CN1336240A - Method and device for electric pace-making - Google Patents
Method and device for electric pace-making Download PDFInfo
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- CN1336240A CN1336240A CN 00120858 CN00120858A CN1336240A CN 1336240 A CN1336240 A CN 1336240A CN 00120858 CN00120858 CN 00120858 CN 00120858 A CN00120858 A CN 00120858A CN 1336240 A CN1336240 A CN 1336240A
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Abstract
A two phase cardiac pace maker is used to increase electric conductivity and contractility. The first stimulating phase acts on heart blood pool. Said stimulating phase possesses presetting polarity, amplitude and duration time. Then the second stimulating phase acts on heart blood pool. Said second phase also possesses presetting polarity, amplitude and duration time. The two phases are applied in succession. The invented mode can increase contratibility through pulse induction of cardiac muscle.
Description
The present invention relates to the method for stimulated muscle tissue on the whole.More specifically, the present invention relates to stimulates and the pace-making heart with two phasic property waveforms, and stimulation is wherein bestowed through the painstaking effort pond.
The function of cardiovascular system is vital for existence.By blood circulation, body tissue obtains necessary nutrient and oxygen, and discharges refuse.Do not had circulation, cell begins to cause dead irreversible change.Myocardial contraction is sanguimotor driving force.
In cardiac muscle, muscle fiber is distributed in branch's network structure of whole heart and interconnection with it from all directions.When any point of this network was stimulated, depolarization wave did not shrink as single a nothing with regard to being delivered to all parts and total.Muscle fiber is being stimulated before shrink, and its film must be polar.Muscle fiber keeps polarized state until being stimulated by some variation in the environment of living in usually.Film can be subjected to stimulation electricity, chemistry, machinery or variations in temperature.Cause that shrinking required minimum stimulation intensity is called threshold stimulus.The maximal stimulus amplitude that does not cause contraction that can bestow is maximum subthreshold amplitude of vibration.
During the electricity irritation film, the required pulse amplitude that induces reaction depends on many factors.At first, be current duration.Because the total electrical charge of transmitting equals current amplitude and multiply by the pulse duration, increase duration of stimulation and reduce with the threshold current amplitude.Secondly, the size of percentage ratio and electrode of crossing over the used electric current of film really is the inverse proportion variation.The 3rd, the percentage ratio of crossing over the used electric current of film really directly changes with the degree of closeness of electrode according to tissue.The 4th, the required pulse amplitude that induces reaction depends on the synchronicity of excited cycle internal stimulus.
Spreading all over heart most is specificity cardiac muscular tissue stick.This tissue comprises conducting system of heart and plays a part to start and depolarization wave is expanded cloth arrive whole cardiac muscle.The significant change that all can cause arrhythmia or cardiac rhythm to any interference or the retardance of cardiac pulses conduction.
The patient who suffers from conductive impairment sometimes can be by means of artificial pacemaker.This device comprises an electrostimulator with little battery-powered.When artificial pacemaker is installed, usually electrode is passed through vein and enter right ventricle, or enter right atrium and right ventricle, and stimulator is implanted shoulder or subcutaneous abdomen.The lead of laying closely contacts with cardiac muscular tissue.Pacemaker passes to heart with the rhythmicity electric pulse then, and is myocardium then be the contractile response of rhythmicity.Those skilled in the art know the implantable medical device that is used for the pace-making heart, and approximately since middle 1960s, they have been used for the mankind.
Cathode current or anode current all can be used for stimulating cardiac muscle.Yet anode current is considered to be unsuitable for clinical practice.Cathode current comprises the cathodic electricity pulse.This type of electric current makes the cell membrane depolarization by allowing membrane capacitance discharge, and transmembrane potential is descended to threshold level.Cathode current directly makes resting membrane electric potential reduce to threshold level, has the threshold current that is lower than anode current 1/2nd to 1/3rd late period at diastole.Anode current comprises the anode electric pulse.The effect of anode current is to make tranquillization film hyperpolarization.If anodic pulse interrupts suddenly, transmembrane potential is recovered to the tranquillization level, surpasses threshold potential, and propagated reaction occurs.Because threshold of stimulation is higher, need use higher electric current therefrom, cause the electric current of implanting device battery to expend and the life-span is cut down, therefore do not encourage usually to use anode current to stimulate cardiac muscle.In addition, owing to suspect that anode current helps depolarization, particularly can when higher voltage, cause arrhythmia, so do not encourage to use the anode current cardiac stimulus.
