CN1305874C - Process for preparing sodium azlocillin - Google Patents
Process for preparing sodium azlocillin Download PDFInfo
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- CN1305874C CN1305874C CNB2005100113763A CN200510011376A CN1305874C CN 1305874 C CN1305874 C CN 1305874C CN B2005100113763 A CNB2005100113763 A CN B2005100113763A CN 200510011376 A CN200510011376 A CN 200510011376A CN 1305874 C CN1305874 C CN 1305874C
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Abstract
The present invention provides a preparing method of azlocillin sodium, which comprises the following steps: (1) slowly adding triethylamine into aqueous solution of ampicillin at 0 to 4 DEG C, and stirring the solution to clarify the reaction liquid; (2) adding 2-imidazolidinyl ketacyl chloride into the solution at 0 to 4 DEG C while dripping aqueous solution of Na2CO3 or NaHCO3, and controlling a pH value at 7.5 to 8.5 to carry out a condensation reaction; (3) adding ethyl acetate into the reaction mixture at 0 to 5 DEG C, and adjusting the pH value to 1.7 to 1.9; (4) carrying out separation to obtain organic phases and remove heat sources and impurities, and obtaining raw crystallization liquid; (5) adding ethyl acetate solution of sodium isocaprylate into the raw crystallization liquid for crystallization, and then carrying out material separation and drying to obtain powdered white azlocillin sodium. The method of the present invention has the advantages of convenient operation, mild reaction conditions, high yield and good product quality.
Description
Technical field
The invention belongs to the medication preparation field, more specifically, the invention provides a kind of Preparation of Azlocillin sodium method.
Background technology
The chemistry of azlocillin sodium (Azlocillin) is called (2S, 5R, 6R)-3, the 3-dimethyl-6-[(R)-and 2-(2-oxo-1-imidazolidine carboxamide base-2-phenylacetylamino)-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-formic acid sodium salt, its chemical formula is suc as formula shown in (I).Azlocillin sodium is not destroyed by the penicillinase that streptococcus aureus produces, effective to producing the enzyme streptococcus aureus, be mainly used in infecting of penicillin-fast streptococcus aureus and staphylococcus epidermidis on every side, comprise the infection at positions such as internal organ, skin and soft tissue, with amikacin, gentamicin, can produce synergy when netilmicin share.
Molecular formula: C
20H
22N
5NaO
6S molecular weight: 483.47
Relevant azlocillin sodium synthetic reported two kinds of synthetic routes and synthetic method separately at present, promptly is starting raw material with 6-APA and is two kinds of routes of starting raw material with the Ampicillin Trihydrate.
With 6-APA is the synthetic route of raw material
Difference by precursor acids (being side-chain acid) synthesis mode reduces following several:
Route 1: synthesize the side chain carbonyl with imines halogenide, and then get azlocillin (United States Patent (USP) 3,933,795 (1978), United States Patent (USP) 4,016,282 (1978), Koealg, HansBodo with the 6-APA condensation; Metzer, KqrlG eorg; Offe, Hansert; Schroeck, wllrried:Azlocilln, A new penicillin the acylureldo serles, Synthesls andchemicalpuopers, Eur.J.Med, Chem-Chim.Ther, 1982; 17 (1): 59-63.).The chemical reaction flow process as shown in Figure 1.
Route 2: form the synthetic side chain carbonyl of acyl chlorides, with 6-APA condensation (NakovA behind the silanization; Atanasova T; Tchoneva D:Method for lyaical control in azlocilllinsynthesis, pHarmazie; 44H, 1:68).The chemical reaction flow process as shown in Figure 2.
Route 3: form active ester, again with 6-APA condensation (Czech CS:218,080 (1985)).The chemical reaction flow process as shown in Figure 3.
Route 4: form behind the mixed acid anhydride again and 6-APA condensation (United States Patent (USP) 4,229,349 (1980)).The chemical reaction flow process as shown in Figure 4.
With the Ampicillin Trihydrate is the synthetic route of raw material
Route 5: active ester method, side chain is made active ester earlier, again with Ampicillin Trihydrate condensation (Czech CS:218,027 (1985); Czech CS:218,031 (1985)).The chemical reaction flow process as shown in Figure 5.
Route 6: the direct and Ampicillin Trihydrate condensation (United States Patent (USP) 4,556,516 (1985)) of two ethyl isocyanates.The chemical reaction flow process as shown in Figure 6.
There is following defective in above-mentioned technology:
The method yield of route 1,5 is low, and activator source difficulty should not adopt.Wherein: the yield of route 1 is 45%, and the yield of route 5 is 78%.
The method steps of route 2 is long, and operational condition requires high, should not adopt.
