CN1309426C - Application of biological active glass in the preparation process of ulcer and erosion wound treating dressing - Google Patents
Application of biological active glass in the preparation process of ulcer and erosion wound treating dressing Download PDFInfo
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- CN1309426C CN1309426C CNB2004100183704A CN200410018370A CN1309426C CN 1309426 C CN1309426 C CN 1309426C CN B2004100183704 A CNB2004100183704 A CN B2004100183704A CN 200410018370 A CN200410018370 A CN 200410018370A CN 1309426 C CN1309426 C CN 1309426C
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Abstract
The present invention relates to application of bioactive glass in the preparation of dressing for treating soft tissue ulcer and long-term erosive wounds. The present invention is mainly characterized in that dry bioactive glass powder with the particle size of less than 100 microns is directly smeared on a wound, or the dry bioactive glass powder is atomized by compression so that the powder is sprayed on the surface of a wound. The bioactive glass powder comprises the following chemical constitutions by weight percentage: 24 to 45% of CaO, 34 to 50% of SiO2, 2 to 25% of Na2O and 5 to 10% of P2O5. The present invention has especially obvious curative effects on arbitrary one kind of or the long-term erosion of cervical erosion, oral cavity ulcer, bedsore, sinuses, fat liquescency wounds, venereal disease ulcer, hemorrhoid, diabetes ulcer and other soft tissue ulcer.
Description
Technical field
The present invention relates to the application of a kind of bioactivity glass in preparation ulcer and erosive wound dressing, particularly relate to the application of the bioactive glass powder in the long-term erosive wound dressing of preparation treatment soft tissue, belong to technical field of biological material.
Background technology
Bioactivity glass has 30 years of researches history, and existing more than 15 year of successful clinical practice is the synthetic material of the growth healing of at present unique growth, bone damaged healing can the promotion again soft tissue that can promote osseous tissue.This artificial synthetic material is compared with the biomaterial that other extracts from allosome, and biggest advantage is its safety, does not worry the infection of other allosome pathogenic bacteria.
These good characteristics of bioactivity glass derive from its surface activity.Current research shows that the surface activity of bioactivity glass can promote the generation of somatomedin, procreation, the activating cell gene expression of promotion cell.Like this, bioactivity glass begins direct control with the gene of process by directly cell cycle being brought out in those adjustings, thereby strengthens and reached the facilitation that tissue is formed growth.
Treating long-term erosive wound is one of puzzlement medical circle difficult problem, does not have very effective and easy drug treatment.Critically ill patient can only clean a wound, sterilize, change dressings and treat by carrying out in hospital every day.At present, there is the somatomedin of taking from allosome allos, to extract to promote the treatment way of wound healing both at home and abroad.This exogenous growth factor may cause scabbing.In addition, because somatomedin extracts preparation mostly from allosome allos, there is the probability of introducing viral infection.Studies show that of past, bioactivity glass can promote the soft tissue healing.Application number is that 97191524 patent " compositions of acceleration of wound and burn-healing and method " and application number are that 99802296 patent " is used bioactive glass treatment of inflammation in skin conditions " and disclosed the application technology of bioactivity glass to skin trauma, burn and inflammation wound healing, proves that bioactivity glass has obvious curative effects to wound healing.But these two inventions all do not relate to the treatment of long-term erosive wound.In addition, (application number: technology 97191524) only relates to bioactive glass powder and at least a antibiotics is used in combination for patent " compositions of acceleration of wound and burn-healing and method ".And use the long-term erosive wound of bioactive glass powder treatment soft tissue never to appear in the newspapers.
Summary of the invention
Application number is that 97191524 patent " compositions of acceleration of wound and burn-healing and method " and application number are that 99802296 patent " has used bioactive glass treatment of inflammation in skin conditions " and disclose bioactivity glass to form application technology to wound healing.Disclosure comprises that also bioactivity glass mixes use with antibiotic; Bioactivity glass mixes use with medicinal ointment, gel, vaseline, light mineral wet goods as carrier.The object of the present invention is to provide the independent application of a kind of bioactivity glass in preparation treatment soft tissue ulcers and long-term rotten to the corn wound dressing.