In fact all artificial pacings all are to use the negative electrode boost pulse to finish, and perhaps when using bipolar DC system, negative electrode is than the more approaching cardiac muscle of anode.In the use of disclosed anode current, anode current is usually as trace quantity electric charge be used to dissipate residual charge on the electrode.Do like this do not influence or regulate the cardiac muscle itself.The United States Patent (USP) 4,543,956 of Herscovici has disclosed this kind application.
People's such as Whigham United States Patent (USP) 4,903,700 and 4,821,724 and people's such as Cals United States Patent (USP) 4,343,312 application of three-phase waveform is disclosed.Here, the no any relation of first phase and third phase and cardiac muscle itself, but reckon with that just they can influence electrode surface itself.So, these mutually in used electric charge be utmost point short arc.
Recently, the United States Patent (USP) 4,402 of Duggan, 322 disclose biphasic stimulation.The purpose of the disclosure is to produce double voltage and big capacitor need not arranged on output circuit.The two-phase size and the persistent period of disclosed biphasic stimulation equate.
Needed is the improvement means of stimulated muscle tissue, and the contractility that wherein causes is enhanced, and near the damage of the tissue the counter electrode reduces.
Can obtain the effect that strengthens myocardial function by two phasic property pace-makings of the present invention.With the negative electrode and the anodic pulse combination of stimulation or adjusting property, the holding anode pace-making is eliminated the shortcoming that increases threshold of stimulation simultaneously to conductivity and inotropic improvement.The result produces the depolarization wave of the spread speed of increase.The spread speed of this increase causes cardiac contractile force to improve and the improvement of hyperamization stream.The stimulation that improves also makes energy dissipation reduce and prolong the life-span of pacemaker battery in low voltage level.At last, the stimulation of the improvement that reaches by realization of the present invention makes and carry out muscle stimulation under the electric lead that will not lay and heart tissue is combined closely.The stimulation that is sent to the standard in painstaking effort pond is not satisfied described threshold of stimulation owing to it, therefore, is invalid in catching cardiac muscle.Owing to can increase the voltage of pulse generator, therefore when cardiac muscle is caught in stimulation, though only wish cardiac stimulus, the voltage of pulse generator is often high to also stimulating skeleton muscle, and causes the pain spasm of thoracic wall.Will further discuss as following,, can strengthen myocardial function by the stimulation in painstaking effort ponds by realization of the present invention.
Because it is the same with cardiac muscle, striped muscle also can be subjected to the stimulation of electricity, chemistry, machinery or temperature change, so when muscle fiber was subjected to motor neuron and stimulates, the neuron transmission stimulated and all muscle fiber excitements that it is controlled, just, those muscle fibers are its motor unit form.The depolarization in a zone of film stimulates adjacent areas that depolarization also takes place, and depolarization wave begins to spread all over film to all directions from excitement.Therefore, when a motor neuron was transmitted an impulsion, all muscle fibers of motor unit were upset and shrink simultaneously.Cause the minimum strength of shrinking and be called threshold stimulus.In case reach the threshold stimulus level, even it has been generally acknowledged that increasing irritation level can not make contraction increase more yet.In addition, since every block of intramuscular muscle fiber is organized into motor unit, and each motor unit is arranged by single neuron, and all muscle fibers in the motor unit were upset in the identical time so.Yet whole muscle is arranged by many different motor units, and the threshold of stimulation of different motor units is different.So when muscle was bestowed in given stimulation, some motor units reacted the then reactionless of other.
The present invention unites and uses negative electrode and anodic pulse that the band muscle contraction is improved, and to the electricity irritation of muscle owing to nerve or muscle injury.When nerve fiber was damaged because of wound or disease, the muscle fiber in the zone of being controlled by the nerve fiber of damaging was tending towards taking place atrophy and completely loses function.The muscle that can not get taking exercise can be reduced to half of its life size in the several months.When not stimulating, muscle fiber is smaller volume not only, and can become fragment or degeneration, and is replaced by connective tissue.Can keep muscular tension by electricity irritation, to such an extent as to after curing or making nerve fiber regeneration, keep the life of muscular tissue.Can obtain the effect that strengthens muscle contraction by biphasic stimulation of the present invention.Unite the negative electrode and the anodic pulse that use zest or the property adjusted, can cause the motor unit contraction of bigger quantity and cause muscle response to raise in low voltage level.
Therefore, the purpose of this invention is to provide the improved stimulating method that is used for cardiac muscular tissue.
Thereby another purpose of the present invention is to cause bigger stroke volume to increase cardiac output by improving cardiac contractile force.
Another object of the present invention is to increase pulse propagation velocity.
It is to prolong the pacemaker battery life-span that the present invention also has a purpose.
Still a further object of the present invention is the effective cardiac stimulation that obtains low voltage level.
Another object of the present invention is to eliminate the necessity of electric lead being laid in the mode that contacts with tissue tight in order to obtain tissue stimulation.
