CN1289052C

CN1289052C - Personal cleansing composition

Info

Publication number: CN1289052C
Application number: CNB008111561A
Authority: CN
Inventors: A·S·－T·李; A·W·纽曼
Original assignee: Ethicon SAS
Current assignee: Johnson and Johnson Medical SAS; Ethicon Inc
Priority date: 1999-06-02
Filing date: 2000-06-02
Publication date: 2006-12-13
Anticipated expiration: 2020-06-02
Also published as: AU769297B2; WO2000072807A2; NZ515838A; WO2000072807A3; CN1615119A; KR20020005773A; JP2004500327A; AU5459900A

Abstract

A personal cleansing composition is provided which comprises: a) at least one polymeric isobutene having from about 12 to about 156 carbon atoms, wherein the polymeric isobutene is liquid at room temperature and pressure; b) at least one dicarboxylic acid having formula (I) or a cosmetically acceptable salt of the dicarboxylic acid, wherein R1 and R3 are each a C6-C10 alkyl group and R2 and R4 are each a C6 to C10 alkylene group; c) at least one surfactant selected from the group consisting of anionic, amphoteric, nonionic, zwitterionic and combinations thereof; and d) water. The composition may also include one or more of the following: a viscosity building agent, an emulsifying agent, an amine-functional silicone and polyethylene glycol. A polyglycerol ester is a compound which provides both emulsification and viscosity control.

Description

Personal cleaning compositions

Invention field

The present invention relates to personal cleaning compositions, it is applicable to cleaning skin and hair.Described personal cleaning compositions is the oil-in-water emulsion form, and this class Emulsion is in stable upon storage, and with contact skin the time breakdown of emulsion, discharge oil phase to play conditioning and to moisten effect.The advantage of this based composition is can provide the cleaning efficacy of improvement and Diazolidinyl Urea or make the tight or irriate of dermal sensation not, and can keep skin complete (skin integrity).

Background of invention

The personal care articles industry is devoted to study basic skin clean activity for a long time.The dirt of removing on the skin is the needs of whole world consumer, already by adopting the skin clean product to realize.In cleaning, surfactant can remove the natural sebum that is used to keep skin supply, moistness and prevents these factor damages.The frequent cleaning product that uses can produce harm (being drying and stimulation) to skin, and this can cause sense of discomfort and possible skin problem.

Dropped into many researchs already in this field and make great efforts with produce not only effective cleaning skin, can also conditioning skin Cleasing compositions.

Some patents and disclosed patent application have disclosed the purposes of dimeric dibasic acid.

JP-A-58027636 (Shiseido) public publish a kind of oil-in-water emulsion, it comprises dimeric dibasic acid, stearic acid, spermol, vaseline, Squalene, glyceryl monostearate, N-stearyl monosodium glutamate, propylene glycol, potassium hydroxide and CVP Carbopol ETD2050.

WO 94/20067 (PCT/EP94/00814) has disclosed the Emulsion of a kind of dicarboxylic acids and emulsifying agent, wherein emulsifying agent is selected so that Emulsion in use can be through shear thickening.Thus, Emulsion can be used for washing one's hands and face in compositions, cosmetic composition and the pharmaceutical composition.

Following patent and publication application have disclosed the purposes of polyisobutylene, and it is also referred to as polymerization isobutene. (polymeric isobutene, polymeric isobutylene and polyisobutene).

US patent 5,658,577 (people such as Fowler) has disclosed the based personal cleansing of non-fretting corrosion thickening, and it has adopted insoluble ultra micro cleaning particles.Pointing out can be used as solid cleaning particulate in general disclosure is polyisobutylene.

Disclose the personal cleansing compositions of oil-in-water emulsion form among the WO 96/32092 (PCT/US96/05038), it has the feature that breakdown of emulsion takes place with contact skin the time.Said composition it is believed that and contains: the copolymer that (1) is specific, and (2) non-emulsifying detergent surfactant, (3) are selected from the oil of specific compound, and (4) water.Two kinds of oil in multiple definite composition be Parleam and 2-Methylpentadecane (according to this patent disclosure, its can be with title " Permethyl 101A " available from Presperse, South Plainfield, the hydrocarbon of NJ).

WO 97/16168 (PCT/US96/17506) has disclosed a kind of personal cleaning compositions, and it contains: (1) surfactant, (2) hydrophobic active component, (3) hydrocarbon components and (4) cationic polymer.Hydrocarbon components can be " permethyl " with following general formula:

CH ₃-(-C(CH ₃) ₂-CH ₂-) _n-C(CH ₃)H-CH ₃

Wherein " n " can be more than about 4-200." n " is respectively 4,16,38 and 214 in the product, and it is said can be respectively with title PERMETHYL 102A, and 104A, 106A and 1082A be available from Presperse, Inc..PERMETHYL 104A and 106A have been adopted in the embodiment.

Disclosed a kind of shampoo in the US patent 5,441,730, rather than cleanser/hand, polyisobutylene and surfactant (it does not comprise cationic surfactant) wherein contained in this shampoo.Also disclosed in the document and contained the hair type combination of cationic surfactant as conditioner.

Skin cleansing compositions must satisfy some standards of accepting for consumer.These standards comprise cleaning, be easy to use with rinse, abundant foam volume, application process in and with after good skin sense, to skin mildness and moistness and conditioning property.Even when frequent application, ideal skin cleaner also should be able to provide these product attributes.

Under the domestic environment of routine, the frequency of washing one's hands generally is about every day 5-10 time.These consumers are ordinary consumer of buying its skin cleaner in local supermarket.Most high-quality skin cleaners in supermarket can satisfy the demands of consumers.

