CN1330959A - Method and equipment for externally mixed biologic artificial liver - Google Patents
Method and equipment for externally mixed biologic artificial liver Download PDFInfo
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- CN1330959A CN1330959A CN 00113083 CN00113083A CN1330959A CN 1330959 A CN1330959 A CN 1330959A CN 00113083 CN00113083 CN 00113083 CN 00113083 A CN00113083 A CN 00113083A CN 1330959 A CN1330959 A CN 1330959A
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Abstract
A method and equipment for supporting the external artificial liver is disclosed. The said method includes plasma displacement, circulating blood in external equipment, adsorptive detoxication of plasma, specific detoxication by biological artifical liver and biological synthesis. The more useful substances in blood are retained while high-activity liver cells are cultured and then provided to patient.
Description
The present invention relates to a kind of therapy and equipment thereof, the rami hepatici of the artificial liver that particularly a kind of temporary replacement human liver is hidden is held method and device thereof.
The rami hepatici method of holding of existing artificial liver generally adopts blood absorption and plasmapheresis dual mode.Blood absorption is directly the intravital blood of patient to be handled with adsorber, utilizes the materials such as active carbon in the adsorber that the toxic component in the blood is carried out adsorption cleaning, reaches liver antidotal purpose; The blood absorbent-type artificial hepaticsupport system who makes according to this method is made of adsorber, blood pump and liquid pipe; It belongs to artificial liver the earliest, during use, its input port and delivery outlet all is communicated with patient's blood vessel, utilizes the absorbent charcoal material in adsorber with physical form the toxic component in the blood to be carried out adsorption cleaning, realizes the liver detoxifcation; Because adsorbing material poor selectivity, and the histocompatibility of material own is relatively poor, in adsorption process, though it can be removed the absorption of the noxious substance in the blood, but it also together adsorbs many materials to the human body beneficial in the blood and removes, cause the particularly hematoblastic minimizing of hemocyte in the blood, therefore, curative effect can not be satisfactory after the clinical practice.Plasmapheresis is to replace the blood plasma that patient's body contains toxicant with normal person's blood plasma, makes blood purification reach the artificial liver therapeutic purposes; The plasmapheresis type artificial hepaticsupport system who makes according to this method belongs to the artificial liver that the second filial generation has certain liver function, and it mainly is to be made of separator, blood pump and liquid pipe; During use, its input port and delivery outlet all are communicated with patient's blood vessel, by separator the separating plasma in the blood is come out, and contain toxicant and the blood plasma of human body beneficial's material is together abandoned this, blood plasma with the normal person injects in patient's body again, thereby patient's blood is purified, realizes liver antidotal purpose; The place that this device is better than aforementioned means is exactly also to replenish the required albumin of certain biotic component such as normal person, thrombin etc. when removing toxicant, therefore be a kind of middle type technology between physical and Biotype artificial liver, it still will abandon many materials to the human body beneficial in the blood plasma, to consume a large amount of normal persons' blood plasma simultaneously, cause many wastes.In a word, with regard to Detoxication, above-mentioned two kinds of devices exist maximum defectives all be remove indiscriminately in the blood samples of patients noxious substance and to human body beneficial's material, can not can be regarded as artificial liver truly, just have to a certain extent mechanicalness Detoxication and the artificial effect that replenishes plasma fraction respectively.Through clinical the showing of above-mentioned two kinds of methods treatment: its jaundice descends generally 10%～30%, albumen in the blood samples of patients will lose 5%～10%, the improvement rate that comprises symptoms such as spirit, poisoning and hepatic coma is 39.1%, final survival rate only is 27% according to foreign data, though and domestic each family's report differs, general less than 20%.
Purpose of the present invention is held method and device thereof with regard to the rami hepatici that provides a kind of external mixed biologic artificial liver, it can keep in the blood on the basis to human body beneficial's material more, only need to use a spot of human normal plasma, utilize active carbon that blood plasma is carried out the adsorption-type detoxifcation.And cultivate hepatocyte by the high activity of artificial culture the toxicant in patient's blood plasma is absorbed absorption, transforms metabolism, realize the liver detoxifcation for a full due, replenish a large amount of bioactive substances to the patient simultaneously by the hepatocyte synthesis secretion.