Still a further object of the present invention provides a kind of stimulating method of improved muscular tissue.
The present invention also has a purpose to provide the method that the muscular movement unit of bigger quantity is shunk in low voltage level.
The method and apparatus that is used for muscular irritation of the present invention comprises bestows muscular tissue with biphasic stimulation, has wherein both bestowed cathode pulse and has also bestowed anodic pulse.One aspect of the present invention is that this stimulation is bestowed cardiac muscle to strengthen the function of cardiac muscle.Another aspect of the present invention is that the painstaking effort pond is bestowed in stimulation, is transmitted to heart tissue then.This makes no longer needs electric lead is carried out cardiac stimulation to lay with the mode that heart tissue closely contacts.Another aspect of the present invention is that stimulation is bestowed striated muscle tissue to arouse muscle response.The pacemaker electronic equipment that those skilled in the art need for implementing method of the present invention is known.Current pacemaker electronic equipment can discharge different pulses by being programmed, and comprises these pulses disclosed by the invention.
Method and apparatus of the present invention comprises that first stimulates phase to stimulate mutually with second, and each stimulation all has polarity, amplitude, waveform and persistent period mutually.In an embodiment preferred, first has different polarity mutually with second mutually.In a selective embodiment, two have different amplitudes mutually.In second selective embodiment, the persistent period difference of two phases.In the 3rd selective embodiment, first is mutually and blocks wave mode.In the 4th selective embodiment, the amplitude of first phase is a ramp type.In the 5th selective embodiment, when finishing all after dates of heart beating/pump, bestow the first phase pulse above 200 milliseconds.In a preferred selective embodiment, first stimulates the anodic pulse of the maximum subthreshold amplitude of vibration that is long duration mutually, and second to stimulate be the cathode pulse of short persistent period and high amplitude mutually.Should be noted that above-mentioned selective embodiment can make up differently.Should also be noted that these selective embodiments only provide by way of example, and do not represent any restriction.
Below accompanying drawing is carried out brief description:
Fig. 1. leading anode biphasic stimulation sketch map;
Fig. 2. leading negative electrode biphasic stimulation sketch map;
Fig. 3. the sketch map that the leading anode excitation of low-level long duration and conventional subsequently negative electrode stimulate;
Fig. 4. the sketch map that stimulates of the leading anode excitation of enhanced low-level long duration and conventional subsequently negative electrode gradually;
Fig. 5. bestow the sketch map that the leading anode excitation of a series of low-level short persistent period and conventional subsequently negative electrode stimulate;
Fig. 6. the curve chart of the pace-making persistent period of leading anode two phasic property pulses being done across the conduction velocity of fiber;
Fig. 7. be parallel to the curve chart that the conduction velocity of fiber was done the pace-making persistent period of leading anode two phasic property pulses.
The present invention relates to two phasic property electricity irritation of muscular tissue.Fig. 1 has described a kind of two phasic property electricity irritation, and wherein first stimulation comprises bestowing to have amplitude 104 and the anode excitation of persistent period 106 102 mutually.Follow immediately after this first stimulation mutually and comprise that second of same intensity and the negative electrode of persistent period stimulation 108 stimulates mutually.
Fig. 2 has described another kind of two phasic property electricity irritation, and wherein first stimulation comprises bestowing to have amplitude 204 and the negative electrode of persistent period 206 stimulation 202 mutually.Follow immediately after this first stimulation mutually and comprise that second of same intensity and the anode excitation of persistent period 208 stimulates mutually.
Fig. 3 has described a preferred embodiment of the present invention, and wherein first stimulates and to comprise the anode excitation 302 of bestowing low-level, the long duration with amplitude 304 and persistent period 306 mutually.After this first stimulation mutually, follow immediately and comprise that second of conventional intensity and the negative electrode of persistent period stimulation 308 stimulates mutually.In a selective embodiment of the present invention, anode excitation 302 carries out with maximum subthreshold amplitude of vibration.In another selective embodiment of the present invention, anode excitation 302 is less than 3 volts.In another selective embodiment of the present invention, the persistent period of anode excitation 302 is approximately 2～8 milliseconds.In a selective embodiment more of the present invention, negative electrode stimulates persistent period of 308 short.In another selective embodiment of the present invention, negative electrode stimulated for 308 persistent period be approximately 0.3～0.8 millisecond.In another selective embodiment of invention, negative electrode stimulates 308 to be stimulations of high amplitude.In another selective embodiment of invention, the amplitude of negative electrode stimulation 308 is about 3～20 volts.The invention another selective embodiment in, negative electrode stimulate 308 persistent period less than 0.3 millisecond voltage greater than 20 volts.In another selective embodiment, bestow anode excitation 302 when after heart beating, surpassing 200 milliseconds.Apparently disclosed mode is changed or change the alternate manner that gets by the disclosed mode of these embodiments and by reading this description, just need not to activate to stimulate the transmembrane potential that obtains maximum mutually first.
