CN1328443A

CN1328443A - Skin deodorizing sanitizing compositions

Info

Publication number: CN1328443A
Application number: CN 99813599
Authority: CN
Inventors: M·T·多德; K·S·魏; T·特里因; M·R·赛恩; R·G·巴托罗; D·A·贾库博威克
Original assignee: Procter and Gamble Ltd
Current assignee: Procter and Gamble Ltd; Procter and Gamble Co
Priority date: 1998-11-23
Filing date: 1999-11-22
Publication date: 2001-12-26
Also published as: EP1131044A1; JP2002530313A; AU1918700A; WO2000030599A1

Abstract

The present invention relates to aqueous compositions comprising an odor controlling agent and select sanitizing agents for deodorizing and sanitizing skin surfaces. Articles of manufacture and methods of deodorizing and sanitizing the skin using disclosed compositions are also disclosed.

Description

Skin deodorizing and sanitizing compositions

Invention field

The present invention relates to contain the odor control agent that is useful on deodorization and disinfecting skin surface and selected sanitizer Aquo-composition.The invention also discloses the goods of the disclosed compositions manufacturing of application and the method for deodorization and disinfecting skin.

Background of invention

The consumer of today is exactissima diligentia pathogenic bacteria and pathogen transmission all.Every day, people are in the place of having a dinner, stadiums, when changing babies' napkin more or use portable closet (as making things convenient for urinal) Shi Douhui to touch pathogenic bacteria.In case touch people's hands, these pathogenic bacterias (promptly such as antibacterial, fungus and/or viral microorganism) are just very fast transmits between individuality, thereby contagion/infectious disease is propagated.Prevent this pathogenic bacteria and/or pathophoresis a kind of preferably and the easiest mode be by daily and wash one's hands in earnest.Recognize under some tour condition and/or this inconvenience or impossible of washing one's hands under the situation it is pressed for time, the product that a lot of manufacturers have just introduced the disinfecting hands comes the disinfecting skin surface, and need not water and/or towel.

Although the product of present disinfecting hands can kill with such as start up the car, the pathogenic bacteria that is associated of changing babies' napkin or these daily routines of hand operated equipment more, they can not eliminate incident foul smell (as smell of petrol).And foul smell can be from not having related activity (abnormal smells from the patient when for example preparation is as food such as Bulbus Allii Cepae, Bulbus Alliis) usually with pathogen transmission.Therefore, need a kind of product of exploitation, it not only can kill the pathogenic bacteria relevant with daily routines, and can eliminate incident foul smell.The inventor finds that containing through the sanitizer of selection and the disinfecting skin composition of odor control agent to provide outstanding antimicrobial acivity and the control of improved abnormal smells from the patient.

Therefore, an importance of the present invention provides a kind of improved skin health sanitizing composition.

Another aspect of the present invention provides a kind of skin health sanitizing composition, and it contains the sanitizer of odor control agent and selection.

To become apparent by the following detailed description these and other aspect of the present invention.

Summary of the invention

That compositions of the present invention relates to is stable, preferably translucent, more preferably clarifying skin health and deodorant compositions, and said composition contains:

A) provide the odor control agent of odor control effect effective dose, this odor control agent is preferably selected from cyclodextrin, water-soluble metal salt, zeolite, soluble carbon hydrochlorate and/or bicarbonate, the water soluble ion polymer, silica gel, SiO 2 molecular sieve, activated bauxite, kieselguhr, bleaching earth, Montmorillonitum, smectite clay, Attagel, bentonite, Paligorskite, kaolinite, illite, halloysite, hectorite, beidellite, nontronite, Pulvis Talci, fiber rod stone kind, Vermiculitum, meerschaum, chlorophyll, soda-lime, calcium oxide, chitin, potassium permanganate, active carbon or activated carbon and composition thereof;

B) provide the sanitizer of the selection of disinfecting effect effective dose, it is preferably selected from alcohol disinfectant, antimicrobial and composition thereof;

C) optionally, the thickening agent of 0-about 10%;

D) optionally, the emollient of 0-about 10%;

F) optionally, the spice of 0-about 1%; With

G) water.

One aspect of the present invention, preferred gel composition.The invention still further relates to the method for using the Personal hygiene sanitizing composition.The invention further relates to the goods of manufacturing, comprise skin health and deodorant compositions in the dispense container of mixing preferably clear.

A kind of preferred skin health of the present invention and deodorant compositions, contain:

A) provide the odor control agent of odor control effect effective dose;

B) alcohol disinfectant of about 40%-about 99%;

C) optionally, the water-soluble metal salt of 0-about 10%;

D) optionally, the thickening agent of 0-about 10%;

E) optionally, the emollient of 0-about 10%;

F) optionally, the spice of 0-about 1%; With

G) water.

Another kind of preferred skin health of the present invention and deodorizing gel compositions, contain:

A) provide the odor control agent of odor control effect effective dose;

B) kill or reduce the sanitizer that contains antimicrobial of growth of microorganism effective dose;

C) thickening agent of 0.01%-about 10%;

D) optionally, the emollient of 0-about 10%;

E) optionally, the spice of 0-about 1%; With

F) water.

The invention still further relates to stable, preferred translucent, more preferably clarifying skin deodorizing gel combination, said composition contains:

A) provide the odor control agent of odor control effect effective dose;

B) thickening agent of 0.01%-about 10%;

C) optionally, the spice of 0-about 1%;

D) optionally, the emollient of 0-about 10%;

E) optionally, the anti-microbial preservative of 0-about 0.2%; With

F) water.

Detailed Description Of The Invention

Skin health of the present invention and deodorant compositions can contain ultimate constituent and the determinant that the present invention describes, and are formed or are made up of them basically by them, also contain any other or optional member, component or the determinant of the present invention's description.

All percents, umber and ratio are all in the gross weight of Personal hygiene sanitizing composition of the present invention, unless otherwise indicated.All these weight are subordinated to listed component owing to them thereby in active quantities, therefore do not comprise the carrier or the by-product that may contain in the commercially available acquisition material, unless otherwise indicated.

Terminology used here " alcohol disinfectant " refers to that under used concentration to killing or reducing the microbial growth that is in contact with it be effective alcohol (or combining form of alcohol), and said microorganism is antibacterial for example.

Terminology used here " moment " refer to compositions of the present invention can be in about 5 minutes, in preferred about 1 minute, more preferably from about do not need soap and water just to sterilize in 20 seconds in 30 seconds even more preferably from about to skin area.

Terminology used here " safe and effective amount " refers to that chemical compound or compositions are enough to produce tangible positive effect but the enough low amount that can avoid serious side effects (rational effect/hazard ratio promptly is provided) in the scope that can judge those skilled in the art, wherein said positive effect is preferably odor control effect and anti-microbial effect, comprises various effect disclosed in this invention independently.

Preferably, disinfecting of the present invention and deodorant compositions are " clarifying ".Here defined term " clarifying " refers to be transparent or semitransparent when seeing through thickness when observing less than the layer of about 10cm, preferably as transparent as " clarification of water ".

Skin health compositions of the present invention be will describe below in detail, its solvent and optional components comprised.

The solvent odor control agent

A kind of basis of the present invention is odor control agent.Here used expression language " odor control agent " comprises one or more materials, itself or when the preparation cost inventive compositions, play a part with the foul smell molecule in conjunction be embedded on its molecular structure or within, or do not discovered by most of people's (if not all) olfactory sensation sense organ with foul smell molecule chemically reactive so that foul smell molecule.The example of suitable odor control agent includes, but is not limited to cyclodextrin, water-soluble metal salt, zeolite, soluble carbon hydrochlorate and/or bicarbonate, the water soluble ion polymer, silica gel, SiO 2 molecular sieve, activated bauxite, kieselguhr, bleaching earth, Montmorillonitum, smectite clay, Attagel, bentonite, Paligorskite, kaolinite, illite, halloysite, hectorite, beidellite, nontronite, Pulvis Talci, fiber rod stone kind, Vermiculitum, meerschaum, chlorophyll, soda-lime, calcium oxide, chitin, potassium permanganate, active carbon or activated carbon and composition thereof, preferred cyclodextrin, water-soluble metal salt, soluble carbon hydrochlorate and/or bicarbonate, the water soluble ion polymer, zeolite and composition thereof, more preferably cyclodextrin, water-soluble metal salt and composition thereof.

As US patent 4,591,497 and 5,556, keratin material hydrolysate and the di-phosphate ester chemical compound described respectively in 614 also can be preferred for the present invention; These two pieces of patents are incorporated herein by reference in full at this.

Such as US patent 4,818,524 and 4,946, the deodorant compositions of describing in 672 also can preferably use in compositions of the present invention; These two pieces of patents are incorporated herein by reference in full at this.Cyclodextrin

Preferred odor control agent comprises cyclodextrin.Terminology used here " cyclodextrin " comprises any known cyclodextrin, for example contains unsubstituted ring dextrin, especially alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin and/or their derivant and/or its mixture of 6-12 glucose unit.

Terminology used here " non-compound cyclodextrin " refers to that the cyclodextrin internal cavities in the solution of the present invention should keep filling substantially in this solution, so that make cyclodextrin can absorb multiple scent molecule from the teeth outwards the time this solution coat.Terminology used here " the non-compound cyclodextrin of water solublity " refers to that the minimal solubility limit is the non-compound cyclodextrin of 1% (dissolving 1g in the 100g water).

At room temperature, the content of non-derivative beta-schardinger dextrin-can be up to its solubility limit of about 1.85%.When beta-schardinger dextrin-being coated on the wiping substrate, can use the content that is higher than its solubility limit.

The cyclodextrin of high water soluble also can be preferred for the present invention, as alpha-cyclodextrin and/or its derivant, gamma-cyclodextrin and/or its derivant, derivatization beta-schardinger dextrin-, and/or their mixture.The water solubility of high water soluble cyclodextrin at room temperature is that dissolving is at least about 10g in the 100ml water, and dissolving is more preferably at room temperature dissolved at least about 25g in the 100ml water at least about 20g in the preferred 100ml water.The derivant of cyclodextrin mainly is made of the molecule that some of them OH group is transformed into the OR group.Cyclodextrin derivative for example comprises the cyclodextrin with short-chain alkyl, and as methylated cyclodextrin and ethylated cyclodextrin, wherein R is methyl or ethyl; Cyclodextrin with hydroxy alkyl, as hydroxypropyl cyclodextrin and/or hydroxyethyl cyclodextrin, wherein R is-CH ₂-CH (OH)-CH ₃Or-CH ₂CH ₂-OH group; Cyclodextrin with (hydroxy alkyl) alkylidene abutment, as the cyclodextrin glycerin ether, (2-hydroxyethyl) ethylidene wherein ,-CH ₂CH (CH ₂OH)-the group bridging is between 2 ' and 3 ' hydroxyl oxygen on the glucosyl group unit; Branched cyclodextrin is as the cyclodextrin of maltose bonding; Cationic cyclodextrin, as contain the cyclodextrin of 2-hydroxyl-3-(dimethylamino) propyl ether, wherein R is CH ₂-CH (OH)-CH ₂-N (CH ₃) ₂, it is cation under low pH; Quaternary ammonium, as 2-hydroxyl-3-(trimethyl ammonium) propyl ether chloride group, wherein R is CH ₂-CH (OH)-CH ₂-N ⁺(CH ₃) ₃Cl ^-The anionic cyclodextrin is as carboxymethyl cyclodextrin, cyclodextrin sulfo group butyl ether, cyclodextrin tetradecasulfate and cyclodextrin succinyl ester; The both sexes cyclodextrin is as carboxymethyl/Quaternised ammonium cyclodextrin; Wherein at least one glucopyranose unit has the cyclodextrin of 3-6-dehydration-ring maltose structure, as one-3-6-dehydration cyclodextrin, as in " optimum performance with minimum chemical modification of cyclodextrin ", F.Diedaini-Pilard and B.Perly, disclosed in " the 7th international cyclodextrin symposium summary ", it is hereby incorporated by; And their mixture.Other cyclodextrin derivative is disclosed in US patent 3,426,011 (Parmerter etc., 1969.2.4 authorizes); 3,453,257,3,453,258,3,453,259 and 3,453,260 (they all belong to people such as Parmerter, and 1969.7.1 authorizes); 3,459,731 (people such as Gramera, 1969.8.5 authorizes); 3,553,191 (people such as Parmerter, 1971.1.5 authorizes); 3,565,887 (people such as Parmerter, 1971.2.23 authorizes); 4,535,152 (people such as Szejtli, 1985.8.13 authorizes); 4,616,008 (people such as Hirai, 1986.10.7 authorizes); 4,678,598 (people such as Ogino, 1987.7.7 authorizes); 4,638,058 (people such as Brandt, 1987.1.20 authorizes); With 4,746,734 (people such as Tsuchiyama, 1988.5.24 authorizes); 5,534,165 (people such as Pilosof, 1996.7.9 authorizes), above-mentioned whole patents are hereby incorporated by.

