CN1328108A - Arylheterocycle substituted naphthopyran-type photochromic compound and its preparing process and usage - Google Patents
Arylheterocycle substituted naphthopyran-type photochromic compound and its preparing process and usage Download PDFInfo
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Abstract
A photochromic compound is prepared through cyclization reaction between beta-naphthol and propynol derivative. Said propynol derivative is prepared through raction between diaryl ketone and sodium (or lithium) acetylide. Said photochromic compound has the advantages of high colour light density and slow attenuation speed, and can be used for photochromic ink, plastic film, and glasses or display material.
Description
The invention belongs to the photochromic material technical field, particularly the aphthopyrans class photochromic compound of fragrant heterocyclic substituted and method for making and purposes.
Photochromic principle roughly can be described below:
A certain photochromic material A (shadow) under light (h υ) irradiation of certain wavelength, can change its molecular structure and form compd B (being colour solid), thereby colour-change takes place.Compd B can other-effect of the light (h υ) of wavelength or heat (Δ) the original color of recovery down, this reversing process just is called photochromism.
Organic photochromic material is compared with inorganic photochromic material to have highly sensitively, and speed of response is fast, easily processing, low cost and other advantages, thereby be subjected to people's very big attention in recent years, and have broad application prospects, be important research and development problem of high-tech sector.Preparation especially for the protective material of the photochromic resin glasses and the vehicles.
The patent of pyrans class photochromic material was reported, but its result and not fully up to expectations.
For example U.S. Pat P3567605 has announced the naphthopyran compounds shown in (A) formula:
Compound (A) has photochromic properties under room temperature (20-30 ℃), but its optical density value that is colour solid is less, so practicality is bad.
The pyrans class photochromic compound of heterocyclic substituted also has report, has announced the aphthopyrans of the heterocyclic substituted shown in (B) formula as European patent EP 629620:
But compound (B) is that the rate of decay of colour solid is very fast, and optical density value is still less, and practicality is bad.
The objective of the invention is to overcome naphthopyran compounds in the past to be the colour solid rate of decay fast, optical density value is little, shortcomings such as practicality is bad provide a class to be the aphthopyrans class photochromic compound of the slow fragrant heterocyclic substituted of colour solid optical density value height, the rate of decay; Another object of the present invention provides the preparation method of the aphthopyrans class photochromic compound of this class virtue heterocyclic substituted; The purposes of the aphthopyrans class photochromic compound of this class virtue heterocyclic substituted also will be provided.
The aphthopyrans class photochromic compound of fragrant heterocyclic substituted of the present invention has general formula shown in (I) formula:
Substituent A r wherein
1And Ar
2Can be identical, also can be different, Ar
1, Ar
2Be following substituting group:
R wherein
1, R
2, R
3, R
4Be hydrogen, methyl, methoxyl group, ethyl or halogen, R
1, R
2, R
3, R
4Can be identical or different.
The preparation method of the naphthopyran compounds of fragrant heterocyclic substituted of the present invention is by 2-Naphthol (II):
Prepare gained with propiolic alcohol derivative (III) reaction cyclization with following general formula.
Ar wherein
1, Ar
2Substituting group in the same compound (I).Reaction is carried out under the catalysis of tosic acid usually, and solvent is non-proton property polar solvent, as toluene.
Compound (III) then is to be made by corresponding diaryl ketone (IV) and sodium carbide or the reaction of acetylene lithium.
Concrete steps are as follows:
Under room temperature and nitrogen protection, sodium carbide reagent or acetylene lithium reagent are joined in the tetrahydrofuran solution of diaryl ketone, stir, wherein: the mole ratio of described diaryl ketone and sodium carbide or acetylene lithium is 1: 1.2～1.5, the weight ratio of tetrahydrofuran (THF) and diaryl ketone is 15: 1～30: 1 in the tetrahydrofuran solution of diaryl ketone, and reaction is 12-30 hour under the room temperature; Reaction finishes, and to neutral, uses the extracted with diethyl ether reaction solution with hydrochloride adjusted solution pH value then, and organic layer is washed the back anhydrous magnesium sulfate drying, filter, and the pressure reducing and steaming solvent, or further handle, get the propiolic alcohol derivative;
Add non-proton property polar solvent and 2-Naphthol in above-mentioned propiolic alcohol derivative, the mole ratio of non-proton property polar solvent and propiolic alcohol derivative is 10: 1～90: 1, and the mole number of 2-Naphthol is identical with propiolic alcohol derivative mole number; After stirring is dissolved 2-Naphthol fully under the room temperature, add a small amount of tosic acid and do the catalyzer initiation reaction, the add-on of tosic acid is as the criterion with solution variable color immediately; Stirred under the room temperature lucifuge 12-30 hour, or lucifuge reflux 3 hours, further aftertreatment obtains the naphthopyran compounds of fragrant heterocyclic substituted.Its structure is shown in (I) formula.
