CN1353620A - Cosmetic deilation kit with photosensitizer - Google Patents
Cosmetic deilation kit with photosensitizer Download PDFInfo
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- CN1353620A CN1353620A CN00808387A CN00808387A CN1353620A CN 1353620 A CN1353620 A CN 1353620A CN 00808387 A CN00808387 A CN 00808387A CN 00808387 A CN00808387 A CN 00808387A CN 1353620 A CN1353620 A CN 1353620A
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- cosmetic tool
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00476—Hair follicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B2018/1807—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using light other than laser radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0644—Handheld applicators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0645—Applicators worn by the patient
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Abstract
A marker substance includes a photosensitive toxic material to tag subcutaneous hair growth cells of a target zone of skin. Illumination apparatus is used to illuminate the skin in the target zone with light of a wavelength selected to effect preferential interaction with the hair growth cells tagged with the marker substance, resulting in a toxic effect inhibiting the hair growth capability of the tagged illuminated cells; wherein, in the kit the marker substance may be provided in a form comprising discrete portions of the photosensitive toxic material and a carrier material, the portions to be mixed prior to application to the target zone. Additionally or alternatively, the illumination apparatus includes an applicator configured to deliver non-laser light and/or configured to be placed against the target zone skin to deliver the illumination to the tagged hair growth cells.
Description
The present invention relates to a kind of cosmetic deilation kit.
It is current a kind of effective and secular method that is used for the hair removing beauty treatment that laser hair is removed.A kind of exemplary laser depilation technology is open in EP-A-0732895.In this technology, the high intensity laser beam energy exposure is to skin, thereby heating ring is around the hair of hair follicle selectively, causes the damage of hair growth tissue.If damage enough fully, then can destroy hair follicle effectively, and hair will not regrowed.This technology exists drawback, and one of them is exactly the formation of cicatrix and the variation of pigment to occur.This situation especially appears at the individual that will treat and has casting skin and/or light hair.This technology is also considerably slow, because the target area need be covered by laser pulse repeatedly.
US-A-5669916 discloses a kind of technology, in this technology, before a kind of heliosensitivity toxic material enters into this hair follicle along the path of removed hair, at first extracts hair from hair follicle.Then, activate this toxic material by using laser irradiation.
Invented a kind of improving technology now.
According to first aspect, the invention provides a kind of cosmetic tool case that is used to forbid hair growth, this workbox comprises:
A) a kind of mark substance comprises a kind of heliosensitivity toxic material, and it is used for the subcutaneous hair growth cell of labelling skin target area; With
B) irradiation unit, it is used to use the skin in a kind of rayed target area of selected wavelength, make it to come the preferential interaction of the hair growth cell of labelling, thereby produce the hair growth ability that a kind of deleterious result suppresses the cell of labelling irradiation with the usage flag material; Wherein:
(i) provide mark substance with a kind of form, what promptly this mark substance comprised this heliosensitivity toxic material and a kind of carrier material separates (non-mixing) part, and before being applied to the target area, this part will be mixed; And or,
(ii) this irradiation unit comprises an applicator, and its configuration is used for transmitting non-laser and/or configuration is used for to the landing area placed, irradiation is passed to the hair growth cell of labelling.
This heliosensitivity toxic material is that a kind of toxicity is exposed to the material of enough energy to increase under the predetermined wavelength irradiation that is transmitted with it substantially.This material is ALA (alanine); This or other material is being known in the art, and for example description is arranged in US-A-5669916.
Preferably a kind of into material of skin that is absorbed easily of carrier material, it is preferably and comprises humidifier or absorbable lubricant, and it carries this heliosensitivity toxic material with a kind of dissolved form or alternate manner.Any disadvantageous interaction takes place in order to suppress material before being applied on the skin of target area, it is crucial keeping this carrier to separate before using with the heliosensitivity toxic material.
Prepare the part of heliosensitivity toxic material and carrier material with a kind of estimated rate.In one embodiment, this ratio can be that about 25% heliosensitivity toxic material is than about 75% carrier material.
This workbox preferably comprises an allotter or a dispensing device for container, and it is used for the distribute labels material.
Be used to hold the container of carrier material and/or heliosensitivity toxic material, preferably can make the heliosensitivity toxic material obtain shielding.
A kind of mixing apparatus preferably is provided, and it is used to mix heliosensitivity toxic material and carrier material.This mixing apparatus allows that preferably heliosensitivity toxic material and carrier material are mixing in the enclosed areas substantially with user.