More preferably alpha-cyclodextrin, beta-schardinger dextrin-, hydroxypropyl alpha-cyclodextrin, hydroxypropyl, methylate-alpha-cyclodextrin, methylate-beta-schardinger dextrin-, cyclodextrin glycerin ether and composition thereof.

Also preferably use the mixture of cyclodextrin.This class mixture is because of can absorb body odor with the odoriferous molecule of the wider more wide region of molecular size is compound widelyr.The content of cyclodextrin is that about 0.1%-of composition weight is about 5%, and preferably about 0.2%-is about 4%, and more preferably from about 0.3%-is about 3%, first-selected about 0.4%-about 2%.

Also can use spissated compositions.When using concentrated product, promptly when used cyclodextrin content be that about 3%-is about 5% the time, be skin sense and/or the undesirable residual quantity of avoiding being clamminess, preferably before being applied to skin, compositions is diluted.Preferably, with the water of the about 50%-of composition weight about 2000% dilution cyclodextrin, more preferably with the water of the about 60%-of composition weight about 1000%, the water of first-selection about 75%-about 500%.

When at first coating dissolved cyclodextrin on the skin, cyclodextrin and scent molecule are very fast compound in the presence of water.Therefore, the effectiveness of dissolved non-compound cyclodextrin is necessary for abnormal smells from the patient control performance effectively and efficiently.

Also preferably use the mixture of cyclodextrin.This class mixture can be compound with the odoriferous molecule of the wider more wide region of molecular size.Preferably, at least a portion of cyclodextrin mixt is alpha-cyclodextrin and derivant thereof, gamma-cyclodextrin and derivant thereof and/or beta-schardinger dextrin-and derivant thereof, and their mixture.

Being particularly preferred for cyclodextrin of the present invention is alpha-cyclodextrin, beta-schardinger dextrin-, hydroxypropyl alpha-cyclodextrin, hydroxypropyl, the alpha-cyclodextrin that methylates, beta-schardinger dextrin-and composition thereof methylates.More preferably be used for of the present invention be alpha-cyclodextrin, beta-schardinger dextrin-, hydroxypropyl, beta-schardinger dextrin-and composition thereof methylates.

For reducing the stink sense on the skin, preferably compositions is used with gel or spray as hands.Preferably, compositions can not distinguished when dry.The typical content of odor control agent is that about 0.1%-of composition weight is about 5%, and preferably about 0.2%-is about 4%, and more preferably from about 0.3%-is about 3%, first-selected about 0.4%-about 2%.

Water-soluble metal salt

Water-soluble metal salt also is a preferred odor control agent in the present composition.Water-soluble metal salt can be present in and is used for absorbing amine and sulfur-containing compound in the deodorant compositions of the present invention.In addition, they can not bring their abnormal smells from the patients own usually.Preferably, water-soluble metal salt is selected from mantoquita, zinc salt and composition thereof.

Based on its relief capabilities to foul smell, preferably zinc salt is the most normal is employed, and for example is used for the oral cavity disinfecting product, as US patent 4,325,939 (1982.4.20 mandate) and 4, disclosed in 469,674 (1983.9.4 mandate) (all the authorizing N.B.Shah etc.), be hereby incorporated by.US patent 3,172,817 (authorizing Leupold etc.) discloses deodorant compositions, wherein contains the acyl group-acetone that is slightly soluble in water and the salt of polyvalent metal, comprises mantoquita and zinc salt.Said patent is hereby incorporated by.

The example of preferred water-soluble zinc salt is zinc chloride, zinc gluconate, zinc lactate, MALEIC ACID, ZINC SALT, zinc salicylate, zinc sulfate or the like.The zinc salt of height ionizing and solubility such as the best that zinc chloride is zinc ion source.The example of preferred mantoquita is copper chloride and copper gluconate.Preferred slaine is zinc chloride and copper chloride, more preferably zinc chloride.

Slaine adds content in the present composition to, and to be generally about 0.01%-of composition weight about 10%, and preferably about 0.2%-is about 7%, and more preferably from about 0.3%-about 5%.When using zinc salt, and when expecting clarifying compositions as slaine, preferably the pH of solution is adjusted to less than about 7, be more preferably less than about 6, first-selected less than about 5, so that keep the solution clarification.

Soluble carbon hydrochlorate and/or bicarbonate

Water soluble alkali metal carbonate and/or bicarbonate can add to as sodium bicarbonate, potassium bicarbonate, potassium carbonate, cesium carbonate, sodium carbonate and composition thereof and to come some acid type abnormal smells from the patient of assist control in the compositions of the present invention.Preferred salt is sodium carbonate monohydrate, potassium carbonate, sodium bicarbonate, potassium bicarbonate and composition thereof.When being added with these salt in the compositions of the present invention, their amount is that about 0.1%-of composition weight is about 5%, and preferably about 0.2%-is about 3%, and more preferably from about 0.3%-about 2%.When being added with these salt in the compositions of the present invention, there is not inconsistent slaine among preferred the present invention.Preferably, when using these salt, should be substantially free of zinc and other inconsistent metal ion in the fluid composition, for example Ca, Fe, Ba etc., it can form water-insoluble salt.

The water soluble ion polymer

Water-soluble anionic polymer, for example polyacrylic acid and water soluble salt thereof can be used for controlling some amine type abnormal smells from the patient in the present invention.The mean molecule quantity of preferred polyacrylic acid and alkali metal salt thereof is less than about 20,000, and preferably less than 10,000, more preferably from about 500-about 5,000.Contain sulfonic group, phosphate, phosphonate group, they water soluble salt and composition thereof and also be suitable for the polymer of the mixture of carboxylic acid group and carboxylate group.

Not only cation functional group but also the water-soluble polymer that contains the anionic functional group also were suitable for.The example of these polymer can be referring to US patent 4,909,986 (1990.3.20 authorizes, and authorizes N.Kobayashi and A.Kawazoe), and it is hereby incorporated by.Not only cation functional group but also another example of containing anionic functional group's water-soluble polymer were chlorination dimethyl diallyl ammonium chloride and acrylic acid copolymer, can be available from Calgon, and commodity are called Merquat280 ^

When using water-soluble polymer, it is about 3% that its amount is generally about 0.001%-of composition weight, and preferably about 0.005%-is about 2%, more preferably from about 0.01%-about 1% even more preferably from about 0.05%-about 0.5%.

Zeolite

A kind of zeolite of preferred type is characterized as being " middle rank " silicate/aluminosilicate zeolitic.This middle rank zeolite is characterised in that SiO ₂/ AlO ₂Mol ratio is less than about 10.Preferably, SiO ₂/ AlO ₂Mol ratio is about 2-about 10.This middle rank zeolite has the advantage that surpasses " senior " zeolite.The middle rank zeolite has stronger affinity to amine type abnormal smells from the patient, because they have bigger surface area, and they are more water-fast and can keep more odor adsorption ability in water than senior zeolite, so they are more effective to absorbing abnormal smells from the patient.Various to be suitable for intermediate zeolite of the present invention be commercially available acquisition, as can be available from Valfor  CP301-68, Valfor  300-63, Valfor  CP300-35 and the Valfor  CP300-56 of Pq Corp. and can be available from the CBV100  series zeolite of Conteka.

Can be available from the commodity of Union Carbide company and UOP Abscents by name ^And Smellrite ^Commercially available zeolitic material also be preferred.These materials generally are to obtain with the white powder of 3-5 micron particle particle size range.For example thio-alcohol, mercaptan geometric ratio middle rank zeolite are more preferred to control sulfur-bearing abnormal smells from the patient for this material.

Activated carbon

Being suitable for carbon class material of the present invention is to be known in the material that is used as the organic molecule absorbent in the business practice and/or is used for the air cleaning purpose.Usually, this type of carbon class material is known as " activity " carbon or " activity " charcoal.The commercially available acquisition of this carbon, for example commodity Calgon-CPG  type by name, PCB  type, SGL  type, CAL  type and OL  type.

Can also use the mixture of above-mentioned odor control agent.Odor control agent such as activated carbon with obvious color and luster are unwell to skin treatment, but can be used for deodorization and/or disinfecting on other apparent unessential surface.

Sanitizer

Sanitizer uses in the present composition can effectively be eliminated or reduce the harmful microbe growth that exists on the processed surface.When containing odor control agent, preferably sanitizer is compatible with odor control agent, promptly sanitizer with said odor control agent not with effective reduction and/or eliminate one of these two kinds of reagent or combination in essence of both active modes, connection, compound, interact and/or react.When having cyclodextrin, preferred sanitizer is that cyclodextrin is compatible, and promptly it does not take place compound with cyclodextrin in itself.Preferred disinfecting activating agent is selected from alcohol disinfectant, antimicrobial activities and composition thereof.

Alcohol disinfectant

Can contain the 40%-that has an appointment about 99%, more preferably from about about 90%, the first-selected about 50%-about 75% of 45%-even the more preferably from about alcohol disinfectant of 55%-about 70% or the mixture of alcohol disinfectant in the compositions of the present invention.The example of suitable alcohol disinfectant includes, but is not limited to ethanol, normal propyl alcohol and isopropyl alcohol or its mixture.Being particularly preferred for alcohol disinfectant of the present invention is ethanol.

Antimicrobial

Antimicrobial activities can be used to provide the disinfecting effect in the present invention.Antimicrobial activities preferably should be compatible with odor control agent.When having cyclodextrin, antimicrobial activities preferably cyclodextrin is compatible, promptly not with compositions in cyclodextrin form complex in itself.Free not compound antimicrobial activities as the antibacterial activity agent, provides best anti-microbial property.