Yet, find that in the clinical practice of our reality the long-term erosion to any and they in the soft tissue ulcers such as diabetic ulcer, cervical erosion, oral ulcer, decubital ulcer, sinus tract, fat liquor voltinism wound, sexually transmitted disease (STD) ulcer, hemorrhoid when bioactive glass powder uses separately as dressing has the obvious treatment effect.
We think that bioactivity glass causes wound healing by the reaction of its surface activity.When bioactive glass particle is put into soft tissue ulcers and long-term rotten to the corn wound, when contacting with the wound sepage, the accelerated surface reaction takes place, its result is: 1, ion discharges; 2, calcium, phosphorus plasma deposition generate a support shape hydroxyapatite layer on the bioactive glass particle surface; 3, the high specific surface area of bioactive glass particle is adsorbed into fine microcell, upper epidermis cell and some protein growth factors, these cells are subjected to the effect of the stable and somatomedin of hydroxyapatite shelf layer, help cell metabolism and make up new tissue, make the bioactive glass particle surface become the base of a connective tissue and epidermal tissue's growth; 4, bioactive glass particle surface reaction and ion release raising wound or soft group of injury region pH can suppress to infect, and also may improve the partial pressure of oxygen at the local place of wound.All these effects have reached the effect that promotes wound and soft tissue injury healing.
The present invention is to be that bioactive glass powder below 100 microns directly acts on soft tissue ulcers and long-term erosive wound with granularity.Concrete grammar can be that bioactive glass powder directly is coated in the wound place, or by common medical compressed gas atomization jetting device powder body is sprayed surface in wound.The chemical composition of this bioactive glass powder is mainly by CaO 24-45%, SiO
234-50%, Na
2O 2-25%, P
2O
5The 5-10% quality is formed.Porous bioglass powder body of the present invention has good biological activity in human body simulation body fluid, can discharge silicon, calcium, sodium plasma in a few hours, and at surface deposition hydroxyapatite crystallite.Bioactive glass powder of the present invention prepares by melting method.Used inorganic raw material is analytical pure.Chemical reagent is needed behind weighing and the mixing 1380-1480 ℃ of following fusion by different component, obtain granularity and be bioactivity glass dry powder body through cooling off, pulverize, sieving again less than 100 microns.
Description of drawings
By following in conjunction with the accompanying drawings with the introduction of embodiment, can the present invention is described in further detail, can understand content mentioned above better.
Figure 1A is the preceding photo of treatment, and the sinus tract cavity is clearly visible.
Figure 1B is that transudate reduces after using bioactive glass powder to treat for 1 week, and wound surface is fresh, and the growth of meat tooth is very fast.
Fig. 1 C is for after treating for 3 weeks, and wound surface heals fully.
Fig. 2 is for adopting bioactive glass treatment ulcer wound surface photo.
Fig. 2 A is for before treating, and ulcer wound surface is high-visible.After Fig. 2 B is 2 weeks of treatment, wound healing 75%.
Fig. 2 C is for after treating for 4 weeks, and wound surface heals fully.
The specific embodiment
Embodiment 1
Patient causes sinus tract before the right lower extremity shin, 2 centimetres of sinus tract diameters, dark 2 centimetres because of wound.Cause the long-term disunion of sinus tract because of suffering from diabetes, sinus tract surrounding tissue color secretly and with dense property oozes out (Figure 1A).Adopting chemical composition is CaO 24.5%, SiO
245%, Na
2O 24.5%, P
2O
56%, granularity is for inserting the sinus tract treatment less than 100 microns bioactivity glass.Shown in Figure 1B, ooze out minimizing after treating for 1 week, wound surface is fresh, and the meat tooth is grown fast.Treatment 3 week back wound surface heal fully (Fig. 1 C).
Embodiment 2
The patient finds that there is 5 * 6 * 0.7 centimetre ulcer wound surface the side through the mastocarcinoma radical operation after 2 weeks.Adopt conventional therapy, the poor effect of changing dressings every day (Fig. 2 A).Beginning the bioactive glass powder that external such as embodiment 1 adopted after 3 weeks treats.Healing speed is obviously accelerated behind the begin treatment, and minimizing is oozed out in treatment 1 week back meat tooth growth, wound healing 50%, 2 week of treatment the back wound healings reach 75% (Fig. 2 B), 4 week of treatment back wound surface heal fully (Fig. 2 C).