The container that is preferably used in splendid attire heliosensitivity toxic material and carrier material comprises sealing area separately, the sealing zone is splendid attire heliosensitivity toxic material and carrier material respectively, this zone design becomes can split selectively or break, and mixes to allow material.Can a mixed zone be set in its contiguous rupturable seal district, this mixed zone preferably distributes outlet to communicate with one.
This irradiation unit preferably comprises window equipment, and it is configured to be used for covering target area skin, and this irradiation is launched via window equipment.
In one embodiment, this irradiation unit comprises an irradiation applicator, and it has flexible structure, and this structural design is used for consistent with target area skin body part.
This device preferably comprises:
(a) a kind of irradiation applicator structure, its configuration are used for transmitting irradiation on a predetermined area;
(b) a kind of waveguide that is connected with this irradiation applicator; With
(c) a kind of along the radiative light source of waveguide.
This irradiation unit preferably comprises a kind of irradiation applicator structure, and it has internal light reflection wall and a light transit area equipment that is associated, and this equipment allows reflected light to pass through.For example, can make the applicator structure comprise one or more snippets optical fiber and make it the function that realizes that above-mentioned permission reflected light passes through, preferably the auroral poles structure has the optical fiber of multistage length, and this length section is configured to can be at the zones of different transmission light of auroral poles structure.
Mark substance preferably can preferentially be absorbed or labelling by the hair growth cell in the target area.The remainder that is not absorbed by the hair growth cell in the used mark substance is preferably by metabolism or the elimination from tissue of normal physical activity.Have been found that this technology according to the present invention is that the machinery/physics that carries out in advance that effective not even needs are mentioned loses hair or feathers in US-A-5669916.This epilation step is discouraging really, because it exists unnecessary damage and misery.
Be used for the hair growth cell that is defined as target preferably so-called ' stem ' cell of labelling, this cell is in hair follicle ' protrusion ' zone (being adjacent to sebaceous gland).In case hair is finished a growth cycle, by destroying effectively or making this ' stem ' cell invalid, will forbid beginning a new hair cycle, it is suitably movable to suppress hair follicle thus.Therefore this mark substance is selected to preferentially labelling ' stem ' cell.
This mark substance preferably is applied on the skin of target area partly.This mark substance penetrates into this skin and comes preferentially target-marking cell (being typically by preferentially absorbing).This mark substance is more preferably and comprises a kind of smooth medicine, for example 5-alanine (5-ALA).Be ideally, provide medicine, for example adopt emulsifiable paste or similar form with a kind of accessible partly form.
Irradiates light and mark substance interact, and are preferably the hair growth that causes expecting and are suppressed.This interaction can come down to photochemistry and/or photothermy.Interact for photochemistry, a kind of light of predetermined wavelength is induced a kind of chemical reaction between the cell of mark substance and labelling, and it causes the destruction of labeled cell or invalid.Interact for photo-thermal, incident illumination makes the temperature in the labeled cell be elevated to a kind of sufficient degree and destroys the cell of labelling or make it and lost efficacy.
The irradiation light wavelength preferably is selected to it can be labeled material (or labeled cell) absorption.The optical absorption characteristic that the irradiation light wavelength is more preferably substantially with mark substance is complementary.
Irradiates light is preferably substantially in the 500nm-1000nm wave-length coverage.Light preferably is concentrated in the narrow relatively bandwidth range, and this bandwidth is in above-mentioned wave-length coverage.Can be by the filtering of light or the light emitting devices of employing emission discrete wavelength (or wavelength band) be reached above-mentioned target.For example adopt the 5-ALA material that serves as a mark to come labeled cell here.Preferably irradiates light comprises one or more wavelength in the 600nm-650nm scope substantially.
This irradiates light for example can be laser (comprising semiconductor laser), white light (preferably filtered) or LED light.
Light intensity is determined by the total amount that this light of needs produces interactional light necessary between labeled cell.Yet usually the intensity that needs will be lower than the light intensity in formerly the laser depilation technology substantially.This makes this technology be fit to guideless " family " more and uses.
This light can be modulated into pulse or use as continuous wave.This light typically covers the target area, and this target area is typically a kind of area in the 0.5cm2-10cm2 scope, is more preferably 1cm2-5cm2.Be applied to the energy preferably substantially in the 40J scope or still less (preferably 25J or still less) of each pulse of target area.