These skin cleaners have adopted surfactant mixture, and this mixture can provide foam characteristics, reduce stimulation simultaneously to greatest extent.The conditioning cleaning formulation that comprises emollient and moisturizing agent can make skin still have the coating sense after rinsing.Apply sense normally because of adopting triglyceride oil to cause so that the required opsonic action of consumer to be provided; , most consumers should not have the problem that is difficult to rinse and applies sense but wishing conditioning effect.

Another part of commercially available prod is the special and professional care product, and its occupation requires them to wash one's hands every day to infect with the hospital that reduces cross infection to greatest extent and cause thus for about 30-50 time.These consumers wish that it can injured skin when the high frequency applications skin cleaner.They have no time, also do not allow to be coated with between washing one's hands sometimes at every turn and use the handguard emulsion.Another product attribute that they seek is that product is easy to eccysis, because they will run between the patient continually.

Thus, need a kind of personal cleaning compositions, its (a) can use at least 30 times and can not cause skin irritation or drying every day, (b) is easy to eccysis and (c) makes skin have the sensation of cleaning and conditioning.

Summary of the invention

Personal cleaning compositions of the present invention can provide effective sanitary characteristics, and it has beautification function and long lasting skin opsonic action, and wetting effect, so that still can keep the integrity of skin under the condition of frequent application.

This personal cleaning compositions comprises:

A) at least aly contain about 156 carbon atoms of about 12-, preferably contain the polyisobutylene of about 156 carbon atoms of about 24-, wherein polyisobutylene is liquid under room temperature and pressure,

B) at least a dicarboxylic acids or its salt that is applicable to cosmetics with following formula

Wherein R1 and R3 are respectively the C6-C10 alkyl, and

R2 and R4 are respectively the C6-C10 alkenyls;

C) at least a surfactant is selected from anion surfactant, amphoteric surfactant, non-ionic surface active agent, zwitterionic surfactant, and their mixture; And

D) water.

Polymeric polyisobutylene and dicarboxylic acids are hydrophobic, and are affinitys to skin.These two kinds of water-fast washing of material, and can provide long-acting conditioning sense and the effect of profit temperature to skin.

Polyisobutylene component in the compositions can provide the long lasting skin opsonic action by deposition hydrophobic membrane on skin.Liquid polyisobutene mainly is used in the cosmetic formulation but not in the personal cleaning compositions.Polyisobutylene can be hydrogenated.The consumption of polyisobutylene preferably account for total composition about 0.1 to about 10%, be more preferably 1 to about 8%.

Dicarboxylic acids is dimeric dibasic acid preferably, and wherein R1 is identical alkyl with R3, and R2 is identical group with R4.The consumption of dicarboxylic acids is preferably about 0.1 to about 10%, more preferably about 1 to about 8%.

The consumption of surfactant preferably accounts for 1% (weight) of composition weight at least, and more preferably about 2 to about 30% (weight), and most preferably is about 5 to about 25% (weight).Surface active agent composition can provide quick and plentiful foam, and this normally is difficult to obtain concerning the compositions that is rich in hydrophobicity and skin condition component.Preferably those also can make compositions have the composition of fast foaming performance to skin is gentle to surfactant.Anion surfactant can provide abundant foam.Both sexes and zwitterionic surfactant can provide foam stability and mildness, and can increased viscosity.Non-ionic surface active agent can provide spatter property and mildness, and also can provide viscosity.

When polyisobutylene, dicarboxylic acids and surfactant do not provide or fully do not provide viscosity and emulsification property, also can randomly further comprise viscosity auxiliary agent and/or emulsifying agent in the said composition.

If exist, the consumption of emulsifying agent is preferably about 0.1 to about 5% (weight), and more preferably about 0.1 to about 2.5% (weight).

If exist, the consumption of viscosity auxiliary agent is preferably about 0.1 to about 5%, more preferably about 0.1 to about 2.5% (weight).

Polyglycerin ester has the dual function of viscosity auxiliary agent and emulsifying agent.Polyglycerin ester can have skin is produced affinity interaction and the additional benefits of long-acting moist effect is provided.When having a large amount of hydrophobic components in the compositions, only depend on surfactant generally to be not enough to make compositions to keep even matter.Thus, polyglycerin ester is preferably to be applicable to the even matter that increases viscosity, emulsifying and maintenance compositions.If exist, the consumption of polyglycerin ester is preferably about 0.1 to about 5% (weight), and more preferably about 0.1 to about 2.5% (weight).

Randomly also comprise at least a amino-functional silicone in the compositions, preferably its consumption is about 0.1 to about 3%, more preferably about 0.1 to about 2% (weight).This component can provide the skin condition effect of affinity, and can reduce and the control combination thing in sticky sense because of adopting polyisobutylene and dicarboxylic acids to produce.

Polyglycerin ester and amino-functional silicone can be present in the compositions simultaneously.But when surfactant (for example, both sexes and non-ionic surface active agent can be used as the viscosity auxiliary agent) provides enough viscosity for compositions in compositions, can adopt amino-functional silicone and do not have polyglycerin ester.

Also can comprise molecular weight in the compositions and be about 1,500,000 to about Polyethylene Glycol of 5,000,000, preferably its consumption is about 0.01 to about 0.7%, more preferably about 0.05 to about 0.4% (weight).This component in use provides lubricated sense.This component is as lubricated or slipping agent.

Unless otherwise indicated, all percentage ratios of the present invention are all accounting for the gross weight of compositions, and all mensuration are all carried out under 25 ℃.Unless otherwise indicated, all wt percentage ratio is all with weight of active ingredient (with respect to the percentage by weight that is purchased material that contains the active component that is in the solvent).

