CN1355055A - Intensity-regualtable X-ray (gamma-ray) apparatus for treating disease - Google Patents
Intensity-regualtable X-ray (gamma-ray) apparatus for treating disease Download PDFInfo
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- CN1355055A CN1355055A CN 00132508 CN00132508A CN1355055A CN 1355055 A CN1355055 A CN 1355055A CN 00132508 CN00132508 CN 00132508 CN 00132508 A CN00132508 A CN 00132508A CN 1355055 A CN1355055 A CN 1355055A
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Abstract
An intensity-regulatable X-ray therapeutic apparatus is composed of internal and external ring frames, radiating sources, collimator system, and radiating field and dosage monitor. The internal ring frame is installed to external one and others are installed to the said internal ring frame. It features that it has 3 radiating sources with 120 deg plane intersecting angle to each other to generate space focusing and providing 1-27 irregular radiating fields in oxo-40X40 cm range.
Description
The X that the present invention relates to use in the tumour radiotherapy (γ) ray intensity modulated therapy device.
Radiotherapy is one of three big main means of oncotherapy, has 65～70% cancer patient will accept radiotherapy to some extent approximately.Conformal radiation therapy (Conformal RadiationTherapy) is a kind of new radiation therapy technology, can make the dose distribution shape of high dose area consistent on three-dimensional with the shape of tumor, effectively dose radiation is focused in the tumor area, the dosage of normal surrounding tissue is minimized, neoplastic lesion is implemented the irradiation of " operation " formula.
Realize three-dimensional conformal, irradiation field and launched field output must be satisfied following condition:
1. on the irradiation field direction, the shape of launched field must be consistent with the projection of shape of neoplastic lesion, avoids the direct irradiation to normal structure;
2. the close rate of all points must be adjusted in the launched field, makes each launched field reach the surface in tumor area and obtains uniform dosage.
Satisfy classical suitable shape of being called of first condition, two conditions satisfy simultaneously is called strength regulated shape-adapted (Intensity-Modulated Radiation Therapy-IMRT).Strength regulated shape-adapted radiation therapeutic (IMRT) will become the mainstream technology of 21 century tumour radiotherapy.
Conformal radiation therapy not only can focus on the dosage of lonizing radiation extent of disease, protection normal surrounding tissue, and can change traditional radiotherapy gradation pattern, increases fractionated dose and shortens cycle of oncotherapy.
Referring to Fig. 1, existing the most frequently used radiotherapy unit is for waiting center rotary-type single cobalt-60 γ line source or accelerator X line source, the employing flat focus, and as the how wild plane angle of cut or launched field rotary irradiation, irradiation field is bigger.
Existing X (γ) DNA mitochondrial DNA directional radiotherapy (being commonly called as X (γ)-cutter) adopts a plurality of little wild space boundling gradation high-dose irradiations.Referring to accompanying drawing 1, the X-cutter is to wait additional three grades of collimators on the centre type accelerator, utilizes the corner of therapeutic bed and the rotation of treatment frame, realizes the non-coplane rotating focus of little wild multi sphere.Referring to accompanying drawing 2, Sweden Elekta knife, and Chinese OUR knife, adopt 201 cobalt-60 source static space-focusings and 30 dynamic rotating focuss in cobalt-60 source respectively.Because the launched field number is more, launched field is very little, is respectively 18mm and 50mm at the maximum gauge of the launched field that waits center knife,, X-cutter.Because a plurality of little wild spaces boundling can be implemented single or gradation high-dose irradiation to pathological changes, and obtained better curative effect in intracranial and incidence and body tumor.But this treatment technology is when tumor size is big, must use big launched field, and this moment, the launched field focusing power of X (γ)-cutter weakened with the expansion of launched field, had greatly limited the tumor with X (γ)-cutter technology treatment large volume.
Centre type cobalt-60 treating machines and medical accelerators such as single radioactive source of the prior art though can utilize the rotation of the corner partner treatment frame of therapeutic bed, realize that non-coplane launched field focuses on irradiation, and weak point is:
1. the bit comparison difficulty is put in treatment, and easily makes mistakes;
2. the monitoring of launched field shape and dosage in the difficult enforcement irradiation;
3. the treatment plan design is difficult;
4. treatment time is longer;
5. do not possess the radiobiology function, promptly can not utilize the close rate factor and time, dosage to divide subfactor.