A) fast-acting type antimicrobial

The present invention preferably uses the fast-acting type antimicrobial.The combining form that terminology used here " fast-acting type antimicrobial " refers to antimicrobial or antimicrobial under the used concentration in about 5 minutes, in preferred about 1 minute, more preferably from about in 30 seconds even more preferably from about just can kill effectively or deactivation microorganism, for example antibacterial, virus or fungus in 20 seconds.The example of suitable fast-acting type antimicrobial includes, but is not limited to quaternary compound such as benzalkonium chloride and benzethonium chloride, acetic acid solution, glutaraldehyde, halazone, chlorobenzene, two (oxidation of 2-mercaptopyridine) zinc, thymol, thimerosal, hexachlorophene, mefenide, the 9-nonoxynolum, the hot menthylphenoxypolyethoxy ethanol of 9-, salicylic acid, selenium sulfide, silver nitrate, silver sulfadiazine, zinc sulfate, hydrogen peroxide, hexadecylpyridinium chloride, formaldehyde, Gentian Violet, hexyl resorcinol, biguanide compound such as chlorhexidine salt; Phenolic compound such as cresol; Iodine compound such as povidon iodine; And pigment compound such as ethacridine, their salt and composition thereof.

Particularly preferred fast-acting type antimicrobial is biguanide compound and quaternary compound.Biguanide compound can play antibacterial/sanitizer and finished product antiseptic, and can be used for compositions of the present invention, comprises 1,1 '-hexa-methylene two (5-(rubigan) biguanide), it is known as chlorhexidine, with and salt, for example with the salt of hydrochloric acid, acetic acid and gluconic acid.Digluconate is a high water soluble, and about 70% is water-soluble, and the water solubility of diacetin is about 1.8%.In the time using chlorhexidine as sanitizer among the present invention, it is about 0.4% that its content is generally about 0.001%-of composition weight, and preferably about 0.002%-is about 0.3%, and more preferably from about 0.05%-about 0.2%.In some cases, to need content be about 1%-about 2% to viricidal activity.Other useful biguanide compound comprises Cosmici ^CQ ^, Vantocil ^IB comprises poly-(hexamethylene biguan-ide) hydrochlorate.Other useful cationic antimicrobial agent comprises two biguanide paraffinics.Above-mentioned available water soluble salt is a chloride, bromide, sulfate, alkylsulfonate such as metilsulfate and ethyl sulfonate, phenylbenzimidazole sulfonic acid salt such as p-methylphenyl sulfonate, nitrate, acetate, gluconate or the like.

Various quaternary compounds also can be as the fast-acting type antimicrobial activities of the present composition.The non-limiting example of available quaternary compound comprises the benzalkonium chloride of (1) benzalkonium chloride and/or replacement, as the Barquat of commercially available acquisition ^(can available from Lonza), Maquat ^(can available from Mason), Variquat ^(can available from Witco/Sherex) and Hyamine ^(can available from Lonza); (2) two (C ₆-C ₁₄) alkyl two short chain (C _1-4Alkyl and/or hydroxy alkyl) quaternary salt, as the Bardac of Lonza ^Product; (3) N-(3-chlorallyl) hexamethylenamine (hexaminium) chloride is as the Dowicide available from Dow ^And Dowicil ^(4) benzethonium chloride is as Rohm ﹠amp; The Hyamine of Haas ^1622; (5) methyl benzethonium chloride, it is represented as Rohm; The Hyamine of Haas ^10X; (6) hexadecylpyridinium chloride, as the Cepacol chloride of Merrell Labs.The example of preferred dialkyl group quaternary compound is two (C ₈-C ₁₂) dialkyl dimethyl ammonium chloride, as DDAC (Bardac 22) and Quaternium 24 (Bardac 2050).It is about 0.8% that the substrate concentration of effectively killing livestock of these quaternary compounds is generally about 0.001%-of composition weight, and preferably about 0.005%-is about 0.3%, more preferably from about 0.01%-is about 0.2%, even 0.03%-about 0.1% more preferably from about.

This fast-acting type antimicrobial is known and in US patent 4,163,800, the US patent 3,152,181, US patent 5,780,064 and Remington ' s pharmaceutical science, have in the 17th edition (AlfonsoR.Gennaro edits, 1985) 1158-1169 page or leaf more fully and describe, all these documents are incorporated herein by reference in full at this.

B) the compatible antimicrobial activities of cyclodextrin

When having cyclodextrin, preferred antimicrobial activities is water miscible effective with low content.The water solubility that can be used for water solublity antimicrobial activities of the present invention for every 100ml water at room temperature at least about 0.3g, promptly greater than about 0.3%, preferably at room temperature greater than about 0.5%.Water solubility less than about 0.3% and molecular structure be fit to easily that the antimicrobial activities of structural cavities of odor control agent is easier to form inclusion complex with odor control agent, make antimicrobial activities and odor control agent very ineffective thus.Therefore, when having cyclodextrin, a lot of known antimicrobial activities are not preferred, the short-chain alkyl ester of P-hydroxybenzoic acid for example, and it is known as p-Hydroxybenzoate usually; N-(4-chlorphenyl)-N '-(3, the 4-Dichlorobenzene base) urea, it is also known as 3,4,4 '-trichlorine carbanilide or triclocarban; 2,4,4 '-three chloro-2 '-hydroxy diphenyl ether, it is known as triclosan usually, because their relative nullity when with the cyclodextrin coupling.Yet, can be very effective when the antimicrobial activities of these poorly water-solubles and some other odor control agent couplings, and be preferred in this case.

By the additional antimicrobial material that contains such as antibiotic property halogenated compound and aromatic alcohol and their chemical compound in compositions of the present invention, can provide the disinfecting effect of improvement.It is about 1% that the thing valid density of killing livestock of these Antimicrobe compounds is generally about 0.001%-of composition therefor weight, and preferably about 0.005%-is about 0.3%, and more preferably from about 0.01%-is about 0.2%, even 0.03%-about 0.1% more preferably from about.

ⅰ) halogenated compound

The preferred antimicrobial activities that uses in the present invention is a halogenated compound.Some non-limiting examples that are fit to the halogenated compound of the present invention's use are:

5-bromo-5-nitro-1,3-diox, trade name Bronidox L ^, Henkel produces.Bronidox L ^Water solubility be about 0.46%.

2-bromo-2-nitro the third-1,3-glycol, trade name Bronopol ^, Inolex produces.Bronopol ^Water solubility be about 25%.

1,1 '-hexa-methylene two (5-(rubigan) biguanide), it is known as chlorhexidine usually, with and salt, for example the salt with acetic acid and gluconic acid can be used as antiseptic of the present invention.Digluconate is a high water soluble, and about 70% is water-soluble, and the water solubility of diacetin is about 1.8%.

1,1,1-three chloro-2-methyl propan-2-ols, it is known as chlorobutanol usually, and water solubility is about 0.8%.

4,4 '-(propylidene dioxy base) two-(3-bromobenzene carbonamidine) dihydroxy ethyl sulfonate, or dibromo Propamidine, water solubility is about 50%.

The mixture that also can use preferred halogenated compound is as antimicrobial activities of the present invention.

ⅱ) aromatic alcohol

Some non-limiting examples that are fit to the aromatic alcohol antimicrobial compound of the present invention's use are:

4,4 '-diamidino-α, ω-two phenoxypropane dihydroxy ethyl sulfonate, it is known as the Propamidine isethionate usually, and water solubility is about 16%; And 4,4 '-diamidino-α, ω-two phenoxy group hexane dihydroxy ethyl sulfonate, it is known as esomedina usually.The typical effective content of these salt is about 0.0002%-about 0.05% of composition therefor weight.

Other example is a benzyl alcohol, and water solubility is about 4%; 2-phenylethanol, water solubility are about 2%; And the 2-phenyl phenol, water solubility is about 2.67%; 2, the 4-dichlorbenzyl alcohol; The 2-phenyl phenol; The phenoxy group isopropyl alcohol; 3-(4-chlorophenoxy)-1, the 2-propylene glycol.

The mixture that also can use the preferred fragrance alcoholic compound is as antimicrobial activities of the present invention.

Can also use above-mentioned sanitizer mixture.When mixing disinfecting and use antimicrobial, the concentration that is used for the above-mentioned alcohols antibacterial of additional disinfecting is suitably about 5% to about 50%, preferably about 10%-about 25%.Water

Personal hygiene sanitizing composition of the present invention contains the water of the 5%-that has an appointment about 70% (weight), and preferably about 10-is about 50%, and more preferably from about 20%-about 50%.Can use any suitable water source.The present invention preferably uses deionized water or distilled water.

The optional ingredient emollient

Optionally, but preferably add emollient to compositions of the present invention.Suitable emollient includes, but is not limited to volatilize and hydro carbons and the nonpolar carboxylic acid and the alcohol ester of nonvolatile silicone oil, highly branched chain, and their mixture.The non-limiting example of this emollient comprises vaseline, mineral oil, microwax, polyalkenes hydrocarbon, paraffin hydrocarbon, azo-bordeaux (cerasin), ceresine, polyethylene and perhydro-squalene, polydimethylsiloxane, Cyclomethicone, dimethiconol, alkylsiloxane, polymethyl siloxane and methyl phenyl silicone and composition thereof.Also can use polyhydric alcohol, as Polyethylene Glycol.More preferably emollient and odor control agent are compatible.Terminology used here " compatible " refers to that this material should not form complex with odor control agent in itself.Here finger-type that used statement " forms complex " has in itself become to cause the performance of odor control agent to reach the complex that disappears or reduce degree.Can be used for emollient of the present invention and also be described in US patent 5,783,536,5,674, in 511 and 4,919,934 (authorize Deckner etc., 1990.4.24 authorizes), these patents are incorporated herein by reference in full at this.

In general, it is about 50% that emollient can account for about 0.5%-of present composition weight altogether, and preferably about 0.5%-is about 25%, and more preferably from about 0.5%-about 10%.Thickening agent

Optionally, but preferred, can add thickening agent to compositions of the present invention.Use thickening agent to prepare the preferred gel combination of the present invention.Gel combination can be applied on the surface of non-horizontal level and be retained in the original place and can not flow.When comparing with the low viscosity compositions of non-gel, this mode can be used more active matter so that reach better and more effective performance on target surface on every surface area, and the low viscosity compositions of said non-gel, if the amount of using is than for a long time minimum, it is can't be retained in effectively on the target surface of non-horizontal level.When disinfecting of the present invention and deodorant compositions contained odor control agent granule such as zeolite, SiO 2 molecular sieve, silica gel, Alumina, kieselguhr, bleaching earth, active carbon or activated carbon, thickening agent was essential composition.Thickening agent helps to make the odor control agent uniform particles to suspend and is dispersed in the compositions, and helps to make compositions to be coated on the target surface securely, so that reach effectively and disinfecting and deodoriging properties efficiently.In addition, gel combination can be kept volatility alcohols disinfectant better here, so that longer and more effective performance of persistent period is provided.

Can be used for thickening agent of the present invention should be compatible with odor control agent.The combination between thickening agent and the odor control agent and/or the ability and the thickening agent that will reduce odor control agent absorption abnormal smells from the patient that interact provide full-bodied ability.When having cyclodextrin, preferred thickening is that cyclodextrin is compatible, and is promptly not compound with cyclodextrin.The example of suitable thickening agent includes, but is not limited to naturally occurring polymer material, as sodium alginate, xanthan gum, snout moth's larva smoke tree seed extract, Tragacanth, starch or the like; The semi synthetic polymer material is as cellulose ethers (for example hydroxyethyl-cellulose, methylcellulose, carboxymethyl cellulose, hydroxypropyl emthylcellulose), polyvinyl pyrrolidone, polyvinyl alcohol, guar gum, hydroxypropyl guar locust beam gum, soluble starch, cationic cellulose, cation guar gum or the like; And the synthetic polymer material, as CVP Carbopol ETD2050, polyacrylic acid, polyvinyl alcohol acrylic acid polymer, polymethacrylic acid polymer, polyvinyl acetate ester polymer, polyvinyl chloride polymer, Vingon polymer or the like.Also can use inorganic thickening agent, as aluminosilicate-type, bentonite for example.In containing the compositions of cyclodextrin not preferably can with the compound thickening agent of cyclodextrin, as polyglycol distearate and distearate.