Wherein, the preparation method of diaryl ketone is different with the difference of substituted aryl: work as Ar
1Be phenyl, 3-chloro-2-benzothienyl or 2-thienyl, Ar
2During for 2-thienyl, 2-methyl-3-benzothienyl or 3-methyl-2-benzothienyl, synthetic method is as follows:
The dichloromethane solution of aluminum trichloride (anhydrous) or the benzole soln of tin tetrachloride are placed in the ice bath, and wherein the weight ratio of aluminum trichloride (anhydrous) and methylene dichloride or tin tetrachloride and benzene was respectively 1: 3～1: 10; Stir, in solution, slowly drip compd A r simultaneously
1-COCl and compd A r
2The methylene dichloride of-H or benzene mixing solutions, the temperature in the control dropping process is at 0 ℃～5 ℃; Compd A r wherein
1-COCl, compd A r
2The mole ratio of-H and aluminum trichloride (anhydrous) or tin tetrachloride is 1: 1: 1～1: 1.5: 1.5, described compd A r
2The methylene dichloride in the dichloromethane solution of the methylene dichloride in the methylene dichloride of-H or the benzene mixing solutions or the consumption of benzene and described aluminum trichloride (anhydrous) or the benzole soln of tin tetrachloride or the consumption of benzene are identical; Dropwise, reacting liquid temperature is slowly risen to room temperature, continue to stir 3～20 hours stopped reaction, in the frozen water that the reaction solution impouring is suitable with the reaction solution volume or the frozen water solution of dilute hydrochloric acid, after ether or benzene extracted organic phase, further handle, the most of solvent of pressure reducing and steaming, then to wherein adding sherwood oil, freezingly separate out solid or separate with silica gel column chromatography, further handle obtaining the diaryl ketone again.
Or
Work as Ar
1Be 2-benzofuryl, Ar
2During for phenyl,
With mole ratio is that 1: 1 salicylic aldehyde and potassium hydroxide joins in the dehydrated alcohol, wherein the weight of dehydrated alcohol is about 5～10 times of salicylic aldehyde weight, stirring and refluxing is to the solution clarification, under reflux state, in clear liquor, drip the ethanol solution of Beta-bromo methyl phenyl ketone, wherein the mole number of Beta-bromo methyl phenyl ketone is identical with the mole number of salicylic aldehyde, the mass percent concentration of the ethanol solution of Beta-bromo methyl phenyl ketone is about 25%, reflux, monitoring reaction to Beta-bromo methyl phenyl ketone disappears substantially, filtered while hot then, the filtrate cooling, there is precipitation to separate out, the solid washing of separating out, ethyl alcohol recrystallization is used in dry back, and obtaining the diaryl ketone is 2-benzofuryl benzophenone.
Advantage of the present invention and effect:
The aphthopyrans class photochromic compound of fragrant heterocyclic substituted of the present invention is at general polarity organic solvent such as toluene, chloroform, and solvability is very good in the tetrahydrofuran (THF).Solution colour is a water white transparency, and good photochromic properties is arranged.Under the room temperature condition, sunlight and UV-light can make it to be coloured form very soon, in the dark then are returned to colourless state very soon.
This compounds also has good photochromic in macromolecule medium, and compound is easy to homodisperse in macromolecule medium, and dispersion process does not have particular requirement yet.
The aphthopyrans class photochromic compound of fragrant heterocyclic substituted of the present invention be colour solid optical density value height, the rate of decay is slow, the optical density value height of maximum absorption wave strong point.Smear and measurement result are shown in embodiment 5 and embodiment 6.
Purposes of the present invention:
The aphthopyrans class photochromic compound of fragrant heterocyclic substituted of the present invention can be widely used in the various technical fields, as can be used for preparing the photochromic ink of antiforge trade mark, photochromic plastics film, organic photochromic resin glasses, and photochromic display material.
