CN1323680C - Medicine for treating monilia vaginitis - Google Patents
Medicine for treating monilia vaginitis Download PDFInfo
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- CN1323680C CN1323680C CNB031121489A CN03112148A CN1323680C CN 1323680 C CN1323680 C CN 1323680C CN B031121489 A CNB031121489 A CN B031121489A CN 03112148 A CN03112148 A CN 03112148A CN 1323680 C CN1323680 C CN 1323680C
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Abstract
The present invention relates to a medicine for treating monilial vaginitis, which is prepared from chicken bile, kuhseng juice and 1% sodium bicarbonate in proportion. The medicine for treating monilial vaginitis has no toxic or side effect on fetuses and pregnant women, has the advantages of short treatment cycle, obvious effect, high curative ratio, low treatment cost, convenient use and no pain, and has a certain tocolysis function. The present invention can be used for treating non-gravidic monilial vaginitis and gravidic monilial vaginitis.
Description
Technical field
The invention provides a kind of especially medicine of monilial vaginitis of vaginitis for the treatment of.
Background technology
Candidiasis (Candida albicans) is condition system bacterium, has approximately in anemia of pregnant woman's vagina of 10% non-anemia of pregnant woman woman and 30% this bacterium parasitism is arranged.Normal health women, itself has self purification vagina, forms the nature defense function.But, cause inflammation when adapting to the candidiasis breeding, so be more common in anemia of pregnant woman and diabetics when intravaginal glycogen increases, acidity increases, local resistance descends.Take a large amount of antibiotic of a large amount of estrogen and prolonged application, changed the mutual restriction relation between the intravaginal microorganism, wear panty girdle, obesity etc. the partial temperature of perineum, humidity increase, oxygen amount are reduced, also easily cause monilial infection.Trimester of pregnancy suffers from serious monilial vaginitis and can cause miscarriage, premature labor, amnionitis and premature rupture of fetal membrane, easily causes soft birth canal laceration, hemorrhage, puerperal wound healing bad etc. during product.Fetus can cause the monilial infection of multi-section position by the birth canal of monilial infection.Therefore, in time, treat concerning women especially puerpera extremely important to monilial infection effectively.
At present, the medicine of treatment monilial vaginitis is more, but toxic and side effects is in various degree arranged, and clearly stipulates trimester of pregnancy and age of sucking forbidding on the medicine description.This is because these medicines can cause miscarriage, premature labor or fetal anomaly etc.As miconazole nitrate (Daktar) at three months trimester of pregnancy forbidding; Fluconazole capsule (UK-49858) has allergies person's forbidding to triazole type, and gestation, women breast-feeding their children should not use; Itraconazole (itraconazole) is a kind of high-efficiency broad spectrum antifungal agent for the treatment of monilial vaginitis at present, but because of causing fetal anomaly, trimester of pregnancy and age of sucking forbidding, the diabetes or the person's forbidding of suffering from the hepatic disease; Ketoconazole (nizoral) trimester of pregnancy or age of sucking and hepatic and kidney function obstacle person can not use; Nystatin is a kind of service time of a long medicine, though clearly do not stipulate the trimester of pregnancy forbidding, its side effect is nausea and vomiting, diarrhoea etc., and diarrhoea can cause miscarriage or premature labor.
Summary of the invention
Technical problem to be solved by this invention is, a kind of medicine for the treatment of monilial vaginitis is provided, and it has no side effect, and treatment cycle is short, instant effect, particularly can be used for the treatment of trimester of pregnancy monilial vaginitis.
The present invention is achieved in that a kind of medicine for the treatment of monilial vaginitis, and the proportioning of described medicine is:
Fel Gallus domesticus 10～20 weight portions
Radix Sophorae Flavescentis juice 10～30 weight portions
1% sodium bicarbonate, 10～30 weight portions
The medicine of this treatment monilial vaginitis has no side effect to fetus and anemia of pregnant woman, and treatment cycle is short, instant effect, the cure rate height is treated with low cost, easy to use, no pain, and have certain anti-abortional effect, can be used for non-pregnancy and trimester of pregnancy monilial vaginitis treatment.
The specific embodiment
Further specify the present invention below.
