CN1331526C - Method for producing turmeric stable prepn. - Google Patents
Method for producing turmeric stable prepn. Download PDFInfo
- Publication number
- CN1331526C CN1331526C CNB2005100191014A CN200510019101A CN1331526C CN 1331526 C CN1331526 C CN 1331526C CN B2005100191014 A CNB2005100191014 A CN B2005100191014A CN 200510019101 A CN200510019101 A CN 200510019101A CN 1331526 C CN1331526 C CN 1331526C
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- China
- Prior art keywords
- turmeric
- curcumin
- oil
- rhizoma curcumae
- curcumae longae
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- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a method for extracting effective components from turmeric plants to prepare a preparation of the stability of a turmeric active substance by an extraction method. After turmeric tubers is crumbled into powder, nonpolar oil-soluble substances hindering the separation of the turmeric class in the turmeric are separated so as to obtain curcumin and turmeric oil by a CO2 supercritical method, and then polyalcohol is used for protecting the curcumin or the turmeric oil or the mixture of the curcumin and the turmeric oil so as to generate the preparation. The method of the present invention has the advantages of simple operation, no harmful residue, difficult discolouration and prolonged storage life.
Description
Technical field:
The present invention relates to extract the method that active substance is produced preparation from plant, specifically is the process that effective component extracting is made Rhizoma Curcumae Longae active substance stability preparation from the curcuma tuber.
Background technology:
Contain chemical compound and the nonpolar oils effective ingredient such as beta-diketon that the polar yellow pigment is a tool phenol in the curcuma Curcuma tuber, its aldehydes matter is rare curcumenol, curzerenone, curdione etc., they are Mulberry Extract strongly, and non-polar oil also has medicinal effects.These effective ingredient are played an important role at anticancer, antiinflammatory, antiviral, blood fat reducing, beauty treatment and food color and so on, have economic worth.
Yet combine closely between curcumin and pectin, starch, cellulose and the non-polar oil, be difficult to separate.Be harmful to traditional organic solvent separation method residual solvent, and pigment that obtains and non-polar oil are easy to oxidation deactivation under light and normality, especially curcumin more.Even in dry lucifuge vessel, also be difficult to stored for a long timely, can fade and influence effectiveness.
Summary of the invention:
The object of the invention is to overcome the conventional organic solvents partition method and produces the defective that the Rhizoma Curcumae Longae preparation exists, and adopts new method extraction curcumin and produces the Rhizoma Curcumae Longae preparation, has both prevented residues of harmful substances, has guaranteed the stable of effective ingredient again.
The method of production Rhizoma Curcumae Longae stabilization formulations provided by the present invention is to adopt CO
2Supercritical methanol technology is added ethanol and once turmeric oil, curcumin liquid is obtained simultaneously, makes them separately with separatory funnel, and the reuse polyhydric alcohol produces preparation to curcumin or turmeric oil or both mixture protected, microwave sterilize in short-term finished product.
The present invention adopts CO
2Supercritical methanol technology is to put into extraction kettle after the Rhizoma Curcumae Longae tuber is broken into powder, adds ethanol in the extraction kettle jacket wall, uses compressor CO
2Introduce extraction kettle, feed separating still circulation 1～5 hour through the choke valve decompression again, then with gas from the emptying of separating still top, take out extract turmeric oil and the mixed liquid of curcumin from the separating still bottom; The reuse separatory funnel separates both. and yield reaches more than 90%.
The polyhydric alcohol of the weight adding 5%～90% of turmeric oil of the present invention or curcumin or both mixture is made emulsion or tablet or powder or capsule.
Polyhydric alcohol of the present invention can arbitrary step adding be made the function preparation in technical process.
The present invention needs to add tunicle and oozes out to prevent yellow substance when the production Formulation, and this tunicle can be used chitin complex or polyacrylate and complex thereof.
The present invention adopts CO
2Supercritical extraction has shortened operating process, and extract had both prevented residues of harmful substances, has guaranteed the stable of effective ingredient again.Put normality with the curcumin that does not add polyhydric alcohol and observe through adding, little with 200 days change color that polyhydric alcohol is protected curcumin liquid active substance, and the ginger color that does not add polyhydric alcohol faded in 100 days substantially.