Description of drawings:
The extinction curve that is colour solid of Fig. 1-embodiment 3 synthetic 3-phenyl-3-(cumarone-2-yl)-3H-naphtho-[2, l-b] pyrans
Further describe the present invention below in conjunction with embodiment:
Synthetic embodiment:
Involved chemical reagent and solvent are the commercial reagent if there is not specified otherwise among the embodiment, and specification is analytical pure.Synthesizing of embodiment 1. 3-(thiophene-2-yl)-3-(3-chloro-thionaphthene-2-yl)-3H-naphtho-[2,1-b] pyrans
(1) .3-chloro-2-thionaphthene formyl chloride is synthetic: reference: " organic chemistry magazine ", the 40th volume, the 21st phase, 1975, the 3037th page of (Tatsuo Higa, Arnold J.Krubsack, Journal ofOrganic Chemistry, Vol.40, No.21,1975,3037) content, concrete grammar is as follows:
Add 10g (0.066mol) styracin in the 250ml there-necked flask, (32g, 0.27mol) thionyl chloride are heated to 120～125 ℃ (130～140 ℃ of oil baths) for 0.68ml (0.008mol) pyridine and 1/4th 20ml.Remaining thionyl chloride dropwised in two hours.Stir, continue heating 1 hour.Cooling adds the 150ml sherwood oil, stirs, and is heated to backflow.While hot clear liquid is inclined to from the pyridine hydrochloride precipitation, cooling, crystallization is filtered, and uses petroleum ether.Get pale yellow crystals 3-chloro-2-thionaphthene formyl chloride 10.4g.Productive rate: 67%, fusing point: 114-117 ℃.
(2) .2-thiophene-(3-chloro-thionaphthene-2-yl) ketone is synthetic:
In the 100ml flask, add 30ml (23g) methylene dichloride and 3.3g (0.025mol) aluminum trichloride (anhydrous).Place in the ice bath, stir the mixed solution of the methylene dichloride of following slowly Dropwise 5 .0g (0.02mol) 3-chloro-2-thionaphthene formyl chloride and 2.4ml (0.03mol) thiophene then, the consumption of methylene dichloride is 30ml (23g), and the temperature of control dropping process is at 0～5 ℃, about 2 hours of dropping time.Reacting liquid temperature is slowly risen to room temperature, continue to stir 13 hours stopped reaction.In reaction solution impouring 70ml frozen water, use extracted with diethyl ether.Ether layer uses sodium carbonate solution and water washing respectively to neutrality, the Calcium Chloride Powder Anhydrous drying.Rotary evaporation in vacuo adds sherwood oil after removing most of ether, and freezing have precipitation to separate out, and precipitation gets light yellow crystal 2-thiophene-(3-chloro-thionaphthene-2-yl) ketone 4.8g, productive rate: 86% with the sherwood oil recrystallization again.Fusing point: 76-78 ℃.
1HNMR(CD
3COCD
3)：7.3(t，1H，thiophene?H)，7.6(t，2H，aromatic?H)，8.0(d，2H，aromatic?H)，8.1(d，2H，thiophene?H)MS：m/z278(M
+)，195(M-83)，167(M-111)，111，83
(3) .1-(thiophene-2-yl)-1-(3-chloro-thionaphthene-2-yl)-1-propiolic alcohol is synthetic:
In the 100ml flask, add 2.4g (0.008mol) 2-thiophene-(3-chloro-thionaphthene-2-yl) ketone and 60ml (53g) tetrahydrofuran (THF), put into nitrogen protection device.It is 18% sodium carbide solution (dimethylbenzene and light mineral oil are made solvent) that stirring at room adds 3.2g (0.012mol) mass percent concentration, stirring at room 12 hours, and reaction finishes.In an amount of dilute hydrochloric acid solution of reaction solution impouring, drip dilute hydrochloric acid again to neutral.Use the extracted with diethyl ether reaction solution, use anhydrous magnesium sulfate drying again after the organic layer washing, filter, filtrate vacuum rotation evaporate to dryness ether gets 1-(thiophene-2-yl)-1-(3-chloro-thionaphthene-2-yl)-1-propiolic alcohol, is brown oil, is directly used in next step reaction.
(4) .3-(thiophene-2-yl)-3-(3-chloro-thionaphthene-2-yl)-3H-naphtho-[2,1-b] pyrans is synthetic:
Added 70ml (60g, 0.56mol) toluene and 1.15g (0.008mol) 2-Naphthol in about 0.008mol 1-(thiophene-2-yl)-1-(3-chloro-thionaphthene-2-yl)-1-propiolic alcohol that the last step makes.Stirring at room adds a small amount of tosic acid and does the catalyzer initiation reaction to the 2-Naphthol dissolving, and the amount of tosic acid is advisable to add the variable color immediately of back solution.Stirring at room is 15 hours under the lucifuge, thin plate chromatography detection reaction process.Rotary evaporation in vacuo is removed in the reaction solution behind most of solvent, silica gel column chromatography separates, make leacheate with 6: 1 sherwood oil of volume ratio and ethyl acetate solution, add sherwood oil then, freezing have solid to separate out, and filters, use petroleum ether, get light yellow solid 3-(thiophene-2-yl)-3-(3-chloro-thionaphthene-2-yl)-3H-naphtho-[2,1-b] pyrans 0.5g, productive rate: 15%.Survey fusing point, have two melting range: 122-126 ℃ and 158-162 ℃.