A kind of optimum ratio for the treatment of the medicine of monilial vaginitis of the present invention is:
Fel Gallus domesticus 20 weight portions
Radix Sophorae Flavescentis juice 20 weight portions
1% sodium bicarbonate, 20 weight portions
Described Radix Sophorae Flavescentis juice is that every 30g Radix Sophorae Flavescentis adds water 1800～2200ml, and decocting to medicine juice is that 900～1100ml makes.
The administrated method of the present invention's medicine is, clean pudendum and vagina with 2% sodium bicarbonate solution, during washing vagina, available No. 14 gum elastic catheters are inserted to the back arched roof along posterior vaginal wall, extract 2% sodium bicarbonate solution with 60 milliliters of empty needles, wash through No. 14 gum elastic catheters.After the flushing, the present invention's medicine is sent into posterior fornix of vagina, every day 1 time, 5 days is a course of treatment.
Fel Gallus domesticus in the present invention's the medicine is nontoxic, and its main effective ingredient is chenodeoxycholic acid (CDCA) and taurine chenodeoxycholic acid (TCDCA), has effects such as antibiotic, antiinflammatory, antiallergic, antiviral, spasmolytic.The in-vitro antibacterial test shows that chenodeoxycholic acid (CDCA) and taurine chenodeoxycholic acid (TCDCA) all have tangible antibacterial action to the gram positive bacteria and the staphylococcus aureus of In vitro culture.Fel Gallus domesticus has the oxygen-adding amount of increasing, and makes vagina tolerate anoxybiotic effect, and monilial vaginitis partly causes because of the partial oxygen amount of perineum reduces.Radix Sophorae Flavescentis antiinflammatory, dampness removing.1% sodium bicarbonate can be used for changing intravaginal acid-base value, makes it form weakly alkaline environment.Under alkaline environment, candidiasis can not be survived.
Main component cholic acid (CA) in the Fel Gallus domesticus has very strong inhibitory action to the contraction of smooth muscle.Uterus muscle belongs to smooth muscle, illustrates that the present invention has certain anti-abortional effect.
It below is the clinical observation on the therapeutic effect data of the present invention's medicine.
The diagnostic criteria of monilial vaginitis is: have that the pudendum scabies is overworked, a burn feeling, redness, leucorrhoea grow in quantity, symptoms such as burn feeling pain are arranged when urinating.Gynecologial examination finds that nympha inboard and vaginal mucosa cover white membranoid substance, and leucorrhea is bean dregs shape or curdled milk sample, contrafluxion, eczema, erosion or table fester.Lab testing: peep out vagina gently with the ting model specula and get the secretions smear and make normal saline sessile drop method microscopy, see candidiasis thallospore and pseudohypha.
Be the medicine that shows the present invention therapeutic effect, select 186 examples to agree to come the pregnancy women of institute's treatment, periodic review, at 23～39 years old age, in pregnant all 6～40 weeks, track to childbirth monilial vaginitis.Simultaneously, select 200 examples to agree to come the non-pregnancy women of institute's treatment, periodic review, 23～39 years old age.Trimester of pregnancy, non-pregnancy women's symptom, gynecologial examination and lab testing meet above-mentioned medical diagnosis on disease standard.
186 example trimester of pregnancy candidal vaginitis patients are divided into two groups at random.Every group 93 example, test group are the A group, treat with the present invention's medicine, and Therapeutic Method is with the administrated method of above-mentioned the present invention's medicine.Treated by the training personnel operation every day.Every day 1 time, 5 days was 1 course of treatment.Observation group is the B group, and its purging method is identical with the A group.After the flushing, place nystatin 500,000 units at posterior fornix.Treated by the training personnel operation every day.Every day 1 time, 5 days is a course of treatment.Pregnancy women is all high-risk pregnant person's forbiddings such as abnormal conditions such as placenta previa, premature rupture of fetal membrane, threatened abortion, premature labor.
200 routine non-gestation group candidal vaginitis patients are divided into 4 groups at random.Every group 50 example.Test group is the A group.Medicine with the present invention is treated, the same gestation group of Therapeutic Method.Matched group is divided into B group, C group, D group.The B group is organized with miconazole nitrate (Daktar bolt), D with itraconazole (its glad core promise), C group and is used nystatin.The Therapeutic Method of D group is with the matched group of gestation group.The administrated method of B group, C group is pressed package insert.4 groups Therapeutic Method is 2% sodium bicarbonate solution flushing back posterior fornix and puts medicine.Every day 1 time, 5 days is a course of treatment.
