CN1356101A

CN1356101A - Spot-removing cream

Info

Publication number: CN1356101A
Application number: CN 01128791
Authority: CN
Inventors: 王海棠
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-09-10
Filing date: 2001-09-10
Publication date: 2002-07-03
Anticipated expiration: 2021-09-10
Also published as: CN1174739C

Abstract

A spot-eliminating cream for treating chloasma and pigmented spots and protecting and whitening skin is prepared from matrix including white oil, self-emulsifying monoglyceride, polyethanediol, propanetiol, etc. liquid extract of Chinese-medicinal material including gingko leaf, liquorice root and Chuan-xiong rhizome, and distrilled water.

Description

QUBAN SHUANG

Described field: the invention belongs to a kind of cosmetics, it comprises the component and the preparation method of the QUBAN SHUANG cosmetics that contain medicinal herb components.The effect that it has treatment chloasma, pigmented spots, blood circulation promoting regulates qi, brightens.

Many patients are because face has pigmented spots, chloasma brings very big misery for patient's physical and mental health, many facial pigmented spots that are used for the treatment of are arranged now, the Chinese herbal medicine of chloasma, be coated in face pigmented spots are arranged, the chloasma part, to eliminate pigmented spots, chloasma, these medicines of CN1050284C as Patent Office of the People's Republic of China's retrieval can only be to the pigmented spots of face, chloasma is treated, and facial integrated beauty is held, skin protection, brighten unsatisfactory curative effect, the skin protection whitening effect that has is good, but do not treat facial pigmented spots, chloasma, and different QUBAN SHUANG ingredient differences, the effect difference.

Summary of the invention: the purpose of this invention is to provide a kind of component and preparation method of QUBAN SHUANG, can reach the effect that treatment chloasma, pigmented spots, blood circulation promoting regulates qi, skin protection are brightened with this QUBAN SHUANG.

The object of the present invention is achieved like this: QUBAN SHUANG, and it comprises that natural Chinese medicine plant and substrate forms, its set of dispense ratio is:

Its mesostroma: white oil 18～22%; Self emulsifying monoglyceride 3～7%; Macrogol 4000 3～7%; Glycerol 3～7%; Octadecanol 1-4%; Isopropyl palmitate 1～4%; Essence of Niobe 0.2～0.5%; Essence 0.8～1.2%;

Chinese medicine extraction liquid: Folium Ginkgo 2～4%; Radix Glycyrrhizae 1～4%; Rhizoma Chuanxiong 0.7～1.2%; All the other adding distil waters to 100%.

Described QUBAN SHUANG, its preparation method is: earlier Chinese medicine is cleaned, add water again, decocted 120 minutes, and filtered clarification then, collect herb liquid, evacuation sinks the vacuum emulsification chain with the water raw material, and the oil phase raw material is added oil tank, start stirring oil phase raw material and slowly sink the emulsifying of emulsifying chain, be warming up to 30 ℃ of 75 ℃-80 ℃ insulations, the pressurization discharging was displayed 24 hours, again check, finished product tinning then, warehouse-in.

Characteristics of the present invention are: because Radix Glycyrrhizae external major function: let out the effect of itching of fire, detoxifcation, detumescence, skin moistening, granulation promoting, pain relieving; The glycyrrhizin protective skin cream is a kind of beauty and skin care, treats dermopathic good cosmetics, is mixed with QUBAN SHUANG with Radix Glycyrrhizae, the Radix Astragali, Radix Puerariae extract, and external cooperates the interior application treatment chloasma, and effective percentage reaches 95%.Folium Ginkgo: washout speckle dispelling, skin whitening, this medicine external curing facial pigmented spots.Rhizoma Chuanxiong: have and regulate the flow of vital energy, blood circulation promoting and blood stasis dispelling, the collateral dredging effect in conjunction with clinical practice, proves that Rhizoma Chuanxiong has blood circulation promoting regulates qi, QUBAN SHUANG whitening efficacy, elects ministerial drug as, auxiliary monarch drug speckle dispelling is pleased color.The QUBAN SHUANG of the present invention preparation contains above-mentioned three kinds of Chinese medicine ingredients, is used for the speckle dispelling appearance can obtain good result.And QUBAN SHUANG of the present invention, prepare docimasiology, guaranteed the quality and the curative effect of medicine.

Described QUBAN SHUANG, medicine inspection method in process of production is:

The Rhizoma Chuanxiong method of inspection: get powder 2g, the 6ml that adds diethyl ether, merceration 4 hours filters, filtrate is concentrated into dried, residue is made test liquid with chloroform 1ml dissolving, and other gets ligustrazine and compares product, point sample is on same aluminium oxide CMC lamellae respectively, launch at 1: 1 with petroleum ether one chloroform, with iodine bismuth potassium reagent colour development, the test liquid chromatograph is showing identical orange colour mottle with reference substance chromatograph relevant position;

The Folium Ginkgo method of inspection: get this product powder 4g, add 50% acetone 100ml, reflux 3 hours, put cold, filter with absorbent cotton, filtrate evaporation acetone is put cold, residual liquid extracts 2 times with ethyl acetate, each 50ml, merge extractive liquid,, evaporate to dryness, residue 15% dissolve with ethanol, be added on the polyamides saddle post, use 5% ethanol elution, collect eluent 200ml, be concentrated into 50ml, put cold, concentrated with ethyl acetate extraction 2 times, 50ml at every turn, merge extractive liquid,, evaporate to dryness, residue makes dissolving with acetone 5ml, as need testing solution, other gets Semen Ginkgo lactone A, B, C and Semen Ginkgo lactone reference substance, add acetone and make the mixed solution that every 1ml contains 0.5mg, product solution is drawn each 5 μ 1 of above-mentioned kind solution in contrast, put respectively on the silica gel H lamellae that the same carboxymethylcellulose sodium solution that contains 4% sodium acetate prepares, with toluene-ethyl acetate-acetone-methanol (10: 5: 5: 0.6) be developing solvent, launching below 15 ℃, take out, dry, about 30 minutes of 140～160 heating, put under the Burdick lamp (365nm) and inspect, in the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color;