The objective of the invention is to realize that by such technical scheme its step is as follows:
1) plasmapheresis: be separated into blood samples of patients invisible and blood plasma that have toxicant and tangible blood concentration components with plasma separator, abandon the blood plasma that has toxicant, tangible blood concentration components is failed back in patient's body, simultaneously, to have the effusive same speed of toxicant blood plasma is injected the normal person in patient's body blood plasma with isolating, tentatively remove the more blood of toxicant with the blood exchange transfusion set;
2) circulating of blood and device outside: continue to be separated into blood samples of patients invisible and blood plasma that have toxicant and tangible blood concentration components with plasma separator, they are failed back in patient's body by path separately respectively, stable the circulating with the balance between realization patient's body inner blood and the device outside;
3) blood plasma adsorptivity detoxifcation: with plasorber to step 2) in the blood plasma path in the blood plasma that has toxicant carry out adsorptivity and handle, the noxious substance in the blood plasma is removed, realize physical property detoxifcation to blood plasma;
4) bioartificial liver's specificity detoxifcation and biosynthesis: with bioreactor to step 2) in the blood plasma path in the blood plasma that has toxicant handle, by highly active cultivation hepatocyte in the bioreactor toxicant in the blood plasma is carried out specific picked-up, conversion, metabolism, simultaneously synthesis secretion discharges the large number of biological active substance and enters blood plasma, realizes detoxifying for a full due and the effect of additional bioactive substance to blood plasma.
Hold device according to the rami hepatici that said method is made, include housing and module control circuit, it is characterized in that: it also includes input channel, detaching mechanism of blood plasma, the blood plasma adsorbing mechanism, biological respinse mechanism, blood plasma output mechanism and output channel, be provided with the blood plasma pond in the intravital incubator of shell, biological respinse mechanism and blood plasma adsorbing mechanism form internal recycle with the blood plasma pond respectively, the blood plasma outfan of the detaching mechanism of blood plasma that input is communicated with input channel is by the liquid pipe, the liquid pipe valve feeds blood plasma pond and useless blood plasma container respectively, the blood concentration components outfan of detaching mechanism of blood plasma by the Meng Fei Shi pipe is communicated with output channel, the blood plasma output mechanism that is communicated with the blood plasma pond passes through Meng Fei Shi and manages and be communicated with output channel.
The present invention is external artificial hepaticsupport system, does not insert in patient's body, but blood samples of patients is drawn, and after the processing through the difference in functionality effect, converges and flows back in patient's body, so repeatedly, finally reaches the effect of artificial liver support and replacement therapy.Its operation principle is described below:
Input channel of the present invention is communicated with patient's tremulous pulse or vein by puncture, output channel is communicated with patient's vein by puncture, to realize the connection of bloody path.
At first, be separated into blood samples of patients invisible and blood plasma that have toxicant and tangible blood concentration components by detaching mechanism of blood plasma, control liquid pipe valve, make the blood plasma that has toxicant through the blood plasma outfan, the liquid pipe is transported in the useless blood plasma container and it is abandoned, the blood concentration components is through blood concentration components outfan, the Meng, Fei Shi managed, output channel flows back in patient's body, simultaneously, under the effect of module control circuit, by blood plasma output mechanism and blood exchange transfusion set in patient's body, to inject normal person's blood plasma with the same speed of the toxic material blood plasma of blood plasma outfan elution band, this process is carried out repeatedly, the blood plasma that has toxicant in useless blood plasma container reaches till institute's plasma volume to be processed, this is the treatment of first step artificial liver, its objective is that the blood plasma that patient's body is contained more toxicant discards, in patient's body, mend normal person's blood plasma, realize detoxifcation and purification blood.