In order to overcome the deficiencies in the prior art, the object of the present invention is to provide a kind of therapy equipment of a new generation, it is X (γ) ray intensity modulated therapy device, it should both have the function of the strong and treatment large volume tumor of the accent of centre type therapy apparatus such as modern Dan Yuan, can keep the characteristics of X (γ)-cutter space-focusing again, and can become that radiotherapy is clinical gives full play to the radiobiology instrument that the close rate factor and time dosage divide subfactor.
In order to finish purpose of the present invention, special a kind of X (γ) ray intensity modulated therapy device that adopts of the present invention, in it comprises, outer two annular frameworks, radioactive source and collimator system thereof, and launched field and dosage monitoring device be loaded on altogether on the annular framework, interior annular framework is loaded on the outer ring frame, it is characterized in that this device adopts three radioactive sources, described three radioactive sources on interior annular framework are each other in 120 ° of plane angles of cut, interior annular framework can be around ± 30 ° of angles of outer ring frame rotation, in, the outer ring frame is together around ° angle, its vertical axis tilt ± 30, form space-focusing, the irregular launched field of the arbitrary shape of 1～27 0 * 0～40cm * 40cm scope is provided.
The radioactive source of described X (γ) ray intensity modulated therapy device be cobalt-60 γ line source or 〉=the 6MV-X radiographic source.Its collimator system is made up of one-level collimator, treatment collimator, and treatment collimator Y direction is a pair of independent collimator, and directions X is a multi-diaphragm collimator.This multi-diaphragm collimator can adopt conventional multi-diaphragm collimator, also can adopt multilobe collimater for regulating intensity.
In addition, the offside of each radioactive source in being installed on the annular framework is equipped with three groups of probe matrix that are used for launched field and dose monitoring independent of each other, and each probe is transferred strong unit launched field corresponding to one, the dosage that monitoring launched field shape and patient receive.
The advantage of X of the present invention (γ) line intensity modulated radiation therapy device is:
1, this device had both kept the characteristics of the how wild space-focusing of X (γ) DNA mitochondrial DNA targeted therapy system, had kept the advantage of the big wild treatment of conventional planning therapy apparatus again, can implement X (γ)-cutter formula irradiation to the large volume tumor.
2, theoretical proof, when the angle of cut between launched field shines tumor between 100 °～120 °, uncomplicated TCP maximum.This device adopts the 120 ° of angles of cut in three radioactive source (three launched fields) planes, has brought into play this advantage fully.
3, this device can provide nearly 9 groups every group 3 to intersect launched fields totally 27 non-coplane launched fields irradiations, fundamentally avoided because of to wear normal structure that the launched field irradiation causes poly-injury.
4, this device adopts many open countries to transfer simultaneously by force, and irradiation time shortens greatly, no matter adopt the irradiation of what launched fields, each treatment only need be put the position once to patient, can obtain the treatment load the same with the conventional therapy single port exposure.This be X (γ)-cutter treatment and conventional therapy can not compare.
5, this device can provide 9 groups every group 3 intersection launched fields, removes outside wherein 3 groups, and all the other 6 groups constitute non-coplane launched field each other.It will be to the clinical instrument that optimization time dosage fractionation of radiation is provided of radiotherapy.Because of 6 groups 3 intersection launched fields all focus on tumor (target area), if 6 groups of irradiations in turn, utilize the strong technology of transferring, can make tumor all obtain the uniform irradiation of high dose at every turn, and normal structure around the tumor and vitals just take turns to once irradiating every 6 times, have lowered the radiation damage of normal structure effectively.
6, this device is equipped with independently probe matrix at the offside of each radioactive source, can monitor the dose distribution of the patient in shape, position and the launched field of launched field simultaneously.