Can also use hydrophilic gelling agent, for example acrylic acid/ethyl acrylate copolymer and carboxy vinyl polymer, the trade name Carbopol that sells by B.F.Goodrich company ^Resin.These resins are made up of crosslinked polyacrylic acid basically, the form that is colloidal attitude water-soluble poly alkenyl polyether, it is the cross linked polymer of acrylic acid and 0.75%-2.00% cross-linking agent, and said cross-linking agent is polyene propyl group sucrose or polyene propyl group tetramethylolmethane for example.Example comprises Carbopol 934, Carbopol 940, Carbopol 950, Carbopol 980, Carbopol 951 and Carbopol 981.Carbopol934 is the crosslinked water-soluble polymer of polyallyl ether of acrylic acid and about 1% sucrose, and wherein every sucrose molecule has average about 5.8 allyl group in the polyallyl ether of said sucrose.The present invention also is fit to the Carbomer acrylate copolymer of commodity in use Carbopol Ultrez 10, Carbopol ETD2020, Carbopol1382 and Carbopol 1342 by name.The present invention also can use the combination of above-mentioned polymer.The preferred and compound material of cyclodextrin is as Permulen TR1.

The cellulose of hydrophobically modified also is fit to the present invention to be used.These celluloses are in US patent 4,228,277 and 5,104, have a detailed description in 646, and these two pieces of patents are incorporated herein by reference in full at this.

Be preferred for the Carbomer of being acrylate copolymer of the present invention, as Carbopol 980, Carbopol 940, Carbopol Ultrez 10, Carbopol ETD2020 and composition thereof.

Also can use above-mentioned mixtures of thickening agents.Thickening agent preferably exists with the concentration of about 0.01%-about 10%, and preferably about 0.1%-is about 5%, and more preferably from about 0.1%-is about 1%, even 0.1%-about 0.5% more preferably from about.Can also use above-mentioned mixtures of thickening agents.Low molecular weight polyols

Having relative high boiling low molecular weight polyols with the water ratio, as ethylene glycol, diethylene glycol, propylene glycol and/or glycerol, is preferred selectivity composition to the abnormal smells from the patient control performance that improves the present composition.

It is believed that polyhydric alcohol and odor control agent example (as cyclodextrin) and some foul smell molecules form ternary complex, thereby improve the abnormal smells from the patient control performance.The preferred polyhydric alcohol that uses is glycerol, ethylene glycol, propylene glycol, dipropylene glycol or its mixture, more preferably ethylene glycol and propylene glycol.When being used for when of the present invention, the cyclodextrin that makes by the technology that can produce this type of polyhydric alcohol of certain level is extremely ideal, because use them can remove polyhydric alcohol.

In general, the addition of the polyhydric alcohol in the present composition is that about 0.01%-of composition weight is about 3%, and preferably about 0.05%-is about 1%, and more preferably from about 0.1%-about 0.5%.The preferred weight ratio of low molecular weight polyols and odor control agent is about 2: 1, about 20: 1 of 000-, and 00, more preferably from about 3: 1, about 15: 1 of 000-, 00, even more preferably from about 5: 1, about 10: 100 of 000-, first-selected about 1: about 7: 100 of 100-.Can also use the mixture of above-mentioned polyhydric alcohol.The skin sensates

Can also contain sensates (sensate) in the skin health sanitizing composition of the present invention.When being used for when of the present invention, the amount of sensates is about 10% for about 0.01%-, and it is about 5% to be generally about 0.1%-, preferably about 0.2%-about 1%.The selection of content should be consumer and the impression of required degree is provided and can changes on demand.Suitable sensates comprises methanol, Eucalyptus oil, 3-1-Herba Menthae oxygen base the third-1,2-glycol, N-replace to terpane-3-benzamide type, acyclic benzamide type and composition thereof.

3-1-Herba Menthae oxygen base the third-1, the 2-glycol has abundant description in US patent 4,459,425 (1984.7.10 authorizes Amano etc.), and its whole content is introduced here as a reference.The commercially available acquisition of this volatile flavor is sold by Takasago spice company limited (Tokyo, Japan).

What N-replaced has abundant description to terpane-3-benzamide type in US patent 4,136,163 (1979.1.23 authorizes Watson etc.), its whole content is introduced here as a reference.This first-selected class volatile flavor is N-ethyl-terpane-3-Methanamide, and it is commercially available that it can press WS-3 from Wilkinson SwordLimited.

The acyclic benzamide type that is suitable for has abundant description in US patent 4,230,688 (1980.10.28 authorizes Rowsell etc.), its whole content is introduced here as a reference.This first-selected class volatile flavor is N, 2, and 3-trimethyl-2-isopropyl butyramide, it is commercially available that it can press WS-23 from Wilkinson SwordLimited.Spice

Skin health of the present invention and deodorant compositions can be optionally provide " fragrance signal " with the form of desirable abnormal smells from the patient, the removing of expression foul smell.When adding spice as the fragrance signal, its addition should be very low, and it is about 0.5% to account for about 0%-of sanitizing compositions weight, and preferably about 0.001%-is about 0.3%, and more preferably from about 0.005%-is about 0.2%, even 0.01%-about 0.1% more preferably from about.

The spice that provides in the product and on skin than breast-high scent can also be provided.When preferred denseer spice, can add the spice of relative more amount, for example the most nearly about 1% of sanitizing compositions weight.Spice that can the admixture any kind in the compositions of the present invention.Suitable spice is described in the US patent 5,723,420, and its whole content is introduced here as a reference.

When having cyclodextrin, the spice in the preferred present composition is that cyclodextrin is compatible.Spice and odor control agent are compatible, though when the addition of spice cause spice all in the compositions compound with odor control agent and/or combine/when interacting, will exist the odor control agent of effective dose that sufficient abnormal smells from the patient control is provided in the solution.Be to preserve the odor control agent of abnormal smells from the patient control effective dose, in general the amount of spice should cause less than about 90% odor control agent and spice compound, preferably less than about 50%, is more preferably less than approximately 30%, and first-selection is less than about 10%.The weight ratio of odor control agent and spice should be preferably greater than about 10: 1 greater than about 8: 1, more preferably greater than about 20: 1, even more preferably greater than about 40: 1, first-selected greater than about 70: 1.

When having cyclodextrin, the hydrophilic fragrance composition is a preferred perfume ingredients.The hydrophilic fragrance composition is more water-soluble and not too easy and cyclodextrin is compound.The water-wetness of fragrance component is relevant with its octanol/water partition coefficient P.The octanol/water partition coefficient of fragrance component is the ratio between its equilibrium concentration in hot alcohol and water.Fragrance component with big partition coefficient P is considered to more hydrophobic.On the contrary, have the fragrance component of less partition coefficient P, be considered to more hydrophilic.Because the value of the partition coefficient of fragrance component is under normal circumstances bigger, be more convenient therefore, the mode that provides of partition coefficient is based on 10 logarithm, LogP.Thus, the LogP of the preferred hydrophilic aromas composition of the present invention is about 3.5 or littler, preferred about 3.0 or littler.

The LogP of a lot of fragrance components is known; For example, just comprised among the Pomona92 data base of daylight Chemical Information System company (Daylight CIS) (Irvine, California) a lot, and the original of quoting.Yet it is most convenient that the LogP value is calculated by for example " CLOGP " program, and this program also can derive from Daylight CIS.This program has also been listed experiment LogP value, and they can obtain from the Pomona92 data base." calculate logP " (ClogP) be by the segmentation method of Hansch and Leo determine (referring to A.Leo, comprehensive medical chemistry, the 4th volume, C.Hansch, P.G.Sammens, J.B.Taylor and C.A.Ramsden edit, p295, Pergamon Press, 1990, introduce here as a reference).Segmentation method is based on the chemical constitution of each fragrance component, and the number of consideration atom is connected and chemical bonding with type, atom.The ClogP value is the most reliable and the most widely used to estimating this physico-chemical property, is used for replacing experiment logP value when the fragrance component of selecting the present invention to suit.

More preferably the non-limiting example of hydrophilic aromas composition is a glycolic acid pi-allyl amyl group ester, allyl hexanoate, pentyl acetate, amyl propionate, anisaldehyde, acetic acid Fructus Foeniculi ester, methoxybenzene, benzaldehyde, benzyl acetate, benzylacetone, benzyl alcohol, benzyl formate, benzyl isovalerate, benzyl propionate, β γ hexenol, U.S. wall algae (calone), Camphora natural gum, left-handed carveol, the dextrorotation carveol, L-CARVONE, cinnamyl alcohol, cinnamyl acetate, cinnamyl alcohol, cinnamyl formate, cinnamyl propionate, cis-jasmone, cis-3-acetic acid hexene ester, coumarin, cumic alcohol, cumaldehyde, cyclal C, ring Gabon acid esters, dihydroeugenol, the 2-n-hexyl-acid esters, dimethyl benzyl carbinol, acetic acid dimethyl benzyl carbinol ester, ethyl acetate, ethyl acetoacetate, ethyl pentyl group ketone, ethyl o-aminobenzoate, ethyl benzoate, ethyl n-butyrate., ethyl cinnamate, ethyl hexyl ketone, ethyl maltol, butanoic acid ethyl-2-methyl ester, glycidic acid ethyl methyl phenyl ester, the acetic acid ethyl phenyl ester, ethyl salicylate, ethyl vanillin, eucalyptole, acetaminol, acetyl eugenol, eugenyl formate, eugenyl methyl ether, fenchol, acetic acid fragrance of a flower ester (flor acetate) (tricyclodecenyl acetate), fructone, propanoic acid tricyclodecenyl ester (frutene), geraniol, geranyl oxyacetaldehyde, piperonal, hexenol, acetic acid hexene ester, Exceed 600, hexyl formate, hinokitol, hydrogenation atropic alcohol, hydroxycitronellal, the hydroxycitronellal diethyl acetal, hydroxycitronellol, indole, isoamyl alcohol, isocyclocitral, isoeugenol, isoeugenol acetate, isomenthone, the different pulegium ester of acetic acid, isoquinolin, CD, ligustral, linalool, linalool oxide, linalyl formate, LYRAL, menthone, methyl acetophenone, methyl amyl ketone, methyl 2-aminobenzoate, essence of Niobe, the methyl-benzyl acetas, methyl cinnamate, MDJ, methyleugenol, methyl heptenone, carbonic acid methyl heptyne ester, methyl heptyl ketone, methyl hexyl ketone., methyl isobutenyl Pentamethylene oxide., o-amino benzoyl acid methyl-N-methyl ester, methyl β naphthyl ketone, acetic acid methyl phenyl carbinol ester, methyl salicylate, nerol, nonalactone, caprylolactone, capryl alcohol (sec-n-octyl alcohol), p-anisaldehyde, paracresol, the p-methylphenyl methyl ether, the p-hydroxybenzene butanone, acetanisole, melilotal, phenyl phenol, propanoic acid phenoxy group ethyl ester, phenyl acetaldehyde, phenyl acetaldehyde Anaesthetie Ether, the phenylethyl oxyacetaldehyde, the acetic acid phenylethylester, phenylethyl alcohol, the phenylethyl dimethylcarbinol, prenyl acetate, propyl butyrate, pulegone, rose oxide, safrole, 1-ally-3,4-methy-lene dioxy benzene, terpinol, vanillin, viridine (viridine) and composition thereof.