Continuation is separated into blood samples of patients invisible and blood plasma that have toxicant and tangible blood concentration components by detaching mechanism of blood plasma, control liquid pipe valve, make the blood plasma that has toxicant through the blood plasma outfan, the liquid pipe is transported in the blood plasma pond, the blood concentration components is still through blood concentration components outfan, the Meng, Fei Shi managed, output channel flows back in patient's body, when treating that blood plasma in the blood plasma pond reach a certain height, start the blood plasma output mechanism, with the blood plasma in the blood plasma pond through the blood plasma output mechanism, the Meng, Fei Shi managed, output channel to be failing back in patient's body with the same speed of the toxic material blood plasma of blood plasma outfan elution band, thereby realizes balance between patient's body inner blood and the device outside and stable circulating.
Secondly, having the blood plasma of toxicant and blood plasma adsorbing mechanism in the blood plasma pond carries out high speed and circulates, the blood plasma adsorbing mechanism with suction dehematize the slurry in most harmful substances, till the adsorbance of blood plasma adsorbing mechanism reaches capacity, thereby realize the physical property detoxifcation to blood plasma, this is the artificial liver treatment of second step.In this process, the blood plasma adsorbing mechanism has also been inhaled in the blood plasma material to the human body beneficial, and this deficiency can be remedied in bioartificial liver's treatment in the 3rd step fully.
The blood plasma of handling through above-mentioned detoxifcation in the blood plasma pond carries out high speed with biological respinse mechanism again and circulates, cultivate in the biological respinse mechanism a large amount of highly active cultivation hepatocyte are arranged, when blood plasma passes through biological respinse mechanism, highly active cultivation hepatocyte carries out specific picked-up to the toxicant in the blood plasma, conversion, metabolism, the large number of biological of synthesis secretion release simultaneously active substance enters blood plasma, so repeatedly, patient's blood plasma is carrying out the antidotal while for a full due in the mode of biology, replenish the large number of biological active substance of needed by human body again, thereby finished the 3rd step bioartificial liver treatment.
In sum, the present invention is as introducing blood samples of patients in external second liver, finishes the physiological function of the liver of loss of function in patient's body, Here it is mixed biologic artificial liver supporting treatment or alternative medicine by external the present invention.By therapeutical effect of the present invention, the patient can recover by self liver regeneration, or recovers as liver transplantation through other treatment.The present invention creates conditions for above-mentioned liver regeneration or liver transplantation etc. just, races against time and chance, and be a kind of effective and requisite treatment means of excessive property, it has great importance aspect redemption liver failure patient life.
Owing to adopted technique scheme, the present invention to have following advantage:
1. method is easy, apparatus structure is simple, easy to use, reliable, and clinical therapeutic efficacy is good: and patient's jaundice descends about 50%, does not influence the protein concentration in the blood samples of patients, be that albumen can not lost, prothrombin time has shortened 3～7 seconds than prior art is obvious, comprises that the improvement rate of symptoms such as spirit, poisoning and hepatic coma is 87.6%, and final survival rate is more than 50%.
2. the blood plasma adsorbing mechanism only carries out the detoxification processing to patient's blood plasma, has protected the visible component in the blood samples of patients, has eliminated any influence to hemocyte;
3. though the blood plasma adsorbing mechanism has still been removed in the blood plasma material to the human body beneficial, this defective is cultivated hepatocyte by the high activity of the artificial culture in the biological respinse mechanism and is released in the blood plasma by synthesis secretion and is remedied fully;
4. cultivate hepatocyte by the high activity of artificial culture in the biological respinse mechanism, toxicant in the blood plasma is absorbed absorption, transforms metabolism, thereby realize liver detoxifcation truly for a full due, can in patient's body, replenish a large amount of bioactive substances simultaneously and make it possess the basic function of normal liver fully by cultivating the hepatocyte synthesis secretion.
Description of drawings of the present invention is as follows:
Fig. 1 is a structural representation of the present invention;
Fig. 2 is the left view of Fig. 1;
Fig. 3 is a schematic diagram of the present invention.