1HNMR(CDCl
3)：6.6(d，1H，pyran?H)，6.9-7.8(m，13H，aromatic?H)，8.0(d，1H，pyranH)MS：m/z430(M
+)，395(M-35)，263(M-167)
Synthesizing of embodiment 2. 3-phenyl-3-(3-methylbenzene thiophthene-2-yl)-3H-naphtho-[2,1-b] pyrans
(1). bromo acetone synthetic, reference: " organic synthesis ", accumulate the 2nd volume, 88-89 page or leaf (P.A.Levene, Bromoacetone, Organic Synthese in 1948, Collective Volume 2, Edited byA.H.Blatt, John Wiley ﹠amp; Sons, Inc.1948, content 88-89), concrete grammar is:
In the 1000ml three-necked bottle, add 600ml water, the 150ml Glacial acetic acid, 300ml (237g, 4.08mol) acetone, heat temperature raising to 65 ℃, (410g, 2.56mol) bromine divide to add in three hours slowly to drip 140ml.After treating that the bromine color is moved back to the greatest extent, allow reaction mixture be cooled to room temperature, add the dilution of 260ml water, under the frozen water cooling, drip saturated sodium carbonate solution and be neutralized to pH=6, leave standstill the back and divide oil-yielding stratum, use the Calcium Chloride Powder Anhydrous drying, underpressure distillation, 28-29 ℃/3mmHg of collection cut (literature value 40-42 ℃/13mmHg) must bromo acetone 125g (0.912mol).Productive rate: 35.6%.
(2). synthesizing of benzene sulfydryl acetone:
Under frozen water cooling, with 67ml (72.3g, 0.657mol) benzene mercapto phenol splashes into 26.3g (0.657mol) sodium hydroxide and is dissolved in the solution of 90ml water, the question response system slowly splashes into the 90g martonite after being cooled to below 25 ℃, drips back stirring at room half an hour.Leaving standstill the back and divide oil-yielding stratum (upper strata), spends the night with anhydrous magnesium sulfate drying in the washing back.Underpressure distillation, collect 119-123 ℃/2mmHg (cut of 142 ℃ of literature values/17mmHg), benzene sulfydryl acetone 80g altogether, productive rate: 73%.
(3) .3-methylbenzene thiophthene is synthetic:
Take by weighing the 280g polyphosphoric acid and on electric furnace, be heated to fusing, add the 35g Vanadium Pentoxide in FLAKES again and continue to be stirred to fine melt, with this mixture pour into be heated to 160 ℃ in the 250ml three-necked flask after, slowly drip 80g benzene sulfydryl acetone, the dropping process is controlled at temperature between 160-180 ℃, dropwises in 20 minutes.Holding temperature continues to stir 4.5 hours.After the cooling mixture poured into hydrolysis in the 200ml water.Tell upper strata oily matter, the water extracted with diethyl ether merges organic phase, is washed to neutrality, anhydrous magnesium sulfate drying.After rotary evaporation in vacuo removes and to desolvate again underpressure distillation collect the cut of 89-91 ℃/2mmHg, 3-methylbenzene thiophthene 45g altogether, productive rate 63%.
(4). synthesizing of (3-methylbenzene thiophthene-2-yl) phenyl ketone:
In the 100ml flask, add 50ml (44g, 0.56mol) benzene and 14.3g (0.055mol) tin tetrachloride, place in the ice bath, stir following mixed solution then to the benzene that wherein slowly drips 7.45g (0.05mol) 3-methylbenzene thiophthene and 7.7g (0.055mol) Benzoyl chloride, the consumption of benzene be 50ml (44g, 0.56mol).Temperature in the control dropping process is at 0～5 ℃, about 1 hour of dropping time.Dropwise, reacting liquid temperature is slowly risen to room temperature, continue to stir 15 hours stopped reaction.Reaction solution is poured in the 100ml 5mol/lHCl frozen water, with three times (30ml * 3) of benzene extraction.Merge organic phase, anhydrous magnesium sulfate drying.Rotary evaporation in vacuo gets brown oil after removing benzene.Near silica gel short column chromatography removes by filter forward position leacheate part and initial point impurity, brown oil, must orange crystallization (3-methylbenzene thiophthene-2-yl) phenyl ketone 11.0g after freezing.Productive rate: 87%.