Claims (3)
1. the application of bioactivity glass in preparation treatment soft tissue ulcers and long-term rotten to the corn wound dressing is characterized in that particle size is directly applied or sprays in the wound less than the independent use of 100 microns bioactive glass powder; The mass percent of described bioactive glass powder chemical composition is CaO 24-45%, SiO
234-50%, Na
2O 2-25%, P
2O
55-10%.
2. by the application in described bioactive glass treatment soft tissue ulcers of claim 1 and the long-term rotten to the corn wound dressing, it is characterized in that described bioactive glass powder prepares by melting method, specifically be by behind chemical composition weighing, the mixing 1380-1480 ℃ of following fusion, make granularity again through cooling off, pulverize, sieving less than 100 microns bioactive glass powder.
3. by the application of the described bioactivity glass of claim 1 in preparation treatment soft tissue ulcers and long-term rotten to the corn wound dressing, it is characterized in that being used in separately any soft tissue ulcers or their long-term erosion in treatment diabetic ulcer, cervical erosion, oral ulcer, decubital ulcer, sinus tract, fat liquor voltinism wound, sexually transmitted disease (STD) ulcer or the hemorrhoid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100183704A CN1309426C (en) | 2004-05-14 | 2004-05-14 | Application of biological active glass in the preparation process of ulcer and erosion wound treating dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100183704A CN1309426C (en) | 2004-05-14 | 2004-05-14 | Application of biological active glass in the preparation process of ulcer and erosion wound treating dressing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1569246A CN1569246A (en) | 2005-01-26 |
| CN1309426C true CN1309426C (en) | 2007-04-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100183704A Active CN1309426C (en) | 2004-05-14 | 2004-05-14 | Application of biological active glass in the preparation process of ulcer and erosion wound treating dressing |
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| CN (1) | CN1309426C (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908692B (en) * | 2014-03-30 | 2016-05-18 | 浙江圣兆医药科技有限公司 | A kind of composite biological material is applied ointment or plaster and preparation method |
| CN104258453A (en) * | 2014-09-24 | 2015-01-07 | 湖北华中医用材料有限公司 | Raw material composition of active wound repair material and preparation method of raw material composition |
| CN105169458A (en) * | 2015-09-25 | 2015-12-23 | 胡方 | Biological activity mineral substance material and application of biological activity mineral substance material to soft tissue anabrosis and long-time erosion wound cell regeneration and melanoma restraining |
| CN105999392A (en) * | 2016-07-01 | 2016-10-12 | 广州华弘生物科技有限公司 | Skin wound active dressing containing glass inorganic active materials |
| CN106138096B (en) * | 2016-07-28 | 2019-08-13 | 赛克赛斯生物科技股份有限公司 | A kind of film for treating oral ulcer and the preparation method and application thereof |
| CN108992699A (en) * | 2018-08-30 | 2018-12-14 | 海南鸿翼医疗器械有限公司 | A kind of functional Wound dressing and preparation method thereof containing active composite material |
| CN111921006B (en) * | 2020-09-08 | 2023-03-03 | 上海硅健生物材料有限公司 | Novel periodontal dressing and preparation method thereof |
| CN112773816B (en) * | 2020-12-29 | 2022-01-11 | 浙江甬誉生物科技有限公司 | Wound repair spray and preparation method and application thereof |
| CN115591009B (en) * | 2022-10-27 | 2023-09-26 | 江苏阳生生物股份有限公司 | Dressing for promoting rapid repair of skin wound surface |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305370A (en) * | 1998-01-23 | 2001-07-25 | 美国生物材料公司 | Bioactive glass treatment of inflammation in skin conditions |
| CN1325291A (en) * | 1998-09-10 | 2001-12-05 | 美国生物材料公司 | Anti-inflammatory and antimicrobial uses for bioactive glass compositions |
-
2004
- 2004-05-14 CN CNB2004100183704A patent/CN1309426C/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305370A (en) * | 1998-01-23 | 2001-07-25 | 美国生物材料公司 | Bioactive glass treatment of inflammation in skin conditions |
| CN1325291A (en) * | 1998-09-10 | 2001-12-05 | 美国生物材料公司 | Anti-inflammatory and antimicrobial uses for bioactive glass compositions |
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| CN1569246A (en) | 2005-01-26 |
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