Among the figure: 1. housing; 2. input channel; 3. output channel; 4. incubator; 5. blood plasma pond; 6. input; 7. blood plasma outfan; 8. blood concentration components outfan; 9. the Meng, Fei Shi managed; 10. separator; 11. heparin infusion appliance; 12. front pump; 13. adsorber; 14. sorption cycle pump; 15. bioreactor; 16. circulating pump; 17. rear pump; 18. photographic head; 19. useless blood plasma container; 20. blood exchange transfusion set.
The invention will be further described below in conjunction with drawings and Examples:
Method of the present invention is to be undertaken by following step:
1) plasmapheresis: be separated into blood samples of patients invisible and blood plasma that have toxicant and tangible blood concentration components with plasma separator, abandon the blood plasma that has toxicant, tangible blood concentration components is failed back in patient's body, simultaneously, with the blood exchange transfusion set to have the effusive same speed of toxicant blood plasma is injected the normal person in patient's body blood plasma with isolating;
2) circulating of blood and device outside: continue to be separated into blood samples of patients invisible and blood plasma that have toxicant and tangible blood concentration components with plasma separator, they are failed back in patient's body by path separately respectively, stable the circulating with the balance between realization patient's body inner blood and the device outside;
3) blood plasma adsorptivity detoxifcation: with plasorber to step 2) in the blood plasma path in the blood plasma that has toxicant carry out adsorptivity and handle, the noxious substance in the blood plasma is removed, realize physical property detoxifcation to blood plasma;
4) bioartificial liver's specificity detoxifcation and biosynthesis: with bioreactor to step 2) in the blood plasma path in the blood plasma that has toxicant handle, by highly active cultivation hepatocyte in the bioreactor toxicant in the blood plasma is carried out specific picked-up, conversion, metabolism, simultaneously synthesis secretion discharges the large number of biological active substance and enters blood plasma, realizes detoxifying for a full due and the effect of additional bioactive substance to blood plasma.
As Fig. 1, shown in 2, the device of making according to said method includes housing 1 and module control circuit, it is characterized in that: as can be known in conjunction with Fig. 3, it also includes input channel 2, detaching mechanism of blood plasma, the blood plasma adsorbing mechanism, biological respinse mechanism, blood plasma output mechanism and output channel 3, incubator in the housing 1 is provided with blood plasma pond 5 for 4 li, biological respinse mechanism and blood plasma adsorbing mechanism form internal recycle with blood plasma pond 5 respectively, the blood plasma outfan 7 of the detaching mechanism of blood plasma that input 6 is communicated with input channel 2 is by the liquid pipe, the liquid pipe valve feeds blood plasma pond 5 and useless blood plasma container 19 respectively, the blood concentration components outfan 8 of detaching mechanism of blood plasma by the Meng Fei Shi pipe 9 is communicated with output channel 3, the blood plasma output mechanism that is communicated with blood plasma pond 5 passes through Meng Fei Shi and manages 9 and be communicated with output channel 3.
As shown in Figure 1, 2, simultaneously as can be known in conjunction with Fig. 3, detaching mechanism of blood plasma is to be made of separator 10, heparin infusion appliance 11 and the front pump 12 that is connected with module control circuit, the input 6 of detaching mechanism of blood plasma is communicated with through the inlet of front pump 12 with separator 10 by the liquid pipe, heparin infusion appliance 11 is communicated with the inlet of separator 10, the blood plasma outlet of separator 10 promptly is the blood plasma outfan 7 of detaching mechanism of blood plasma, and the blood concentration components outlet of separator promptly is the blood concentration components outfan 8 of detaching mechanism of blood plasma.
As shown in Figure 1, 2, and as can be known in conjunction with Fig. 3, the blood plasma adsorbing mechanism is to be made of liquid pipe, adsorber 13 and the sorption cycle pump 14 that is connected with module control circuit, after the inlet of the adsorbing mechanism that is communicated with blood plasma pond 5 was connected in series adsorber 13 and sorption cycle pump 14 mutually by the liquid pipe, its outlet was communicated with blood plasma pond 5.