Fig. 4 has described the selective preferred embodiment of the present invention, bestows anode excitation 402 with the intensity level 406 that raises gradually within 404 during wherein first stimulation is included in mutually.Gradually the gradient of the intensity level 406 of Sheng Gaoing linear or non--linear, slope can be different.Follow immediately after this anode excitation and comprise that second of conventional intensity and the negative electrode of persistent period stimulation 408 stimulates mutually.In of the present invention one selective embodiment, anode excitation 402 rises to maximum subthreshold amplitude of vibration.In another selective embodiment, anode excitation 402 rises to the peak swing less than 3 volts.In another selective embodiment of invention, 402 persistent period of anode excitation are approximately 2～8 milliseconds.In another selective embodiment of invention, negative electrode stimulates 408 persistent period weak point.In the another selective embodiment of invention, negative electrode stimulates 408 approximately to continue 0.3～0.8 millisecond.In another selective embodiment of invention, negative electrode stimulates 408 to be high amplitudes.In a selective embodiment again of invention, negative electrode stimulates 408 amplitude to be approximately 3～20 volts.In another selective embodiment of invention, negative electrode stimulate 408 the duration less than 0.3 millisecond and amplitude greater than 20 volts.In another selective embodiment of invention, bestow anode excitation 402 when after heart beating, surpassing 200 milliseconds.Apparently disclosed mode is changed or change the alternate manner that gets by the disclosed mode of these embodiments and by reading this description, need not to activate just can stimulate and obtain maximum transmembrane potential mutually first.
Fig. 5 has described another two phasic property electricity irritation, and wherein first stimulation comprises a series of anodic pulses 502 of bestowing with amplitude 504 mutually.In one embodiment, the intermission 506 equals between stimulation period 508, and imposes basal amplitude.In another selective embodiment, 508 do not wait and impose basal amplitude between intermission 506 and stimulation period.Intermission 506 occurs after each stimulation period 508, comprises that except following immediately after series 502 finishes second of conventional intensity and the negative electrode of persistent period stimulation 510 stimulates mutually.In selective embodiment of the present invention, the total electrical charge of transmitting by serial anode excitation 502 is maximum subthreshold level.In another selective embodiment of the present invention, bestow a series of first boost pulse 502 when after heart beating, surpassing 200 milliseconds.In another embodiment of the present invention, negative electrode stimulates 510 persistent period weak point.In the selective embodiment of another one of the present invention, negative electrode stimulates 510 approximately to continue 0.3～0.8 millisecond.In another selective embodiment of the present invention, negative electrode stimulates 510 to be high amplitudes.In another selective embodiment of the present invention, the about scope of amplitude of negative electrode stimulation 510 is 3～20 volts.In the selective embodiment more of the present invention, negative electrode stimulate persistent period of 510 less than 0.3 millisecond voltage greater than 20 volts.
Use opposed polarity and pulse mutually on isolated heart, to study the excitement and the transport properties of cardiac muscle.Test is carried out on the rabbit heart of 5 isolated Langendorff perfusions.Use the bipolar electrode array to measure the visceral pericardium conduction velocity.Between 6 millimeters and 9 millimeters of distance stimulation points, measure.With buoyant intracellular microelectrode record transmembrane potential.Scheme below having detected: single-phase cathode pulse, single-phase anodic pulse, leading negative electrode two phasic property pulses and the two phasic property pulses of leading anode.
Table 1 has been listed the conduction velocity across machine direction that stimulates by each stimulation protocol, and stimulation voltage is 3,4 and 5 volts, and the pulse duration is 2 milliseconds.
Table 1
Across the conduction velocity of machine direction, stimulus duration is 2 milliseconds
3V 4V 5V
Negative electrode monophasic pulses if 18.9 ± 2.5cm/sec 21.4 ± 2.6cm/sec 23.3 ± 3.0cm/sec
The leading anode two phasic property pulses of the leading negative electrode two phasic property pulses of anode monophasic pulses if 24.0 ± 2.3cm/sec 27.5 ± 2.1cm/sec 31.3 ± 1.7cm/sec 27.1 ± 1.2cm/sec 28.2 ± 2.3cm/sec, 27.5 ± 1.8cm/sec 26.8 ± 2.1cm/sec 28.5 ± 0.7cm/sec 29.7 ± 1.8cm/sec
Table 2 has been listed the conduction velocity along machine direction that stimulates by each stimulation protocol, and stimulation voltage is 3,4 and 5 volts, and the pulse duration is 2 milliseconds.
