CN1330152A - 一种生物光盘 - Google Patents

一种生物光盘 Download PDF

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Publication number
CN1330152A
CN1330152A CN 00106356 CN00106356A CN1330152A CN 1330152 A CN1330152 A CN 1330152A CN 00106356 CN00106356 CN 00106356 CN 00106356 A CN00106356 A CN 00106356A CN 1330152 A CN1330152 A CN 1330152A
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optical disk
bio
upholder
probe
metallic reflector
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肖乐义
董建军
赵天增
薛歧庚
郭唯
王时征
米明仁
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00536—Sheets in the shape of disks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

一种生物光盘,属生物工程技术领域。包括支持物和探针,支持物和探针之间有金属反射层,支持物和金属反射层间有有机染料层,光盘上探针呈同心圆环状或螺旋状排列。该生物光盘点阵密度高,在与其它试剂反应后用计算机光驱、VCD、SVCD、DVD播放机等光盘阅读装置拾取反应信号包括荧光信号,用计算机分析判断结果,阅读方式多样化,使用非常方便,使用成本得以降低。

Description

一种生物光盘
本发明属于生物工程技术领域，特别涉及一种生物光盘。
目前使用的生物芯片包括基因芯片、肽芯片，从结构上来说，它们都由支持物或片基和探针层组成，这类芯片必须用专用的芯片分析仪才能检测出结果，使用很不方便，成本太高。
本发明目的在于提供一种使用方便的生物光盘。
为达上述目的，本发明采用如下技术方案：一种生物光盘，包括支持物和探针，在支持物和探针之间有金属反射层。
在支持物和金属反射层之间设有有机染料层。
有机染料选用花菁。
光盘上探针呈同心圆环状排列或螺旋状排列。
支持物选用聚碳酸酯，金属反射层选用金、银或铝。
图1为现有生物光盘结构示意图；
图2为本发明结构示意图；
图3为实施例2结构示意图。
本发明采用在支持物和探针之间增设金属反射层，或增设金属反射层及有机染料层的设计，使得生物芯片结构类似光盘结构，我们称其为生物光盘或叫生物芯片。它与普通光盘区别在于：普通光盘中存储的是数据信息，本发明中则是探针，该探针可与其他试剂反应而提供某种信息；普通光盘用激光将信息以凸凹形式进行记录并读取，而本发明则先将探针固定于金属反射层面上，通过与其它试剂反应提供某种信息；普通光盘结构上有一层保护层，本发明则无此保护层，如果在其探针上设保护层，则无法进行反应。它可以在与其它试剂反应后用计算机光驱、VCD、SVCD、DVD播放机等光盘阅读装置拾取反应信号包括荧光信号，用计算机分析判断结果，阅读方式多样化，使用非常方便，使用成本得以降低。探针采用同心圆环状或螺旋状点阵，点阵可用原位合成、光刻、机器人点样、硅烷化连接、自组装单分子层或生物素——亲和素体系排布于金属反射层上，点阵密度更高，光盘容量增大。
下面结合附图进一步说明本发明。
实施例1，一种生物光盘，包括支持物1和探针层2，在支持物和探针层间设一金属反射层3。其制作过程参照光盘制作过程。支持物选用聚碳酸酯，金属反射层选用金。
实施例2，一种生物光盘，本实施例中，在金属反射层与支持物间增设有机染料层4。有机染料层选用花菁，其他同实施例1。

Claims (5)

1、一种生物光盘，包括支持物和探针，本发明特征在于，在支持物和探针之间有金属反射层。
2、如权利要求1所述的生物光盘，其特征在于，在支持物和金属反射层之间设有有机染料层。
3、如权利要求2所述的生物光盘，其特征在于，有机染料选用花菁。
4、如权利要求1或2或3所述的生物光盘，其特征在于，光盘上探针呈同心圆环状排列或螺旋状排列。
5、如权利要求4所述的生物光盘，其特征在于，支持物选用聚碳酸酯，金属反射层选用金、银或铝。
CN 00106356 2000-06-17 2000-06-17 一种生物光盘 Pending CN1330152A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 00106356 CN1330152A (zh) 2000-06-17 2000-06-17 一种生物光盘

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 00106356 CN1330152A (zh) 2000-06-17 2000-06-17 一种生物光盘

Publications (1)

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CN1330152A true CN1330152A (zh) 2002-01-09

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CN 00106356 Pending CN1330152A (zh) 2000-06-17 2000-06-17 一种生物光盘

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1869693B (zh) * 2005-05-19 2010-09-01 索尼株式会社 生物鉴定用基板和装置、以及基板的制造方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1869693B (zh) * 2005-05-19 2010-09-01 索尼株式会社 生物鉴定用基板和装置、以及基板的制造方法

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