(5) .1-phenyl-1-(3-methyl-thionaphthene-2-yl)-1-propiolic alcohol is synthetic:
In the 250ml flask, add 5.0g (0.02mol) (3-methylbenzene thiophthene-2-yl) phenyl ketone and 100ml (89g) tetrahydrofuran (THF), put into nitrogen protection device.It is 50% acetylene lithium solution (toluene and diethylamine solution) that stirring at room adds 5.0g (0.027mol) mass percent concentration, room temperature reaction 20 hours.Reaction finishes in an amount of dilute hydrochloric acid solution of reaction solution impouring, drips dilute hydrochloric acid again to neutral.Use the extracted with diethyl ether reaction solution, use anhydrous magnesium sulfate drying again after the organic layer washing.Filter, filtrate vacuum rotation evaporate to dryness ether gets 5g1-phenyl-1-(3-methyl-thionaphthene-2-yl)-1-propiolic alcohol, is brown oil, is directly used in next step reaction.
(6) .3-phenyl-3-(3-methylbenzene thiophthene-2-yl)-3H-naphtho-[2,1-b] pyrans is synthetic:
Added 70ml (60g in about 5.0g (by 0.01mol) 1-phenyl-1-(3-methyl-thionaphthene-2-yl)-1-propiolic alcohol that the last step makes, 0.56mol) toluene and 1.44g (0.01mol) 2-Naphthol, stirring at room is made catalyzer to the tosic acid that adds again about 50mg after 2-Naphthol dissolves fully, and reflux is 3 hours under the lucifuge.Rotary evaporation in vacuo is removed toluene, and silica gel column chromatography separates, and use sherwood oil: chloroform (volume ratio 2: 1) is made leacheate.Separate 2.0g yellow solid 3-phenyl-3-(3-methylbenzene thiophthene-2-yl)-3H-naphtho-[2,1-b] pyrans.Productive rate: 49%.Fusing point: 108-110 ℃.
1HNMR(CDCCl
3)：2.3(s，3H，-CH
3)，6.3(d，1H，pyran?H)，7.2-7.7(m，15H，aromaticH)，8.0(d，1H，pyran?H)MS：m/z404(M
+)，389(M-15)，327(M-77)，257(M-147)
Synthesizing of embodiment 3. 3-phenyl-3-(cumarone-2-yl)-3H-naphtho-[2,1-b] pyrans
(1) .2-benzofuryl phenyl ketone is synthetic:
In the 250ml flask, add 5.4ml (6.1g, 0.05mol) salicylic aldehyde, 2.8g (0.05mol) potassium hydroxide and 60ml (47g) dehydrated alcohol.Stirring and refluxing drips the solution (mass percent concentration is 25%) of 40ml (3lg) dehydrated alcohol and 10.3g (0.05mol) Beta-bromo methyl phenyl ketone under reflux state to the solution clarification.Dropwise, continue to reflux extremely to react in 4 hours and finish substantially.Filtered while hot, the filtrate cooling has precipitation to separate out, and filters, and uses the 25ml ethyl alcohol recrystallization behind the filter cake washing and drying, gets water white transparency needle-like crystal 2-benzofuryl phenyl ketone 6.9g, productive rate: 62%.Fusing point: 84-86 ℃.
(2) .1-phenyl-1-(cumarone-2-yl)-1-propiolic alcohol is synthetic:
In the 250ml flask, add 5.0g (0.02mol) 2-benzofuryl phenyl ketone and 100ml (89g) tetrahydrofuran (THF), put into nitrogen protection device.Stirring at room adds the toluene and the diethylamine solution of 5.0g (0.027mol) mass percent 50% acetylene lithium, stirs room temperature reaction 30 hours.Reaction finishes, and in an amount of dilute hydrochloric acid solution of reaction solution impouring, drips dilute hydrochloric acid again to neutral.Use the extracted with diethyl ether reaction solution, use anhydrous magnesium sulfate drying again after the organic layer washing.Filter, filtrate vacuum rotation evaporate to dryness ether gets the brown oily crude product of 1-phenyl-1-(cumarone-2-yl)-1-propiolic alcohol, is directly used in next step.
(3) .3-phenyl-3-(cumarone-2-yl)-3H-naphtho-[2,1-b] pyrans is synthetic:
Add 30ml (0.28mol) toluene and 1.44g (0.01mol) 2-Naphthol in 1-phenyl-1-(cumarone-2-the yl)-thick product of 1-propiolic alcohol (about 0.01mol) that makes last going on foot, stirring at room is made catalyzer to adding the 50mg tosic acid again after 2-Naphthol dissolves fully, the lucifuge reaction is 12 hours under the room temperature, silica gel column chromatography separates after revolving most of toluene, be 8: 1 sherwood oil then with volume ratio, the ethyl acetate solution recrystallization gets 3-phenyl-3-(cumarone-2-yl)-3H-naphtho-[2,1-b] pyrans white crystal 1.5g twice.Productive rate: 40%.Fusing point: 146-149 ℃.