The method yield of route 3 low (42%), activator preparation difficulty, operational requirement is higher, should not adopt.
Though the method yield of route 4 is high, severe reaction conditions, reagent dimethylamino propyl alcohol source difficulty should not adopt.
The method of route 6 is simple to operate, the yield height, but the two ethyl isocyanate preparations of raw material are complicated, should not adopt.
In order to overcome above-mentioned defective, be necessary to develop new azlocillin sodium preparation method.
Summary of the invention
The invention provides a kind of Preparation of Azlocillin sodium method, this method comprises following step:
(1) in 0-4 ℃, in the aqueous solution of Ampicillin Trihydrate, slowly add triethylamine, be stirred to the reaction solution clarification;
(2) in 0-4 ℃, in solution, add 2-imidazolidone acyl chlorides, drip Na simultaneously
2CO
3Or NaHCO
3The aqueous solution, control pH value is carried out condensation reaction at 7.5-8.5;
(3), in reaction mixture, add ethyl acetate, and regulate the pH value to 1.7-1.9 in 0-5 ℃;
(4) separate, get organic phase, behind thermal source and impurity, get crystallization stoste;
(5) ethyl acetate solution of Sodium isooctanoate is added above-mentioned crystallization stoste, crystallization appears and after, get rid of material, drying, make the white powder azlocillin sodium;
Wherein, above-mentioned 2-imidazolidone acyl chlorides, Ampicillin Trihydrate and Sodium isooctanoate by weight amount ratio be: 1: 1.0～1.15: 1.05～1.15.
Wherein comprise in the step (4) get remove thermal source and impurity after the organic phase before, with 20%NaCl solution washing organic phase.
In described step (4), remove thermal source and realize by charcoal absorption.
Preparation of Azlocillin sodium method provided by the present invention is easy to operate, reaction conditions gentleness, yield height (about 87.79%), good product quality (very easily dissolving, about 1.5 minutes).And method of the present invention has solved " three wastes " of pharmaceutical industry well and has handled problems, the recyclable utilization of the ethyl acetate in the waste liquid, and the gac residue in the azlocillin sodium salification process is also recyclable.
Description of drawings
Fig. 1 is the chemical reaction flow process figure of route 1.
Fig. 2 is the chemical reaction flow process figure of route 2.
Fig. 3 is the chemical reaction flow process figure of route 3.
Fig. 4 is the chemical reaction flow process figure of route 4.
Fig. 5 is the chemical reaction flow process figure of route 5.
Fig. 6 is the chemical reaction flow process figure of route 6.
Fig. 7 is the chemical reaction flow process figure of route 7 of the present invention.
Fig. 8 is the process flow sheet of an azlocillin sodium preparation method's of the present invention embodiment.
Embodiment
The following examples have further been explained content of the present invention, but the scope that does not limit the present invention in any way.
Embodiment 1
(1) raw material
Table 1 proportioning raw materials
| Material name | Charging capacity | Molar weight | Mol ratio | Remarks |
| The Ampicillin Trihydrate | 1400g | 3.47 | 1.05 | |
| Deionized water | 14L | |||
| 2-imidazolidone acyl chlorides | 490g | 3.3 | 1 | |
| Triethylamine | 506mL | 3.47 | 1.05 | |
| Ethyl acetate | 17L | |||
| Anhydrous sodium carbonate | 368g | |||
| Methyl alcohol | 2.3L | |||
| 3N hydrochloric acid | 1.47L | |||
| Ethyl acetate | 6L | |||
| Sodium isooctanoate | 608.5g | 3.64 | 1.1 | |
| Ethyl acetate | 5L | The washing finished product |
(2) processing step
Add 14 liter water in 50 liter retort, be cooled to 4 ℃, stir adding 1400g Ampicillin Trihydrate down, in 4 ℃ of slow Dropwise 5 06ml triethylamines, drip half an hour approximately, continue to stir afterreaction liquid clarification half an hour, the pH value is 8.5.At this moment, the gradation of 490g 2-imidazolidone acyl chlorides is added in the retort, temperature of reaction still is controlled at 4 ℃, drips 10%Na simultaneously
2CO
3The aqueous solution, control pH value is 7.5, adds in about 1 hour.The pH value still is controlled at 7.5 and reacts half an hour.Add 14 liter ethyl acetate, controlled temperature adds 1.47 liter 3N HCl at 5 ℃ and regulates pH value to 1.7.Add the back standing demix, divide water layer down, ethyl acetate layer is stayed in the jar, water layer with the washing of 3 liter ethyl acetate, is abandoned it with water layer after washing, behind the combined ethyl acetate layer again, with the washing of 10 liter 20%NaCl water liquid, wash the back layering, salt solution is told aftertreatment, treat down to criticize and apply mechanically, the 70g gac is joined in the ethyl acetate, stir half an hour, after taking off intracellular toxin and impurity, 0.22 μ m filter membrane is crossed in press filtration, enter in the crystallizer, standby.