Table 2
Along the machine direction conduction velocity, stimulus duration is 2 milliseconds
The leading anode two phasic property pulses of 3V 4V 5V negative electrode monophasic pulses if 45.3 ± 0.9cm/sec 47.4 ± 1.8cm/sec 49.7 ± 1.5cm/sec anode monophasic pulses if 48.1 ± 1.2cm/sec, 51.8 ± 0.5cm/sec, 54.9 ± 0.7cm/sec leading negative electrode two phasic property pulses 50.8 ± 0.9cm/sec, 52.6 ± 1.1cm/sec, 52.8 ± 1.7cm/sec 52.6 ± 2.5cm/sec 55.3 ± 1.5cm/sec 54.2 ± 2.3cm/sec
Find: single-phase at negative electrode, anode is single-phase, have significant difference (p＜0.001) between the conduction velocity of leading negative electrode two phasic properties and the two phasic property pulses of leading anode.From the measurement result of transmembrane potential, find that the maximum up stroke ((dV/dt) max) of action potential and the variation of vertical conduction velocity have good dependency.When 2 milliseconds of persistent period pulses of 4 volts, (dV/dt) max of cathode pulse is 63.5 ± 2.4 V/sec, and (dV/dt) max of anodic pulse is 75.5 ± 5.6 V/sec.
Use is analyzed the influence of different pacing protocol to cardiac electrophysiology by the isolated rabbit heart of Langendorff preparation.The stimulation that is used for heart is the voltage stabilizing rectangular pulse.Scheme below having detected: single-phase anodic pulse, single-phase cathode pulse, leading anode two phasic property pulses, leading negative electrode two phasic property pulses.Male or female stimulates used voltage to increase progressively to 5 volts from 1 volt with 1 volt step.Persistent period increases progressively from 2 milliseconds to 10 milliseconds with 2 milliseconds step.Measure between 3～6 millimeters of distance lv free walls (free wall) along with visceral pericardium conduction velocity across the left ventricle machine direction.Fig. 6 and 7 has described the influence to conduction velocity of boost pulse persistent period and used stimulation protocol.
Fig. 6 has described the speed across machine direction that records between the 3-6 millimeter.In this zone, the single-phase stimulation 602 of negative electrode all demonstrates the slowest conduction velocity in each boost pulse persistent period of being tested.Follow by single-phase stimulation 604 of anode and leading negative electrode biphasic stimulation 606.The result shows that also the conduction velocity of leading anode biphasic stimulation 608 is the fastest.
Fig. 7 has described the speed that is parallel to machine direction that records between 3 millimeters and 6 millimeters.In this scope, the single-phase stimulation 702 of negative electrode all demonstrates the slowest conduction velocity in each boost pulse persistent period of being tested.The single-phase stimulation 704 of anode is similar to the speed result of leading negative electrode biphasic stimulation 706, and shows that the speed of the single-phase stimulation of anode is fast slightly.The result shows that also the conduction velocity of leading anode biphasic stimulation 708 is the fastest.
One aspect of the present invention is that cardiac muscle is bestowed in electricity irritation.The anode excitation component of two phasic property electricity irritation is organized in excited preceding hyperpolarization by making, causes pulse conduction, more intracellular Ca2+ release faster and causes that stronger heart contraction increases cardiac contractile force.Negative electrode stimulates component to eliminate the shortcoming of anode excitation, and making effectively to stimulate heart under than the lower voltage of the independent voltage levvl required with anode excitation.So conversely, prolonged life-span of pacemaker battery and reduced tissue injury.
A second aspect of the present invention is that the painstaking effort pond is bestowed in two phasic property electricity irritation, promptly enters and center on the blood of heart.Like this can cardiac stimulus and need not the pace-making electric lead therefore to have reduced probability to this tissue injury to lay with the mode that heart tissue contacts closely.The threshold of stimulation of the biphasic stimulation of bestowing by the painstaking effort pond and the standard stimulus that is directly transferred to cardiac muscle are in same scope.Use by to the two phasic property electricity irritation in painstaking effort pond can reach the enhancing cardiac contractility, and skeleton muscle contractility not take place, myocardial damage or to the adverse effect in painstaking effort pond.
Third aspect present invention is that striated muscle tissue is bestowed in two phasic property electricity irritation.Anode and negative electrode stimulate combination to cause having in low voltage level the contraction of the muscular movement unit of bigger quantity, thereby improve muscle response.