As shown in Figure 1, 2, and as can be known in conjunction with Fig. 3, biological respinse mechanism is by the liquid pipe, places the bioreactor 15 in the incubator 4 to constitute with the circulating pump 16 that is connected with module control circuit, after the inlet of the biological respinse mechanism that is communicated with blood plasma pond 5 was connected in series bioreactor 15 and circulating pump 16 mutually by the liquid pipe, its outlet was communicated with blood plasma pond 5.
As shown in Figure 1, 2, and as can be known in conjunction with Fig. 3, the blood plasma output mechanism be the liquid pipe that is communicated with blood plasma pond 5 by the rear pump 17 that is connected with module control circuit afterwards with the Meng Fei Shi manage 9 and be communicated with, blood exchange transfusion set 20 is communicated with the input port of rear pump 17.
As shown in Figure 2, and in conjunction with Fig. 3 as can be known, for the ease of observing plasma volume and blood plasma liquid level situation in the blood plasma pond 5, operate and use this device better, the side in blood plasma pond 5 is provided with the blood plasma liquid level monitoring arrangement that is connected with module control circuit.The blood plasma liquid level monitoring arrangement can be a photographic head 18.
The present invention is external artificial hepaticsupport system, does not insert in patient's body, but blood samples of patients is drawn, and after the processing through the difference in functionality effect, converges and flows back in patient's body, so repeatedly, finally reaches the effect of artificial liver support and replacement therapy.Now, its operation principle is described below in conjunction with Fig. 1,2 and Fig. 3:
At first, module control circuit control front pump 12 is sent into patient's blood in the separator 10, separator 10 is separated into blood samples of patients invisible and blood plasma that have toxicant and tangible blood concentration components, control liquid pipe valve, make the blood plasma that has toxicant through blood plasma outfan 7, the liquid pipe is transported in the useless blood plasma container 19 and it is abandoned, the blood concentration components is through blood concentration components outfan 8, the Meng, the Fei Shi pipe 9, output channel 3 flows back in patient's body, simultaneously, under the effect of module control circuit, by rear pump 17 and blood exchange transfusion set 20 in patient's body, to inject normal person's blood plasma with the same speed of the toxic material blood plasma of blood plasma outfan 7 elution bands, this process is carried out repeatedly, the blood plasma that has toxicant in useless blood plasma container reaches till institute's plasma volume to be processed, this is the treatment of first step artificial liver, its objective is that the blood plasma that patient's body is contained more toxicant discards, in patient's body, mend normal person's blood plasma, realize detoxifcation and purification blood.
Continuation is sent into patient's blood in the separator 10 by module control circuit control front pump 12, separator 10 is separated into blood samples of patients invisible and blood plasma that have toxicant and tangible blood concentration components, control liquid pipe valve, make the blood plasma that has toxicant through blood plasma outfan 7, the liquid pipe is transported in the blood plasma pond 5, the blood concentration components is still through blood concentration components outfan 8, the Meng, the Fei Shi pipe 9, output channel 3 flows back in patient's body, when treating that blood plasma in the blood plasma pond 5 reach a certain height, start rear pump 17, with the blood plasma in the blood plasma pond 5 through rear pump 17, the Meng, the Fei Shi pipe 9, output channel 3 to be failing back in patient's body with the same speed of the toxic material blood plasma of blood plasma outfan 7 elution bands, thereby realizes balance between patient's body inner blood and the device outside and stable circulating.
In the above-mentioned blood circulation flow process, in separator 10, inject heparin by heparin infusion appliance 11 all the time, in case hemostasis liquid solidifies in the process of circulating.
Keeping on the mobile basis of above-mentioned blood circulation, module control circuit control sorption cycle pump 14 makes the blood plasma that has toxicant in the blood plasma pond and adsorber 13 carry out high speed and circulates, utilize the active carbon in the adsorber 13 to inhale most harmful substances in the slurry of dehematizing, till the adsorbance of adsorber 13 reaches capacity, thereby realize the physical property detoxifcation to blood plasma, this is the artificial liver treatment of second step.In this process, adsorber 13 is also inhaled and have been gone in the blood plasma human body beneficial's material, and this deficiency can be remedied in bioartificial liver's treatment in the 3rd step fully.
