CN1352997A

CN1352997A - High-power semiconductor laser apparatus for treating tumors

Info

Publication number: CN1352997A
Application number: CN 00120556
Authority: CN
Inventors: 陶文基; 黄玉峰
Original assignee: Individual
Current assignee: Individual
Priority date: 2000-11-04
Filing date: 2000-11-04
Publication date: 2002-06-12

Abstract

A high-power semiconductor laser apparatus for treating tumor is composed of semiconductor laser device, current regualtor of light source, light power display, electronic timing indicator, alarm, overcurrent protector and voltage-stabilized power supply. Its advantages include continuously regulatable high power (100-1000 mw), 0.630-0.750 microns of wavelength, small size, light weight, low working voltage and high safety.

Description

High-power semiconductor laser apparatus for treating tumors

The invention belongs to physiotherapeutic instruments, a kind of high-power semiconductor laser apparatus for treating tumors of more specifically saying so.

In recent years, laser physical therapy is used widely.Theoretical research and clinical practice that laser power is learned show: because photosensitizer hematoporphyrin derivative (HPD) is woven with stronger affinity and photoreactivity to tumor group, behind HPD injection human body, the absorption strength of tumor tissues will be higher than 2～10 times of normal structures, selecting in the specific time, use the laser irradiation tumor locus, make the tumor cell that has absorbed the high concentration photosensitizer under photochemical action, produce singlet oxygen, destroy tumor cell and tumor vessel, cause tumor tissue necrosis, thereby reach selectivity kill tumor cell, the purpose that the cell injury of normal structure is reduced as far as possible.But, the present laser therapeutic apparatus of producing, the therapeutic instrument that for example adopts helium neon laser to do, its optical output power≤50mw do not satisfy the treatment needs of human body profound level, many vascular sites, and curative effect is not remarkable, in addition, also there are shortcomings such as volume is big, running voltage is high, poor stability.

The purpose of this invention is to provide a kind of high-power semiconductor laser apparatus for treating tumors, it can adapt to, and treatment partes corporis humani position is good, the needs of malignant tumor.

In order to realize above-mentioned task, the technical measures that the present invention takes are: this therapeutic instrument comprises two rectifying voltage regulator U1, IC1 and U2, IC2, provides working power to circuit such as intervalometer, timing display, alarm and laser instrument, source current actuator, luminous power detection display respectively; An electronic timer D3, its drive output is connected with the input of timing display II2, another output divides two-way, one the tunnel is connected with the start-up control end b1 of alarm HA, another road is connected with the controlled end b2 of relay K 1, outfan and luminous power that the controlled contact K1-1 of K1 is serially connected in IC1 detect between the feeder ear of display, and controlled contact K1-2, K1-3 are serially connected in respectively between the interchange input two ends and T1 output two ends of U2; The input of a luminous power display H1 is connected with the drive output of detector D2, and the input of detector is connected with the outfan of detection head; It is characterized in that, it also comprises: optical output power scope 100～1000mw, a laser wavelength range are that 0.630～0.750 micron the high power semiconductor lasers LD and the outfan of a source current actuator are in series, between the outfan that is attempted by described IC2 was held together, laser was exported through optical fiber by the photo-coupler coupling.

But laser instrument LD both monomer uses, also can use in parallel more than two.

Advantage of the present invention is: 1, optical output power is big, and 〉=100～1000mw is high approximately 10 times compared with similar products, and under be limited to the upper limit and can carry out regulating arbitrarily continuously, can satisfy the needs of optimum, the malignant tumor at any position of clinical treatment human body fully.2, running voltage is low, and the highest have only 6V, and be provided with overcurrent protective device, safe and reliable.3, volume little, in light weight, also be provided with timing, digital display, alarm device, use that operation is very easy.

Fig. 1 is the contour structures sketch map of this instrument.

Fig. 2 is the operation principle block diagram.

Fig. 3 is the internal circuit diagram of Fig. 1.

Below in conjunction with accompanying drawing the present invention is done to describe in further detail.