Can see that from following description this device has fundamentally solved the kill tumor in puzzlement oneth century of radiotherapy circle and wanted basic contradiction fast, that normal structure need be repaired its damage for more time.Just say on this meaning that this device is not only the strong therapy apparatus of physical modulated of latest generation, Xin Yidai Biotherapeutics machine especially.
Brief Description Of Drawings:
The key diagram that accompanying drawing 1 rotates for the existing non-coplane of X ray stereotactic irradiation multi-radian based on linear accelerator commonly used.
Accompanying drawing 2 is Elekta knife, and OUR knife, device sketch map.
Accompanying drawing 3 is intensity modulated therapy schematic representation of apparatus of the present invention.
Accompanying drawing 4 is intensity modulated therapy device cross-sectional view of the present invention.
Accompanying drawing 5 is the sketch map of intensity modulated therapy device of the present invention at ° angle, cross section internal rotation ± 30.
Accompanying drawing 6 is the tilt sketch map at ± 30 ° of angles of intensity modulated therapy device of the present invention in cross section.
Below with reference to the further indefiniteness of drawings and Examples ground the present invention is described.
Embodiment 1
Referring to accompanying drawing 4, a kind of X (γ) ray intensity modulated therapy device, adopt three radioactive sources (1,2,3) technology that (three launched fields) 120 ° of planes angle of cut is three-dimensional focuses on (being that flat focus and longitudinal and transverse section revolution space focus on), it can provide the irregular launched field (referring to accompanying drawing 3) of the arbitrary shape of 1～27 0 * 0～40cm * 40cm scope according to the needs of patient treatment.This device is three groups of collimator system independent of each other of three radioactive sources (6MV-X line source or cobalt-60 γ line sources) configuration, and every group of collimator system is made up of one-level collimator (4), treatment collimator (5).Treatment collimator (5) Y direction is a pair of independent collimator, and directions X is that one group of multi-diaphragm collimator is transferred by force.At the offside of radioactive source, three groups of probe matrix of being made up of semiconductor probe independent of each other (6) are housed, each probe is transferred strong unit launched field (5mm * 5mm, or 10mm * 10mm), monitoring launched field shape and patient's dosage corresponding to one.
Referring to accompanying drawing 4, whole therapy equipment is divided into interior annular framework (7), outer ring frame (8), and on the annular framework, interior annular framework was loaded on the outer ring frame in radioactive source and collimator system thereof and launched field and dosage monitoring device were loaded on altogether.
Referring to accompanying drawing 3, accompanying drawing 5 and accompanying drawing 6, interior annular framework can rotate ± 30 ° of angles around the outer ring frame, and inside and outside annular frame is together around ° angle, its vertical axis tilt ± 30.
110cGy/min (5000 Curie) is adopted in each cobalt-60 source, and the moment close rate that waits center (being focus) to locate can reach 330cGy/min (15000 Curie), reaches almost the same with accelerator 6MV-X line output dose rate.In addition, also can adopt accelerator 6MV-X line source, the single source dosage dose rate is 250cGy/min, to etc. the center close rate up to 750cGy/min.If 27 launched fields shine simultaneously in once irradiating, concerning the dark tumor of 10CM, the target dose rate is 1500～1800cGy/min (cobalt-60); 4000～4700cGy/min (6MV-X), and PDR≤110cGy/min that normal surrounding tissue is subjected to (cobalt-60); ≤ 250cGy/min (6MV-X).The treatment gain coefficient of obtaining because of the difference of close rate can reach 〉=14 (cobalts-60); 〉=16 (6MV-X).
Experimental example 1
To patient with esophageal carcinoma, 5 times weekly, 1 time on the 1st, the every group 3 wild wheel of intersection shines, totally 24 times, the tumor single dose is 300cGy, and accumulated dose is 72Gy, every wild tumor degree of depth is 10cm, cobalt-60 γ line 10cm * 10cm launched field, PDD=57%, every wild prescribed dose is Dm=175cGy, be that the normal structure maximal dose is 175cGy, shine weekly less than once, only be subjected to 4 irradiations total course of treatment, the treatment ratio of gains that obtains because of the improvement of time dose factor is:
Because the dosage that is involved in the normal structure in the launched field is all less than maximal dose 175cGy, the actual treatment ratio of gains that obtains is much larger than 14.
