CN1285191A - Medicine for treating epidemic poultry and animal diseases - Google Patents
Medicine for treating epidemic poultry and animal diseases Download PDFInfo
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- CN1285191A CN1285191A CN 99111531 CN99111531A CN1285191A CN 1285191 A CN1285191 A CN 1285191A CN 99111531 CN99111531 CN 99111531 CN 99111531 A CN99111531 A CN 99111531A CN 1285191 A CN1285191 A CN 1285191A
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Abstract
The present invention discloses a veterinary medicine for curing epidemic diseses of fowl and livestock, and is characterized by that it is made up by adopting the medicinal materials containing broad-spectrum antibiotic and antiviral drug and mixing them according to the weight mixing ratio of 1.5-7 portions and 3-13 portions. Said invention possesses excellent medicinal synergistic action and obvious antibacterial, anti-inflammatory and antiviral action, specially it is suitable for curing bacterium and virus mixed infection desease of fowl and livestock.
Description
The present invention relates to the veterinary and use preparation, specifically be applicable to the veterinary drug for the treatment of epidemic poultry and animal diseases.
Treating epidemic poultry and animal diseases as, laryngotracheitis, influenza etc. all be the fowl poultry see disease and regular incidence more.This class disease can be passed through air or contact infection usually, and causes large tracts of land popular.Whole fowl drove body in case this type of disease takes place, usually just can be involved because breed quantity is big, the fowl poultry is concentrated in general plant in a few days.This class disease usually can continue the 4-5 time-of-week as not adding control and treatment, not only causes fowl domestic animal poor growth, and the birds laying rate descends, and can also cause mortality.For addressing this problem, CN103839 discloses peaceful feed additive of a kind of compound recipe fowl plague and method for making, it mainly is to adopt to contain antibacterial peptide, antitoxic Chinese medicine, mineral element as feed additive, to strengthen the defence capability of chicken, the chicken group that influenza takes place do not had effective disease treatment and control action to disease.At present, mostly plant is or adopts in antibiotic such as the north toxin, enrofloxacin to treat, or adopt antiviral class medicines such as Moroxydine or ribavirin to treat, the problem that these methods exist is, drug dose is big, for example, use every chicken of enrofloxacin will restrain with 0.1 at least every day, as use ribavirin also to want every chicken will restrain with 0.075-0.1 every day, use antibiotic and antiviral drugs in a large number for the chicken and duck class, can cause the chicken and duck drug disposition to accumulate, can cause indirect medicine infringement to the mankind itself so undoubtedly.In addition, said method also can not be controlled spreading that chicken suffers from rapidly, and its course of treatment is also longer, and cure rate is lower, because of rather than a kind of ideal medicine.
Purpose of the present invention just provides the medicine of a kind of good effect, short treating period, consumption is few, cost is low treatment treating epidemic poultry and animal diseases.
The present invention be directed to that infectiousness is propped up, laryngotracheitis, influenza disease is the characteristics of antibacterial and the mixed infection of virus height, filters out to have good synergistic medicine and carry out the compatibility preparation.
The present invention is made by the following weight proportion raw material: broad ectrum antibiotic (following represent with A) 1.5-7 part, antiviral class medicine (following represent with B) 3-13 part.
A can be broad ectrum antibiotic such as kitasamycin, quinolones, and B can be Moroxydine, ribavirin, Aminodiamantane.
Take medicine for ease of sick birds, the present invention preferably adds an amount of cosolvent (following represent with C), and C can be sodium bicarbonate, sodium carbonate, sodium hydroxide, wherein with sodium carbonate for most preferably.Add cosolvent, just can make the mixture of A and B soluble in water, medicine of the present invention is positioned in the drinking water of birds, the disease chicken is taken medicine in the drinking-water process naturally, its weight proportion is A1.5～7 part, B3～13 part, C1.5～3.2 part.
The preferred weight proportion scope of the present invention is A4～6 part, B8～12 part, 6～3 parts of C2., its better efficacy like this.
For ease of accurately holding the dosage of giving birds, preferably in A, B, C compositions, add additive again, as starch, dextrin or glucose, wherein with glucose for most preferably, because so both can times release thing, can increase again disease fowl nutrition, strengthen the body constitution of sick fowl.
Component A of the present invention preferably selects quinolones for use, most preferably be grace husky star, B preferably selects ribavirin for use, the synergism of these two kinds of medicines is best, therapeutic effect is more obvious.
The present invention can be prepared into tablet, injection, powder, mixture, and is wherein the simplest with the powder preparation method, easy to use and easy to store.
The preparation method of powder is to select for use commercially available A, B crude drug by weight proportion requirement of the present invention, mix homogeneously after the weighing.Weighing is distributed into bag.
Medicine of the present invention can be used for treating that birdss such as chicken and duck prop up, laryngotracheitis and influenza, also can be used for the disease of the same race of pig.
Its usage and dosage is, is used for each every of disease pig and takes and contain A, B mixture 0.15 gram-0.2 gram, logotype 2-3 days; When being used for chicken and duck, every chicken was taken and contained A, B mixture 0.015 gram every day, serve on 3.
For being easy to accurately hold the dose of chicken, desirable 15 restrain A, B mixture, add the C of 2.8 grams again, add additive to 100 gram again, when feeding chicken, water in the water fountain of 100 gram mixture adding chickens are dissolved it, drink for 1000 chicken whole days to finish again.
The present invention is used to suffer from that infectiousness is propped up, the chicken of laryngotracheitis, influenza, and cure rate is significantly improved, and the treatment natural law has also shortened 2-3 days by general 7 days.