The non-limiting example that can be used for other preferred hydrophilic fragrance composition of flavor compositions of the present invention is an allyl heptanoate, amyl benzoate, anethole, benzophenone, carvacrol, citral, citronellol, 3,7-Dimethyl-6-octenenitrile, ethyl cyclohexyl base ethyl ester, umbrella flower aldehyde (cymal), the 4-decenal, the 2-n-hexyl-acid esters, dihydromyrcenol, glycidic acid ethyl methyl phenyl ester, acetic acid turnip ester, fragrance of a flower aldehyde (florhydral), nonyl lactone, geranyl formate, geranonitrile, isopropylformic acid. hexene ester, α-Zi Luolantong, isobornyl acetate, isobutyl benzoate, isononyl alcohol, isomenthol, the cumic aldehyde ethylhexanal, different pulegol, linalyl acetate, the 2-methoxynaphthalene, menthyl acetate, methyl chavicol, muscone, the betanaphthol methyl ether, neral, aldehyde C-9, the phenyl enanthol, phenyl hexanol, tirpinyl acetate, veratryl alcohol (Veratrol), β naphthyl methyl ether and composition thereof.Low odor detection threshold fragrance component

The odor detection threshold of odoring substance is the minimum vapour concentration of the odoring substance that can be discovered by olfactory sensation.At for example " standardization people olfactory sensation lower bound " (M.Devos etc., Oxford University Press IRLPress, 1990) and " aroma and flavor threshold data compilation " (F.A.Fazzalari edits, ASTM DS DS 48A, U.S.'s test and materials association, odor detection threshold and some odor detection threshold have been discussed 1978), and above-mentioned two pieces of public publications are all introduced here as a reference.Use the fragrance component have low odor detection threshold on a small quantity can improve the odor characteristics of spice, even they are hydrophilic unlike above-mentioned (a) group fragrance component that provides.Do not belong to above-mentioned (a) group, but the fragrance component that can be used for the present composition with obviously low detection threshold is selected from ambrox, bacdanol, benzyl salicylate, butyl anthranilate, cetalox, damascenone, α-damascone, the γ dodecalactone, Scobis Diospyroris Ebeni alcohol (ebanol), herbavert, salicylic acid cis-3-hexene ester, α-Zi Luolantong, alpha, beta-lonone, α-Yi Jiajiziluolantong, lilestralis, methyl nonyl ketone, the γ undecalactone, undecenal and composition thereof.Except that (a) group hydrophilic composition, preferably also have a spot of these materials, in general less than about 20%, preferably less than about 15%, be more preferably less than about 10%, in the total flavor compositions weight of the present invention.Yet, only need be effective on a small quantity.

(a) hydrophilic composition with obviously low detection threshold is also arranged in the group, and be particularly suitable in compositions of the present invention, using.The example of these compositions is glycolic acid pi-allyl amyl group esters, anethole, benzylacetone, calone, cinnamyl alcohol, coumarin, ring Gabon acid esters, cyclal C, umbrella flower aldehyde (cymal), the 4-decenal, the 2-n-hexyl-acid esters, ethyl o-aminobenzoate, butanoic acid ethyl-2-methyl ester, glycidic acid ethyl methyl phenyl ester, ethyl vanillin, acetaminol, acetic acid fragrance of a flower ester, fragrance of a flower aldehyde, fructone, the tricyclic decenyl propionic ester, piperonal, CD, indole, isocyclocitral, isoeugenol, LYRAL, carbonic acid methyl heptyne ester, linalool, methyl 2-aminobenzoate, MDJ, methyl isobutenyl Pentamethylene oxide., methyl β naphthyl ketone, the Beta Naphthol 99MIN methyl ether, nerol, p-anisaldehyde, the p-hydroxybenzene butanone, phenyl acetaldehyde, vanillin and composition thereof.Use the fragrance component of low odor detection threshold can reduce Organic substance and be discharged into amount in the environment.

Can also use the mixture of above-mentioned spice.Surfactant

Optional surfactant provides low surface tension, thereby allows compositions expansion and more even easily on skin surface and other surface, and improves the disinfecting effect.The surfactant that is used for the present composition should be compatible with odor control agent.Be suitable for the silicone surfactant that the non-limiting example of surfactant of the present invention includes, but is not limited to select and the block copolymer of oxirane and expoxy propane.Polysiloxane surfactant

One class preferred surfactants is the polyoxyalkylene polysiloxanes with dimethyl polysiloxane hydrophobic part and one or more hydrophilic polyalkylene side chains, and it has following general formula:

R ¹-(CH ₃) ₂SiO-[(CH ₃) ₂SiO] _a[(CH ₃) (R ¹) SiO] _b-Si (CH ₃) ₂-R ¹Wherein a+b is that about 1-is about 50, and preferably about 3-is about 30, and more preferably from about 10-is about 25, and each R ¹Identical or inequality and be selected from methyl and have poly-(ethylene oxide/propylene oxide) copolymer group of following formula:

-(CH ₂) _nO (C ₂H ₄O) _c(C ₃H ₆O) _dR ²And at least one R ¹Be poly-(ethylene oxide/propylene oxide) copolymer group, and wherein n is 3 or 4, preferably 3; The total value of c (for all polyoxyalkylene side groups) is that 1-is about 100, preferably about 6-about 100; The summation of d is that 0-is about 14, and preferred 0-is about 3, and more preferably d is 0; The total value of c+d is about 150 for about 5-, preferably about 9-about 100; Each R ²Identical or inequality, and be selected from hydrogen, have the alkyl and the acetyl group of 1-4 carbon atom, preferred hydrogen and methyl.Each polyoxyalkylene polysiloxanes has at least one R ¹Group is poly-(ethylene oxide/propylene oxide) copolymer group.

The non-limiting example of this type list surface-active agent is can be available from the Silwet of OSi Specialties company (Danbury, Connecticut) ^Surfactant.Representational Silwet ^Surfactant is as follows.Summation L-7608 600 1 9L-7607 1 of the average c of the average a+b of title average MW, 000 2 17L-77,600 1 9L-7605 6,000 20 99L-7604 4,000 21 53L-7600 4,000 11 68L-7657 5,000 20 76L-7602 3,000 20 29

Polyoxyalkylene group (R ¹) molecular weight be less than or equal to about 10,000.Preferably, it is about 8,000 that the molecular weight of polyoxyalkylene group is less than or equal to, and first-selectedly is about 300-about 5,000.Therefore, the value of c and d can be to make the numerical value of molecular weight in said scope.Yet, polyether chain (R ¹) in ethylene oxide unit (C ₂H ₄O) number must enough make the polyoxyalkylene polysiloxanes be water dispersible or water solublity.If have propylene oxide group in the polyoxyalkylene chain, then they can be in chain random or exist as block.Preferred Silwet surfactant is L-7600, L-7602, L-7604, L-7605, L-7622, L-7657 and composition thereof.Except that surface activity, the polyoxyalkylene polysiloxane surfactant can also provide other benefit, as lubricated and skin softness.

Polyoxyethylene-polyoxypropylene block polymer surfactant

Suitable polyoxyethylene-polyoxypropylene block polymer the surfactant compatible with most of odor control agent such as cyclodextrin comprises with ethylene glycol, propylene glycol, glycerol, trimethylolpropane and the ethylenediamine polymer as the initial reactivity hydrogen compound.By precursor compound and a hydrogen atoms (as C _12-18Aliphatic alcohol) it is generally not compatible with some odor control agent (as cyclodextrin) that order is carried out the polymer compound that ethoxylation and propoxylation make.Called after Pluronic ^And Tetronic ^Some block polymer surfactant compounds be easier to obtain, produce by BASF-Wyandotte company (Wyandotte, the state of Michigan).

The non-limiting example of the surfactant that this class is suitable comprises: the Pluronic surfactant has general formula H (EO) _n(PO) _m(EO) _nH, wherein EO is an ethylene oxide group, PO is a propylene oxide group, and n and m are the numerals of group average in the presentation surface activating agent.The representative instance of Pluronic surfactant is: the average mL-101 3 of the average n of title average MW, 800 4 59L-81 2,750 3 42L-44 2,200 10 23L-43 1,850 6 22L-38 4,700 43 16L-84 4,200 19 43 and composition thereof.The Tetronic surfactant has general formula:

Wherein EO, PO, n and m are identical with above implication.The representative instance of Tetronic surfactant is: average m901 4,700 3 18,908 25,000 114 22 of the average n of title average MW and composition thereof.

" anti-phase " Pluronic and Teronic surfactant have following general formula: anti-phase Pluronic surfactant: H (PO) _m(EO) _n(PO) _mThe anti-phase Teronic surfactant of H

Wherein EO, PO, n and m are identical with above implication.The representative instance of anti-phase Pluronic and Tetronic surfactant is: anti-phase Pluronic surfactant: the average m10 R5 1 of the average n of title average MW, 950 8 2225 R1 2, the average m130 R2 7 of the 700 21 6 average n of anti-phase Tetronic surfactant title average MW, 740 9 2670 R2 3,870 4 13 and composition thereof.

Other useful surfactant is disclosed in the US patent 5,783,200, and its whole content is introduced here as a reference.

Can also use above-mentioned surfactant mixtures.It is about 5% that the content of this surfactant in skin health sterilization and deodorant compositions is generally about 0.01%-of composition weight, and preferably about 0.03%-is about 2%, and more preferably from about 0.05%-about 1%.The selectivity antiseptic

Optionally, if when sanitizer enough or does not exist, can add dissolved water solublity anti-microbial preservative to compositions of the present invention, so that sufficient anticorrosion activity is provided.This additional anticorrosion activity is useful especially when using some organic odor control agent, when particularly using cyclodextrin, it is the chemical compound with glucose unit of variable number, can become the original breeding place of certain micro-organisms, especially when in Aquo-composition.

The preferred broad-spectrum preservative that uses is for example to antibacterial (Gram-positive and Gram-negative) and all effective antiseptic of fungus.Antiseptic that can antimicrobial spectrum is limited for example only to a quasi-microorganism such as the effective antiseptic of fungus, share with broad-spectrum preservative, perhaps share with the limited antiseptic of other active antimicrobial spectrum complementary and/or that replenish.Also can use the mixture of broad-spectrum preservative.In some wherein (for example Gram-negative) in the situation that goes wrong of one group of specific microorgranic contaminant, can use amino carboxylation chelating agen separately or as synergist and other antiseptic coupling.These chelating agen comprise for example ethylenediaminetetraacetic acid (EDTA), hydroxyethylenediamine tetracetic acid, diethylene-triamine pentaacetic acid and other amino carboxylation chelating agen and composition thereof and their salt and their mixture, these chelating agen can increase the antiseptic effect to gram negative bacteria, especially to certain antibacterial of Rhodopseudomonas.