6 liter ethyl acetate are pumped in the 20 liter lass lining jars, start stirring, add Sodium isooctanoate 603g.Add the 30g gac after the stirring and dissolving, stir half an hour after, in 16 ℃ of press filtrations, filtering membrane enters in the crystallizer, after being stirred to crystallization and occurring, slowly stirred crystallization is 2 hours, and discharging is got rid of after filter does, with 5 liter ethyl acetate washing finished product, got rid of discharging then after the drying again 20 minutes.Vacuum-drying discharging after 3 hours gets white powder azlocillin sodium 1407g.Yield: 87.7%.
Making lot number with identical processing method is 040201,040202 and 040,203 3 batch of product, and its result is as follows:
| Lot number | Charging capacity | Quantum of output | Yield | Proterties | Specific optical rotation (°) |
| The imidazolidone acyl chlorides | Azlocillin sodium | ||||
| 040201 | 490g | 1407g | 87.70％ | White powder | 184.3° |
| 040202 | 490g | 1390g | 86.70％ | White powder | 182.4° |
| 040203 | 490g | 1404g | 87.50％ | White powder | 183.6° |
Embodiment 2
(1) raw material
Table 2 proportioning raw materials
| Material name | Charging capacity | Molar weight | Mol ratio | Remarks |
| The Ampicillin Trihydrate | 1467g | 3.64 | 1.10 | |
| Deionized water | 14L | |||
| 2-imidazolidone acyl chlorides | 490g | 3.3 | 1 | |
| Triethylamine | 530mL | 3.64 | 1.10 | |
| Ethyl acetate | 17L | |||
| Anhydrous sodium carbonate | 368g | |||
| Methyl alcohol | 2.3L | |||
| 3N hydrochloric acid | 1.47L | |||
| Ethyl acetate | 6L | |||
| Sodium isooctanoate | 636.2g | 3.83 | 1.15 | |
| Ethyl acetate | 5L | The washing finished product |
(2) processing step
Add 14 liter water in 50 liter retort, be cooled to 0 ℃, stir adding 1467g Ampicillin Trihydrate down, in 0 ℃ of slow Dropwise 5 30ml triethylamine, continue to stir afterreaction liquid clarification half an hour, the pH value is 9.0.At this moment, the gradation of 490g 2-imidazolidone acyl chlorides is added in the retort, temperature of reaction still is controlled at 0 ℃, drips 10%NaHCO simultaneously
3The aqueous solution, control pH value is 8.5.The pH value still is controlled at 8.5 and reacts half an hour.Add 14 liter ethyl acetate, controlled temperature adds 1.47 liter 3N HCl for 0 ℃ and regulates pH value to 1.9.Add the back standing demix, divide water layer down, ethyl acetate layer is stayed in the jar, water layer with the washing of 3 liter ethyl acetate, is abandoned it with water layer after washing, behind the combined ethyl acetate layer again, with the washing of 10 liter 20%NaCl water liquid, wash the back layering, salt solution is told aftertreatment, treat down to criticize and apply mechanically, the 70g gac is joined in the ethyl acetate, stir half an hour, after taking off intracellular toxin and impurity, 0.22 μ m filter membrane is crossed in press filtration, enter in the crystallizer, standby.
6 liter ethyl acetate are pumped in the 20 liter lass lining jars, start stirring, add Sodium isooctanoate 636.2g.Add the 30g gac after the stirring and dissolving, stir half an hour after, in 20 ℃ of press filtrations, filtering membrane enters in the crystallizer, after being stirred to crystallization and occurring, slowly stirred crystallization is 2 hours, and discharging is got rid of after filter does, with 5 liter ethyl acetate washing finished product, got rid of discharging after the drying again 20 minutes.Vacuum-drying discharging after 3 hours gets white powder azlocillin sodium 1425g.Yield: 88.1%.