Owing to can use low-intensity and non-laser, thereby also make can a more large-area target area simultaneously illuminatedly, and reduced the danger of skin calcination.This technology is therefore more safely with quick.
Only further describe the present invention with one below with reference to accompanying drawings as the specific embodiment of example, in these accompanying drawings:
Fig. 1 is the schematic diagram of mammal hair follicle;
Fig. 2 is the schematic diagram that is similar to Fig. 1, the phase I during its expression alopecia technology is used;
Fig. 3 is the schematic diagram that is similar to Fig. 1 and Fig. 2, and it represents the stage afterwards in this technology;
Fig. 4 and Fig. 5 are respectively a kind of schematic plan view and side view that is used for the dispensing device for container of mark substance according to the present invention;
Fig. 6 and Fig. 7 represent the alternative conventional embodiment of the irradiation unit that includes in the workbox of the present invention;
Fig. 8 is a kind of laser diode irradiation unit sketch that includes in the workbox of the present invention;
Fig. 9 is a kind of LED irradiation unit sketch that includes in the workbox of the present invention;
Figure 10 includes " white light " irradiation unit sketch in the workbox of the present invention;
Figure 11 is alternative " white light " irradiation unit sketch that includes in the workbox of the present invention;
Figure 12 is a kind of pad or the lamellar applicator structured illumination device sketch that includes in the workbox of the present invention;
Figure 13 is the applicator pad of Figure 12 or the perspective view of sheet;
Figure 14 is used for the pad of Figure 12 and 13 or the optical fiber cutaway view of sheet; With
Figure 15 is the summary rip cutting figure of the optical fiber of Figure 14.
With reference to these figure and at first with reference to figure 1, the figure invading the exterior shows people's hair follicle, and it supports a hair and does 1, and this hair is done epidermis 2 and the corium 3 that the skin of mammal skin tissue is passed in growth." stem " cell 7 appears at " protrusion " zone 4, this region adjacent sebaceous gland 5.Stalk cell has high relatively renewal/life cycle and is the reason that causes that hair is periodically grown from hair follicle.
The invention provides the pharmaceutical formulation of a kind of 5-of comprising alanine (5-ALA), be applied to the outer surface of skin 6 with a kind of Local treatment form.Selecting medicine 5-ALA is that it can optionally be absorbed and be retained in the stalk cell 7 because when it penetrates into skin corium 3 (via epidermis 2), thus labelling stalk cell effectively.The medicine concentrate that can not be absorbed in the stalk cell 7 is eliminated by metabolism and from tissue by the normal activity of health.
Through a predetermined period time, make excessive " labelling " medicine from the tissue of target area, remove (rather than from " labelling " stalk cell 7 place to go), adopt the target area of a kind of irradiation unit 9 from the outside direct irradiation skin of health, this device provides a kind of light of preselected wavelength, the distinctive absorbing wavelength of its wavelength and labeled drug preliminary election be complementary (now labelling stalk cell 7)
The light intensity that control provides and the persistent period of light, so no matter to be that the photochemistry of the stalk cell 7 of light and labelling interacts or carries out the control that photo-thermal interacts (or comprising both), this effect causes the inefficacy of the stalk cell 7 of being correlated with or destroyed, and the organization material around not destroying substantially or make it to lose efficacy.The activity inhibited of consequently labelling and stalk cell that lost efficacy makes it and can not produce hair again from relevant hair follicle.
This technology by labelling/demarcation optionally with preferentially destroy stalk cell (with the relevant matches of irradiates light wavelength) and make it possible to use relative low intensive light, the light of this intensity can cover bigger skin target area, makes that a relatively large hair district that covers skin can be simultaneously processed.Typically, the light that sends from irradiation unit 9 is modulated into pulse, makes skin heat relax and appears between the consecutive pulses.Typically, before allowing that the tangible heat of skin is lax, the energy that offers skin surface by irradiation unit 9 can not exceed 25J.
Irradiation unit can comprise laser instrument, semiconductor laser, white light device (be typically and have a wave filter) or a LED matrix.The wavelength bandwidth of emission preferably (can be finished by filtering) in the 600nm-650nm scope substantially if desired, here with the 5-ALA thing that serves as a mark.
