CN1358719A

CN1358719A - Process for synthesizing sertaconazole

Info

Publication number: CN1358719A
Application number: CN 01127506
Authority: CN
Inventors: 陈宝泉; 赵煜松; 马宁; 曾海霞
Original assignee: HEBEI MEDICINE INST
Current assignee: HEBEI MEDICINE INST
Priority date: 2001-09-26
Filing date: 2001-09-26
Publication date: 2002-07-17
Anticipated expiration: 2021-09-26
Also published as: CN1191250C

Abstract

The present invention provides a phase transfer catalytic synthesis method of shetaconzole nitrate, said method includes: using 1-(2,4-dichlorophenyl)-2-(1-imidazole) ethyl alcohol and 3-bromomethyl-7-chlorobenzo [b] thiophene as raw material, using methylbenzene and water as solvent and using tetrabutyl ammonium chloride as catalyst, in the presence of sodium hydroxide making phase transfer catalytic reaction to prepare shetaconzole nitrate. Said ivnention is simple and convenient in operation, and utilizes element analysis, infrared spectrum, NMR hydrogen spectrum, NMR carbon spectrum and mass spectrum to confirm its chemical structure, its content is greater than 98.5%.

Description

A kind of synthetic method of sertaconazole

Technical field

The present invention relates to a kind of synthetic method of sertaconazole, belong to technical field of organic synthesis, be applicable to preparation medicine material or intermediate.

Background technology

Desenex's sertaconazole (Sertaconazole Nitrate), molecular formula: C ₂₀H ₁₅C ₁₃N ₂₀S HNO ₃Develop by Spain, and apply for a patent, as EP151477 multinational; ES529608; ED535656, JP60/181186, US51335943 etc.; its synthetic route adopts with 1-(2; the 4-dichlorobenzene)-2-(1-imidazoles) ethanol and 3-brooethyl-7-chlorobenzene also [b] thiophene be raw material, under protection of inert gas, obtain Sertaconazole, refabrication nitrate with the sodium hydride reaction.Reaction formula is as follows:

The weak point of above-mentioned synthetic method is:

1, reaction needed is finished under protection of inert gas;

2, used sodium hydride meet water can the reaction of blasting property, and meet lower alcohols and also intense reaction can take place, the releasing hydrogen gas burning, so reaction must be operated under anhydrous, oxygen free condition, solvent for use is also must drying anhydrous or do not have a lower alcohols material;

3, used HMPA is toxic substance and costs an arm and a leg;

4, reaction is loaded down with trivial details, condition is restive, cost is higher.

Summary of the invention

The object of the present invention is to provide a kind of phase-transfer catalysis synthetic method of sertaconazole,, reduce preparation cost to simplify synthetic route.

Technical scheme of the present invention is achieved in that the synthetic method of this sertaconazole comprises with 1-(2, the 4-dichlorobenzene)-2-(1-imidazoles) ethanol and 3-brooethyl-7-chlorobenzene also [b] thiophene be raw material, with toluene, water is that solvent, tetrabutylammonium chloride are catalyzer, in the presence of sodium hydroxide, carry out phase-transfer-catalyzed reactions, the preparation sertaconazole.

The synthetic method of described sertaconazole, 1), with the 1-(2 of 0.2mol its feature comprises:, the 4-dichlorobenzene)-also [b] thiophene, 12g sodium hydroxide, the 16ml 50% tetrabutylammonium chloride aqueous solution are dissolved in 240ml toluene, the 80ml water for 3-brooethyl-7-chlorobenzene of 2-(1-imidazoles) ethanol, 0.2mol, be warming up to 80 ℃, constant temperature stirred 4 hours, cooling; 2), add 80ml water, use the 4L extracted with diethyl ether for several times then, merge organic layer, use anhydrous sodium sulfate drying, filtration; 3), add the 12ml concentrated nitric acid under the stirring at room, separate out solid, filter; 4), use 95% ethyl alcohol recrystallization, drying under reduced pressure, the white solid sertaconazole.

The technical solution used in the present invention, easy and simple to handle, reaction conditions requires not harsh; Stable yield, cost is lower, is suitable for suitability for industrialized production.

1), embodiment embodiment: with the 1-(2 of 0.2mol, the 4-dichlorobenzene)-also [b] thiophene, 12g sodium hydroxide, the 16ml50% tetrabutylammonium chloride aqueous solution are dissolved in 240ml toluene, the 80ml water for 3-brooethyl-7-chlorobenzene of 2-(1-imidazoles) ethanol, 0.2mol, be warming up to 80 ℃, constant temperature stirred 4 hours, cooling; 2), add 80ml water, use the 4L extracted with diethyl ether for several times then, merge organic layer, use anhydrous sodium sulfate drying, filtration; 3), add the 12ml concentrated nitric acid under the stirring at room, separate out solid, filter; 4), use 95% ethyl alcohol recrystallization, drying under reduced pressure, white solid sertaconazole 59g, yield 59%, mp157-158 ℃.

Reaction of the present invention is as follows:

The present invention compares with the synthetic method of prior art, has following advantage: 1, the present invention utilizes phase-transfer-catalyzed reactions, and is easy and simple to handle, is suitable for suitability for industrialized production; 2, do not need to control anhydrous, oxygen free operation condition, cost is lower, stable yield; 3, by elementary analysis, infrared spectrum, proton nmr spectra, carbon-13 nmr spectra, mass spectrum Deng its chemical constitution of affirmation, content is greater than 98.5%.

Claims

1, a kind of synthetic method of sertaconazole, its feature comprises with 1-(2, the 4-dichlorobenzene)-2-(1-imidazoles) ethanol and 3-brooethyl-7-chlorobenzene also [b] thiophene be raw material, with toluene, water is that solvent, tetrabutylammonium chloride are catalyzer, in the presence of sodium hydroxide, carry out phase-transfer-catalyzed reactions, the preparation sertaconazole.

2, the synthetic method of sertaconazole according to claim 1,1), with the 1-(2 of 0.2mol its feature comprises:, the 4-dichlorobenzene)-also [b] thiophene, 12g sodium hydroxide, the 16ml50% tetrabutylammonium chloride aqueous solution are dissolved in 240ml toluene, the 80ml water for 3-brooethyl-7-chlorobenzene of 2-(1-imidazoles) ethanol, 0.2mol, be warming up to 80 ℃, constant temperature stirred 4 hours, cooling; 2), add entry, extracted with diethyl ether, merge organic layer, use anhydrous sodium sulfate drying, filtration; 3), add the 12ml concentrated nitric acid under the stirring at room, separate out solid, filter; 4), use 95% ethyl alcohol recrystallization, drying under reduced pressure, the white solid sertaconazole.