After having described basic conception of the present invention, to those skilled in the art, it is apparent that aforesaid disclosing in detail only provides by way of example, and do not represent any restriction.Those skilled in the art can not have various changes, improvement and the change of expressly stating in this literary composition.These changes, improvement and the change being had a mind to carry out by this paper enlightenment are included within the spirit and scope of the invention.In addition, the pacemaker impulse of describing in description is also within the range of capacity of the pacemaker electronic equipment of existing suitable programming.Therefore, the present invention only is subjected to the restriction of claim and their equivalent.
Claims (46)
1. one kind is used for electric cardiac pacing method, comprising:
The equipment of the painstaking effort pond being bestowed electricity irritation is provided, and the wherein said equipment that is used for electricity irritation need not to combine closely with heart tissue; And
Biphasic electricity irritation is bestowed the painstaking effort pond to carry out cardiac pacing, and wherein said electricity irritation comprises:
Having first of the first phase polarity, the first phase amplitude, first phase waveform and first phase duration stimulates mutually; With
Having second of the second phase polarity, the second phase amplitude, second phase waveform and second phase duration stimulates mutually;
Wherein the first phase polarity is positive.
2. the cardiac pacing method that is used for electricity of claim 1 wherein stimulates mutually described first and bestows the painstaking effort pond mutually with second stimulation in turn.
Claim 1 described be used for the electricity the cardiac pacing method, the wherein said first phase amplitude is maximum subthreshold amplitude of vibration.
Claim 3 described be used for the electricity the cardiac pacing method, wherein said maximum subthreshold amplitude of vibration is about 0.5～3.5 volt.
5. the described cardiac pacing method that is used for electricity of claim 1, wherein the persistent period of first phase is isometric with second mutually persistent period at least.
Claim 1 described be used for the electricity the cardiac pacing method, wherein the persistent period of first phase is about 1～9 millisecond.
Claim 1 described be used for the electricity the cardiac pacing method, wherein the persistent period of second phase is about 0.2～0.9 millisecond.
Claim 1 described be used for the electricity the cardiac pacing method, wherein the second phase amplitude is about 2～20 volts.
9. the described cardiac pacing method that is used for electricity of claim 1, wherein first to stimulate be to begin after 200 milliseconds cardiac cycle is finished after mutually again.
10. one kind is used for electric cardiac pacing method, comprising:
The equipment of the painstaking effort pond being bestowed electricity irritation is provided, and the wherein said equipment that is used for electricity irritation need not to combine closely with heart tissue; And
Biphasic electricity irritation is bestowed the painstaking effort pond to carry out cardiac pacing, and wherein said electricity irritation comprises:
Having first of the first phase polarity, the first phase amplitude, first phase waveform and first phase duration stimulates mutually; With
Having second of the second phase polarity, the second phase amplitude, second phase waveform and second phase duration stimulates mutually;
Wherein the first phase amplitude is lower than the second phase amplitude.
11. a cardiac pacing method that is used for electricity comprises:
The equipment of the painstaking effort pond being bestowed electricity irritation is provided, and the wherein said equipment that is used for electricity irritation need not to combine closely with heart tissue; And
Biphasic electricity irritation is bestowed the painstaking effort pond to carry out cardiac pacing, and wherein said electricity irritation comprises:
Having first of the first phase polarity, the first phase amplitude, first phase waveform and first phase duration stimulates mutually; With
Having second of the second phase polarity, the second phase amplitude, second phase waveform and second phase duration stimulates mutually;
Wherein the first phase amplitude be by the basic value ramp rise to second value.
12. the described cardiac pacing method that is used for electricity of claim 11, wherein said second value equals the second phase amplitude.
13. the described cardiac pacing method that is used for electricity of claim 11, wherein said second value is maximum subthreshold amplitude of vibration.
14. the described cardiac pacing method that is used for electricity of claim 13, wherein said maximum subthreshold amplitude of vibration is about 0.5～3.5 volt.
15. claim 11 is described to be used for the cardiac pacing method of electricity, wherein the persistent period of first phase is isometric with second mutually persistent period at least.
16. the described cardiac pacing method that is used for electricity of claim 11, wherein the persistent period of first phase is about 1～9 millisecond.
17. the described cardiac pacing method that is used for electricity of claim 11, wherein the persistent period of second phase is about 0.2～0.9 millisecond.
18. the described cardiac pacing method that is used for electricity of claim 11, wherein the second phase amplitude is about 2～20 volts.
19. claim 11 is described to be used for the cardiac pacing method of electricity, wherein the persistent period of second phase less than 0.3 millisecond and the second phase amplitude greater than 20 volts.