Follow up a case by regular visits to after the treatment 3 times.Followed up a case by regular visits to trimester of pregnancy patient's the first time after the last medication three days, and followed up a case by regular visits to for the second time, follow up a case by regular visits to for the third time, check the neonate situation to childbirth in following up a case by regular visits to for the first time the back the 15th day; Non-pregnancy for the first time, follow up a case by regular visits to the trimester of pregnancy patient for the second time, followed up a case by regular visits to for the third time in premenstrual 2～3 days, this be because before the menstruation because the change of hormonal readiness, monilial vaginitis recurs before menstruation easily.The improvement situation of clinical symptoms and sign behind the recording medicine when following up a case by regular visits to, conventional vaginal secretions microscopy candidiasis.
Curative effect judging standard is to cure: microscopy does not have pathogen, no pruritus vulvae, vaginal secretions normal (being bean dregs shape or curdled milk sample unusually), no frequent micturition, dysurea, absence of vagina hyperemia; Do not heal: opposite with in the inspection of above-mentioned healing or the symptom one, be and do not heal.
Trimester of pregnancy monilial vaginitis therapeutic effect Lie Gebiao as follows.
Table 1 trimester of pregnancy group is checked effect relatively for the third time
| Group | The example number | Pathogen | Pruritus vulvae | Vaginal secretions | Frequent micturition, dysurea | Vaginal congest | |||||
| Do not have | Have | Do not have | Gently | Normally | Unusually | Do not have | Gently | Do not have | Gently | ||
| A | 93 | 84 | 9 | 83 | 10 | 88 | 5 | 92 | 1 | 89 | 4 |
| B | 93 | 68 | 25 | 62 | 31 | 80 | 13 | 85 | 8 | 61 | 32 |
Statistical procedures P＜0.01
Trimester of pregnancy, the beads vaginitis was checked for the third time, and handle microscopy pathogen X by statistics
2=9.21, P＜0.005; The overworked symptom X of pudendum scabies
2=7.44, P＜0.01; Vaginal secretions is observed X
2=3.90, P＜0.05; Frequent micturition dysurea symptom X
2=2.76, P＞0.05; Vaginal congest is checked X
2=9.07, P＜0.001; Two groups of contrasts are learned by statistics and are handled except that frequent micturition, dysurea symptom P＞0.05; All the other all have the significance meaning.Divide the puerperium to check the neonate situation, no abnormal.
Table 2 trimester of pregnancy group is checked effect for the second time relatively
| Group | The example number | Cure | Do not heal | Cure rate % |
| A | 93 | 91 | 2 | 97 |
| B | 93 | 71 | 22 | 76.34 |
X2=13.74＞6.63, P＜0.01 has highly significant
The therapeutic effect of non-pregnancy monilial vaginitis is Lie Gebiao as follows.
The non-gestation group treatment of table 3 back is checked effect for the first time relatively
| Group | The example number | Pathogen | Pruritus vulvae | Vaginal secretions | Frequent micturition, dysurea | Vaginal congest | |||||
| Do not have | Have | Do not have | Gently | Normally | Unusually | Do not have | Have | Do not have | Have | ||
| A | 50 | 48 | 2 | 45 | 5 | 48 | 2 | 49 | 1 | 48 | 2 |
| B | 50 | 39 | 11 | 40 | 10 | 40 | 10 | 47 | 3 | 40 | 10 |
| C | 50 | 36 | 14 | 30 | 20 | 37 | 13 | 45 | 5 | 39 | 11 |
| D | 50 | 37 | 13 | 32 | 18 | 37 | 13 | 47 | 3 | 38 | 12 |
Check for the first time effect behind the non-pregnancy women beads vaginitis treatment relatively, pathogen microscopy A group and B, C, D organize contrast, X
2Difference=7.16,10.71,9.49＞6.63 is so all there is highly significant P＜0.01; The pruritus vulvae symptom is removed the A group and is compared X with the B group
2=1.96＞1.32, outside the no significance in P＞0.05, the A group is compared X with C, D group
2Difference=12,9.54＞6.63 is so all there is highly significant P＜0.01; Vaginal secretions is observed the A group and is compared X with the B group
2=6.06＞5.02, there is significance P＜0.025, and the A group is compared X with C, D group
2Difference=9.49＞5.02, P＜0.01 has highly significant; Frequent micturition, dysurea symptom A group are compared P＞0.05 not statistically significant with B, C, D group; Vaginal congest inspection discovery A group is compared X with the B group
2=6.06＞5.02, there is the significance meaning P＜0.025; The A group is compared X with the C group with the D group
2Difference=7.16,8.13＞6.63, P＜0.01 has highly significant.
