CN1318538A - Method of extracting octaverine from Chinese medicine material immature bitter orange - Google Patents
Method of extracting octaverine from Chinese medicine material immature bitter orange Download PDFInfo
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- CN1318538A CN1318538A CN 01106994 CN01106994A CN1318538A CN 1318538 A CN1318538 A CN 1318538A CN 01106994 CN01106994 CN 01106994 CN 01106994 A CN01106994 A CN 01106994A CN 1318538 A CN1318538 A CN 1318538A
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- CN
- China
- Prior art keywords
- extracting
- synephrine
- octaverine
- chinese medicine
- bitter orange
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Abstract
The octaverine extracting process includes water extraction of immature bitter orange, concentrating, ethanol precipitation of the extract liquid, ethanol recovery, sand filtering, water flushing and ammonia water elution in cation resin column, direct crystal separation of concentrating ammonia water elution liquid, and recrystallization. It has the advantages of simple operation process and low production cost.
Description
The present invention relates to a kind of method of from the Chinese medicine dried immature fruit of citron orange, extracting the medicinal raw material synephrine.
Synephrine (Synephrine) is a main effective constituent in the dried immature fruit of citron orange, be used for antishock and anti-mental and physical efforts alpine rush or palm-bark rain cape exhausts, from the dried immature fruit of citron orange, extract in the prior art of synephrine, its technological process comprises water extraction, concentrates, alcohol precipitation, recovery ethanol, filtration, ion exchange resin column chromatography, precipitation, ethyl acetate extraction, precipitation, ion exchange resin column chromatography, fibre column chromatography, concentrate step, complicated operations such as crystallization, recrystallization, preparation cycle is long, the industrial production cost height.
The object of the present invention is to provide a kind of method of from the Chinese medicine dried immature fruit of citron orange, extracting synephrine simply, cheaply.
Method of the present invention is to use the water extraction dried immature fruit of citron orange, and extracting solution is gone up cation exchange resin column then through concentrated, alcohol precipitation, recovery ethanol, sand filtration, wash with suitable quantity of water earlier, use certain density ammoniacal liquor wash-out again, the ammoniacal liquor elutriant is through concentrating direct crystallization, and recrystallization promptly gets synephrine.
Present method is simple to operate, production cost is low, and through trial production, the synephrine extraction yield can reach more than 70%, and content can be more than 99.5%.
Embodiment: get the dried immature fruit of citron orange, extracting in water secondary, extracting solution are evaporated to relative density about 1.1, add ethanol and reach more than 70%, left standstill 12 hours, get supernatant liquor and reclaim ethanol to containing the alcohol amount, concentrated solution adds suitable quantity of water, filters with the sand filtration post, and filtrate adds cation exchange resin column, with the suitable quantity of water flushing, use certain density ammoniacal liquor wash-out more earlier, collect elutriant, cryoconcentration leaves standstill crystallization to an amount of, filters, recrystallization, getting white crystals is synephrine.