This technology used according to the invention is finished the low-intensity performance of the light that depilation needs, and when comparing with laser capillary method removal technology formerly, makes the safety that this technology can be relative.Preparation and the irradiation unit that can therefore sell medicine are used for " family " use as a kind of userkit.
With reference to figure 4 to 15, a kind of " domestic " workbox that is used to improve looks depilation will typically comprise a power supply and light-emitting device 10,11 (seeing Fig. 6 and 7) is used to be directly connected to main power source.Device 10,11 or comprise and be electrically connected to a light source 12 flexibly, it is used for the application of illumination radiation to skin, or " fixing " light source 13 and fiber optic connector 14, and it is connected to an applicator 16.
The necessary assembly of other of this workbox is a mark substance, and this mark substance generally (is seen Figure 4 and 5) in container 20, and this container comprises a heat seal plastic containers/allotter 20 with closed chamber 21,22,23.
Closed chamber 21 contains the ALA material, and closed chamber 23 has humidifier/lubricant carrier cream.Hands is pinched pressure breaks sealing wax 24,25, and corresponding material is advanced in the mixing chamber 22 from chamber 21,23, this indoor they become and fully directly mix.Lid 26 ends at spout 27 break subsequently, allow that under hand ALA and carrier mixture are extruded dispensing device for container 20.
Dispensing device for container 20 guarantees that ALA medicine and carrier are mixed in proportion exactly, and this mixing can be performed until when using.
Next mixture is applied to the skin target area partly, the time period that wait subsequently needs allows the concentration of the ALA in the non-destination organization to reduce to need low-level, and irradiation unit is arrived skin and opening power.
Can use multi-form irradiation unit.Device 110 among Fig. 8 comprises a laser diode light source 125, and it is included in the containment vessel 126, and comprises focusing lens 127, and disposing this eyeglass is to penetrate by protection window 128 in order to ensure light.Typically keep the skin of 128 pairs of landing areas of window to guarantee that irradiates light is delivered to the target area exactly.
In the embodiment shown in Fig. 9, utilize a kind of two dimension (2D) array LED (light emitting diode) 225.Focusing lens 227 guarantees that light launches by protecting window 228, and the configuration among this window and Fig. 8 is similar.
In device shown in Figure 10, use a kind of electric lamp filament " white light " source.Light source 325 is surrounded by a containment vessel 326, and this containment vessel comprises a suitable reflecting surface 327, and it is configured to a light and launches this shell via protection window 328.
In the embodiment shown in fig. 11, use a kind of white light filament sources 325 again.In this embodiment, use a kind of internal reflection light pipe (for example optical fiber).This optical fiber can be connected to an optoacoustic and extremely go up, and this applicator as mentioned below is connected on the skin.
The device of Figure 12 is represented a kind of applicator pad or chip architecture 426, and it typically is flexible in fact, allows pad 426 consistent with the shape of its human body parts that is applied to.In addition, shown in Figure 13 to 15, light shines pad or chip architecture 426 by a flexible optical fiber 435, and this optical fiber has a connector 436, and its configuration corresponding connector 437 that is used to be connected, this connector are used for pad or chip architecture.This pad or chip architecture 426 have the fiber array 440 of an embedding, and it comprises the gap length section of a series of optical fiber 441, and this optic fibre extension passes this pad or chip architecture.In the embodiment shown in fig. 13, fiber path length forms a kind of snakelike arrangement, though the path of many connections arranged side by side will also provide a kind of suitable and spendable arrangement.As shown in figure 14, optical fiber 440 comprises a reflecting surface coating 442, and it surrounds a center 443.This overlay coating 442 is guaranteed total internal reflection around the circumference of optical fiber, but except the exposed length of window 445, can be by this window emission light.
Pad shown in Figure 13 to 15 or chip architecture provide a suitable arrangement, and in this was arranged, light can suitablely be distributed on the large area skin surface with mode safety widely with a kind of.
Distinctive advantage of the present invention is that it is designed to carrier and is in the light sensitivity toxic material and separates , independently in the packaged unit, and mix easily when needing, thereby guarantee to avoid because of easily mixed Close or the inaccurate adverse effect that causes of dosage. Be configured to transmit non-laser and/or be configured to and use Come the irradiation unit to the landing area placed, also have safe advantage, and guarantee in the treatment phase Between the degree of skin raying consistent. Above-mentioned advantage is so that this tool box is particularly suitable for user/family expenses.