Detailed Description Of The Invention

Personal cleaning compositions is provided among the present invention, and it comprises:

A) at least a about 24 the polyisobutylene that contain to about 156 carbon atoms, wherein polyisobutylene is liquid at normal temperatures and pressures;

B) at least a dicarboxylic acids that is shown below or its are applicable to the salt of cosmetics

Wherein R1 and R3 are respectively the C6-C10 alkyl, and

R2 and R4 are respectively the C6-C10 alkenyls;

D) water.

Liquid polyisobutene

Be applicable to that polyisobutylene of the present invention contains about 12 to about 156 carbon atoms, preferably contains about 24 to about 156 carbon atoms.Polyisobutylene is liquid (free-pouring liquid is to viscous liquid) at normal temperatures and pressures, and can provide the long lasting skin opsonic action by deposition hydrophobic membrane on skin.Liquid polyisobutene mainly is used in the cosmetic formulation but not in the personal cleaning compositions.Liquid polyisobutene is called as " permethyl " sometimes, and can be available from Presperse, Inc..This class material has following general formula:

CH ₃-(-C(CH ₃) ₂-CH ₂-) _n-C(CH ₃)H-CH ₃

Wherein " n " can be about 2 to more than 200." n " is respectively 2,3,4,16 and 38 in the product, it is said can be respectively with title PERMETHYL 99A, 101A, 102A, 104A and 106A available from Presperse, Inc..This class polyisobutylene at room temperature is to viscous liquid from free-pouring liquid.

Table A: PERMETHYL product viscosity

PERMETHYL viscosity

20 ℃ of following 1 centipoises of 99A (CI2)

25 ℃ of following 4 centipoises of 101A (C16)

25 ℃ of following 16 centipoises of 102A (C20)

40 ℃ of following 7600 centipoises of 104A (C68)

100 ℃ of following 3200 centipoises of 106A (C156)

Can prepare these polyisobutylene by various suitable methods, as be disclosed in the method among US patent 4,061,780 and the WO 96/32092 (PCT/US96/05038), its combination in the present invention as a reference.For the purposes of the present invention, can choose wantonly and adopt U.S.4, the step of hydrogenation in 061,780.Note that the PERMETHYL material contains some degrees of unsaturation.

Dicarboxylic acids

Be applicable to that dicarboxylic acids of the present invention has following formula:

Or it is applicable to the salt of cosmetics,

Wherein R1 and R3 are respectively the C6-C10 alkyl, and

R2 and R4 are respectively the C6-C10 alkenyls.

The carbon chain lengths of preferred R1 and R3 is identical, and the carbon chain lengths of R2 and R4 is identical.In one embodiment, the carbon chain lengths of all R1, R2, R3 and R4 is all identical, and for example R1 and R3 are the C8 alkyl, and R2 and R4 are the C8 alkenyls.

Dicarboxylic acids can make through dimerization reaction by unsaturated C18 fatty acid (for example linoleic acid).But understand, also may adopt other synthetic methods.This class dicarboxylic acids for example can trade name EMPOL dimeric dibasic acid available from Henkel Corp., as EMPOL 1008 and with trade name " Pripol " available from Unichema International, as Pripol 1006 and Pripol1009." Pripol " dimeric dibasic acid is through hydrogenant.

Polymeric polyisobutylene and dicarboxylic acids are hydrophobic, and affine with skin.These two kinds of water-fast washing of material, and can long-acting conditioning sense is provided and moisten effect skin.The consumption of polyisobutylene is preferably about 1 to about 5%.The consumption of dicarboxylic acids is preferably about 1 to about 10%.Dicarboxylic acids is dimeric dibasic acid preferably, and wherein R1 is identical alkyl with R3, and R2 is identical group with R4.Dimeric dibasic acid has the bells and whistles that is used as antifree radical agent in sunscreen.Unless otherwise indicated, all percentage number averages are to account for composition total weight.

Surfactant

Said composition preferably also comprises the surfactant that is selected from anion surfactant, amphoteric surfactant, non-ionic surface active agent, zwitterionic surfactant and their mixture.Surface active agent composition can provide quick and abundant foam, and this normally is difficult to obtain concerning the compositions that is rich in hydrophobicity and skin condition component.Preferably those also can make compositions have the composition of fast foaming performance to skin is gentle to surfactant.Anion surfactant can provide abundant foam.Amphoteric surfactant can provide foam stability and mildness.Non-ionic surface active agent can provide spatter property and mildness.

This class surfactant is known, and is commercially available.Can be referring to U.S. patent 5,441,730; 5,534,265; 5,585,104; With 5,658,577, all in conjunction with in the present invention as a reference.

Suitable anion surfactant is: alkyl sulfate, alkyl ether sulfate, alkylaryl sulfonate, alkyl succinate, alkyl succinic acid sulfonated ester, the N-alkyl sarcosine salt, alkylphosphonic, alkyl ether phosphate, alkyl ether carboxy acid salt, and alpha-alkene sulfonate, particularly their sodium salt, magnesium salt, ammonium salt and single-, two-and triethanolamine salt.Alkyl generally contains 8-18 carbon atom, and can be undersaturated.Can contain 1-10 oxirane and/or propylene oxide units among per molecule alkyl ether sulfate, alkyl ether phosphate and the alkyl ether carboxy acid salt, preferred per molecule contains 2-3 ethylene oxide unit.

The example of the anion surfactant that other are suitable for comprises: acyl group sodium isethionate, acyl group sodium taurocholate, oil base sodium succinate; succinic acid Lauryl Ester ichthyodin, ammonium lauryl sulfate, dodecylbenzene sodium sulfonate; DBSA triethanolamine and N-sodium lauryl sarcosinate.Other anion surfactants that are suitable for comprise sodium lauryl sulfate, triethanolamine lauryl sulfate, single lauryl nitranol, sodium laureth sulfate 1EO, 2EO and 3EO, ammonium lauryl sulfate and Zetesol AP 1EO, 2EO and 3EO.Here " EO " of Cai Yonging is meant oxyethylene group.

