CN1316236A - Minite-quantity separating and packing method for superfine powder - Google Patents
Minite-quantity separating and packing method for superfine powder Download PDFInfo
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- CN1316236A CN1316236A CN 01110738 CN01110738A CN1316236A CN 1316236 A CN1316236 A CN 1316236A CN 01110738 CN01110738 CN 01110738 CN 01110738 A CN01110738 A CN 01110738A CN 1316236 A CN1316236 A CN 1316236A
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- superfines
- emulsion
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- container
- filling
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Abstract
A method for dividing the superfine powder and loading micro quantity of said powder in containers includes such steps as mixing said superfine powder with particular solvent to obtain emulsion, quantitatively spraying the emulsion onto internal surface of container, and evaporating the solvent. Its advantages include no crystallizing, high precision, simple method, low cost and no pollution to the powder.
Description
The present invention relates to the method that a kind of superfines is packed as micro-equal portions, mainly with the accurate micro-packing of field of medicaments to dry powder formulations.
At the field of medicaments dry powder formulations is one of main preparation of medicine, and this preparation is divided in each container by each requirement, its minute loading amount be generally less than 50mg.This preparation is water miscible, preserves with the dry powder shape, uses water dissolution in use.At present freeze drying process is adopted in the packing of superfines, the shortcoming of this method is: be prone to crystallization icing behind the powder dissolution in process again, make its granularity become big, do not reach nanoscale; Freeze dried equipment complexity, the production cost height; The contaminated chance of medicine is many.
Purpose of the present invention just provides a kind of powder size that do not influence, and is simple to operate, production cost is low, reduce the micro-method for filling of the superfines of opportunities for contamination.
Technical scheme of the present invention is to comprise following relating to suddenly:
1) superfines and specific solvent are mixed in proportion, emulsion is made in emulsifying.
2) amount on demand quantitatively sprays to above-mentioned emulsion on the container inner wall to be installed.
3) scribble the container heating of emulsion or slowly dry up container intracavity above-mentioned with hot blast, the solvent evaporation in the turbid liquid, the solute of remaining trace is the powder that packing finishes in the container.
Described fine powder is water miscible, average diameter of particles＜30 μ m.
Described specific solvent be not with the volatile solvent of superfines phased soln to be packed.
Described emulsion is quantitatively sprayed employing micro sample adding appliance or automatic ration Spray painting tool.
Advantage of the present invention is that the immiscible solvent of employing and subpackaged powder is made emulsion evaporate to dryness again, can not produce crystallization, and granule is littler, and the packing precision is higher, and equipment is simple, production cost is low, divides process of assembling simple, and the weak point evaporate to dryness is fast, and the contaminated chance of medicament is few.
The invention will be further described below in conjunction with embodiment.
Embodiment 1:
The 1g edetate is packed as every part of 5mg.Its packing step is:
1, select for use ethanol as holding agent, powder and ratio of solvent are 1g: 20ml, mix back mulser emulsifying.
2, emulsion is coated onto on the inwall of 200 molten devices with micro sample adding appliance then, the amount of powder in each container is 1/200g, i.e. 5mg.
3, container is heated promptly obtain the dry preparation of every part of 5mg after the packing after the solvent evaporated.
Embodiment 2
10g fluoridized to receive be packed as every part of 10mg.
1, selecting 20ml ethanol for use is solvent, mixing, emulsifying.
2,10mg fluoridizes to receive and is divided into 1000 parts.Spray on 1000 container inner walls with the emulsion of automatic packer after emulsifying.
3, container is heated promptly get the preparation of every part of 10mg of packing behind the evaporate to dryness ethanol.
Claims (4)
1, a kind of micro-method for filling of superfines is characterized in that may further comprise the steps:
1) superfines and specific solvent are mixed in proportion, emulsion is made in emulsifying.
2) amount on demand quantitatively sprays to above-mentioned emulsion on the container inner wall to be installed.
3) slowly dry up container intracavity with the above-mentioned container heating that scribbles emulsion or with hot blast, the solvent evaporation in the emulsion keeps away in the container and stays the dried vestige of emulsion, is the powder of the trace that packing finishes.
2, require the micro-method for filling of 1 described superfines according to power, it is characterized in that: described superfines is water miscible, average diameter of particles＜30 μ m.
3, require the micro-method for filling of 1 described superfines according to power, it is characterized in that: described specific solvent for not with superfines phased soln volatile solvent to be packed.
4, require the micro-method for filling of 1 described superfines according to power, it is characterized in that: described emulsion is quantitatively sprayed adopt micro sample adding appliance or automatic ration Spray painting tool.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01110738 CN1316236A (en) | 2001-04-18 | 2001-04-18 | Minite-quantity separating and packing method for superfine powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01110738 CN1316236A (en) | 2001-04-18 | 2001-04-18 | Minite-quantity separating and packing method for superfine powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1316236A true CN1316236A (en) | 2001-10-10 |
Family
ID=4658801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01110738 Pending CN1316236A (en) | 2001-04-18 | 2001-04-18 | Minite-quantity separating and packing method for superfine powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1316236A (en) |
-
2001
- 2001-04-18 CN CN 01110738 patent/CN1316236A/en active Pending
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