Under definite sorption cycle pump 14 out-of-work prerequisites, module control circuit control circulating pump 16 makes the blood plasma of handling through above-mentioned detoxifcation in the blood plasma pond 5 carry out high speed with bioreactor 15 again and circulates, bioreactor 15 is hollow fiber bioreactor, its inner chamber is cultivated a large amount of highly active cultivation hepatocyte, when blood plasma passes through bioreactor 15 exocoels, carry out two-way mass exchange and exchange with highly active cultivation hepatocyte by the semipermeable membrane on the doughnut, highly active cultivation hepatocyte carries out specific picked-up to the toxicant in the blood plasma, conversion, metabolism, the large number of biological of synthesis secretion release is simultaneously lived. and the property material enters blood plasma, so repeatedly, patient's blood plasma is carrying out the antidotal while for a full due in the mode of biology, replenish the large number of biological active substance of needed by human body again, thereby finished the 3rd step bioartificial liver treatment.
In sum, the present invention is as introducing blood samples of patients in external second liver, finishes the physiological function of the liver of loss of function in patient's body, Here it is mixed biologic artificial liver supporting treatment or alternative medicine by external the present invention.By therapeutical effect of the present invention, the patient can recover by self liver regeneration, or recovers as liver transplantation through other treatment.The present invention creates conditions for above-mentioned liver regeneration or liver transplantation etc. just, races against time and chance, and be a kind of effective and requisite treatment means of excessive property, it has great importance aspect redemption liver failure patient life.
Claims (8)
1. the rami hepatici of an external mixed biologic artificial liver is held method, and its step is as follows:
1) plasmapheresis: be separated into blood samples of patients invisible and blood plasma that have toxicant and tangible blood concentration components with plasma separator, abandon the blood plasma that has toxicant, tangible blood concentration components is failed back in patient's body, simultaneously, with the blood exchange transfusion set to have the effusive same speed of toxicant blood plasma is injected the normal person in patient's body blood plasma with isolating;
2) circulating of blood and device outside: continue to be separated into blood samples of patients invisible and blood plasma that have toxicant and tangible blood concentration components with plasma separator, they are failed back in patient's body by path separately respectively, stable the circulating with the balance between realization patient's body inner blood and the device outside;
3) blood plasma adsorptivity detoxifcation: with plasorber to step 2) in the blood plasma path in the blood plasma that has toxicant carry out adsorptivity and handle, the noxious substance in the blood plasma is removed, realize physical property detoxifcation to blood plasma;
4) bioartificial liver's specificity detoxifcation and biosynthesis: with bioreactor to step 2) in the blood plasma path in the blood plasma that has toxicant handle, by highly active cultivation hepatocyte in the bioreactor toxicant in the blood plasma is carried out specific picked-up, conversion, metabolism, simultaneously synthesis secretion discharges the large number of biological active substance and enters blood plasma, realizes detoxifying for a full due and the effect of additional bioactive substance to blood plasma.
2. the rami hepatici of an external mixed biologic artificial liver according to claim 1 is held method and the rami hepatici made is held device, include housing (1) and module control circuit, it is characterized in that: it also includes input channel (2), detaching mechanism of blood plasma, the blood plasma adsorbing mechanism, biological respinse mechanism, blood plasma output mechanism and output channel (3), incubator (4) lining in the housing (1) is provided with blood plasma pond (5), biological respinse mechanism and blood plasma adsorbing mechanism form internal recycle with blood plasma pond (5) respectively, the blood plasma outfan (7) of the detaching mechanism of blood plasma that input (6) is communicated with input channel (2) is by the liquid pipe, the liquid pipe valve feeds blood plasma pond (5) and useless blood plasma container (19) respectively, the blood concentration components outfan (8) of detaching mechanism of blood plasma is communicated with output channel (3) by Fei Shi pipe in the Meng (9), and the blood plasma output mechanism that is communicated with blood plasma pond (5) is by being communicated with output channel (3) by Fei Shi pipe in the Meng (9).