The non-gestation group treatment of table 4 back is checked effect for the second time relatively
| Group | The example number | Cure | Do not heal | Cure rate % |
| A | 50 | 50 | 0 | 100 |
| B | 50 | 45 | 5 | 90 |
| C | 50 | 38 | 12 | 76 |
| D | 50 | 39 | 11 | 78 |
X
2＝35.41＞12.84，P＜0.01
Press touchstone: B arrangement of mirrors inspection pathogen is found spore 3 examples, no mycelia, and pruritus that pudendum is slight 4 examples are surplus no abnormal; C arrangement of mirrors inspection pathogen is found spore 8 examples, finds no mycelia, overworked 6 examples of the slight scabies of pudendum; Vaginal congest 2 examples, surplus no abnormal; D arrangement of mirrors inspection pathogen detects spore 6 examples, overworked 7 examples of the slight scabies of pudendum, and vaginal congest 2 examples, surplus no abnormal.
The non-pregnancy monilial vaginitis is checked for the third time and was arranged in menstruation preceding second to four day.
Check effect for the third time relatively after the non-gestation group treatment of table 5
| Group | The example number | Cure | Do not heal | Cure rate % |
| A | 50 | 50 | 0 | 100 |
| B | 50 | 46 | 4 | 92 |
| C | 50 | 44 | 6 | 88 |
| D | 50 | 43 | 7 | 86 |
X
2＝8.496＞7.81，P＜0.05
C, B group respectively recurs 1 example, 2 examples, and except that no frequent micturition, dysurea symptom, surplus touchstone is all positive, and other cases that do not heal are individual event or two the positives by touchstone, all do not have frequent micturition, dysurea symptom.
Claims (2)
1, a kind of medicine for the treatment of monilial vaginitis is characterized in that, the set of dispense ratio of described medicine is:
Fel Gallus domesticus 10～20 weight portions
Radix Sophorae Flavescentis juice 10～30 weight portions
1% sodium bicarbonate, 10～30 weight portions
2, a kind of medicine for the treatment of monilial vaginitis as claimed in claim 1 is characterized in that, described Radix Sophorae Flavescentis juice is that every 30g Radix Sophorae Flavescentis adds water 1800～2200ml, and decocting to medicine juice is that 900～1100ml makes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031121489A CN1323680C (en) | 2003-04-14 | 2003-04-14 | Medicine for treating monilia vaginitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031121489A CN1323680C (en) | 2003-04-14 | 2003-04-14 | Medicine for treating monilia vaginitis |
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| Publication Number | Publication Date |
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| CN1537560A CN1537560A (en) | 2004-10-20 |
| CN1323680C true CN1323680C (en) | 2007-07-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB031121489A Expired - Fee Related CN1323680C (en) | 2003-04-14 | 2003-04-14 | Medicine for treating monilia vaginitis |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1108571A (en) * | 1994-12-31 | 1995-09-20 | 姜璞 | "Youshengling" for giving a good birth |
| CN1161199A (en) * | 1996-04-03 | 1997-10-08 | 山西省派尔保健日化厂 | Liquid bathing prepn. made from light yellow sophora root |
| CN1185913A (en) * | 1998-01-15 | 1998-07-01 | 郝斌香 | Health-care jujube for curing diabetes |
-
2003
- 2003-04-14 CN CNB031121489A patent/CN1323680C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1108571A (en) * | 1994-12-31 | 1995-09-20 | 姜璞 | "Youshengling" for giving a good birth |
| CN1161199A (en) * | 1996-04-03 | 1997-10-08 | 山西省派尔保健日化厂 | Liquid bathing prepn. made from light yellow sophora root |
| CN1185913A (en) * | 1998-01-15 | 1998-07-01 | 郝斌香 | Health-care jujube for curing diabetes |
Non-Patent Citations (1)
| Title |
|---|
| 动物胆汁药用研究的概况与展望 王凯平等，中国中医药科技，第7卷第5期 2000 * |
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| CN1537560A (en) | 2004-10-20 |
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