The specific embodiment:
The Rhizoma Curcumae Longae tuber is cleaned up, be cut into about thickness 0.2cm thin slice, break into 20-80 order powder in 70 ℃ of left and right sides hot-air seasonings.Powder is put into extraction kettle, add ethanol between the extraction kettle jacket wall, amount is about the 5%-6% of material, makes CO
2Introduce extraction kettle from steel cylinder with compressor compresses, feed separating still, CO through the choke valve decompression again
2By compressor cycle motion, through 1～6 hour with CO
2Gas is from the emptying of separating still top, and extract takes out from the still bottom, and what obtained this moment is turmeric oil and curcumin mixture, and two liquid are also immiscible, separate with separatory funnel..
Example 1:
5kg Rhizoma Curcumae Longae oven dry powder is put in the extraction kettle, adds ethanol 250 grams between the extraction kettle jacket wall, by compression CO
2, pressure 20-30Mpa, 31 ℃～55 ℃ of temperature are again with CO
2Enter separating still through the choke valve decompression, by compressor Xun ring running 5 hours, with CO
2Emptying from separating still, extract self-separation still bottom emits, and obtains about 290 gram turmeric oil and curcumin mixtures, and mixture is fed separatory funnel, take out the upper strata, get 175 gram curcumins, with 825 gram cyclodextrins absorption, drying, add polyhydric alcohol 500 grams and be pressed into tablet, go into cylinder with the polyacrylate film forming, microwave is transferred the sterilization in 50 seconds of 100 degree, gets finished product.
Claims (3)
1. a method of producing the Rhizoma Curcumae Longae stabilization formulations is characterized in that curcumin and the turmeric oil mixed liquor adding polyhydric alcohol prepared by the Rhizoma Curcumae Longae tuber are protected, and the addition of polyhydric alcohol is 5%～90% of curcumin and a turmeric oil mixed liquor gross weight.
2. the method for production Rhizoma Curcumae Longae stabilization formulations as claimed in claim 1 is characterized in that stabilization formulations is emulsion or tablet or powder or capsule.
3. the method for production Rhizoma Curcumae Longae stabilization formulations as claimed in claim 1 or 2 adopts the polyacrylate tunicle to prevent that yellow substance from oozing out when it is characterized in that producing tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100191014A CN1331526C (en) | 2005-07-15 | 2005-07-15 | Method for producing turmeric stable prepn. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100191014A CN1331526C (en) | 2005-07-15 | 2005-07-15 | Method for producing turmeric stable prepn. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1724063A CN1724063A (en) | 2006-01-25 |
| CN1331526C true CN1331526C (en) | 2007-08-15 |
Family
ID=35923781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100191014A Expired - Fee Related CN1331526C (en) | 2005-07-15 | 2005-07-15 | Method for producing turmeric stable prepn. |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1331526C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100875B (en) * | 2011-01-28 | 2012-02-01 | 张海 | Process method for microwave assistant supercritical extraction of active ingredients of curcuma |
| WO2020060384A1 (en) * | 2018-09-18 | 2020-03-26 | De Celis Carrillo Ruth Araceli | Food product for chronic degenerative patients and method for preparing same |
| BR112021018749A2 (en) * | 2019-04-15 | 2021-12-21 | Unilever Ip Holdings Bv | Process for producing a personal care composition comprising tetramethylcurcumin |
| CN110240541A (en) * | 2019-07-08 | 2019-09-17 | 哈尔滨工业大学 | It is a kind of to use vacuum couplings ultrasonic wave-supercritical CO2The method of extraction extraction curcumin |
| CN112998271A (en) * | 2021-04-12 | 2021-06-22 | 吉林省百利生物科技有限公司 | Water-soluble microcapsule and solid beverage containing curcuma oil and curcumin and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319418A (en) * | 2001-01-20 | 2001-10-31 | 广州美晨药业有限公司 | Supercritica CO2 extraction and separation method of effective components of curcumae longae rhizome |
-
2005
- 2005-07-15 CN CNB2005100191014A patent/CN1331526C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319418A (en) * | 2001-01-20 | 2001-10-31 | 广州美晨药业有限公司 | Supercritica CO2 extraction and separation method of effective components of curcumae longae rhizome |
Non-Patent Citations (3)
| Title |
|---|
| 姜黄素制剂稳定性实验研究 谭俊等，中药材，第25卷第8期 2002 * |
| 超临界C02萃取测定姜黄中姜黄素的实验研究 宿树兰等，中国中药杂志，第29卷第9期 2004 * |
| 超临界C02萃取测定姜黄中姜黄素的实验研究 宿树兰等，中国中药杂志，第29卷第9期 2004;姜黄素制剂稳定性实验研究 谭俊等，中药材，第25卷第8期 2002 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1724063A (en) | 2006-01-25 |
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