Can be used for anti-microbial preservative of the present invention and comprise Biocidal compounds, get final product the material of kill microorganisms; Perhaps press down biologic artifact, promptly can suppress and/or regulate the material of growth of microorganism.Preferred anti-microbial preservative is water miscible and is effective under the low content, because the organic anti-corrosive agent can form inclusion complex with cyclodextrin molecular, and, make cyclodextrin become invalid abnormal smells from the patient control activating agent thus with foul smell molecule competition cyclodextrin hole.Can be used for waterborne-type preservation of the present invention, its water solubility at room temperature is that every 100ml water is at least about 0.3g, promptly greater than about 0.3%, preferably at room temperature greater than about 0.5%.

It is about 0.2% that the content of antiseptic is generally about 0.0002%-of composition weight, preferably about 0.0003%-about 0.1%.

Preferred waterborne-type preservation includes organic sulfur compound, halogenated compound, ring-type organonitrogen compound, low-molecular-weight aldehydes, quaternary ammonium compound, dehydroactic acid, phenyl and oxybenzene compound and composition thereof.

It below is the non-limiting example of the preferred waterborne-type preservation that uses among the present invention.Organosulfur compound

The preferred waterborne-type preservation that uses is an organosulfur compound among the present invention.Some non-limiting examples that are suitable for organosulfur compound of the present invention are:

(a) a kind of preferred antiseptic of 3-isothiazolone compounds is the antimicrobial organic anti-corrosive agent that contains the 3-isothiazolone group of following formula:

Wherein Y is unsubstituted alkyl, alkenyl or the alkynyl group of about 18 carbon atoms of about 1-, the cycloalkyl that does not replace or replace with about 6 carbocyclic rings of about 3-and maximum about 12 carbon atoms, the aralkyl that does not replace or replace of maximum about 10 carbon atoms, the perhaps not replacement of maximum about 10 carbon atoms or the aryl of replacement;

R ¹Be hydrogen, halogen or (C ₁-C ₄) alkyl; And R ²Be hydrogen, halogen or (C ₁-C ₄) alkyl is preferred, when Y is methyl or ethyl, R ¹And R ²Should not simultaneously be hydrogen.Salt by these chemical compounds that acid reactions such as chemical compound and all example hydrochloric acids, nitric acid, sulphuric acid are formed also suits.

This compounds is disclosed in the US patent 4,265,899 (Lewis etc., 1981.5.5 authorizes), and introduces here as a reference.Said examples for compounds is: 5-chloro-2-methyl-4-isothiazoline-3-ketone; 2-normal-butyl-3-isothiazolone; 2-benzyl-3-isothiazolone; 2-phenyl-3-isothiazolone; 2-methyl-4,5-dichloro isothiazolone; 5-chloro-2-methyl-3-isothiazolone; 2-methyl-4-isothiazoline-3-ketone and composition thereof.Preferred antiseptic is the water soluble mixt of 5-chloro-2-methyl-4-isothiazoline-3-ketone and 2-methyl-4-isothiazoline-3-ketone, the mixture of 77%5-chloro-2-methyl-4-isothiazoline-3-ketone and about 23%2-methyl-4-isothiazoline-3-ketone more preferably from about, it is a kind of broad-spectrum preservative, can be by Rohm ﹠amp; Haas company obtains its aqueous solution of 1.5% with trade name Kathon  CG.

When using Kathon ^During as antiseptic of the present invention, its amount is that about 0.0001%-of composition weight is about 0.01%, and preferably about 0.0002%-is about 0.005%, and more preferably from about 0.0003%-is about 0.003%, first-selected about 0.0004%-about 0.002%.

Other isothiazolone comprises 1, and the 2-benzisothiazole-3-ketone can trade name Proxel ^Product obtains; 2-methyl-4,5-propylidene-4-isothiazoline-3-ketone can trade name Promexal ^Obtain.Proxel and Promexal are Zeneca and produce.Their in very wide pH scope (being 4-12) are all stablized.Do not have a kind ofly to contain reactive halogen and be not the formaldehyde release-type antiseptic.When content use about 0.5% with the about 0.001%-of composition therefor weight, preferably about 0.05%, the first-selected about 0.01%-about 0.02% of about 0.005%-, Proxel and Promexal are effective to typical Gram-negative and positive bacteria, fungus and yeast.

(b) 2-mercaptopyridine sodium oxide

Another kind of preferred organic sulfur antiseptic is a 2-mercaptopyridine sodium oxide, and its water solubility is about 50%.When using 2-mercaptopyridine sodium oxide as antiseptic in compositions of the present invention, it is about 0.01% that its amount is generally about 0.0001%-of composition therefor weight, and preferably about 0.0002%-is about 0.005%, and more preferably from about 0.0003%-about 0.003%.

Can also use the mixture that preferably has organic sulfur compound as antiseptic of the present invention.

Halogenated compound

The preferred antiseptic that uses in the present invention is a halogenated compound.Some non-limiting examples that are fit to the halogenated compound of the present invention's use are:

5-bromo-5-nitro-1, the 3-diox, trade name Bronidox L , Henkel produces.Dissolubility is about 0.46% in the water of Bronidox L .When using Bronidox as antiseptic of the present invention, it is about 0.02% that its amount is generally about 0.0005%-of composition therefor weight, preferably about 0.001%-about 0.01%.

2-bromo-2-nitro the third-1, the 3-glycol, trade name Bronopol , Inolex produces.Dissolubility is about 25% in the water of Bronopol.When using Bronopol as antiseptic of the present invention, it is about 0.1% that its amount is generally about 0.002%-of composition therefor weight, preferably about 0.005%-about 0.05%.

1,1 '-hexa-methylene two (5-(rubigan) biguanide), it is known as chlorhexidine usually, with and salt, can be used as antiseptic of the present invention as salt with acetic acid and gluconic acid.Digluconate is a high water soluble, and about 70% is water-soluble, and dissolubility is about 1.8% in the water of diacetin.When using chlorhexidine as antiseptic of the present invention, it is about 0.04% that its amount is generally about 0.0001%-of composition therefor weight, preferably about 0.0005%-about 0.01%.

1,1,1-three chloro-2-methyl propan-2-ols, it is known as chlorobutanol usually, and water solubility is about 0.8%; The typical effective content of chlorobutanol is about 0.1%-about 0.5% of composition therefor weight.

4,4 '-(propylidene dioxy base) two (3-bromobenzene carbonamidine) dihydroxy ethyl sulfonate, or dibromo Propamidine, water solubility is about 50%; When using the dibromo Propamidine as antiseptic of the present invention, it is about 0.05% that its amount is generally about 0.0001-% of composition therefor weight, preferably about 0.0005%-about 0.01%.

The mixture that also can use preferred halogenated compound is as antiseptic of the present invention.

The ring-type organonitrogen compound

Being preferred for waterborne-type preservation of the present invention is the ring-type organonitrogen compound.Some non-limiting examples that are suitable for ring-type organonitrogen compound of the present invention are: (a) imidazole alkane dione compounds

Being preferred for antiseptic of the present invention is the imidazolidimedione chemical compound.Some non-limiting examples that are suitable for imidazolidimedione chemical compound of the present invention are:

1,3-two (hydroxymethyl)-5,5-dimethyl-2,4-imidazole alkane diketone is known as dihydroxymethyl dimethyl hydantoin or DMDM Hydantoin, can derive from for example Glydant of Lonza ^The water solubility of DMDM Hydantoin is greater than 50%, and mainly effective to antibacterial.When using DMDM Hydantoin, preferably with broad-spectrum preservative such as Kathon CG ^Or formaldehyde share.Preferred mixture is about 95: 5 DMDM Hydantoin and 3-butyl-2-iodine propinyl carbamic acid ester admixture, can derive from the commodity Glydant Plus of Lonza ^When using Glydant Plus ^During as antiseptic of the present invention, its amount is generally about 0.005%-about 0.2% of composition therefor weight.

N-[1,3-two (hydroxymethyl) 2,5-dioxo-4-imidazolidinyl]-N, N '-two (hydroxymethyl) urea is known as diazolidinylurea, and commodity are called Germall II ^, can derive from SuttonLaboratories company (Sutton), can be used as antiseptic of the present invention.When using GermallII ^During as antiseptic of the present invention, its amount is generally about 0.01%-about 0.1% of composition therefor.

N, N " methylene two N '-[1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl] urea }, be known as imidazolidinyl urea, for example the Abiol of 3V-Sigma product ^, the UnicideU-13 that produces of Induchem ^, the Germall 115 that produces of Sutton ^, can be used as antiseptic of the present invention.When using imidazolidinyl urea as antiseptic of the present invention, its amount is generally about 0.05%-about 0.2% of composition therefor.

The mixture that can use preferred imidazolidimedione chemical compound is as antiseptic of the present invention.

(b) polymethoxy bicyclic oxazolidine

Another kind of preferred water solublity ring-type organic nitrogen antiseptic is a polymethoxy bicyclic oxazolidine, and it has following general formula: Wherein n is the value of about 0-about 5, and can derive from Huls America, and commodity are called Nuosept ^C.When using Nuosept ^C is during as antiseptic, and its amount is generally about 0.005%-about 0.1% of composition therefor.

The mixture that can also use preferred ring-type organonitrogen compound is as antiseptic of the present invention.

The low-molecular-weight aldehydes

(a) formaldehyde

It is a kind of that to be preferred for antiseptic of the present invention be formaldehyde.Formaldehyde is broad-spectrum preservative, and generally formaldehyde is the formalin that can 37% formalin obtains.When using formaldehyde as antiseptic of the present invention, it is about 0.2% that its amount is generally about 0.003%-of composition therefor weight, and preferably about 0.008%-is about 0.1%, and more preferably from about 0.01%-about 0.05%.

(b) glutaraldehyde

It is a kind of that to be preferred for antiseptic of the present invention be glutaraldehyde.Glutaraldehyde is the water solublity broad-spectrum preservative, normally obtains with 25% or 50% aqueous solution.When using glutaraldehyde as antiseptic of the present invention, it is about 0.1% that its amount is generally about 0.005%-of composition therefor weight, preferably about 0.01%-about 0.05%.

Quaternary compound

Being preferred for antiseptic of the present invention is cation and/or anion quaternary compound.This chemical compound comprises poly-aminopropyl biguanide, also is known as poly hexamethylene biguanide, and it has following general formula:

HCl·NH ₂-(CH ₂) ₃-[-(CH ₂) ₃-NH-C(＝NH)-NH-C(＝NH·HCl)-NH-(CH ₂) ₃-]x-

(CH ₂) ₃-NH-C(＝NH)-NH·CN

Poly-aminopropyl biguanide is the water solublity broad-spectrum preservative, and it can derive from ICI Americas company, and commodity are called Cosmocil CQ ^20% aqueous solution, perhaps derive from the Mikrokill of Brooks company ^

1-(3-chlorallyl)-3,5,7-three azepines-1-nitrogen diamantane (obsolete) chloride can obtain from for example Dow Chemical, and commodity are called Dowicil 200, and it is effective quaternary ammonium antiseptic; It can be free water-soluble; Yet its easy variable color (yellow) is not very preferred therefore.

The mixture that also can use preferred quaternary ammonium compound is as antiseptic of the present invention.

When using quaternary ammonium compound as antiseptic of the present invention, it is about 0.2% that their amount is generally about 0.005%-of composition therefor weight, preferably about 0.01%-about 0.1%.Dehydroactic acid

It is a kind of that to be preferred for antiseptic of the present invention be dehydroactic acid.Dehydroactic acid is a broad-spectrum preservative, is preferably the form of sodium salt or potassium salt, so that be water solublity.The effect of this antiseptic is more as pressing down biological preservative but not the thing antiseptic of killing livestock.When using dehydroactic acid as antiseptic of the present invention, it is about 0.2% that its amount is generally about 0.005%-of composition therefor weight, and preferably about 0.008%-is about 0.1%, and more preferably from about 0.01-about 0.05%.