Making lot number with identical processing method is 040204,040205 and 040,206 3 batch of product, and its result is as follows:
| Lot number | Charging capacity | Quantum of output | Yield | Proterties | Specific optical rotation (°) |
| The imidazolidone acyl chlorides | Azlocillin sodium | ||||
| 040204 | 490g | 1425g | 89.32％ | White powder | 183.8° |
| 040205 | 490g | 1408g | 88.25％ | White powder | 183.1° |
| 040206 | 490g | 1385g | 86.81％ | White powder | 182.6° |
Claims (3)
1, a kind of Preparation of Azlocillin sodium method, this method comprises following step:
(1) in 0-4 ℃, in the aqueous solution of Ampicillin Trihydrate, slowly add triethylamine, be stirred to the reaction solution clarification;
(2) in 0-4 ℃, in solution, add 2-imidazolidone acyl chlorides, drip Na simultaneously
2CO
3Or NaHCO
3The aqueous solution, control pH value is carried out condensation reaction at 7.5-8.5;
(3), in reaction mixture, add ethyl acetate, and regulate the pH value to 1.7-1.9 in 0-5 ℃;
(4) separate, get organic phase, behind thermal source and impurity, get crystallization stoste;
(5) ethyl acetate solution of Sodium isooctanoate is added above-mentioned crystallization stoste, crystallization appears and after, get rid of material, drying, make the white powder azlocillin sodium;
Wherein, above-mentioned 2-imidazolidone acyl chlorides, Ampicillin Trihydrate and Sodium isooctanoate by weight amount ratio be: 1: 1.0～1.15: 1.05～1.15.
2, preparation method as claimed in claim 1, wherein comprise in the step (4) get remove thermal source and impurity after the organic phase before, with 20%NaCl solution washing organic phase.
3, preparation method as claimed in claim 1 or 2 is characterized in that, in described step (4), removes thermal source and realizes by charcoal absorption.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100113763A CN1305874C (en) | 2005-03-03 | 2005-03-03 | Process for preparing sodium azlocillin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100113763A CN1305874C (en) | 2005-03-03 | 2005-03-03 | Process for preparing sodium azlocillin |
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| CN1683375A CN1683375A (en) | 2005-10-19 |
| CN1305874C true CN1305874C (en) | 2007-03-21 |
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| CNB2005100113763A Expired - Fee Related CN1305874C (en) | 2005-03-03 | 2005-03-03 | Process for preparing sodium azlocillin |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102367259A (en) * | 2010-12-14 | 2012-03-07 | 海南美好西林生物制药有限公司 | Method for preparing azlocillin sodium |
| CN102161665B (en) * | 2011-05-05 | 2012-11-14 | 苏州二叶制药有限公司 | Preparation method of azlocillin sodium and azlocillin sodium used for injection |
| CN102311450B (en) * | 2011-09-23 | 2012-12-26 | 江苏汉斯通药业有限公司 | Preparation method for Azlocillin sodium |
| CN103265561B (en) * | 2013-06-09 | 2015-09-09 | 四川省惠达药业有限公司 | Azlocillin sodium compound, its preparation method and pharmaceutical composition thereof |
| CN104130270B (en) * | 2014-02-25 | 2017-01-04 | 拜徳里希医药保健有限公司 | Celbenin crystal formulations and preparation method thereof |
| CN106967087A (en) * | 2017-05-25 | 2017-07-21 | 瑞阳制药有限公司 | The preparation technology of mezlocillin sodium |
| CN107129507A (en) * | 2017-06-01 | 2017-09-05 | 四川制药制剂有限公司 | The high efficiency preparation method of azlocillin sodium for injection |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4016282A (en) * | 1970-05-25 | 1977-04-05 | Bayer Aktiengesellschaft | Ureidoacetamido-penicillins |
| DD281391A5 (en) * | 1987-07-03 | 1990-08-08 | Dresden Arzneimittel | METHOD FOR PRODUCING ACYLUREIDO-BENZYLPENICILLINES |
| DD288151A5 (en) * | 1987-10-14 | 1991-03-21 | Veb Arzneimittelwerk Dresden,De | METHOD FOR PRODUCING STABILE AZLOCILLIN-NA DRY SALT |
| DD295852A5 (en) * | 1988-07-18 | 1991-11-14 | Arzneimittelwerk Dresden Gmbh,De | METHOD FOR THE PRODUCTION OF ACYLUREIDO BENZYLPENICILLINES AND THEIR SALTS |
-
2005
- 2005-03-03 CN CNB2005100113763A patent/CN1305874C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4016282A (en) * | 1970-05-25 | 1977-04-05 | Bayer Aktiengesellschaft | Ureidoacetamido-penicillins |
| DD281391A5 (en) * | 1987-07-03 | 1990-08-08 | Dresden Arzneimittel | METHOD FOR PRODUCING ACYLUREIDO-BENZYLPENICILLINES |
| DD288151A5 (en) * | 1987-10-14 | 1991-03-21 | Veb Arzneimittelwerk Dresden,De | METHOD FOR PRODUCING STABILE AZLOCILLIN-NA DRY SALT |
| DD295852A5 (en) * | 1988-07-18 | 1991-11-14 | Arzneimittelwerk Dresden Gmbh,De | METHOD FOR THE PRODUCTION OF ACYLUREIDO BENZYLPENICILLINES AND THEIR SALTS |
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