CN1287835A - Medical ointment for periodontal disease - Google Patents

Abstract

The present invention discloses a medicine for treating periodental diseases, in particular, a medicinal ointment for treating periodental disease. Said medicinal ointment is prepared from camphor phenol liquid and compound sulfamethoxazole powder or sulfsomezole powder and through mixing. The invented ointment possesses the functions of inhibiting bacteria, relieving inflammation, stopping pain, etc.

Description

A kind of periodontal disease ointment

The present invention relates to a kind of ointment for the treatment of oral inflammation, especially a kind of ointment for the treatment of periodontal disease.

Periodontal disease is meant the disease that the tooth supporting tissue takes place, its type has gingival, periodontitis, juvenile periodontitis and periodontal atrophy etc., wherein general with periodontitis especially, periodontal disease is the same with dental caries to be human a kind of frequently-occurring disease and commonly encountered diseases, the sickness rate of periodontal disease can reach 82-90%, the periodontal disease clinical manifestation is that gingiva is bled, pyorrhea, halitosis, swelling, pain, odontoseisis etc., masticatory function is descended, therefore severe patient can lose tooth, according to BJ Stomatological Hospital's chin face surgery investigation statistics, in the out-patient, account for 37.23% of exodontia sum because of the periodontal disease exodontia, as seen periodontal disease is to lose tooth to chew one of key factor of organ pipe with destruction, affects people's healthy and normal social communication constantly.The cause of disease of periodontal disease is a lot, the pathogenic factor that has is simple, but mostly is by due to the complicated factors, be generally local factor of branch and systemic factor, local factor comprises antibacterial, bacterial plaque, soft dirt, tartar, food impaction, Occlusal Trauma, bad habit, bad method for brushing teeth, the bad dummy in the oral cavity or in the periodontal tissue; Systemic factor comprises malnutrition, dysbolismus, systemic disease, endocrine disturbance etc.Domestic conventional treatments is at present: at first remove local excitation, carry out Drug therapy again, and all similar aspect the removal local excitation, be generally ultrascnic scaling and manual scaling.Be divided into systemic administration and local application again at drug treatment, systemic administration generally has: (1) medicine that diminishes inflammation, as spiramycin, metronidazole, (2) promote periodontal tissue to repair medicine, as paradental medicine, (3) improve nutrient drug, as the vitamin C of heavy dose, appropriate vitamin A, D etc.Local application generally has: (1) anti-inflammation drugs, as iodine phenol, glycerinum iodi compositum, (2) rinsing the mouth medicine as, mouthful plain gargarism, refined bodyguard collutorium etc.The above therapeutic scheme of analysis-by-synthesis, though preventing and treating in the process of periodontal disease can obtain certain curative effect, but effect is not really desirable, simultaneously, also there are some bad phenomenon, long as treatment time, some untoward reaction can appear behind the long-term prescription, if iodine phenol overflows periodontal pocket, corrode periodontal tissue easily and curative effect is low.Bring a lot of troubles in clinical treatment, for doctor and patient.

It is low to the purpose of this invention is to provide a kind of cost, the ointment of the treatment periodontal disease that curative effect is high.

Technical scheme of the present invention is: a kind of periodontal disease ointment, this ointment is by bactrim powder or Sulfamethoxazole powder or sulfadiazine powder and camphor and phenol solution mixing back furnishing pasty state.

Adopt the made ointment of technique scheme can kill the antibacterial that causes periodontal disease in a short time, improve the pathologic condition of periodontal tissue, make periodontal disease especially gingivitis can obtain rational and effective treatment in a short time, particularly suffers from gingival hemorrhage, patient's medication of halitosis just can stop hemorrhage 1 to 2 time, eliminate halitosis, according to the clinical treatment experience more than 3 years, follow-up investigation, draw this medicine characteristics: instant effect, dosage is little, and side effect is little, and the medicine local concentration is big, discharge fast, the curative effect height, easy to use, patient's no pain, with after have no side effect, be easy to be accepted by oral cavity doctor and patient.Now the drug action mechanism of this ointment is done following introduction: camphor and phenol solution contains: Camphora, phenol, ethanol.Camphora is applied to the mucocutaneous refrigerant sense that similar Herba Menthae is arranged, and analgesic activity and weak corrosion-resisting function are preferably arranged, and can alleviate the corrosiveness of phenol, strengthens the permeability of medicine.

Phenol has corrosivity, and corrodible periodontal pocket inwall, epithelial tissue and granulation tissue reduce the generation of pus.

Ethanol can immerse in the bacterial body, and makes albumen query solid degeneration kill bacteria.

Bactrim contains Sulfamethoxazole (SMZ) and trimethoprim (TMP), SMZ is the white crystalline powder, mildly bitter flavor, almost insoluble in the water, antibacterial action is strong, and to most gram negative bacterias and gram and the effectively strong inhibitory action of gram positive bacteria, its antibacterial mechanisms is because sulphonamides (SMZ) is made with the dihydrofolate synthetase of aminobenzoic acid competition antibacterial, producing the necessary material of breeding because aminobenzoic acid is an antibacterial, also is the raw material of the synthetic folic acid of antibacterial.And folic acid is to form nucleic acid, guarantees that bacterial growth breeds necessary nutrient substance.The dihydrofolate synthetase of antibacterial just can't utilize the raw material of aminobenzoic acid as synthetic folic acid with after sulfonamides (SMZ) combines, and the growth of antibacterial, breeding are suppressed.