Ionic surfactant pack is drawn together aliphatic series (C ₈-C ₁₈) polycondensation product of straight or branched primary alconol or secondary alcohol or phenol and alkylene oxide, alkylene oxide oxirane normally wherein, and generally contain about 6 to about 30 EO groups.

Other ionic surfactant pack that are suitable for are drawn together: single-or two-alkyl alkanolamide and alkyl poly glucoside.Example comprise cocos nucifera oil single-or two-glycollic amide, the single isopropanol amide of cocos nucifera oil, cocos nucifera oil bioside.

Both sexes and zwitterionic surfactant comprise: alkyl amine oxide; alkyl betaine; the alkyl amido CAB, alkyl sulfobetaines, alkyl glycinate; the alkyl carboxyl glycinate; alkyl both sexes propionate, alkyl both sexes glycinate, alkyl amido propyl hydroxy sulfobetaines; acyl taurine salt and acyl glutamate, wherein alkyl and acyl group contain 8-19 carbon atom.Example comprises lauryl amine oxide, coco dimethyl sulfopropyl betaine, and preferred lauryl betaine, cocoamidopropyl and cocos nucifera oil both sexes sodium propionate.

The total amount of surfactant material preferably accounts for 1% (weight) of compositions at least in the present composition, and more preferably about 2 to about 30% (weight) and most preferably be about 5 to about 25% (weight).

Can adopt the various emulsifying agents of the stability of emulsion that can provide necessary, the example of this class emulsifying agent is known in the art, does not do too much discussion.

If desired or be suitable for, emulsifying agent can be served as by any surfactant as detergent materials in the compositions, or is made of other surface active agent compositions of only using its emulsifying agent characteristic.

Particularly preferred emulsifying agent is an anion emulsifier, as the poly-alkoxyl ethylidene sulfate (alkylarylpolyalkoxyethylene sulfate) of alkaryl base, for example alkyl phenyl polyethoxy ethylidene sodium sulfate (sodium alkylphenylpolyethoxyethylenesulfate) can for example be purchased with title Alipal CO-433.

Emulsifying agent can be used by any suitable consumption, to adapt with operating condition and material therefor.For example the suitable consumption of emulsifying agent can be about 0.1 to about 10% (weight), is preferably about 1 to about 5% (weight).

Polyglycerin ester

Preferably also comprise at least a polyglycerin ester in the compositions, preferably its consumption is about 0.25 to about 2%.This component is an affinity to skin, and long-acting moist effect can be provided and make the emulsive effect of component in the compositions.When having a large amount of hydrophobic components in the compositions, only the application surface activating agent generally is not enough to keep the even matter of compositions.Polyglycerin ester is used for emulsification composition and keeps the even matter of compositions.This class material is commercially available, for example is available from Lonza, Inc., Fair Lawn, the product of the trade mark of NJ POLYALDO by name.Comprising: Polyaldo 3-1-S (Tripolyglycerol monostearates), Polyaldo 6-2-0 (six polyglycereol dioleates), Polyaldo 6-4-0 (six polyglycereol, four oleates), Polyaldo6-2-P (six polyglycereol dipalmitates), Polyaldo 6-2-S (six polyglycereol distearates), Polyaldo 10-1-0 (ten polyglycereol monoleates), Polyaldo 10-6-0 (ten polyglycereol, six oleates), Polyaldo 10-10-0 (ten polyglycereol, ten oleates), Polyaldo 10-2-P (ten polyglycereol dipalmitates) and Polyaldo 10-1-S (ten polyglycereol monostearates).The polyglycerin ester that is suitable for comprises and is disclosed in the following document those: U.S.3,936,391, its contain 3-10 glycerol unit and 1-2 individual each contain the saturated fatty acyl group ester group of 16-20 carbon atom.U.S.4,950,441 and 5,247,114 and WO 96/01616 (Lonza) in polyglycerin ester that is suitable for and preparation method thereof is disclosed.U.S.3,936,391; 4,950,441; With 5,247,114 and WO 96/01616 (Lonza) all in conjunction with in the present invention as a reference.

Amino-functional silicone

Preferably also comprise at least a amino-functional silicone in the compositions, its consumption is preferably about 0.25 to about 2%.This component can provide affine skin condition effect, and can reduce and control the sticky sense because of adopting polyisobutylene and dicarboxylic acids to cause.This material is commercially available, for example is the product available from the commodity " Silsoft " by name of Witco; Commodity " Abil " and " Tegosoft " by name available from Goldschmidt; And available from the commodity of the Dow Corning for example product of Dow Corning 344 Fluid by name.

Polyethylene Glycol

Preferably also comprise molecular weight in the compositions and be about 1,500,000 to about Polyethylene Glycol of 5,000,000, its consumption is preferably about 0.01 to about 0.7%.This component in use provides lubricated sense.This component can be used as lubricant.

Polyethylene Glycol is the material of knowing, and CAS is numbered 25322-68-3.It is also referred to as poly-(oxygen ethylene), polyglycols and PTMEG.Polyethylene Glycol can adopt the polycondensation of ethylene glycol or ethylene oxide and water to form.This class material also is commercially available, for example is that as PEO-18, it is PEG-90M available from the product of the commodity PEO by name of R.I.T.A..This class material also can be available from Amerchol.