In sum, X of the present invention (γ) ray intensity modulated therapy device has unique radiobiology characteristics.
Claims (5)
1. an X (γ) ray intensity modulated therapy device, in it comprises, outer two annular frameworks, radioactive source and collimator system thereof, and launched field and dosage monitoring device be loaded on altogether on the annular framework, interior annular framework is loaded on the outer ring frame, it is characterized in that this device adopts three radioactive sources, described three radioactive sources on interior annular framework are each other in 120 ° of plane angles of cut, interior annular framework can be around ± 30 ° of angles of outer ring frame rotation, in, the outer ring frame is together around ° angle, its vertical axis tilt ± 30, form space-focusing, the irregular launched field of the arbitrary shape of 1～27 0 * 0～40cm * 40cm scope is provided.
2. X according to claim 1 (γ) ray intensity modulated therapy device, it is characterized in that described radioactive source be cobalt-60 γ line source or 〉=the 6MV-X radiographic source.
3. X according to claim 1 and 2 (γ) ray intensity modulated therapy device is characterized in that collimator system is made up of one-level collimator, treatment collimator, and treating collimator Y direction is a pair of independent collimator, and directions X is a multi-diaphragm collimator.
4. X according to claim 3 (γ) ray intensity modulated therapy device is characterized in that described multi-diaphragm collimator can adopt conventional multi-diaphragm collimator, also can adopt multilobe collimater for regulating intensity.
5. X according to claim 1 (γ) ray intensity modulated therapy device, the offside of each radioactive source in it is characterized in that being installed on the annular framework, three groups of probe matrix that are used for launched field and dose monitoring independent of each other are housed, each probe is transferred strong unit launched field corresponding to one, the dosage that monitoring launched field shape and patient receive.
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| CNB001325086A CN1160134C (en) | 2000-11-24 | 2000-11-24 | Intensity-regualtable X-ray (gamma-ray) apparatus for treating disease |
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| CNB001325086A CN1160134C (en) | 2000-11-24 | 2000-11-24 | Intensity-regualtable X-ray (gamma-ray) apparatus for treating disease |
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Cited By (13)
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|---|---|---|---|---|
| WO2012041127A1 (en) * | 2010-09-30 | 2012-04-05 | 宋世鹏 | Self-focusing radiation source apparatus and emission apparatus thereof |
| WO2012055098A1 (en) * | 2010-10-27 | 2012-05-03 | 玛西普医学科技发展(深圳)有限公司 | Radiotherapy apparatus guided by images |
| CN103105620A (en) * | 2013-01-10 | 2013-05-15 | 合肥超安医疗科技有限公司 | Photon energy deposition obtaining method based on three-dimensional mixing limited pencil-beam energy deposition core |
| CN103260700A (en) * | 2010-12-13 | 2013-08-21 | 皇家飞利浦电子股份有限公司 | Therapeutic apparatus comprising a radiotherapy apparatus, a mechanical positioning system, and a magnetic resonance imaging system |
| CN103386168A (en) * | 2013-07-17 | 2013-11-13 | 官爱平 | Radiotherapy system integrated with digital imaging equipment |
| WO2015062093A1 (en) * | 2013-11-01 | 2015-05-07 | 西安大医数码技术有限公司 | Multipurpose radiotherapy system |
| WO2019023901A1 (en) * | 2017-07-31 | 2019-02-07 | 西安大医数码科技有限公司 | Method and apparatus for controlling radiotherapy device, and radiotherapy system |
| CN109381161A (en) * | 2017-08-11 | 2019-02-26 | 维布络有限公司 | Cancer discrimination method and device |