Phenyl and oxybenzene compound

Some non-limiting examples that are suitable for phenyl of the present invention and oxybenzene compound are:

4,4 '-diamidino-α, ω-two phenoxypropane dihydroxy ethyl sulfonate, it is known as the Propamidine isethionate usually, and water solubility is about 16%; And 4,4 '-diamidino-α, ω two phenoxy group hexane dihydroxy ethyl sulfonate, it is known as esomedina usually.The typical effective content of these salt is about 0.0002%-about 0.05% of composition therefor weight.

Other example is a benzyl alcohol, and water solubility is about 4%; 2-phenylethanol, water solubility are about 2%; And the 2-phenyl phenol, water solubility is about 2.67%; The typical effective content of these phenyl and phenoxy group alcohol is about 0.1%-about 0.5% of composition therefor.

Their mixture

Antiseptic of the present invention can mixture form use so that control the microorganism of wide model.Other selectivity composition

Can contain various optional ingredients in the compositions of the present invention." CTFA international cosmetic ingredient dictionary ", nineteen ninety-five the 6th edition has been described indefiniteness cosmetics and ingredient commonly used in the various skin care industry, its whole content is introduced here as a reference, and wherein described composition is adapted at using in the compositions of the present invention.The non-limiting example of function class composition is described in the 537th page of this handbook.The example of these function class compositions comprises: abrasive material; anti-acne agents; anticaking agent; antioxidant; binding agent; bio-additive; extender; chelating agen; chemical addition agent; coloring agent; the cosmetics astringent; the cosmetics Biocide; denaturant; the medicine astringent; emulsifying agent; external-use analgesic; film former; aromatised fraction; heat preserving agent; opacifier; plasticizer; antiseptic; propellant; Reducing agent; Porcelana Skin Bleaching Agent Porcelana; skin conditioning agent (wetting agent; solvent naphtha and occludent); Derma-Guard; solvent; foaming agent; hydrotropic agent; solubilizing agent; suspending agent (non-surface-active agent); sunscreen; UV absorbent and viscosifier (moisture and water-free).Other example that can be used for function class material of the present invention is well known to a person skilled in the art, comprises solubilizing agent, sequestering agent and keratolytic agent or the like.

Water insoluble substrates

Compositions of the present invention can also optionally be spiked in the insoluble substrate used of coating skin, for example to handle the form of wiping.Suitable water insoluble substrates material and the visible Riedel of manufacture method " non-woven Method for bonding and material ", the nonwoven world (1987); The America encyclopedia, the 11st volume, 147-153 page or leaf, the 21st volume, 376-383 page or leaf and the 26th volume, 566-581 page or leaf (1984); US patent 4,891,227 (Thaman etc., 1990.1.2 authorizes) and US patent 4,891,228 and US patent 5,686,088 (Mitra etc., 1997.11.11 authorizes); US patent 5,674,591 (James etc., 1997.10.7 authorizes); All documents are all introduced here as a reference with its whole content.Skin degerming and deodorant method

Skin health sanitizing composition of the present invention is suitable for the sterilization and the deodorization of skin.In general, skin degerming and deodorisation process comprise the present composition to local skin coating safety effective dose.In the time can not utilizing or be inconvenient to utilize the cleaning course that needs soap and water, can utilize the present invention.The coating weight of compositions, coating number of times and life cycle depend on required sterilization and deodorization degree and extensively change, for example depend on the degree of microbial contamination and/or the degree of foul smell.The typical amounts of skin health sanitizing composition is preferably the about 20mg/cm of about 0.1%- ²Skin area to be cleaned, more preferably from about 0.5mg/cm ²-Yue 10mg/cm ², first-selected about 1mg/cm ²-Yue 5mg/cm ²Skin area to be cleaned.Preferably, use skin health sanitizing composition of the present invention to come people's hands and/or the pawl of animal are carried out disinfecting and deodorization.

The present invention also is included in the disinfecting of the present invention of using effective dose on the non-skin surface and the method for deodorant compositions, and family surface for example is as cabinet top, surface, kitchen, cook with surface (chopping board, plate, basin and pan or the like); The principal home uses equipment, as refrigerator, refrigerator, washing machine, automatic drier, baking box, microwave oven, dish-washing machine; Cabinet; Wall; The floor; Bathroom surfaces, shower curtain; Refuse receptacle and/or collection box etc.The goods of making

The invention still further relates to the goods of manufacturing, comprise the dispense container that contains deodorization and sanitizing compositions.Said dispense container can be formed by the conventional material structure that any making container is used, and includes, but is not limited to polyethylene; Polypropylene; Polyacetals; Merlon; Polyethylene terephthalate; Polrvinyl chloride; Polystyrene; The blend of polyethylene, vinyl acetate and rubber elastomer.Other material can comprise rustless steel and glass.Preferred container is made with transparent material, as polyethylene terephthalate.

Also preferred wherein dispense container is the goods of the manufacturing of spray dispenser.As is known, said spray dispenser is any manual active device that is used for spraying drop.Preferred automiser spray is made by transparent material, as polyethylene terephthalate.

Embodiment

Below skin health sterilization and/or deodorant compositions be to the illustrating of skin health sterilization of the present invention and/or deodorant compositions specific embodiments, but the invention is not restricted to this.Those skilled in the art can make other improvement under the prerequisite that does not deviate from the spirit and scope of the invention.

All compositionss of giving an example can prepare by routine preparation and hybrid technology.The amount of listed component and does not comprise submember by weight percentage, as diluent, filler or the like.Therefore, cited prescription has comprised listed component and any submember that is associated with these components.

Example I

The following examples are spraying disinfecting and deodorising products (using conventional pump formula spreader system) that admixture has the present composition.Form compositions by using routine techniques that the composition in each hurdle is merged and mixes, be coated with the compositions of Sq then to skin.

	Example I a	Example I b
	Example I a	Example I b	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	40	?55	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	40	?55	Water	54.8	?44
Isopropyl alcohol (99%)	3	?—	Water	54.8	?44
Isopropyl alcohol (99%)	3	?—	Hydroxypropyl	1	?1
Zinc chloride	1	?—	Hydroxypropyl	1	?1
Zinc chloride	1	?—	Benzalkonium chloride	0.2	?—

Example II

	Example II a	Example II b
	Example II a	Example II b	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	55	?55	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	55	?55	Water	40.8	?41
Isopropyl alcohol (99%)	3	?3	Water	40.8	?41
Isopropyl alcohol (99%)	3	?3	Hydroxypropyl	1	?—
Benzalkonium chloride	0.2	?—	Hydroxypropyl	1	?—
Benzalkonium chloride	0.2	?—	EPC-K ²	—	?1

EXAMPLE III

	EXAMPLE III a	EXAMPLE III b
	EXAMPLE III a	EXAMPLE III b	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	55	?55	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	55	?55	Water	43.8	?40
Isopropyl alcohol (99%)	—	?3	Water	43.8	?40
Isopropyl alcohol (99%)	—	?3	Hydroxypropyl	0.5	?—
Alpha-cyclodextrin	0.5	?—	Hydroxypropyl	0.5	?—
Alpha-cyclodextrin	0.5	?—	The methylated beta cyclodextrin	—	?1
Benzethonium chloride	0.2	?—	The methylated beta cyclodextrin	—	?1
Benzethonium chloride	0.2	?—	Zinc chloride	—	?1

Test products is clarifying, and the control of onion flavor is better than reference product.

EXAMPLE IV

	EXAMPLE IV a	EXAMPLE IV b
	EXAMPLE IV a	EXAMPLE IV b	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	40	?55	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	40	?55	Water	55.4????????	?41
Isopropyl alcohol (99%)	3	?3	Water	55.4????????	?41
Isopropyl alcohol (99%)	3	?3	Chlorhexidine gluconate	1	?—
The α cyclodextrin	0.4???????	?0.5	Chlorhexidine gluconate	1	?—
The α cyclodextrin	0.4???????	?0.5	Hydroxypropyl	0.2?????	?0.5

EXAMPLE V

Composition	Consumption (wt%)
Composition	Consumption (wt%)	Ethanol ¹	55
Water	41.4	Ethanol ¹	55
Water	41.4	Isopropyl alcohol (99%)	3
Alpha-cyclodextrin	0.4	Isopropyl alcohol (99%)	3
Alpha-cyclodextrin	0.4	Beta-schardinger dextrin-	0.2

Example VI

The following examples are gel disinfecting and deodorising products that admixture has the present composition.Form compositions by using routine techniques that the composition in each hurdle is merged and mixes, be coated with the compositions of Sq then to skin.

	Example VI a	Example VI b
	Example VI a	Example VI b	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	40	?55	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	40	?55	Water	55.85	?41.04
Isopropyl alcohol	3	?3	Water	55.85	?41.04
Isopropyl alcohol	3	?3	Glycerol	0.01	?0.01
Propylene glycol	0.02	?0.02	Glycerol	0.01	?0.01
Propylene glycol	0.02	?0.02	Alpha-cyclodextrin	0.4	?—
Beta-schardinger dextrin-	0.2	?—	Alpha-cyclodextrin	0.4	?—
Beta-schardinger dextrin-	0.2	?—	Benzalkonium chloride	0.2	?—
Abscents?2000 ³	—	?0.6	Benzalkonium chloride	0.2	?—
Abscents?2000 ³	—	?0.6	Carbopol?980 ⁴	0.22	?0.22
The amino methyl propanol	0.11	?0.11	Carbopol?980 ⁴	0.22	?0.22

Example VII A

	Example VII A a	Example VII A b
	Example VII A a	Example VII A b	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	40	?55	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	40	?55	Water	54.99	?41.04
Isopropyl alcohol (99%)	3	?3	Water	54.99	?41.04
Isopropyl alcohol (99%)	3	?3	Glycerol	0.01	?0.01
Propylene glycol	0.02	?0.02	Glycerol	0.01	?0.01
Propylene glycol	0.02	?0.02	Alpha-cyclodextrin	0.4	?0.4
Beta-schardinger dextrin-	0.2	?0.2	Alpha-cyclodextrin	0.4	?0.4
Beta-schardinger dextrin-	0.2	?0.2	Chlorhexidine gluconate (20%w/v aqueous solution)	0.5	?—
Carbopol?980 ⁴	0.22	?0.22	Chlorhexidine gluconate (20%w/v aqueous solution)	0.5	?—
Carbopol?980 ⁴	0.22	?0.22	Spice	0.05	?—
The amino methyl propanol	0.05	?0.11	Spice	0.05	?—

Example VII A I

Composition	Consumption (wt%)
Composition	Consumption (wt%)	Ethanol ¹	55
Water	40.99	Ethanol ¹	55
Water	40.99	Isopropyl alcohol (99%)	3
Glycerol	0.01	Isopropyl alcohol (99%)	3
Glycerol	0.01	Propylene glycol	0.02
EPC-K ²	0.6	Propylene glycol	0.02
EPC-K ²	0.6	Carbopol?980 ⁴	0.22
The amino methyl propanol	0.11	Carbopol?980 ⁴	0.22
The amino methyl propanol	0.11	Spice	0.05