20. a cardiac pacing method that is used for electricity comprises:
The equipment of the painstaking effort pond being bestowed electricity irritation is provided, and the wherein said equipment that is used for electricity irritation need not to combine closely with heart tissue; And
Biphasic electricity irritation is bestowed the painstaking effort pond to carry out cardiac pacing, and wherein said electricity irritation comprises:
Having first of the first phase polarity, the first phase amplitude, first phase waveform and first phase duration stimulates mutually; With
Having second of the second phase polarity, the second phase amplitude, second phase waveform and second phase duration stimulates mutually;
Wherein second phase duration less than 0.3 millisecond and the second phase amplitude greater than 20 volts.
21. a cardiac pacing method that is used for electricity comprises:
The equipment of the painstaking effort pond being bestowed electricity irritation is provided, and the wherein said equipment that is used for electricity irritation need not to combine closely with heart tissue; And
Biphasic electricity irritation is bestowed the painstaking effort pond to carry out cardiac pacing, and wherein said electricity irritation comprises:
Having first of the first phase polarity, the first phase amplitude, first phase waveform and first phase duration stimulates mutually; With
Having second of the second phase polarity, the second phase amplitude, second phase waveform and second phase duration stimulates mutually;
Wherein said first stimulates the boost pulse that also comprises a series of predetermined amplitudes, polarity and persistent period mutually; And
Wherein said first stimulation also comprises a series of intermission mutually.
22. the described cardiac pacing method that is used for electricity of claim 21, first stimulation of wherein using also is included in the intermission of using basal amplitude after at least one boost pulse mutually.
23. the described cardiac pacing method that is used for electricity of claim 22, the wherein said intermission equals the persistent period of boost pulse.
24. cardiac pacing equipment that is used for electricity, this equipment comprises the lead that is used for the painstaking effort pond is bestowed electricity irritation, with the stimulus generator that is connected with lead, wherein said stimulus generator produces two phasic property electrical waveform formulas stimulates the painstaking effort pond to play the effect of cardiac pacing by lead, and described electric wave form comprises:
Having first of the first phase polarity, the first phase amplitude, first phase waveform and first phase duration stimulates mutually; With
Having second of the second phase polarity, the second phase amplitude, second phase waveform and second phase duration stimulates mutually;
Wherein the first phase polarity is positive.
25. the described cardiac pacing equipment that is used for electricity of claim 24 wherein stimulates mutually described first and bestows the painstaking effort pond mutually with second stimulation in turn.
26. the described cardiac pacing equipment that is used for electricity of claim 24, the wherein said first phase amplitude is maximum subthreshold amplitude of vibration.
27. the described cardiac pacing equipment that is used for electricity of claim 26, wherein said maximum subthreshold amplitude of vibration is about 0.5～3.5 volt.
28. claim 24 is described to be used for the cardiac pacing equipment of electricity, wherein the persistent period of first phase is isometric with second mutually persistent period at least.
29. the described cardiac pacing equipment that is used for electricity of claim 24, wherein first phase duration is about 1～9 millisecond.
30. the described cardiac pacing equipment that is used for electricity of claim 24, wherein second phase duration is about 0.2～0.9 millisecond.
31. the described cardiac pacing equipment that is used for electricity of claim 24, wherein the second phase amplitude is about 2～20 volts.
32. the described cardiac pacing equipment that is used for electricity of claim 24, wherein first stimulation is to begin surpass 200 milliseconds after cardiac cycle is finished after mutually again.
33. a cardiac pacing equipment that is used for electricity, this equipment comprises:
Be used for the painstaking effort pond is bestowed the lead of electricity irritation, with the stimulus generator that is connected with lead, wherein said stimulus generator produces two phasic property electrical waveform formulas stimulates the painstaking effort pond to play the effect of cardiac pacing by lead, and described electric wave form comprises:
Having first of the first phase polarity, the first phase amplitude, first phase waveform and first phase duration stimulates mutually; With
Having second of the second phase polarity, the second phase amplitude, second phase waveform and second phase duration stimulates mutually;
Wherein the first phase amplitude is lower than the second phase amplitude.
34. a cardiac pacing equipment that is used for electricity, this equipment comprises:
Be used for the painstaking effort pond is bestowed the lead of electricity irritation, with the stimulus generator that is connected with lead, wherein said stimulus generator produces two phasic property electrical waveform formulas stimulates the painstaking effort pond to play the effect of cardiac pacing by lead, and described electric wave form comprises:
Having first of the first phase polarity, the first phase amplitude, first phase waveform and first phase duration stimulates mutually; With
Having second of the second phase polarity, the second phase amplitude, second phase waveform and second phase duration stimulates mutually;
Wherein the first phase amplitude be by the basic value ramp rise to second value.
35. the described cardiac pacing equipment that is used for electricity of claim 34, wherein said second value equals the second phase amplitude.