| CN109513116A (en) * | 2017-09-18 | 2019-03-26 | 胡逸民 | A kind of ray intensity modulated therapy device |
| CN109513119A (en) * | 2018-11-12 | 2019-03-26 | 武汉大学 | A kind of volume rotation intensity modulated radiation therapy plan collimator orientation optimization method |
| CN111068191A (en) * | 2019-12-30 | 2020-04-28 | 上海联影医疗科技有限公司 | Radiotherapy system |
| US10716956B2 (en) | 2015-04-21 | 2020-07-21 | Our United Corporation | Radiotherapeutic device |
| US10806949B2 (en) | 2016-11-15 | 2020-10-20 | Our United Corporation | Method and system of generating radiation treatment plan |
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2000
- 2000-11-24 CN CNB001325086A patent/CN1160134C/en not_active Expired - Lifetime
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| CN102446571A (en) * | 2010-09-30 | 2012-05-09 | 上海世鹏实验室科技发展有限公司 | Self-focusing radioactive source device and radiation device thereof |
| WO2012041127A1 (en) * | 2010-09-30 | 2012-04-05 | 宋世鹏 | Self-focusing radiation source apparatus and emission apparatus thereof |
| CN102446571B (en) * | 2010-09-30 | 2014-03-05 | 上海世鹏实验室科技发展有限公司 | Self-focusing radioactive source device and radiation device thereof |
| WO2012055098A1 (en) * | 2010-10-27 | 2012-05-03 | 玛西普医学科技发展(深圳)有限公司 | Radiotherapy apparatus guided by images |
| CN103260700A (en) * | 2010-12-13 | 2013-08-21 | 皇家飞利浦电子股份有限公司 | Therapeutic apparatus comprising a radiotherapy apparatus, a mechanical positioning system, and a magnetic resonance imaging system |
| US9511242B2 (en) | 2010-12-13 | 2016-12-06 | Koninklijke Philips Electronics N.V. | Therapeutic apparatus comprising a radiotherapy apparatus, a mechanical positioning system, and a magnetic resonance imaging system |
| CN103105620B (en) * | 2013-01-10 | 2016-06-08 | 合肥克瑞斯信息科技有限公司 | A kind of photon energy deposition acquisition methods based on the limited form of a stroke or a combination of strokes beam energy deposition core of three-dimensional hybrid |
| CN103105620A (en) * | 2013-01-10 | 2013-05-15 | 合肥超安医疗科技有限公司 | Photon energy deposition obtaining method based on three-dimensional mixing limited pencil-beam energy deposition core |
| CN103386168A (en) * | 2013-07-17 | 2013-11-13 | 官爱平 | Radiotherapy system integrated with digital imaging equipment |
| CN103386168B (en) * | 2013-07-17 | 2016-09-14 | 官爱平 | A kind of radiotherapy system of integrated digital imaging device |
| WO2015062093A1 (en) * | 2013-11-01 | 2015-05-07 | 西安大医数码技术有限公司 | Multipurpose radiotherapy system |
| US9526919B2 (en) | 2013-11-01 | 2016-12-27 | Cybermed Technologies (Xi'an) Co., Ltd. | Multi-purpose radiation therapy system |
| US10716956B2 (en) | 2015-04-21 | 2020-07-21 | Our United Corporation | Radiotherapeutic device |
| US11116997B2 (en) | 2015-04-21 | 2021-09-14 | Our United Corporation | Radiotherapeutic device |
| US10806949B2 (en) | 2016-11-15 | 2020-10-20 | Our United Corporation | Method and system of generating radiation treatment plan |
| WO2019023901A1 (en) * | 2017-07-31 | 2019-02-07 | 西安大医数码科技有限公司 | Method and apparatus for controlling radiotherapy device, and radiotherapy system |
| CN109381161A (en) * | 2017-08-11 | 2019-02-26 | 维布络有限公司 | Cancer discrimination method and device |
| CN109381161B (en) * | 2017-08-11 | 2022-02-08 | 维布络有限公司 | Cancer identification method and apparatus |
| CN109513116A (en) * | 2017-09-18 | 2019-03-26 | 胡逸民 | A kind of ray intensity modulated therapy device |
| CN109513119A (en) * | 2018-11-12 | 2019-03-26 | 武汉大学 | A kind of volume rotation intensity modulated radiation therapy plan collimator orientation optimization method |
| CN111068191A (en) * | 2019-12-30 | 2020-04-28 | 上海联影医疗科技有限公司 | Radiotherapy system |
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