Example I X

	Example I Xa	Example I Xb
	Example I Xa	Example I Xb	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	55	?55	Composition	Consumption (wt%)	Consumption (wt%)
Ethanol ¹	55	?55	Water	40.89	?—
Isopropyl alcohol (99%)	3	?3	Water	40.89	?—
Isopropyl alcohol (99%)	3	?3	Glycerol	0.01	?0.01
Propylene glycol	0.02	?0.02	Glycerol	0.01	?0.01
Propylene glycol	0.02	?0.02	Polydimethylsiloxane is polyhydric alcohol altogether ⁵	0.05	?0.05
Alpha-cyclodextrin	0.4	?0.6	Polydimethylsiloxane is polyhydric alcohol altogether ⁵	0.05	?0.05
Alpha-cyclodextrin	0.4	?0.6	Beta-schardinger dextrin-	0.2	?—
?Carbopol?Ultrez?10 ⁴	0.22	?0.17	Beta-schardinger dextrin-	0.2	?—
?Carbopol?Ultrez?10 ⁴	0.22	?0.17	The amino methyl propanol	0.11	?0.08
Spice	0.10	?0.10	The amino methyl propanol	0.11	?0.08

Embodiment X

	Embodiment Xa	Embodiment Xb	Embodiment Xc
	Embodiment Xa	Embodiment Xb	Embodiment Xc	Composition	Consumption (wt%)	Consumption (wt%)	Consumption (wt%)
Beta-schardinger dextrin-	1	—	?—	Composition	Consumption (wt%)	Consumption (wt%)	Consumption (wt%)
Beta-schardinger dextrin-	1	—	?—	Hydroxypropyl	—	0.5	?—
Beta-schardinger dextrin-methylates	—	—	?0.6	Hydroxypropyl	—	0.5	?—
Beta-schardinger dextrin-methylates	—	—	?0.6	Alpha-cyclodextrin	—	0.5	?0.4
Carbopol?980 ⁴	0.2	0.2	?0.2	Alpha-cyclodextrin	—	0.5	?0.4
Carbopol?980 ⁴	0.2	0.2	?0.2	Propylene glycol	0.1	0.03	?0.6
Spice	0.04	0.08	?0.05	Propylene glycol	0.1	0.03	?0.6
Spice	0.04	0.08	?0.05	Kathon?CG	3ppm	3ppm	?3ppm
Water	Surplus	Surplus	Surplus	Kathon?CG	3ppm	3ppm	?3ppm

Embodiment XI

	Embodiment XIa	Embodiment XIb	Embodiment XIc
	Embodiment XIa	Embodiment XIb	Embodiment XIc	Composition	Consumption (wt%)	Consumption (wt%)	Consumption (wt%)
Beta-schardinger dextrin-	0.5	?—	?—	Composition	Consumption (wt%)	Consumption (wt%)	Consumption (wt%)
Beta-schardinger dextrin-	0.5	?—	?—	Hydroxypropyl	—	?1	?—
Beta-schardinger dextrin-methylates	—	?—	?0.5	Hydroxypropyl	—	?1	?—
Beta-schardinger dextrin-methylates	—	?—	?0.5	Alpha-cyclodextrin	0.5	?—	?0.5
Zinc chloride	—	?1	?0.5	Alpha-cyclodextrin	0.5	?—	?0.5
Zinc chloride	—	?1	?0.5	Benzalkonium chloride ⁶	0.03	?—	?—
Dioctyl ammonium chloride ⁷	—	?—	?0.04	Benzalkonium chloride ⁶	0.03	?—	?—
Dioctyl ammonium chloride ⁷	—	?—	?0.04	Carbopol?980 ⁴	0.2	?0.2	?0.2
Propylene glycol	0.1	?0.03	?0.6	Carbopol?980 ⁴	0.2	?0.2	?0.2
Propylene glycol	0.1	?0.03	?0.6	Spice	0.05	?0.05	?0.05
Water	Surplus	Surplus	Surplus	Spice	0.05	?0.05	?0.05

Embodiment XII

	Embodiment XIIa	Embodiment XIIb	Embodiment XIIc
	Embodiment XIIa	Embodiment XIIb	Embodiment XIIc	Composition	Consumption (wt%)	Consumption (wt%)	Consumption (wt%)
Beta-schardinger dextrin-	0.2	—	—	Composition	Consumption (wt%)	Consumption (wt%)	Consumption (wt%)
Beta-schardinger dextrin-	0.2	—	—	Hydroxypropyl	—	?0.4	—
Beta-schardinger dextrin-methylates	—	?—	1	Hydroxypropyl	—	?0.4	—
Beta-schardinger dextrin-methylates	—	?—	1	Alpha-cyclodextrin	0.4	?0.6	—
Zinc chloride	—	?—	0.5	Alpha-cyclodextrin	0.4	?0.6	—
Zinc chloride	—	?—	0.5	The chlorination chlorhexidine	0.02	?0.01	—
DDAC ⁸	—	?—	0.04	The chlorination chlorhexidine	0.02	?0.01	—
DDAC ⁸	—	?—	0.04	Carbopol?980 ⁴	0.2	?0.2	0.2
The polyoxyalkylene polysiloxanes ⁹	0.1	?—	0.1	Carbopol?980 ⁴	0.2	?0.2	0.2
The polyoxyalkylene polysiloxanes ⁹	0.1	?—	0.1	Propylene glycol	0.1	?0.03	0.6
Spice	0.04	?0.08	0.1	Propylene glycol	0.1	?0.03	0.6
Spice	0.04	?0.08	0.1	Water	Surplus	Surplus	Surplus

¹200 verification levels ²DL-α-the fertility of Senju Pharm Pur GmbH (Japan, Osaka)-L-ascorbic acid 2-0 di-phosphate ester or L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl three decyls)-2H-.alpha.-5:6-benzopyran-6-base phosphoric acid hydrogen] potassium salt ³Can derive from the close organic molecule sieve of UOP ⁴Can derive from the cross linked polyacrylate (before being incorporated into example formulation with NaOH/KOH processing Carbopol thickening agent/gellant, so that obtain compatible pH (the about 5-of pH about 9, preferably about 6-about 8)) of B.F.Goodrich ⁵Dow Corning modifier Q2-5220 ⁶Can derive from Lonza company (Fair Lawn, Barquat 4250 N.J.) ⁷Can derive from Lonza company (Fair Lawn, Barquat 2050 N.J.) ⁸Can derive from Lonza company (Fair Lawn, Barquat 22 N.J.) ⁹Silwet L-7600

Claims

1. a skin health is sterilized and the deodorant compositions, contains

A) provide the odor control agent of odor control effect effective dose;

C) thickening agent of 0.01%-about 10%;

D) optionally, the crystallization that prevents cyclodextrin crystallization of 0-10% prevents or inhibitor;

E) optionally, the emollient of 0-10%;

F) optionally, the spice of 0-1%;

G) water.

2. the skin health of claim 1 sterilization and deodorant compositions, the non-compound cyclodextrin of wherein said water solublity is selected from alpha-cyclodextrin, the alpha-cyclodextrin that methylates, beta-schardinger dextrin-, the beta-schardinger dextrin-that methylates, ethoxy alpha-cyclodextrin, ethoxy beta-schardinger dextrin-, hydroxypropyl alpha-cyclodextrin, hydroxypropyl, beta-schardinger dextrin-glycerin ether and composition thereof.

3. each skin health sterilization and deodorant compositions of aforementioned claim, wherein said thickening agent is selected from polyacrylic acid, cross linked polyacrylate and composition thereof.

4. each skin health sterilization and deodorant compositions of aforementioned claim also contains slaine, and the amount that wherein said slaine is zinc chloride and wherein said slaine is the 0.2%-5% of said composition weight.

5. each skin health sterilization and deodorant compositions of aforementioned claim, wherein the amount of spice is 0.005%-0.5%, and the ratio of odor control agent and spice was greater than 40: 1.

6. each skin health sterilization and deodorant compositions of aforementioned claim, wherein the amount of spice is the 0.001%-0.5% of composition weight, and contains the fragrance component less than 3.5 CLogP of having in flavor compositions weight at least 50%.

7. each skin health sterilization and deodorant compositions of aforementioned claim, wherein said spice also comprises the ambrox that is selected from flavor compositions weight maximum 10%, bacdanol, benzyl salicylate, butyl anthranilate, cetalox, damascenone, α-damascone, γ-dodecalactone, Scobis Diospyroris Ebeni alcohol, herbavert, salicylic acid cis-3-hexene ester, α-Zi Luolantong, alpha, beta-lonone, α-Yi Jiajiziluolantong, lilestralis, methyl nonyl ketone, the γ undecalactone, the fragrance component of undecenal and composition thereof.

8. each skin health sterilization and deodorant compositions of aforementioned claim also contains emollient.

9. a skin health is sterilized and the deodorant compositions, contains:

A) provide the odor control agent of odor control effect effective dose;

C) optionally, the thickening agent of 0.01%-10%;

D) optionally, the emollient of 0-10%;

E) optionally, the spice of 0-1%; With

F) water wherein compositions do not conform to cyclodextrin is arranged, its salt or derivatives thereof.

10. each skin health sterilization and deodorant compositions of aforementioned claim, wherein antimicrobial is to be selected from quaternary compound, biguanide compound, phenolic compound, iodine compound and pigment compound, the quick-acting antimicrobials of the mixture of their salt and mixture and these chemical compounds.

11. each skin health sterilization and deodorant compositions of aforementioned claim, wherein antimicrobial is a cyclodextrin compatibility antimicrobial, is selected from halogenated compound, aromatic alcohol compound and composition thereof.

12. each skin health sterilization and deodorant compositions of aforementioned claim, wherein halogenated compound is selected from 5-bromo-5-nitro-1,3-diox, 2-bromo-2-nitro the third-1,3-glycol, 1,1 '-hexa-methylene two (5-(rubigan) biguanide), 1,1,1-three chloro-2-methyl propan-2-ols, 4,4 '-(propylidene dioxy base) two (3-bromobenzene carbonamidine) dihydroxy ethyl sulfonate or dibromo Propamidine, their salt, their derivant and their mixture.

13. each skin health sterilization and deodorant compositions of aforementioned claim, wherein the aromatic alcohol mixture is selected from 4,4 '-diamidino-α, ω-two phenoxypropane dihydroxy ethyl sulfonate, 4,4 '-diamidino-α, ω-two phenoxy group hexane dihydroxy ethyl sulfonate, benzylalcohol, 2-phenylethanol, 2-phenyl phenol, 2, the 4-dybenal; The 2-phenyl phenol; The phenoxy group isopropyl alcohol; 3-(4-chlorophenoxy)-1,2-propane diol, their salt, derivant and mixture.

14. a skin health is sterilized and the deodorant compositions, contains:

A) provide the odor control agent of odor control effect effective dose;

C) alcohol disinfectant of 5%-25%;

D) thickening agent of 0.01%-10%;

E) optionally, the emollient of 0-10%;

F) optionally, the spice of 0-1%; With

G) water.

15. a skin health is sterilized and the deodorant liniment, contains:

A) one or more layers water-insoluble substrate; With

B) sterilization of a kind of skin health of safe and effective amount and deodorant compositions contain

ⅰ) provide the odor control agent of odor control effect effective dose;

ⅱ) kill or reduce the sanitizer that contains antimicrobial of growth of microorganism effective dose;

ⅲ) the thickening agent of 0.01%-10%;

ⅳ) optionally, the spice of 0-1%;

ⅴ) optionally, the lubricant of 0-10%; With

ⅵ) water.

16. the goods of a manufacturing comprise each compositions of the aforementioned claim that is present in the dispense container.