Other compositions

Can comprise also in the present composition that a spot of one or more are usually used in adjuvant composition in the personal cleaning compositions.This class supplementary element comprises: foam booster, pearling agent, opacifier, suspending agent, antiseptic, essence, dyestuff, coloring agent, viscosity modifier, protein, polymer, buffer agent, polyhydric alcohol and other wetting agents, and medical herbs and other plant extract.

Compositions of the present invention is preferably based on aqueous emulsion, generally is made of at least one component of continuous phase water.Said composition, during in particular as hair care composition, water content is preferably about 30 to about 90% (weight), most preferably is about 40 to about 70% (weight).

Embodiment

Adopt sensory evaluation group, emphasis group (focus group), biophysics mensuration, housebroken clinical speciality personnel, digital image-forming photography and/or technical staff that the characteristic of following compositions embodiment is assessed.

Sensory evaluation group is made of technology and non-technical personnel, and they use product according to hiding labelling, and provide feedback opinion according to use feeling.The emphasis group personnel also assess the product of not knowing manufacturer.In addition, they also will assess and evaluate product whether its beneficial effect that will provide is provided.

The clinical speciality personnel comprise the visual inspection of the skin degree with evaluation erythema and decortication the assessment of skin.

Constant high resolution and color rendition that the digital image-forming photography can provide common photography not provide.

Technical staff's assessment comprises to be carried out the mensuration of physical property and assesses product in the characteristic aspect the organoleptic parameters (as olfactory sensation, skin sense etc.) the assessment of beauty treatment outward appearance, employing instrument such as pH instrument, viscometer, microscope, spectrophotometer etc.

Material therefor:

Adopt the preparation of the following material preparation embodiment of the invention:

Table B

Trade (brand) name (supplier)	Describe	Function
Trade (brand) name (supplier)	Describe	Function	Polyado HGDS(Lonza) Mapeg 6000(PPG) Empicol AL 70/A (Albright & Wilson) Standapol EA-2 (Henkel/Cospha) Atlas G-4280(ICI) Mackam CBS-50G (McIntyre) Silsoft A-858 (OSI/Witco) Lexorez-100(Inolex) Arlacel 80(ICI)	The amino-terminated dimethicone copolyol adipic acid/diethylene glycol (DEG) of six polyglycerol distearate PEG150 distearate Texapon Special Zetesol AP polyoxyethylene (80) monolaurate [PEG-80 laurate Isosorbide Dinitrate] cocounut oil acylamino-propyl hydroxy sulfobetaines trimethyl silyls/glycerine cross-linked polymer Arlacel-80	Emulsifying agent/thickener/wetting agent (moisturizer) thickener/skin conditioning agent high-foaming anion surfactant moderate applies and adheres to strong emulsifying agent/non-ionic surface to the gentle zwitterionic surfactant/foam booster of the coating of anion surfactant skin and the adhesion/thickener skin adherence agent/smoothing preparation skin that highly foams

Dimeric dibasic acid (Henkel) Permethyl 104A (Presperse; Inc.) Carbopol ETD 2020 (B.F.Goodrich) Dowicil 200 (Dow Chemical) D.I. water Empicol LX-100 (Albright ﹠ Wilson) Empicol ESD FEA (Albright ﹠ Wilson) Eucarol AGE-EC (Pilot Chemical) PEO-18 (R.I.T.A.) Seafoam (Firmenich) Mackanate EL (McIntyre) Tego Betaine L-7 (Goldschmidt Chem.) Ritamectant PCA (R.I.T.A.) glycerine (Witco, Corp.) Stepanate SXS (Stepan) Monateric 1023 (Mona Indus.) Empicol ESB 70/FEA (Albright ﹠ Wilson) TECH-O#11-070

EMPOL 1008 polyisobutene acrylate copolymer polyquaternium (Quaterium)-15 NaLS sodium laureth sulfate cocounut oil glucoside disodium citrate PEG-90M spices lauryl ether disodium sulfosuccinate cocoamidopropyl Anjidew NL50 glycerine sodium xylene sulfonate lauroyl both sexes PG-acetic acid esters sodium phosphate sodium laureth sulfate oatmeals

In active agent carrier/coating agent coating agent/skinfeel/adhesion auxiliary agent thickener/suspension agent/viscosity conditioning agent anticorrisive agent high-foaming anion surfactant the middle degree of the middle degree foaming amophoteric surface active agent NMF moisturizing agent high-foaming anion surfactant of degree to the middle degree of the middle degree foaming anion surfactant anti-friction agent/smooth feeling of the anion surfactant gentleness that highly foams/conditioner spices gentleness to the anion surfactant gentleness that highly foams/foam promoter gentleness in the amophoteric surface active agent of highly foaming degree to anion surfactant thickener, adhesive and the albumen of highly foaming

(Beacon CMP Corp.) Ritacomplex J (R.I.T.A.) Witconate AOS (Witco Corp.) VERSENE NA (Dow Chemical) Empicol EAC 70/EP (Albright & Wilson) Amphoterge K-2 (Lonza) LANETTE 14 NF (Henkel/Cospha)

(CAS#134134-86-4) cocoyl sodium lactate/GMS/ 16/octadecanol (Cetearyl alcohol) alkyl (C ₁₄-C ₁₆) alkene sulfonate Na ₂H ₂EDTA·2H ₂O Zetesol AP cocounut oil both sexes disodium beclomethasone myristyl alcohols (CAS#112-72-1)

Source conditioner, emollient anion surfactant chelating agent moderate are to the anion surfactant high-foaming amphoteric surfactant emollient/conditioner that highly foams

Compound method:

Unless otherwise indicated, the preparation in following examples all adopts following method preparation:

1. about 40% of the total consumption of required water is added in the blender, under agitation be heated to 65-70 ℃.