Claims (1)
1, a kind of method of from the dried immature fruit of citron orange, extracting synephrine, comprise and use the water extraction dried immature fruit of citron orange, extracting solution is through concentrated, alcohol precipitation, recovery ethanol, it is characterized in that adopting again in this method sand filtration, cation exchange resin column on the filtrate with the suitable quantity of water flushing, is used certain density ammoniacal liquor wash-out earlier again, the ammoniacal liquor elutriant concentrates directly crystallization of back, and recrystallization promptly gets synephrine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01106994 CN1318538A (en) | 2001-04-11 | 2001-04-11 | Method of extracting octaverine from Chinese medicine material immature bitter orange |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01106994 CN1318538A (en) | 2001-04-11 | 2001-04-11 | Method of extracting octaverine from Chinese medicine material immature bitter orange |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1318538A true CN1318538A (en) | 2001-10-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01106994 Pending CN1318538A (en) | 2001-04-11 | 2001-04-11 | Method of extracting octaverine from Chinese medicine material immature bitter orange |
Country Status (1)
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| CN (1) | CN1318538A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101875703A (en) * | 2010-05-28 | 2010-11-03 | 砀山宇宁生物科技有限公司 | Method for extracting pectin and synephrine by utilizing peels and marc |
| CN102050855A (en) * | 2010-12-28 | 2011-05-11 | 陕西嘉禾植物化工有限责任公司 | Method for comprehensively extracting synephrine and hesperidine from immature bitter orange raw material |
| CN102106918A (en) * | 2011-02-22 | 2011-06-29 | 中国中医科学院中医基础理论研究所 | Method for simultaneously preparing volatile oil, total flavones and total alkaloids from immature bitter oranges |
| CN101402577B (en) * | 2008-10-23 | 2011-07-20 | 浙江工商大学 | Method for extracting and separating levorotation-synephrine from green tangerine orange peel |
| CN102286111A (en) * | 2011-07-06 | 2011-12-21 | 砀山宇宁生物科技有限公司 | Novel process for extracting pectin from pear skin at normal temperature |
| CN1903279B (en) * | 2005-07-29 | 2012-02-22 | 天津天士力制药股份有限公司 | Method for extraction and separation of Immature Bitter orange |
| CN105358170A (en) * | 2013-07-03 | 2016-02-24 | 韩国百鸥思特公司 | Composition for treating or preventing inflammatory skin disease, comprising, as active ingredient, immature citrus fruit extract, or synephrine or salt thereof |
| CN106278912A (en) * | 2016-08-03 | 2017-01-04 | 绵阳迪澳药业有限公司 | Crystallization process is utilized to prepare the production technology of high-purity Neosynephrine |
| CN113527120A (en) * | 2021-07-19 | 2021-10-22 | 江西岐黄农业科技有限公司 | Extraction process of levo-synephrine |
-
2001
- 2001-04-11 CN CN 01106994 patent/CN1318538A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903279B (en) * | 2005-07-29 | 2012-02-22 | 天津天士力制药股份有限公司 | Method for extraction and separation of Immature Bitter orange |
| CN101402577B (en) * | 2008-10-23 | 2011-07-20 | 浙江工商大学 | Method for extracting and separating levorotation-synephrine from green tangerine orange peel |
| CN101875703A (en) * | 2010-05-28 | 2010-11-03 | 砀山宇宁生物科技有限公司 | Method for extracting pectin and synephrine by utilizing peels and marc |
| CN102050855A (en) * | 2010-12-28 | 2011-05-11 | 陕西嘉禾植物化工有限责任公司 | Method for comprehensively extracting synephrine and hesperidine from immature bitter orange raw material |
| CN102106918A (en) * | 2011-02-22 | 2011-06-29 | 中国中医科学院中医基础理论研究所 | Method for simultaneously preparing volatile oil, total flavones and total alkaloids from immature bitter oranges |
| CN102106918B (en) * | 2011-02-22 | 2012-03-28 | 中国中医科学院中医基础理论研究所 | Method for simultaneously preparing volatile oil, total flavones and total alkaloids from immature bitter oranges |
| CN102286111A (en) * | 2011-07-06 | 2011-12-21 | 砀山宇宁生物科技有限公司 | Novel process for extracting pectin from pear skin at normal temperature |
| CN102286111B (en) * | 2011-07-06 | 2014-02-05 | 砀山宇宁生物科技有限公司 | Process for extracting pectin from pear skin at normal temperature |
| CN105358170A (en) * | 2013-07-03 | 2016-02-24 | 韩国百鸥思特公司 | Composition for treating or preventing inflammatory skin disease, comprising, as active ingredient, immature citrus fruit extract, or synephrine or salt thereof |
| CN106278912A (en) * | 2016-08-03 | 2017-01-04 | 绵阳迪澳药业有限公司 | Crystallization process is utilized to prepare the production technology of high-purity Neosynephrine |
| CN113527120A (en) * | 2021-07-19 | 2021-10-22 | 江西岐黄农业科技有限公司 | Extraction process of levo-synephrine |
| CN113527120B (en) * | 2021-07-19 | 2023-08-18 | 江西岐黄农业科技有限公司 | Extraction process of levo synephrine |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |