CN1358478A

CN1358478A - Apparatus for measuring blood flow velocity and rate

Info

Publication number: CN1358478A
Application number: CN 01129820
Authority: CN
Inventors: 邱汉婴; 李迪俊
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-10-29
Filing date: 2001-10-29
Publication date: 2002-07-17
Also published as: WO2003037180A1

Abstract

The present invention discloses a device for measuring blood flow velosity and rate, said device is formed from conduits with thermistor which are placed all around its surface. When the 5% glucose injection whose temp. is 0-5 deg.C is injected from end hole or side hole of the conduit, the blood whose temp. is reduced can be passed through for positions with thermistors, and the known distance between two points selected from the above-mentioned four positions is divided by the time required by blood flow passing through said two points, so that the instantaneous blood flow rate A and instantaneous blood flow rate B of said two positions of said arterial blood vessel or venous blood vessel can be calculated, and the A is divided by B, so that the instantaneous blood flow rate can be obtained.

Description

A kind of device of measuring blood flow rate and blood flow rate ratio thereof

The present invention relates to a kind of device of measuring blood flow rate and blood flow rate ratio thereof in the lumen of vessels.

Big in tremulous pulse and Venous system in the basis and clinical research of medium-sized blood vessel, often needs to understand the functional status of blood vessel, and wherein blood flow rate is one of important indicator.Big in the past, the blood flow rate of medium-sized tremulous pulse and vein blood vessel is measured three kinds of main method: 1, and utilize principle of Doppler to detect blood flow rate with the ultrasonic probe of ultrasonic doppler instrument; 2, utilize the Electromagnetic Flow principle to detect probe and settle its blood flow of position, calculate mean blood flow velocity according to this place's blood vessel cross-sectional area again; 3, utilize blood heat to change perception principle, detect blood flow rate with the Swan-Ganz conduit that is mounted with critesistor.At present, use always, the method of measuring blood flow rate in the lumen of vessels is a ultrasound Doppler's method, this method is that the ultrasonic probe with the ultrasonic doppler instrument makes the intravascular epidural catheter placement intracavity, utilize principle of Doppler to detect blood flow rate, but, in basis and clinical research work, be difficult to promote because this probe manufacturing process complexity costs an arm and a leg.The another kind of method of measuring blood flow rate in the lumen of vessels is that blood heat changes the perception method, to be mounted with the Swan-Ganz catheter positioning of critesistor in pulmonary artery in catheter proximal end, change by the perception blood heat, produce potential change, draw the temperature dilution curve, and calculate PBF speed.This blood flow rate algoscopy only can be measured PBF speed, and calculates the computational process complexity of PBF speed from the temperature dilution curve.

The objective of the invention is to provide a kind of and change perception principle according to blood heat, in lumen of vessels, measure greatly more easily, the device of the blood flow rate of medium-sized tremulous pulse and vein blood vessel and blood flow rate ratio thereof, so that big in tremulous pulse and Venous system, use in the basis of medium-sized blood vessel and the clinical research work, have characteristics simple in structure, that safety cost is low simultaneously.

The object of the present invention is achieved like this: the device that this kind measured blood flow rate and blood flow rate ratio thereof is the conduit that can insert in the lumen of vessels, its surface has everywhere (at a distance of known distance) to be mounted with can detect the critesistor that blood heat changes, it can link to each other with interface by lead, and interface can link to each other with the instrument of detecting and write down variations in temperature.Two openings (stomidium of catheter proximal end and the side opening of rear end of conduit) are arranged in the both sides that are mounted with the critesistor place, and link to each other with liquid injection port by pipeline.When measuring blood flow rate and blood flow rate rate of change thereof, when the contrary blood flow direction of this conduit is placed, inject 0-5 ℃ 5% glucose injection from the front opening of conduit, this place's blood heat descends, and the blood antegrade blood flow that temperature descends is successively by being mounted with four positions of critesistor on this conduit; When conduit antegrade blood flow direction is placed, inject 0-5 ℃ 5% glucose injection from the rear end side opening of conduit, this place's blood heat descends, and the blood that descends of temperature also antegrade blood flow successively by being mounted with four positions of critesistor on this conduit; Divided by this point-to-point transmission known distance, can calculate the instantaneous blood flow rate of this tremulous pulse or vein blood vessel with 2 points (two positions of selected combination in being mounted with four positions of the critesistor) required times (two temperature variation curve that occurs according to time order and function) of blood flow by selected combination in these 4.Because having everywhere (at a distance of known distance) to be mounted with, this catheter surface can detect the critesistor that blood heat changes, therefore, the instantaneous blood flow rate (instantaneous blood flow rate A and instantaneous blood flow rate B) at this tremulous pulse or two positions of vein blood vessel can be detected simultaneously, instantaneous blood flow rate ratio can be obtained divided by instantaneous blood flow rate B with instantaneous blood flow rate A.