2. add POLYALDO HGDS and MAPEG 6000 in blender, appropriateness stirs down mixes 15-20 minute until homogenize.Solution is smooth and be creamy white.

3. in another mixer, PEO-18 (PEG-90M) is mixed (attention prevents in the air introducing solution) with remaining required water.

4. reduction mixing velocity is carried out slight-moderate agitation.Add STEPANATE SXS and Witconate AOS-anion surfactant (if you are using), continue again to mix 30 minutes.(note: mixing velocity should be not produce foam or air admission solution to be as the criterion.)

5. improve the mixing velocity that contains first container that adds component slightly, and beginning slowly adds PEO-18 solution (prehydration).Begin to cool down system, but temperature should be remained on 55-60 ℃.

6. if adopt CARBOMER (ETD-2020), its Ying Jing is similar to PEO-18 and operates, preparation prehydration solution, and as slow adding as described in the step 5.

7. the demand according to each independent preparation can add following product in this step: EMPICOLESB 70/FEA, EMPICOL AL 70/A, STANDAPOL EA-2, EMPICOL LX-100, EUCAROL AGE-EC.MACKANATE EL and MONATERIC 1023.After adding these compositions, can add TEGO BETAINE L-7, and mix 20 minutes.Keep good and mix,, but should not produce foam or make air admission solution simultaneously by raising mixing velocity thickening solution.In this step, begin increase in temperature to 65-70 ℃.

8. add ATLAS G-4280, ARLACEL 80, MACKAM CBS-50G, SILSOFTA-858, and LEXOREZ-100 (if requiring in the preparation).Mix then and maintained the temperature at 65-70 ℃ in 20 minutes simultaneously.

9. add dimeric dibasic acid (EMPOL 1008), add PERMETHYL 104A then.Improve mixing velocity, keep well mixing, but do not produce foam or air (bubble) is entered in the solution.

10. mixed 90 minutes down at 60-65 ℃.Before carrying out next step, be cooled to 45 ℃ then.

11. add RITAMECTANT PCA, add KEMSTRENE (glycerol) then.Mixed 5 minutes.

12. add DOWICIL 200 (if employing), add VERSENE NA then.Mixed 5 minutes.

13. adding spice continues to mix 20 minutes, product is cooled to 25-30 ℃ simultaneously.

14. adopt (20%) citric acid and/or (20%) sodium hydroxide with pH regulator to 5.5.

Reach final weight 15. add water, need not to heat and continue down to mix 15-20 minute.Embodiment 1462-126 and 1462-127

Preparation 14621-126 and 1462-127 are mixed with washing liquid shape outward appearance, and have improved foaming and long-acting conditioning effect.Dimeric dibasic acid and polyisobutylene are used to produce long-acting conditioning effect.The amino-terminated dimethicone copolyol of trimethyl silyl is used to reduce the viscosity sense of touch characteristic of dimeric dibasic acid.Adopt emulsifying agent such as PEG-80 sorbitan laurate and Arlacel-80 to keep the even matter of preparation.

Preparation 1462-126 1462-127

Composition %w/w %w/w

Six polyglycereol distearates 1.00 1.00

PEG-150 distearate 2.00 2.00

Ammonium lauryl sulfate 8.76 8.76

Zetesol AP 1.00 0.75

Adipic acid/diethylene glycol/glycerol cross linked polymer 0.50 1.00

PEG-80 sorbitan laurate 1.44 1.44

Cocos nucifera oil acylamino-propyl hydroxy sulfobetaines 2.00 2.00

Arlacel-80 1.00 1.00

Dimeric dibasic acid 2.50 2.50

Polyisobutylene (Permethyl 104A) 2.50 2.50

Acrylate copolymer 0.50 0.50

The poly dimethyl silica 1.75 1.50 that trimethyl silyl is amino-terminated

The alkane copolyol

Polyquaternary ammonium salt-15 0.05 0.05

EDTA disodium 0.10 0.10

Spice 0.50 0.50

D.I. water 65.59 66.70

Misc. ^* 8.90 7.70

Amount to 100.00 100.00

Attention: " Misc. " that is used for embodiment of the invention preparation comprises contained impurity in the commercially available prod of the composition of listing in carrier (generally being water) and the preparation.

Embodiment 1462-151 and 1462-161

Formulated 1462-151 and 1462-161 make product have lubricated sense when being applied to hands.Polyethylene Glycol is used to provide this sense of touch characteristic.PEG-90M is used for this class embodiment.

The sensory evaluation group that is made up of 25 personnel uses these two kinds of preparations and benchmark product (concealing the product sign for the group member).Each assessment panel member adopts every kind of preparation wash one's hands every day at least 3 times (daily life of a family is used) respectively, adopt the standard of 0-7 to estimate, wherein " 7 " represent the highest satisfaction of group member to some concrete property, except wherein " there being to apply and feeling " the highest satisfaction of " 0 " representative in.The results are shown in Table 1.

Table 1

Characteristic	-151	Contrast	-161
Characteristic	-151	Contrast	-161	Product denseness likability, (Like product consistency) coating easness foaming easness foaming easiness likability, (Like amount of lather) foam volume	5.32 5.80 4.96 5.04 4.44	5.96 6.28 5.92 5.92 5.36	2.08 2.60 3.04 2.92 3.08

Foam volume likability (Like amount of lather) ^*Lubricated sense in the use ^*The rinsing easness ^*Apply sense (numerical value is low more good more) usability likability of washing one's hands ^*Moistening moisture feeling ^*With the whole likability of back 30 minutes moistening moisture feeling

4.80 5.76 5.40 3.36 5.56 4.88 4.16 5.00

5.80 5.76 5.08 3.84 5.16 4.36 3.80 4.96

3.36 4.60 2.92 3.80 4.32 3.88 3.28 2.76

One of enforcement purpose of the present invention provides a kind of skin cleaner, and it has long-acting opsonic action, comprises moistening moisturizing properties.Being and implementing the relevant project of this purpose of labelling " * ".Comprising applying the sense project, because of it is the sign of user's acceptance level.