In Fig. 1, the 1st, the housing of instrument, all circuit are installed in the housing, and the 2nd, power line, X1 are attaching plugs.Luminous power display screen H1 and time display screen H2 are installed on the housing front plate, be respectively applied for the luminous power and the timing working time that show output in real time, HA is an alarm, when timing working time arrives, automatically cut off the power supply of laser instrument and luminous power display part, sound simultaneously gives a warning.Control button and photo-coupler are installed in the panel bottom, wherein, S1 is a total power switch, and RP1 is the regulator potentiometer of photoelectric current, and S2 is the start button of electronic timing display, S3 is the zero clearing SR, S4 and S5 are respectively the position and the buttons that is provided with of tens of timing, and setting-up time is from 1 minute～99 minutes, reverse countdown, g1 is an optocoupler interface, can be connected with optical fibers.From Fig. 2 and Fig. 3 as seen, circuit mainly detects display, electronic timing display alarm and overcurrent protector by rectifying pressurizer, laser instrument (source) rheonome, laser instrument (source), photo-coupler, optical fibers, luminous power and forms.Among Fig. 3, plug X1, total power switch S1, protective tube FU, transformator T1, bridge rectifier U1, U2, three end integrated voltage regulator source IC1, IC2, filter capacitor C1～C4, C14～C17 constitute two rectifications, filtering, mu balanced circuit, one is output as+5V, provide stable working power to electronic timing display alarm and luminous power detection display, another is output as+6V, provides stable working power to rheonome, the lasing light emitter of laser instrument.Laser instrument (source) is laser tube LD itself, be connected with optical fibers g2 by photo-coupler g1, the luminous power of LD is designed to 500mW, if two synthetic uses, the output of light can increase to 1000mW, and laser wavelength range is set at 0.630～0.75 micron (HONGGUANG).The rheonome of laser instrument is used to control output, by divider resistance R17, regulator potentiometer RP1, isolation resistance R18, prime adjustment pipe V4, output resistance R27, operational amplifier N1, divider resistance R25, R23, isolation resistance R24, the back level is adjusted pipe V5 and is constituted, V4 is connected into emitter-follower and uses, the bias voltage of its base stage is obtained by R17 and RP1 dividing potential drop, outfan connects the in-phase input end of N1, divider resistance R25, the mid point of R23 is connected the inverting input of N1, the comparative voltage benchmark is provided, the outfan of N1 connects the input of V5, the outfan of V5 and LD, current-limiting resistance R26 series connection is attempted by the two ends of working power, regulate RP1 the voltage at LD two ends is changed between 0～2.5V, thereby the output of light also is limited between 0～500mW and changes.LED1 is a light emitting diode, and R20 is its current-limiting resistance, makes display lamp and uses.Optical output power detects display and is used to show real-time optical output power, is made of detection head silicon cell B1, A/D conversion, decoder driver D2, display screen H1 and peripheral cell diode D1～D3, capacitor C 9～C13, resistance R 10～R16.RP2 is to be more accurate potentiometer than zero potential device, RP3, and these two potentiometers are just to use during for professional's adjusting instrument, generally need not.D1 is a negative supply, negative voltage about 4V is provided for 26 feet of D2 with it.D2 is a large scale integrated circuit, and it comprises double integration A/D converter (the analog quantity electrical signal conversion of input is become digital electric signal output), BCD seven-segment decoder and driver, can directly drive H1, and have automatic demonstration, time zero power energy.When the laser direct irradiation of optical fiber output was on B1, the voltage that B1 produces was from the 31 feet input of D2, handled directly driving H1 and demonstrate data through D2.The electronic timing display alarm is by two two---and decimal scale (BCD) system switch D3, timing display H2, S2～S5, buzzer HA, transistor V1, V2, relay K 1 and resistance R 1～R9, capacitor C 5～C8 constitute, and the timing constant is by R1, C5, C6 decision.K1 has three pairs of normally-closed contacts; outfan and luminous power that a pair of K1-1 is serially connected in IC1 detect between the feeder ear of display; two couples of K1-2, K1-3 are serially connected in the two ends that U2 exchanges input respectively in addition; S2 is a start button; S3 is the reset button that resets; S4 and S5 are respectively the keys that is provided with of the units of BCD system switch and tens, and VD4 is that protection diode, LED2 are light emitting diodes, makes display lamp and uses.When connecting intervalometer and mixing up timing, this moment, the A point was an electronegative potential, and V1, V2 all end, and LED2 is luminous, and HA, K1 all do not work; When preset time one arrives, D310 foot output high level, the saltus step of A point is a high potential, V1, V2 saturation conduction, all normally-closed contacts are drawn back in the K1 action, cut off the power supply of laser instrument, luminous power display etc., and instrument quits work, the while buzzer call.Overcurrent protector is made of dividing potential drop sample resistance R21, R27, amplifier N2, isolation resistance R19, transistor V3; the mid point of dividing potential drop sample resistance R21, R27 is connected the inverting input of N2; the collector and emitter of V3 is connected on the two ends of RP1 respectively; when the excessive overload of the electric current that flows through LD; for example surpass 500mA; its overcurrent protection process is as follows: the LD electric current ↑ → supply voltage ↓ → N2 (-) ↓ → the V3b utmost point ↑ → the V3C utmost point ↓ → the V4b utmost point ↓ → the V4e utmost point ↓ → N1 (+) ↓ → the V5b utmost point ↓ → V5 ends; laser instrument quits work, thereby LD is protected.

The work process of entire circuit is:

1, the S1 that closes, U1, IC1, IC2 detect circuit supplies such as display to intervalometer, laser instrument, luminous power respectively.

2, with fiber-optic illuminated B1, observe the H1 display digit and check whether optical output power meets the requirements prescribed, if undesirable, should adjust.

3, press toggle switch (BCD) S4 and S5 to the required time, click S2 and start intervalometer work.Instrument gets final product work.

4, show the required time when the time one to H2 of presetting, the 10 feet output high level of intervalometer D3, make the V1 saturation conduction, HA gets electric work, buzzer call, meanwhile, V2 is saturation conduction also, and K1 gets electronic work, and three pairs of normally-closed contacts of K1-1～K1-3 are drawn back, cut off the power supply of laser instrument and detector, instrument promptly quits work.

Claims

1, a kind of high-power semiconductor laser apparatus for treating tumors, it comprises:

---two rectifying voltage regulator U1, IC1 and U2, IC2, respectively to two parts circuit supply;

---an electronic timer D3, its drive output is connected with the input of timing display H2, another outfan divides two-way, one the tunnel is connected with the start-up control end b1 of alarm HA, another road is connected with the controlled end b2 of relay K 1, outfan and luminous power that the controlled contact K1-1 of K1 is serially connected in IC1 detect between the feeder ear of display, and controlled contact K1-2, K1-3 are serially connected in respectively between the interchange input two ends and T1 output two ends of U2;

---the input of a luminous power display H1 is connected with the drive output of detector D2, and the input of detector is connected with the outfan of detection head;

It is characterized in that it also comprises:

---optical output power scope 100～1000mw, a laser wavelength range are that 0.630～0.750 micron the high power semiconductor lasers LD and the outfan of a source current actuator are in series, between the outfan that is attempted by described IC2 was held together, laser was exported through optical fiber by the photo-coupler coupling.

2, high-power semiconductor laser apparatus for treating tumors according to claim 1 is characterized in that: but both monomer uses of LD, also can use in parallel more than two.