1HNMR(CDCl
3)：6.3(d，1H，pyran?H)，6.8(s，1H，benzofuran?H)，7.0-7.8(r，15H，aromatic?H)，8.0(d，1H，pyran?H)MS：m/z374(M
+)，297(M-77)
For the ease of measuring absorbancy and the life-span that compound of the present invention is colour solid, synthetic compound (B) contrasts:
Synthesizing of embodiment 4. compounds (B) 3-phenyl-3-(thiophene-2-yl)-3H-naphtho-[2,1-b] pyrans
Reference: European patent EP 629620
(1) .2-thienyl phenylketone is synthetic:
In 100 ml flasks, add 10g (0.075mol) aluminum trichloride (anhydrous) and 30ml (22.6g) and heavily steam the methylene dichloride of handling, 0～5 ℃ of ice bath, stir, isolated steam drips 6.0g (0.071mol down, 5.7ml) thiophene, 10.5 (0.075mol, 9.4ml) Benzoyl chloride and 23ml (17.4g) heavily steam the mixed solution of methylene dichloride to gram, dropwise in 3.5 hours.Continue to stir 15 hours after slowly rising to room temperature.Then reaction solution is poured in the 53ml frozen water, use extracted with diethyl ether.Ether layer sodium carbonate solution, water washing to neutrality, the Calcium Chloride Powder Anhydrous drying.Rotary evaporation in vacuo adds sherwood oil after removing most of ether, and freezing have precipitation to separate out.Get the white crystal 11.0g of 2-thienyl phenylketone again with the sherwood oil recrystallization, productive rate: 83%.Fusing point: 55-56 ℃.
(2) .1-phenyl-1-(thiophene-2-yl)-1-propiolic alcohol is synthetic:
In the 250ml flask, add 5.7g (0.03mol) 2-thienyl phenylketone and 100ml (89g) tetrahydrofuran (THF), put into nitrogen protection device.It is 18% sodium carbide solution (dimethylbenzene and light mineral oil are made solvent) that stirring at room adds 12g (0.045mol) mass percent concentration, stirring reaction 20 hours.In an amount of dilute hydrochloric acid solution of reaction solution impouring, drip dilute hydrochloric acid again to neutral.Use extracted with diethyl ether, use anhydrous magnesium sulfate drying again after the organic layer washing.Filter, rotary evaporation in vacuo is removed in the filtrate most of solvent to there being solid to separate out.Remove by filter the solid of separating out, adding sherwood oil in the filtrate has solid to separate out again, removes by filter.The thin plate chromatography detects that alkynol accounts for the overwhelming majority to the filtrate.
(3) .3-phenyl-3-(thiophene-2-yl)-3H-naphtho-[2,1-b] pyrans is synthetic:
The step makes on adding respectively in the 100ml flask about 0.01mol 1-phenyl-1-(thiophene-2-yl)-1-propiolic alcohol, 30ml (0.28mol) toluene and 1.44g (0.01mol) 2-Naphthol.Stirring at room adds a small amount of tosic acid initiation reaction to the 2-Naphthol dissolving, the amount of tosic acid is advisable to add the variable color immediately of back solution.Spend the night lucifuge reaction of stirring, thin plate chromatography detection reaction process.Rotary evaporation in vacuo is removed in the reaction solution behind most of solvent, and silica gel column chromatography separates, and is 2: 1 chloroform with volume ratio, and petroleum ether solution is made leacheate.The filtrate that is connect has been threaded to a large amount of crystal and has separated out, and filters and use petroleum ether, gets 3-phenyl-3-(thiophene-2-yl)-3H-naphtho-[2,1-b] pyrans white crystal 1.5g, productive rate: 44%.Fusing point: 138-139 ℃.
The smear example:
Embodiment 5
500mg polymethyl acrylate (PMMA) is dissolved in the 5ml toluene wiring solution-forming;
3 of the sheet glass of preparation 0.8 * 38 * 26mm ± 0.5 size;
With synthetic photochromic compound (B) 3-phenyl-3-(thiophene-2-yl)-3H-naphtho-[2 among the embodiment 4,1-b] pyrans 0.015mol, synthetic photochromic compound 3-phenyl-3-(3-methylbenzene thiophthene-2-yl)-3H-naphtho-[2 among the embodiment 2,1-b] synthetic photochromic compound 3-phenyl-3-(cumarone-2-yl)-3H-naphtho-[2 among pyrans 0.015mol and the embodiment 3,1-b] pyrans 0.015mol is dissolved in respectively in the above-mentioned polymethyl acrylate solution of 0.5ml, be coated in respectively on above-mentioned 3 blocks of sheet glass, be put in the dark place solvent film forming of volatilizing naturally, it is respectively film 1, film 2, film 3.