The assessment result of sensory evaluation group shows that 1462-151 has moistening moisturizing properties, but compares with benchmark product [Olay  (Oil of Olay) moist bath lotion], and its foaming characteristic is lower slightly.Whole likability is suitable with preference.When requiring the group member to point out in 3 groups favorite product, the result shows that 40% people selects 1462-151, and 48% people selects the benchmark product.

Preparation preparation 1462-161, before sensory evaluation group member uses to initial characteristic such as viscosity without assessment.Think that the characteristic of preparation 1462-161 is not so good as preparation 1462-151 and benchmark product.This part be since its viscosity greater than other two kinds of tested preparations.Because viscosity is big, the group member is difficult to take from container product.This produces disadvantageous halo effect to the preparation characteristic.It is believed that it is that itself and other composition reacts to each other and may form micelle owing to adopted lauryl ether disodium sulfosuccinate (because not adopting) in preparation 1462-151 that viscosity increases.It is believed that the concentration that reduces this composition, for example reduce to about 1.5% (weight) (consumption of cocos nucifera oil glucosides disodium citrate among the preparation 1462-151) and can improve this high viscosity problem, make low viscosity product.

One of enforcement purpose of the present invention provides skin cleaner, but uses at least its every day 30 times and can not cause skin irritation or drying.The technical staff wash one's hands every day 30 times through a week with assessment preparation 1462-151.Adopt of the effect of digital image-forming photo record skin cleaner to hand.Before take a picture using with digital camera, after 2 days, after 4 days and the situation after 7 days.Photo show frequently washed one's hands 7 after skin do not have obvious stimulation or drying.

1462-151 1462-161

Composition %w/w %w/w

Six polyglycereol distearates 1.50 1.50

PEG-150 distearate 2.00 2.00

Sodium lauryl sulfate 7.68 2.88

Sodium laureth sulfate 1.40 3.50

Cocos nucifera oil glucosides disodium citrate 1.50 0.00

PEG-80 sorbitan laurate 1.44 1.44

Cocos nucifera oil acylamino-propyl hydroxy sulfobetaines 2.00 2.00

Arlacel-80 1.00 1.00

Dimeric dibasic acid 2.50 2.50

Polyisobutylene 2.50 2.50

Lauryl ether disodium sulfosuccinate 0.00 3.20

The poly dimethyl silica 2.00 1.50 that trimethyl silyl is amino-terminated

The alkane copolyol

PEG-90M 0.40 0.40

Polyquaternary ammonium salt-15 0.05 0.05

EDTA disodium 0.10 0.10

Spice 0.50 0.50

D.I. water 66.90 65.90

Misc. 6.50 9.0

Amount to 100.00 100.00

Embodiment 1488-57,1488-58 and 1488-59

Preparation 1488-57,58 and 59 is other preparations of amino-terminated dimethicone copolyol, PCA sodium, glycerol and spice of the sodium laureth sulfate, sodium xylene sulfonate, cocos nucifera oil acylamino-propyl hydroxy sulfobetaines, the trimethyl silyl that contain variable concentrations.

In four emphasis groups that participated in by the theatre sister are discussed, when assessing aspect the moist effect that skin cleaner is provided and cleaning action and the situation about can under hospital environment, frequently use, preparation 1488-59 bubbling character, skin sense and moist aspect obtain good assessment result.

The technical staff adopted preparation 1488-59 to wash one's hands continuously in one day 35 times.Do not feel zest, do not find the hand drying yet.

3 technical staff according to the same way as of preparation 1488-59, with preparation 1488-57 and 1488-58 washing.These two kinds of preparations have good foaming effect, spatter property, feel and moist effect with the back.Do not feel zest, do not find the hand drying yet.

1488-57 1488-58 1488-59

Composition %w/w %w/w %w/w

Six polyglycereol distearates 0.75 0.75 0.75

PEG-150 distearate 1.00 1.00 1.00

Sodium laureth sulfate 9.10 8.40 9.10

Sodium xylene sulfonate 1.20 0.80 0.80

PEG-80 sorbitan laurate 2.88 2.88 2.88

Cocoamidopropyl 1.80 1.80 1.80

Cocos nucifera oil acylamino-propyl hydroxy sulfobetaines 2.00 1.75 2.00

Dimeric dibasic acid 2.50 2.50 2.50

Polyisobutylene (Permethyl 104A) 2.50 2.50 2.50

What trimethyl silyl was amino-terminated gathers 1.00 0.50 0.50

The methylsiloxane copolyol

PEG-90M 0.30 0.30 0.30

PCA disodium 1.00 0.75 0.75

Glycerol 6.00 4.00 4.00

Polyquaternary ammonium salt-15 0.05 0.05 0.05

EDTA disodium 0.10 0.10 0.10

Spice 0.50 0.40 0.40

D.I. water 52.80 59.70 58.20

Misc. 14.50 11.80 12.40

Amount to 100.00 100.00 100.00

Compositions of the present invention can be prepared by following generalized universal method.At first PEG-90M is scattered in 65 ℃ of water in one approach.Add polyglycerin ester and PEG-150 distearate then.Add various surfactants and emulsifying agent then.Note reducing to greatest extent in the whole process and charge into gas in the mixture.Mixture temperature is remained on 65 ℃, add dimeric dibasic acid and liquid polyisobutene then.Remove thermal source this moment, and add heat preserving agent, glycerol and PCA sodium.Add antiseptic, polyquaternary ammonium salt-15 and EDTA disodium (versene NA) then.After mixture is cooled to 40 ℃, add spice.Adopt citric acid or sodium hydroxide solution that final pH value is adjusted to about 5.5.

