CN1292659C

CN1292659C - Biological disinfectant

Info

Publication number: CN1292659C
Application number: CNB200410022896XA
Authority: CN
Inventors: 袁洪; 陽国平
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-02-16
Filing date: 2004-02-16
Publication date: 2007-01-03
Anticipated expiration: 2024-02-16
Also published as: CN1559218A

Abstract

The present invention relates to a biological disinfectant which is characterized in that the present invention is prepared from the raw materials according to the following weight percentage by the method, wherein the raw materials comprise 0.1 to 1% of lactoferrin and 0.001 to 0.01% of chlorhexidine, and the rest is distilled water; the preparation method comprises the steps: the 0.1 to 1% of lactoferrin is dissolved in the distilled water; in addition, the 0.001 to 0.01% of chlorhexidine is dissolved in the distilled water; thus, the disinfectant is obtained by mixing the two liquids. In the present invention, because the lactoferrin which is biological engineering product is added, the thickness of the chlorhexidine is greatly reduced; thus, the side effect on human body skins is reduced; antimicrobic effect is improved because of the synergistic effect from the lactoferrin and chlorhexidine.

Description

Biotype disinfectant and preparation method

Technical field:

The present invention relates to a kind of disinfectant, be specifically related to a kind of disinfectant and preparation method who contains biological products.

Background technology:

At present, be used for that the disinfectant of human body skin or mucous membrane is most to be synthetic, for example quaternary amine, chloride goods, this class disinfectant toxic and side effect is big, in the kill harmful microorganism, also can cause certain injury to human body skin, big for environment pollution in addition.

Summary of the invention:

Technical problem to be solved by this invention is the defective that overcomes above-mentioned prior art, and a kind of Disinfection Effect is good, nontoxic to human body skin, have no side effect biotype disinfectant and preparation method are provided.

The present invention solves the problems of the technologies described above by following technical scheme.It is characterized in that it is to constitute with following weight percentages: lactoferrin is 0.1%～1%, and hibitane is 0.001%～0.01%, and all the other are distilled water; Its preparation method is: get 0.1%～1% lactoferrin, and the adding distil water dissolving, other gets 0.001%～0.01% hibitane, the adding distil water dissolving, two liquid mix promptly.

The present invention passes through to add the Bio-engineering Products lactoferrin, thereby the concentration of hibitane is descended greatly, has reduced the side effect to human body skin, and because the synergy of hibitane and lactoferrin, antimicrobial effect is strengthened greatly.

Embodiment:

At present, along with the develop rapidly of biotechnology, have that various biological products are manufactured to come out.The Bio-engineering Products lactoferrin is the important component in the human milk, be that molecular weight is the glycoprotein of 78 kilodaltons, it is a member in the transferrins family, other member who belongs to transferrins has structural homology highly, the monomer glycoprotein that all has an about 80kD of big molecular group is made up of in conjunction with leaf (or zone) the iron of two repetitions.Although yet their structure is closely similar, lactoferrin demonstrates stronger IBC, particularly lactoferrin can keep iron in a wider pH scope and the performance combination stability that taps a blast furnace, and this is the key property of lactoferrin iron in conjunction with function.

Because the unique texture of lactoferrin, thus show antibacterial action, and can prophylaxis of microbial infect.Lactoferrin has three kinds of different mechanism of action to bacterium, and the first, the bacteriostasis of lactoferrin, this height iron binding affinity with it is relevant, and it can make bacterium lose the basic nutrient iron of required growth, stops biomembranous formation; The second, the bactericidal action of lactoferrin, it directly plays bactericidal action by lactoferrin N-terminal strong cation sterilization zone; The 3rd, lactoferrin can also be replied and brings into play antimicrobial acivity except being had antibacterial and bactericidal action by regulating general immunity.

In addition, because lactoferrin is to the high-affinity of iron, thereby make the living environment iron deficiency of bacterium, bacterium enters the environment that a kind of mobile status (this state can make them seek environment preferably) is replied certain nutritional deficiency by conversion, the immune defense that when bacterium is moved, is vulnerable to the host attack and the attack of other material (as antimicrobial agents, disinfectants etc.), this is with other medicines synergistic effect basis to take place.

It is the biguanides disinfectant that hibitane has another name called chlorhexidine, is a kind of toxicity, the safe disinfection agent that corrosivity and excitant are all very low.Can be widely used in the sterilization of skin and mucosa, the surface of a wound and urinary organ.

The present invention is by the mechanism of action and the physio-biochemical characteristics of the above-mentioned two kinds of materials of research, a kind of biotype disinfectant has been proposed, described this biotype disinfectant comprises lactoferrin, two kinds of compositions of hibitane, wherein lactoferrin concentration is between 0.1%～1%, and it is to make by gene engineering, and hibitane concentration is between 0.001%～0.01%, far below 0.01%～0.1% concentration in the prior art, solvent is a distilled water, has further reduced the toxicity of its preparation, uses safer.

Its preparation method is: get 0.1%～1% lactoferrin, and the adding distil water dissolving, other gets 0.001%～0.01 hibitane, the adding distil water dissolving, two liquid mix promptly.

The present invention all has more powerful killing action to all kinds of pathogenic microorganisms such as bacterium, mould, trichomonad, conveyor screws.Results of pharmacodynamic test shows that effect of the present invention 2 minutes is respectively 99.96% and 99.94% to staphylococcus aureus, colibacillary killing rate; Effect of the present invention 5 minutes is 99.73% to the oidiomycetic killing rate of white.Toxicity test through every standard, comprise skin irritatin test (average integral=0.0), mucomembranous irritant test (stimulation index=0.0), marrow polychromatic erythrocyte micronucleus test (opinion) to the micronucleus effect, cumulative toxicity test (cumulative coefficient＞5*, annotate *: cumulative coefficient is big more, safety is high more, 5 is the peak of this test) or the like, every test index is all qualified.

Claims

1, a kind of biotype disinfectant is characterized in that it is to constitute with following weight percentages:

Lactoferrin is 0.1%～1%, and hibitane is 0.001%～0.01%, and all the other are distilled water.

2, a kind of preparation method of biotype disinfectant is characterized in that: get 0.1%～1% lactoferrin, and the adding distil water dissolving, other gets 0.001%～0.01% hibitane, the adding distil water dissolving, two liquid mix promptly.