Claims (15)
1, a kind ofly be used to forbid hair growth cosmetic tool case, this workbox comprises:
A) a kind of mark substance comprises a kind of heliosensitivity toxic material, and it is used for the subcutaneous hair growth cell of labelling skin target area; With
B) be used to use the irradiation unit of the skin in a kind of rayed target area of selected wavelength, under this wavelength, irradiates light and usage flag material come the hair growth cell of labelling to realize preferential the interaction, cause a kind of deleterious result, suppress the hair growth ability of the cell of labelling irradiation; Wherein:
(i) provide mark substance with following form: this mark substance comprises the separated portions of this heliosensitivity toxic material and a kind of carrier material, and this part will be mixed before being applied to the target area; And or,
(ii) this irradiation unit comprises an applicator, and its configuration is used for transmitting non-laser and/or configuration and is used for the landing area placed is transmitted the irradiation of the hair growth cell of labelling.
2, a kind of cosmetic tool case according to claim 1 is wherein prepared the part of heliosensitivity toxic material and carrier material with a kind of estimated rate.
3, a kind of cosmetic tool case according to claim 1 and 2 comprises an allotter, and it is used for the distribute labels material.
4,, comprise that one is used to hold carrier material and or the container of heliosensitivity toxic material according to the described a kind of cosmetic tool case of any one claim of front.
5, a kind of cosmetic tool case according to claim 4, wherein this container shield heliosensitivity toxic material.
6,, wherein be provided for mixing the mixing apparatus of heliosensitivity toxic material and carrier material according to the described a kind of cosmetic tool case of any one claim of front.
7, a kind of cosmetic tool case according to claim 6, wherein this mixing apparatus allows that heliosensitivity toxic material and carrier material mix substantially with in the user enclosed areas at one.
8, according to the described a kind of cosmetic tool case of any one claim of front, wherein a kind of container that is used to hold heliosensitivity toxic material and carrier material comprises sealing area separately, the sealing zone holds heliosensitivity toxic material and carrier material respectively, dispose this zone and be used for selectively breach or break, thereby allow that material mixes.
9, a kind of cosmetic tool case according to claim 8 wherein provides a mixed zone, its contiguous rupturable seal district, and this mixed zone distributes outlet to communicate with one.
10, according to the described a kind of cosmetic tool case of any one claim of front, wherein this irradiation unit comprises the window equipment surface, and it is configured to cover target area skin, and this irradiation is launched via window equipment.
11, according to the described a kind of cosmetic tool case of any one claim of front, wherein this irradiation unit comprises an irradiation applicator, and it has flexible structure, disposes the body part that this structure meets target region skin.
12, according to the described a kind of cosmetic tool case of any one claim of front, wherein this device comprises:
(a) a kind of irradiation applicator structure, its configuration are used for transmitting irradiation on a large tracts of land;
(b) a kind of waveguide that is connected with this irradiation applicator; With
(c) a kind of along the radiative light source of waveguide.
13, according to the described a kind of cosmetic tool case of any one claim of front, wherein this device comprises a kind of irradiation applicator structure, and it has the internal light reflection wall light transit area equipment related with one, and this equipment allows reflected light to pass through.
14, a kind of cosmetic tool case according to claim 13, wherein this applicator structure comprises one or more fiber lengths sections.
