntheticum 12-32 part nanometer Borax 12-32 part
Nanometer Gypsum Fibrosum 42-82 part nanometer Matrii Sulfas Exsiccatus 42-62 part
The optimum weight proportioning of medicine of the present invention is:
22 parts of 22 parts of nanometer Boraxs of nanometer Borneolum Syntheticum
62 parts of 62 parts of nanometer Matrii Sulfas Exsiccatus of nanometer Gypsum Fibrosum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio,, make pill, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, must ice boron preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer ice boron preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common ice boron powder preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that the pill, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum of nanometer ice boron preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for oral ulcer, sublinguitis, pertussis, rib adenitis, herpes zoster, cervical erosion, omphalitis of newborn, tinea, tension force blister, impetigo, colitis, all eczema of ear, treatment of conditions such as otitis media, clinical efficacy significantly is better than traditional BINGPENG SAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
22 parts of 22 parts of nanometer Boraxs of nanometer Borneolum Syntheticum
62 parts of 62 parts of nanometer Matrii Sulfas Exsiccatus of nanometer Gypsum Fibrosum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the agent of nanometer ice boron film, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nanometer ice boron preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Borneolum Syntheticum 10-40 part nanometer Borax 10-40 part
Nanometer Gypsum Fibrosum 32-92 part nanometer Matrii Sulfas Exsiccatus 32-72 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer ice boron preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Borneolum Syntheticum 12-32 part nanometer Borax 12-32 part
Nanometer Gypsum Fibrosum 42-82 part nanometer Matrii Sulfas Exsiccatus 42-62 part
3, nanometer ice boron preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
22 parts of 22 parts of nanometer Boraxs of nanometer Borneolum Syntheticum
62 parts of 62 parts of nanometer Matrii Sulfas Exsiccatus of nanometer Gypsum Fibrosum
4, according to claim 1 or 2 or 3 described nanometer ice boron preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5, according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer ice boron preparation medicines, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100156 CN1362066A (en) | 2001-01-04 | 2001-01-04 | Nano Bingpeng medicine and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100156 CN1362066A (en) | 2001-01-04 | 2001-01-04 | Nano Bingpeng medicine and its prepn |
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| Publication Number | Publication Date |
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| CN1362066A true CN1362066A (en) | 2002-08-07 |
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| CN 01100156 Pending CN1362066A (en) | 2001-01-04 | 2001-01-04 | Nano Bingpeng medicine and its prepn |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102204929A (en) * | 2011-05-11 | 2011-10-05 | 夏勇 | Chuihou powder preparation and preparation method thereof |
| CN103599165A (en) * | 2013-11-22 | 2014-02-26 | 安徽天恒药业有限公司 | Traditional Chinese medicine composition for treating acute laryngeal infection and throat-entwining wind |
| CN104224833A (en) * | 2014-06-26 | 2014-12-24 | 吴祖池 | Method for treating herpes zoster |
| CN109223823A (en) * | 2018-10-26 | 2019-01-18 | 邸树红 | A kind of acute lumbar muscle sprain eye droppings dissipates and preparation method thereof |
-
2001
- 2001-01-04 CN CN 01100156 patent/CN1362066A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102204929A (en) * | 2011-05-11 | 2011-10-05 | 夏勇 | Chuihou powder preparation and preparation method thereof |
| CN102204929B (en) * | 2011-05-11 | 2012-08-29 | 夏勇 | Chuihou powder preparation and preparation method thereof |
| CN103599165A (en) * | 2013-11-22 | 2014-02-26 | 安徽天恒药业有限公司 | Traditional Chinese medicine composition for treating acute laryngeal infection and throat-entwining wind |
| CN104224833A (en) * | 2014-06-26 | 2014-12-24 | 吴祖池 | Method for treating herpes zoster |
| CN109223823A (en) * | 2018-10-26 | 2019-01-18 | 邸树红 | A kind of acute lumbar muscle sprain eye droppings dissipates and preparation method thereof |
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