The present invention only need settle three sleeving temperatures to change perception circuit (comprising critesistor and coupled lead) in the rear end of former Swan-Ganz conduit critesistor arrangement place again, just can be directly from greatly, survey blood flow rate and blood flow rate ratio thereof in medium-sized tremulous pulse and the venous lumen of vessels, and can simplify the computational process of blood flow rate and blood flow rate ratio thereof.Have characteristics easy and simple to handle, safe and reliable, that cost is low simultaneously.

(Fig. 1, Fig. 2 Fig. 3) provide concrete structure of the present invention by following embodiment and accompanying drawing thereof.

Accompanying drawing be the perspective view (Fig. 1) of the mensuration blood flow rate that proposes according to the present invention and blood flow rate rate of change device thereof and fundamental diagram (Fig. 2, Fig. 3).

Describe the details and the working condition of the concrete device that proposes according to the present invention in detail below in conjunction with accompanying drawing.This device is the different conduit of a Gent, its front end has a stomidium [1], it links to each other with liquid injection hole [2] by pipeline, and the place is mounted with critesistor [3,4 respectively in distance conduit stomidium different distance, 5,6] coupled lead and interface [7,8,9,10] link to each other, and interface can link to each other with the instrument of detecting and write down variations in temperature.In addition at the opposite side of this conduit that is mounted with critesistor, a side opening [11] is arranged, it is by pipeline link to each other with liquid injection hole [12] (Fig. 1).When the contrary blood flow direction [13] of conduit is placed (Fig. 2), 5% glucose injection from a certain amount of 0-5 ℃ of conduit liquid injection port [2] injection, glucose injection is in catheter proximal end opening [1] intravasation, this place's blood heat descends, and the blood antegrade blood flow that temperature descends is successively by being mounted with four positions [3 of critesistor, 4,5,6]; When conduit antegrade blood flow direction [14] is placed (Fig. 3), 5% glucose injection from a certain amount of 0-5 ℃ of conduit liquid injection port [12] injection, in the transcatheter rear end of glucose injection side opening [11] intravasation, this place's blood heat descends, and the blood that temperature descends also antegrade blood flow successively by being mounted with four positions [6 of critesistor, 5,4,3]; By connecting line through interface [10,9,8,7] link to each other with the instrument of detecting and write down variations in temperature, write down out four temperature variation curves according to time order and function, pass through two point [(3 of selected combination with blood flow, 4) or (5,6)] required time divided by selected combination this two the point [(3,4) or (5,6) known distance] can calculate the instantaneous blood flow rate (instantaneous blood flow rate A and instantaneous blood flow rate B) at two positions of this tremulous pulse or vein blood vessel, can obtain instantaneous blood flow rate ratio with instantaneous blood flow rate A divided by instantaneous blood flow rate B.

Claims

1, a kind of device of measuring blood flow rate and blood flow rate ratio thereof, this device is made of the conduit that is mounted with the critesistor of detecting the blood heat variation, it is characterized in that: have on this conduit at a distance of being mounted with everywhere of known distance and detect the critesistor [3 that blood heat changes, 4,5,6], it can be by lead and interface [7,8,9,10] link to each other, and interface can link to each other with the instrument of detecting and write down variations in temperature, two openings are arranged in the both sides that are mounted with the critesistor place, be the stomidium [1] of catheter proximal end and the side opening [11] of rear end of conduit, and link to each other by pipeline and liquid injection port [2,12].

2, a kind of device of measuring blood flow rate and blood flow rate ratio thereof according to claim 1, it is mounted with critesistor everywhere, and critesistor arrangement place is at a distance of certain distance.