15, according to claim 13 or 14 described a kind of cosmetic tool casees, wherein this applicator structure comprises a plurality of fiber lengths sections, disposes this length and is used for transmitting light in the zones of different of applicator.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9912998.3 | 1999-06-04 | ||
| GBGB9912998.3A GB9912998D0 (en) | 1999-06-04 | 1999-06-04 | Depilation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1353620A true CN1353620A (en) | 2002-06-12 |
Family
ID=10854730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00808387A Pending CN1353620A (en) | 1999-06-04 | 2000-06-05 | Cosmetic deilation kit with photosensitizer |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1183071A1 (en) |
| JP (1) | JP2003501168A (en) |
| KR (1) | KR20020023947A (en) |
| CN (1) | CN1353620A (en) |
| AU (1) | AU5094500A (en) |
| BR (1) | BR0012108A (en) |
| CA (1) | CA2376204A1 (en) |
| GB (1) | GB9912998D0 (en) |
| IL (1) | IL146816A0 (en) |
| MX (1) | MXPA01012416A (en) |
| NO (1) | NO20015808L (en) |
| WO (1) | WO2000074781A1 (en) |
| ZA (1) | ZA200109721B (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107149726A (en) * | 2017-06-21 | 2017-09-12 | 张健 | Weak pulse washes life cosmetology depilator off |
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| EP1566149A1 (en) | 1998-03-12 | 2005-08-24 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation of the skin |
| US6458257B1 (en) | 1999-02-09 | 2002-10-01 | Lynntech International Ltd | Microorganism control of point-of-use potable water sources |
| EP1665996A3 (en) * | 2001-03-02 | 2007-11-28 | Palomar Medical Technologies, Inc. | Apparatus and method for photocosmetic and photodermatological treatment |
| DE10112470B4 (en) * | 2001-03-15 | 2008-02-28 | Keller, Ruprecht, Priv.-Doz. Dr.Dr. | A method for sample identification in a mammal and kit for carrying out this method |
| ATE521296T1 (en) * | 2001-05-23 | 2011-09-15 | Palomar Medical Tech Inc | COOLING SYSTEM FOR A PHOTOCOSMETIC DEVICE |
| AU2002316500A1 (en) | 2001-07-02 | 2003-01-21 | Palomar Medical Technologies, Inc. | Laser device for medical/cosmetic procedures |
| CN1329008C (en) | 2002-06-19 | 2007-08-01 | 帕洛玛医疗技术公司 | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
| US7856985B2 (en) | 2005-04-22 | 2010-12-28 | Cynosure, Inc. | Method of treatment body tissue using a non-uniform laser beam |
| JP5010327B2 (en) | 2006-06-26 | 2012-08-29 | パナソニック株式会社 | Hair growth regulator |
| US7586957B2 (en) | 2006-08-02 | 2009-09-08 | Cynosure, Inc | Picosecond laser apparatus and methods for its operation and use |
| KR100817363B1 (en) * | 2007-04-09 | 2008-03-26 | 김동호 | An irradiator for laser treatment |
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| GB9325109D0 (en) | 1993-12-08 | 1994-02-09 | Sls Wales Ltd | Depilation |
| US5474528A (en) * | 1994-03-21 | 1995-12-12 | Dusa Pharmaceuticals, Inc. | Combination controller and patch for the photodynamic therapy of dermal lesion |
| US5519534A (en) * | 1994-05-25 | 1996-05-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane |
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| WO1999010046A1 (en) * | 1997-08-25 | 1999-03-04 | Advanced Photodynamic Technologies, Inc. | Treatment device for topical photodynamic therapy and method of making same |
-
1999
- 1999-06-04 GB GBGB9912998.3A patent/GB9912998D0/en not_active Ceased
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2000
- 2000-06-05 BR BR0012108-8A patent/BR0012108A/en not_active Application Discontinuation
- 2000-06-05 WO PCT/GB2000/002170 patent/WO2000074781A1/en not_active Application Discontinuation
- 2000-06-05 CN CN00808387A patent/CN1353620A/en active Pending
- 2000-06-05 KR KR1020017015638A patent/KR20020023947A/en not_active Application Discontinuation
- 2000-06-05 MX MXPA01012416A patent/MXPA01012416A/en unknown
- 2000-06-05 JP JP2001501311A patent/JP2003501168A/en not_active Withdrawn
- 2000-06-05 CA CA002376204A patent/CA2376204A1/en not_active Abandoned
- 2000-06-05 IL IL14681600A patent/IL146816A0/en unknown
- 2000-06-05 EP EP00935403A patent/EP1183071A1/en not_active Withdrawn
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107149726A (en) * | 2017-06-21 | 2017-09-12 | 张健 | Weak pulse washes life cosmetology depilator off |
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|---|---|
| IL146816A0 (en) | 2002-07-25 |
| NO20015808L (en) | 2002-01-21 |
| CA2376204A1 (en) | 2000-12-14 |
| NO20015808D0 (en) | 2001-11-28 |
| BR0012108A (en) | 2002-07-02 |
| EP1183071A1 (en) | 2002-03-06 |
| JP2003501168A (en) | 2003-01-14 |
| ZA200109721B (en) | 2002-09-25 |
| WO2000074781A1 (en) | 2000-12-14 |
| AU5094500A (en) | 2000-12-28 |
| MXPA01012416A (en) | 2005-04-19 |
| GB9912998D0 (en) | 1999-08-04 |
| KR20020023947A (en) | 2002-03-29 |
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