Amount of samples:
Synthetic photochromic compound (B) 3-phenyl-3-(thiophene-2-yl) among the film 1-embodiment 4-3H-naphtho-[2,1-b] pyrans 0.015mmol;
Synthetic photochromic compound 3-phenyl-3-(3-methylbenzene thiophthene-2-yl) among the film 2--embodiment 2-3H-naphtho-[2,1-b] pyrans 0.015mmol;
Synthetic photochromic compound 3-phenyl-3-(cumarone-2-yl) among the film 3--embodiment 3-3H-naphtho-[2,1-b] pyrans 0.015mmol;
Measure example:
Embodiment 6
3 glass membranes that embodiment 5 makes are put into the DMS-300 ultraviolet spectrophotometer, high voltage mercury lamp with 500W is a light source, shone 1 minute, and reached photo-equilibrium, survey is the maximum absorption wavelength λ max of colour solid, optical density value, colour generation body life time and the rate of decay constant of maximum absorption wave strong point.Experimental result sees Table 1 and Figure of description.From the table data as can be seen, the synthetic compound is compared with compound (B) among embodiment 3 and the embodiment 4, the colour generation body life time improves 2.3 times and 1.8 times respectively, the optical density value of maximum absorption wave strong point improves 0.5 times and 1.2 times respectively.
Table 1 compound photophysical property compound is the colour solid maximum absorption wavelength and is colour solid absorbancy colour generation body life time rate of decay constant
(nm) (min) (* 10-2S-1) compound (B) 440 0.8 0.37 4.50
Synthetic compound 440 1.23 1.24 1.34 among the embodiment 2.
Synthetic compound 470 1.78 1.04 1.60 among the embodiment 3.
Claims (5)
1. the aphthopyrans class photochromic compound of a fragrant heterocyclic substituted, it is characterized in that: described photochromic compound has general formula shown in (I) formula:
Substituent A r wherein
1And Ar
2Be selected from following substituting group:
R wherein
1, R
2, R
3, R
4Be hydrogen, methyl, methoxyl group, ethyl or halogen.
2. the method for making of the aphthopyrans class photochromic compound of a fragrant heterocyclic substituted, it is characterized in that: under room temperature and nitrogen protection, sodium carbide reagent or acetylene lithium reagent are joined in the tetrahydrofuran solution of diaryl ketone, stir, wherein: the mole ratio of described diaryl ketone and sodium carbide or acetylene lithium is 1: 1.2～1.5, the weight ratio of tetrahydrofuran (THF) and diaryl ketone is 15: 1～30.1 in the tetrahydrofuran solution of diaryl ketone, and reaction is 12-30 hour under the room temperature; Reaction finishes, and to neutral, uses the extracted with diethyl ether reaction solution with hydrochloride adjusted solution pH value then, and organic layer is washed the back anhydrous magnesium sulfate drying, filter, and the pressure reducing and steaming solvent, or further handle, get the propiolic alcohol derivative;
Add non-proton property polar solvent and 2-Naphthol in above-mentioned propiolic alcohol derivative, the mole ratio of non-proton property polar solvent and propiolic alcohol derivative is 10: 1～90: 1, and the mole number of 2-Naphthol is identical with propiolic alcohol derivative mole number; After stirring is dissolved 2-Naphthol fully under the room temperature, add a small amount of tosic acid and do the catalyzer initiation reaction, the add-on of tosic acid is as the criterion with solution variable color immediately; Stirred under the room temperature lucifuge 12-30 hour, or lucifuge reflux 3 hours, further aftertreatment obtains the naphthopyran compounds of fragrant heterocyclic substituted.