This medicine of TMP is the sulphonamides synergist, TMP cooperates the mechanism of usefulness to be with SMZ: Sulfamethoxazole suppresses dihydrofolate synthetase and stops the synthetic of dihydrofoilic acid, and trimethoprim suppresses dihydrofolate reductase, make dihydrofoilic acid can not be reduced to tetrahydrofolic acid, hinder the synthetic of ribonic acid, thereby suppress the growth of antibacterial, both share and can make the folic acid metabolism of antibacterial be subjected to double blocking, make the bacteriostasis of sulphonamides (SMZ) strengthen several times to tens times, and can reduce the appearance of Resistant strain, heighten the effect of a treatment, because antibacterial can develop immunity to drugs quickly to TMP, so should not use separately, normal and sulfonamides share, with the gingivitis that treatment Gram-negative anaerobic bacillus(cillus anaerobicus) causes, periodontitis.The mechanism of camphor and phenol solution and bactrim combination drug is: bactrim is to causing gingivitis, the Gram-positive of periodontitis and gram negative bacilli, particularly the Gram-negative anaerobic bacillus(cillus anaerobicus) has stronger inhibitory action, after the periodontal disease ointment affacts periodontal pocket, bactrim in the ointment is soon with the antibacterial in the periodontal pocket, bacterial plaque suppresses its growth and breeding, the refrigerant sense of camphor and phenol solution can be alleviated little bitterness of TMP-SMZ, and can increase the permeability of medicine TMP-SMZ, the curative effect of ointment is strengthened, can also corrode simultaneously the slough in the periodontal pocket, make the periodontal pocket inwall form new wound surface, help the healing of inflammation.Owing to contain the antibacterial action that a large amount of aminobenzoic acid (PABA) can weaken sulphonamides in pus and the slough, camphor and phenol solution not only can corrode the slough in the periodontal pocket, but also can reduce the formation of pus in the periodontal pocket, to strengthening the bacteriostasis of bactrim, improve the therapeutic effect of periodontal disease ointment, play an important role.

The compound method of periodontal disease ointment: get bactrim tablet 5 grams, being ground into powder or getting Sulfamethoxazole (or sulfadiazine) 5 restrains and 3 milliliters of all even milky pastel that mix of camphor and phenol solution.

Its pharmacological action: the bacteriostatic test result shows in the body, oral cavity periodontal tissue flora obviously changes, after with ointment with periodontal disease gram negative bacilli in close relations as bacteroides fragilis, producing melanin bacillus and nucleic acid shape bacillus obviously reduces or complete obiteration, this periodontal disease ointment is a topical application, main resisting gram-positive and gram negative bacteria, particularly anti-Gram-negative anaerobic bacillus(cillus anaerobicus) is used for the treatment of periodontal disease.

The using method of periodontal disease ointment: earlier tooth is made pus and foreign body in cleaning (removal stimulus object), the flushing periodontal pocket, again gingiva is wiped away driedly, dip in probe then and get a little ointment and put in people's diastema or the periodontal pocket and get final product.

The medication points for attention:

1, can not brush teeth in three hours after the medication, take food, gargle, saliva and oral secretion are not swallowed, in case medicine is rinsed dilution.

2, pus and slough contain the antibacterial action that a large amount of aminobenzoic acids (PABA) can weaken sulfonamide, so answer pus in the cleaning down periodontal pocket during medication.

3, the local anaesthetics procaine in vivo hydrolysis produce PABA, should note when using this medicine hyperirritability body constitution, particularly to sulfa drugs allergy sufferers forbidding, antenatal 3 months forbiddings of anemia of pregnant woman.

Use this ointment sensation ability to speak refrigerant, do not see untoward reaction.

Periodontal disease ointment therapeutic effect and conventional periodontal disease medication effect relatively are divided into treatment group and matched group.Gingival hemorrhage is few after the medication, and halitosis disappears to effectively.After the medication: gingiva does not have hemorrhage, and halitosis is eliminated fully, and the red swelling of gingiva tooth mobility that disappears fully alleviates, and the X sheet shows that alveolar bone has the hypertrophy phenomenon.The long-time observation do not have recurrence for curing.

Treatment group situation: totally 123 people, male 82 people, women 41 people, minimal ages 20 years old, maximum 67 years old age, 39 years old mean age, gingivitis patients 102 people, patients with periodontitis 21 people, earlier with ultrasonic cavitron do on the gum, scaling reuse H under the gum ₂O ₂The flushing periodontal pocket is wiped away dried gingiva then, dips in probe and gets a little ointment and put into periodontal pocket (later further consultation does not remake scaling, can directly wash periodontal pocket, medicine-feeding), (three times is a course of treatment to the lighter's medication a course of treatment, medication every day is once), can cure, heavy person needs cure two courses of treatment.Generally should continue medication 1 to 2 time after the healing.According to statistics, 2 people's medications are invalid, follow-up investigation after a year, and 2 people have rebound phenomenon, and the effective percentage of ointment is 98.32%, and cure rate is 96.75%.

The matched group situation: totally 112 people, male 60 people, women 52 people, minimum 21 years old, maximum 65 years old, 37 years old mean age, gingivitis patients 90 people, patients with periodontitis 22 people, earlier with the excusing from death ripple machine of cleaning one's teeth do on the gum, scaling under the gum, reuse H ₂O ₂The flushing periodontal pocket is wiped away dried gingiva then, and dip in probe and get a little iodine phenol liquid and place in the periodontal pocket, once a day, medication 5-6 time, other whole body oral medication spiramycin, metronidazole, paradental medicine, vitamin C.The lighter takes a turn for the better, and weight person can not cure, and has 23 routine patient's gum that corrosion feedback infections is arranged, and 18 people are invalid, and " Invest, Then Investigate " had 53 people recurrence in 1 year, and effective percentage is 83.92%, and cure rate is 36.6%.

Claims (1)

1, a kind of periodontal disease ointment is characterized in that, this ointment is by bactrim powder or Sulfamethoxazole powder or sulfadiazine powder and camphor and phenol solution mixing back furnishing pasty state.