3. the rami hepatici of external mixed biologic artificial liver as claimed in claim 2 is held device, it is characterized in that: detaching mechanism of blood plasma is by separator (10), heparin infusion appliance (11) constitutes with the front pump that is connected with module control circuit (12), the input of detaching mechanism of blood plasma (6) is communicated with through the inlet of front pump (12) with separator (10) by the liquid pipe, heparin infusion appliance (11) is communicated with the inlet of separator (10), the blood plasma outlet of separator (10) promptly is the blood plasma outfan (7) of detaching mechanism of blood plasma, and the blood concentration components outlet of separator promptly is the blood concentration components outfan (8) of detaching mechanism of blood plasma.
4. the rami hepatici of external mixed biologic artificial liver as claimed in claim 2 is held device, it is characterized in that: the blood plasma adsorbing mechanism is to be made of liquid pipe, adsorber (13) and the sorption cycle pump (14) that is connected with module control circuit, the inlet of the adsorbing mechanism that is communicated with blood plasma pond (5) by the liquid pipe with adsorber (13) and sorption cycle pump (14) is mutual be connected in series after, its outlet is communicated with blood plasma pond (5).
5. the rami hepatici of external mixed biologic artificial liver as claimed in claim 2 is held device, it is characterized in that: biological respinse mechanism is by the liquid pipe, places the bioreactor (15) in the incubator (4) to constitute with the circulating pump that is connected with module control circuit (16), the inlet of the biological respinse mechanism that is communicated with blood plasma pond (5) by the liquid pipe with bioreactor (15) and circulating pump (16) is mutual be connected in series after, its outlet is communicated with blood plasma pond (5).
6. the rami hepatici of external mixed biologic artificial liver as claimed in claim 2 is held device, it is characterized in that: the liquid pipe that the blood plasma output mechanism is with blood plasma pond (5) are communicated with is communicated with Fei Shi pipe in the Meng (9) by rear pump (17) back that is connected with module control circuit, and blood exchange transfusion set (20) is communicated with the input port of rear pump (17).
7. hold device as the rami hepatici of claim 2,3,4,5,6 described external mixed biologic artificial livers, it is characterized in that: the side of blood plasma pond (5) is provided with the blood plasma liquid level monitoring arrangement that is connected with module control circuit.
8. the rami hepatici of external mixed biologic artificial liver as claimed in claim 7 is held device, it is characterized in that: the blood plasma liquid level monitoring arrangement is photographic head (18).
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| CNB001130838A CN1137733C (en) | 2000-06-29 | 2000-06-29 | Method and equipment for externally mixed biologic artificial liver |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB001130838A CN1137733C (en) | 2000-06-29 | 2000-06-29 | Method and equipment for externally mixed biologic artificial liver |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106267402A (en) * | 2016-07-29 | 2017-01-04 | 武汉仝干医疗科技股份有限公司 | Semipermeable membrane layer-stepping bioartificial liver's on-line monitoring and heated at constant temperature integrated system |
| WO2019148611A1 (en) * | 2018-02-01 | 2019-08-08 | 南方医科大学珠江医院 | Combined bioartificial liver support system |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100335142C (en) * | 2004-12-24 | 2007-09-05 | 浙江大学 | Apparatus adapted for artificial liver |
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2000
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106267402A (en) * | 2016-07-29 | 2017-01-04 | 武汉仝干医疗科技股份有限公司 | Semipermeable membrane layer-stepping bioartificial liver's on-line monitoring and heated at constant temperature integrated system |
| CN106267402B (en) * | 2016-07-29 | 2018-07-17 | 武汉仝干医疗科技股份有限公司 | Semi-permeable membrane layer-stepping bioartificial liver monitors on-line and heated at constant temperature integrated system |
| WO2019148611A1 (en) * | 2018-02-01 | 2019-08-08 | 南方医科大学珠江医院 | Combined bioartificial liver support system |
| US11911552B2 (en) | 2018-02-01 | 2024-02-27 | Southern Medical University Zhujiang Hospital | Combined bio-artificial liver support system |
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