3. as the method for making of the aphthopyrans class photochromic compound of fragrant heterocyclic substituted as described in the claim 2, it is characterized in that: described diaryl ketone obtains by the following method:
Work as Ar
1Be phenyl, 3-chloro-2-benzothienyl or 2-thienyl, Ar
2During for 2-thienyl, 2-methyl-3-benzothienyl or 3-methyl-2-benzothienyl,
The dichloromethane solution of aluminum trichloride (anhydrous) or the benzole soln of tin tetrachloride are placed in the ice bath, and wherein the weight ratio of aluminum trichloride (anhydrous) and methylene dichloride or tin tetrachloride and benzene was respectively 1: 3～1: 10; Stir, in solution, slowly drip compd A r simultaneously
1-COCl and compd A r
2The methylene dichloride of-H or benzene mixing solutions, the temperature in the control dropping process is at 0 ℃～5 ℃; Compd A r wherein
1-COCl, compd A r
2The mole ratio of-H and aluminum trichloride (anhydrous) or tin tetrachloride is 1: 1: 1～1: 1.5: 1.5, described compd A r
2The methylene dichloride in the dichloromethane solution of the methylene dichloride in the methylene dichloride of-H or the benzene mixing solutions or the consumption of benzene and described aluminum trichloride (anhydrous) or the benzole soln of tin tetrachloride or the consumption of benzene are identical; Dropwise, reacting liquid temperature is slowly risen to room temperature, continue to stir 3～20 hours stopped reaction, in the frozen water that the reaction solution impouring is suitable with the reaction solution volume or the frozen water solution of dilute hydrochloric acid, after ether or benzene extracted organic phase, further handle, the most of solvent of pressure reducing and steaming, then to wherein adding sherwood oil, freezingly separate out solid or separate with silica gel column chromatography, further handle obtaining the diaryl ketone again;
Or
Work as Ar
1Be 2-benzofuryl, Ar
2During for phenyl,
With mole ratio is that 1: 1 salicylic aldehyde and potassium hydroxide joins in the dehydrated alcohol, wherein the weight of dehydrated alcohol is about 5～10 times of salicylic aldehyde weight, stirring and refluxing is to the solution clarification, under reflux state, in clear liquor, drip the ethanol solution of Beta-bromo methyl phenyl ketone, wherein the mole number of Beta-bromo methyl phenyl ketone is identical with the mole number of salicylic aldehyde, the mass percent concentration of the ethanol solution of Beta-bromo methyl phenyl ketone is about 25%, reflux, monitoring reaction to Beta-bromo methyl phenyl ketone disappears substantially, filtered while hot then, filtrate cooling, there is precipitation to separate out, the solid washing of separating out, ethyl alcohol recrystallization is used in dry back, obtains the diaryl ketone.
4. as the method for making of the aphthopyrans class photochromic compound of fragrant heterocyclic substituted as described in the claim 2, it is characterized in that described non-proton property polar solvent is a toluene.
5. the purposes of the aphthopyrans class photochromic compound of a fragrant heterocyclic substituted is characterized in that being used to prepare the photochromic ink of antiforge trade mark, photochromic plastics film, organic photochromic resin glasses or photochromic display material.
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Cited By (5)
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| CN101738645A (en) * | 2008-11-10 | 2010-06-16 | 江国庆 | Portable device of variable screen |
| CN101503484B (en) * | 2009-03-04 | 2010-11-17 | 东北师范大学 | Method for synthesizing photochromic cross-linked polymer containing naphthyl hydroxide pyran group |
| CN102532088A (en) * | 2003-03-20 | 2012-07-04 | 光学转变公司 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles |
| CN103087032A (en) * | 2013-01-18 | 2013-05-08 | 常州南京大学高新技术研究院 | Method for preparing naphthopyran compound |
| CN107987291A (en) * | 2017-12-04 | 2018-05-04 | 吉林大学 | A kind of circularly polarized luminescence based on crystalline state nano-cellulose, preparation method and its application on false proof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102532088A (en) * | 2003-03-20 | 2012-07-04 | 光学转变公司 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles |
| CN102532088B (en) * | 2003-03-20 | 2016-10-12 | 光学转变公司 | The photochromatic benzopyran class that indenes condenses, aphthols and photochromic article |
| CN101738645A (en) * | 2008-11-10 | 2010-06-16 | 江国庆 | Portable device of variable screen |
| CN101503484B (en) * | 2009-03-04 | 2010-11-17 | 东北师范大学 | Method for synthesizing photochromic cross-linked polymer containing naphthyl hydroxide pyran group |
| CN103087032A (en) * | 2013-01-18 | 2013-05-08 | 常州南京大学高新技术研究院 | Method for preparing naphthopyran compound |
| CN103087032B (en) * | 2013-01-18 | 2015-01-07 | 常州南京大学高新技术研究院 | Method for preparing naphthopyran compound |
| CN107987291A (en) * | 2017-12-04 | 2018-05-04 | 吉林大学 | A kind of circularly polarized luminescence based on crystalline state nano-cellulose, preparation method and its application on false proof |
| CN107987291B (en) * | 2017-12-04 | 2020-12-22 | 吉林大学 | Circular polarization luminescent material based on crystalline nano-cellulose, preparation method and application of circular polarization luminescent material in anti-counterfeiting |
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