The Radix Glycyrrhizae method of inspection: get this product powder 1g, the 40ml that adds diethyl ether, reflux 1 hour, filter, medicinal residues add methanol 30ml, reflux 1 hour, filter, filtrate evaporate to dryness, residue add water 40ml makes dissolving, with n-butanol extraction 3 times, each 20ml merges n-butyl alcohol liquid, wash with water 3 times, evaporate to dryness, residue add methanol 5ml makes dissolving, as need testing solution, extracting liquorice control medicinal material 1g shines medical material solution in pairs with legal system in addition, again extracting liquorice acid ammonium reference substance, add methanol and make the solution that every 1ml contains 2ml, product solution is drawn each 1-2 μ l of above-mentioned three kinds of solution in contrast, puts respectively on the silica gel g thin-layer plate of using the preparation of 1% sodium hydroxide solution, with ethyl acetate-formic acid-glacial acetic acid-water (15: 1: 1: 2) be developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, it is clear to be heated to speckle colour developing at 105 ℃, puts under the ultraviolet light modulation (365nm) and inspects, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show same color fluorescence speckle; With contrast chromatograph corresponding position on, show identical orange-yellow fluorescence speckle.The present invention will be further described below in conjunction with the embodiment logic diagram.

Accompanying drawing 1 is the production preparation process logic diagram of embodiment QUBAN SHUANG.

As shown in the figure: earlier Chinese medicine is cleaned, add water again, decocted 120 minutes, filter clarification then, collect herb liquid, evacuation, the water raw material is sinked the vacuum emulsification chain, the oil phase raw material is added oil tank, start stirring oil phase raw material and slowly sink the emulsifying of emulsifying chain, be warming up to 30 ℃ of 75 ℃-80 ℃ insulations, the pressurization discharging was displayed 24 hours, check again, finished product tinning then, warehouse-in.

Claims

1, QUBAN SHUANG, it comprises that natural Chinese medicine plant and substrate forms, its set of dispense ratio is:

Chinese medicine extraction liquid: Folium Ginkgo 2～4%; Radix Glycyrrhizae 1～4%; Rhizoma Chuanxiong 0.7～1.2%; All the other

Adding distil water to 100%.

2, QUBAN SHUANG according to claim 1, its preparation method is: earlier Chinese medicine is cleaned, add water again, decocted 120 minutes, and filtered clarification then, collect herb liquid, evacuation sinks the vacuum emulsification chain with the water raw material, and the oil phase raw material is added oil tank, start stirring oil phase raw material and slowly sink the emulsifying of emulsifying chain, be warming up to 30 ℃ of 75 ℃-80 ℃ insulations, the pressurization discharging was displayed 24 hours, again check, finished product tinning then, warehouse-in.

3, QUBAN SHUANG according to claim 1, medicine inspection method in process of production is:

The Folium Ginkgo method of inspection: get this product powder 4g, add 50% acetone 100ml, reflux 3 hours, put cold, filter with absorbent cotton, filtrate evaporation acetone is put cold, residual liquid extracts 2 times with ethyl acetate, each 50ml, merge extractive liquid,, evaporate to dryness, residue 15% dissolve with ethanol, be added on the polyamides saddle post, use 5% ethanol elution, collect eluent 200ml, be concentrated into 50ml, put cold, concentrated with ethyl acetate extraction 2 times, 50ml at every turn, merge extractive liquid,, evaporate to dryness, residue makes dissolving with acetone 5ml, as need testing solution, other gets Semen Ginkgo lactone A, B, C and Semen Ginkgo lactone reference substance, add acetone and make the mixed solution that every 1ml contains 0.5mg, product solution is drawn each 5 μ 1 of above-mentioned kind solution in contrast, put respectively on the same silica gel H lamellae for preparing with the carboxymethylcellulose sodium solution that contains 4% sodium acetate, with toluene-ethyl acetate-acetone-methanol (10: 5: 5: 0.6) be developing solvent, launching below 15 ℃, take out, dry, about 30 minutes of 140～160 heating, put under the Burdick lamp (365nm) and inspect, in the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color;

The Radix Glycyrrhizae method of inspection: get this product powder 1g, the 40ml that adds diethyl ether, reflux 1 hour, filter, medicinal residues add methanol 30ml, reflux 1 hour, filter, filtrate evaporate to dryness, residue add water 40ml makes dissolving, with n-butanol extraction 3 times, each 20ml merges n-butyl alcohol liquid, wash with water 3 times, evaporate to dryness, residue add methanol 5ml makes dissolving, as need testing solution, extracting liquorice control medicinal material 1g shines medical material solution in pairs with legal system in addition, again extracting liquorice acid ammonium reference substance, add methanol and make the solution that every 1ml contains 2ml, product solution is drawn each 1-2 μ l of above-mentioned three kinds of solution in contrast, puts respectively on the silica gel g thin-layer plate of using the preparation of 1% sodium hydroxide solution, with ethyl acetate-formic acid-glacial acetic acid-water (15: 1: 1: 2) be developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, it is clear to be heated to speckle colour developing at 105 ℃, puts under the ultraviolet light modulation (365nm) and inspects, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show same color fluorescence speckle; With contrast chromatograph corresponding position on, show identical orange-yellow fluorescence speckle.