36. the described cardiac pacing equipment that is used for electricity of claim 34, wherein said second value is maximum subthreshold amplitude of vibration.
37. the described cardiac pacing equipment that is used for electricity of claim 36, wherein said maximum subthreshold amplitude of vibration is about 0.5～3.5 volt.
38. claim 34 is described to be used for the cardiac pacing equipment of electricity, wherein the persistent period of first phase is isometric with second mutually persistent period at least.
39. the described cardiac pacing equipment that is used for electricity of claim 34, wherein first phase duration is about 1～9 millisecond.
40. the described cardiac pacing equipment that is used for electricity of claim 34, wherein second phase duration is about 0.2～0.9 millisecond.
41. the described cardiac pacing equipment that is used for electricity of claim 34, wherein the second phase amplitude is about 2～20 volts.
42. claim 34 is described to be used for the cardiac pacing equipment of electricity, wherein second phase duration less than 0.3 millisecond and the second phase amplitude greater than 20 volts.
43. a cardiac pacing equipment that is used for electricity, this equipment comprises:
Be used for the painstaking effort pond is bestowed the lead of electricity irritation, with the stimulus generator that is connected with lead, wherein said stimulus generator produces two phasic property electrical waveform formulas stimulates the painstaking effort pond to play the effect of cardiac pacing by lead, and described electric wave form comprises:
Having first of the first phase polarity, the first phase amplitude, first phase waveform and first phase duration stimulates mutually; With
Having second of the second phase polarity, the second phase amplitude, second phase waveform and second phase duration stimulates mutually;
Wherein second phase duration less than 0.3 millisecond and the second phase amplitude greater than 20 volts.
44. a cardiac pacing equipment that is used for electricity, this equipment comprises:
Be used for the painstaking effort pond is bestowed the lead of electricity irritation, with the stimulus generator that is connected with lead, wherein said stimulus generator produces two phasic property electrical waveform formulas stimulates the painstaking effort pond to play the effect of cardiac pacing by lead, and described electric wave form comprises:
Having first of the first phase polarity, the first phase amplitude, first phase waveform and first phase duration stimulates mutually; With
Having second of the second phase polarity, the second phase amplitude, second phase waveform and second phase duration stimulates mutually;
Wherein said first stimulates the boost pulse that also comprises a series of predetermined amplitudes, polarity and persistent period mutually; And
Wherein said first stimulation also comprises a series of intermission mutually.
45. the described cardiac pacing equipment that is used for electricity of claim 44, first stimulation of wherein using also is included in the intermission of using basal amplitude after at least one boost pulse mutually.
46. the described cardiac pacing equipment that is used for electricity of claim 45, the wherein said intermission equals the persistent period of boost pulse.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00120858 CN1336240A (en) | 2000-08-02 | 2000-08-02 | Method and device for electric pace-making |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00120858 CN1336240A (en) | 2000-08-02 | 2000-08-02 | Method and device for electric pace-making |
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| CN1336240A true CN1336240A (en) | 2002-02-20 |
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| CN 00120858 Pending CN1336240A (en) | 2000-08-02 | 2000-08-02 | Method and device for electric pace-making |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004014480A1 (en) * | 2002-08-07 | 2004-02-19 | Universidade De Santiago De Compostela | Two-phase current ventricular electrical stimulator for heart failure and stimulation method |
| CN103099677A (en) * | 2013-01-17 | 2013-05-15 | 杨明亮 | Method for building network in organism and method for periodic signal release through network |
| CN101868280B (en) * | 2007-09-25 | 2014-04-16 | 心脏起搏器股份公司 | Neurostimulation systems for cardiac conditions |
-
2000
- 2000-08-02 CN CN 00120858 patent/CN1336240A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004014480A1 (en) * | 2002-08-07 | 2004-02-19 | Universidade De Santiago De Compostela | Two-phase current ventricular electrical stimulator for heart failure and stimulation method |
| ES2199691B2 (en) * | 2002-08-07 | 2004-09-16 | Universidade De Santiago De Compostela | VENTRICULAR ELECTRIC STIMULATOR OF BIFASSIC CURRENT FOR CARDIAC FAILURE AND STIMULATION METHOD. |
| CN101868280B (en) * | 2007-09-25 | 2014-04-16 | 心脏起搏器股份公司 | Neurostimulation systems for cardiac conditions |
| CN103099677A (en) * | 2013-01-17 | 2013-05-15 | 杨明亮 | Method for building network in organism and method for periodic signal release through network |
| CN103099677B (en) * | 2013-01-17 | 2016-05-11 | 杨明亮 | A kind ofly build in vivo network and by the method for network signal deenergized period |
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