In other method, also can prepare the present composition as follows.Polyglycerin ester and PEG-150 distearate added in 65-70 ℃ the water.After the even matter of mixture, in mixture, add sodium xylene sulfonate.The PEG-90M that will be scattered in another container then in the water adds in the primary tank.Order adds remaining surfactant, amino-terminated dimethicone copolyol, dimeric dibasic acid, liquid polyisobutene, PCA sodium, glycerol, antiseptic and the spice of trimethyl silyl then, and each component is all mixed after adding.Adopt sodium citrate and sodium hydroxide solution to regulate final pH.

Embodiment: 1488-94 ,-92 and-78

In this embodiment, adopt 3 kinds of preparations of following ingredients preparation:

Preparation:

Preparation number: (94) (92) (78)

POLYALDO HGDS FG 0.75％ 0.75％ 0.75％

MAPEG 6000 -- 1.00％ 1.00％

EMPICOL ESB 70/FEA 9.1％ 7.0％ 9.1％

STEPANATE SXS 0.8％ 0.8％ 0.8％

ATLAS G-4280 2.88％ 2.88％ 2.88％

TEGO BETAINE L-7 1.8％ 1.8％ 1.8％

MACKEM CBS-50G 2.0％ 1.0％ 1.0％

SILSOFT A-858 0.5％ 0.5％ 0.5％

Dimeric dibasic acid 2.5% 2.0% 2.0%

PERMETHYL 104A 2.5％ 2.0％ 2.0％

PEO-18(PEG 90M) 0.3％ 0.2％ 0.2％

RITAMECTANT PCA 0.75％ -- --

R.I.T.A. (cocoyl sodium lactate/GMS) 1.5% 2.0% 3.0%

VERSENE EDTA 0.1％ 0.1％ 0.1％

Spice 0.2% 0.5% 0.5%

WITCONATE AOS -- 1.2％ 0.8％

Citric acid (20%) or NaOH (20%)-pH regulator agent 5.5% 5.5% 5.5%

ARLACEL 80 (Arlacel-80) 1.00% 1.25% 1.25%

DOWICIL 200 0.05％ 0.05％ 0.05％

Glycerol 4.0% 4.0%--

D.I. water 60.8% 61.5% 65.4%

Misc. 3.0％ 4.0％ 1.4％

Amount to 100% 100% 100%

Attention: go up percent in the table be meant contained in the preparation (on show among the B be purchased in the product contained) amount of active component.

With every kind of above-mentioned preparation continuous washing 35 times, every kind of not same angel of preparation uses in one day for 3 technical staff.These preparations have good foaming effect, cleaning action, feel and moist effect with the back.Do not feel zest, do not find the hand drying yet.

Embodiment: 1524D-086

In this embodiment, adopt the method in the previous embodiment to prepare another preparation of the present invention.

Component %w/w

Deionized water 61.65

VERSENE NA 0.10

POLYALDO HGDS 0.50

TECH-O#11-070 2.00

ARLACEL 80 2.50

EMPICOL EAC 70/EP 12.50

AMPHOTERGE K-2 1.00

DOWICIL 200 0.05

TEGO BETAINE L-7 10.00

Spice 0.20

Dimeric dibasic acid 2.00

LEXOREZ 100 1.00

PERMETHYL 104A 5.00

LANETTE 14 NF 1.50

Amount to % → 100.00

Attention: go up in the table percent in contained in the preparation (on show among the B be purchased in the product contained) active component.

3 technical staff in one day with each above-mentioned preparation continuous washing 35 times.These preparations have good foaming effect, cleaning action, feel and moist effect with the back.Do not feel zest, do not find the hand drying yet.

Claims

1. personal cleaning compositions, it comprises:

A) account at least a polyisobutylene that contains 24 to 156 carbon atoms of composition total weight meter 0.1 to 10 weight %, wherein polyisobutylene is liquid at normal temperatures and pressures;

B) account at least a dicarboxylic acids or its salt that is applicable to cosmetics of composition total weight meter 0.1 to 10 weight % with following formula

Wherein R1 and R3 are respectively the C6-C10 alkyl, and

R2 and R4 are respectively the C6-C10 alkenyls;

C) account at least a surfactant of composition total weight at least 1 weight %, be selected from anion surfactant, amphoteric surfactant, non-ionic surface active agent, zwitterionic surfactant, and their mixture; And

D) water.

2. the compositions of claim 1, its also comprise be selected from the viscosity auxiliary agent, the emulsifying agent that accounts for composition total weight meter 0.1 to 5 weight % that account for composition total weight meter 0.1 to 5 weight %, when accounting for composition total weight meter 0.1 to 5 weight % as viscosity auxiliary agent and the reagent of emulsifying agent and the component of their mixture.

3. the compositions of claim 2, wherein said component comprises at least a polyglycerin ester that accounts for composition total weight meter 0.1 to 5 weight %.

4. the compositions of claim 1, it also comprises at least a amino-functional silicone that accounts for composition total weight meter 0.1 to 3 weight %.

5. the compositions of claim 4, it also comprises at least a polyglycerin ester that accounts for composition total weight meter 0.1 to 5 weight %.

6. the compositions of claim 1, it also comprises the molecular weight that has that accounts for composition total weight meter 0.01 to 0.7 weight % is 1,500,000 to 5,000,000 Polyethylene Glycol.