One of innovative point of the present invention is to adopt broad ectrum antibiotic and antiviral agents and uses, produced good synergism, experiment shows uses enrofloxacin separately, every chicken need restrain with 0.1 every day, use ribavirin separately, every chicken need be taken 0.075～0.1 gram every day, and the medication natural law is general all at 5-7 days.Using every chicken of the present invention only to obey enrofloxacin every day is 0.005, ribavirin is 0.01, healing time is 2-3 days, this shows, medicine of the present invention has not only shortened administration time greatly, but also greatly reduce its dosage, thus also greatly reducing the medical expense of disease chicken, its effect is very significant.
Two of innovative point of the present invention is to filter out the best ratio range of each component, makes medicine reach best therapeutic effect.
Three of innovative point of the present invention is to filter out the pharmaceutical preparation of taking applicable to sick fowl, so both can guarantee taking medicine of disease fowl, has reduced keeper's workload again
Below be specific embodiments of the invention and concrete experimental data,, therefrom can further see beneficial effect of the present invention by embodiment and application thereof.
Embodiment 1 selects ciprofloxacin 700 grams, ribavirin 800 grams, sodium bicarbonate 320 grams for use, and being mixed adds glucose 8180 grams by times interpretation of the law, after being mixed, is distributed into every bag 100 gram, standby.
Embodiment 2-5, its preparation method are the proportioning difference of each component all with embodiment 1.
Embodiment 2-5
Press the medicine of embodiment 5 preparation, during use, after taking by weighing by aforesaid dose, gavage to chicken.
Press the medicine of embodiment 6 preparations, can directly be dissolved in the gauge water, drink for chicken.
Below be the contrast experiment who carries out with the medicine (trade name is decided to be bacterium and goes out) that embodiment 2 prepares.
Experiment component is 1,2,3,4 group.
Take octicin solution for the 1st group, dose is a gram octicin solution every every day 0.1.
Take enrofloxacin for the 2nd group, dose is a gram enrofloxacin every every day 0.1.
Take ribavirin for the 3rd group, dose is a gram ribavirin every every day 0.1.
The 4th group of blank group refused to obey any medicine.
The kind of four groups of chickens has Hai Sai, parts in Beijing opera spoken in Beijing dialect, Ni Ke, and chicken week is divided into four groups at random at 7-25 week in age.
Table 1 treatment infectiousness is propped up, the laryngotracheitis result of the test
| Test group | Case | Cure number | Cure rate | Curative day |
| ????1 | ?4300 | ?4244 | ?98.7 | ????3 |
| ????2 | ?2000 | ?1752 | ?87.6 | ????6 |
| ????3 | ?1000 | ?862 | ?86.2 | ????5 |
| ????4 | ?400 | Spontaneous recovery 59 | ?14％ | ???——— |
Table 2 treatment influenza test comparing result
| Test group | Case load | Cure number | Cure rate | Curative day |
| ????1 | ?3650 | ?3537 | ???96.9 | ????3 |
| ????2 | ?1000 | ?223 | ???22.3 | ????6 |
| ????3 | ?2000 | ?1781 | ???89.0 | ????7 |
| ????4 | ?500 | Spontaneous recovery 51 | ???10％ | ???——— |
From table 1, table 2, can further confirm, bacterium goes out, and the treatment infectiousness is propped up, laryngotracheitis is higher by 10% than using enrofloxacin separately, than high by 12.7% with ribavirin separately, curative day has shortened three days, the treatment influenza is sick than high by 72.69% with enrofloxacin separately, has also shortened three days than independent with high 11.13% curative day of ribavirin.
Though the group medication of above-mentioned three groups of medications is 0.1 gram, because bacterium goes out and contains additive.So the 1st group of actual enrofloxacin of taking of sick chicken only is that 0.004 gram, ribavirin only are the consumption of 0.012 gram.
Quite remarkable by synergism than visible medicine of the present invention.Have extremely strong antibiotic, antiinflammatory, antivirus action.The special complication that is applicable to antibacterial, virus mixed infection.
The present invention has doubly drunk by the super at every turn therapeutic dose 3-6 of every chicken and has tested, and observes bad variation such as its spirit of chicken that the result does not find to take medicine, appetite, feces, plumage color 1 month.Anatomy experiment is not found the ANOMALOUS VARIATIONS of substantial viscera.Show that thus toxic and side effects of the present invention is not remarkable, treatment consumption safety range is big.
Claims (7)
1, a kind of medicine that is used for treating epidemic poultry and animal diseases is characterized in that component contains broad ectrum antibiotic, antiviral class medicine, and the weight proportion of its component is 1.5～7 parts of broad ectrum antibiotic, 3～13 parts of antiviral class medicines.
2, compound medicine according to claim 1 is characterized in that containing cosolvent in the said component, and its weight proportion is 1.5～7 parts of broad ectrum antibiotic, 3～13 parts of antiviral agents, 1.5～3.2 parts of cosolvents.
3, medicine according to claim 2 is characterized in that the weight proportion of said each component is: 4～6 parts of broad ectrum antibiotic, 8～12 parts of antiviral agents, 2.6～3 parts of cosolvents.
4, medicine according to claim 2 is characterized in that said component contains additive.
5, medicine according to claim 2 is characterized in that said broad ectrum antibiotic is a quinolone antibiotic, and antiviral agents is a ribavirin, and cosolvent is a sodium carbonate.
6, medicine according to claim 5 is characterized in that said quinolone antibiotic is an enrofloxacin.
7, medicine according to claim 3 is characterized in that said additive is a glucose powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99111531 CN1114412C (en) | 1999-08-20 | 1999-08-20 | Medicine for treating epidemic poultry and animal diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99111531 CN1114412C (en) | 1999-08-20 | 1999-08-20 | Medicine for treating epidemic poultry and animal diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1285191A true CN1285191A (en) | 2001-02-28 |
| CN1114412C CN1114412C (en) | 2003-07-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99111531 Expired - Fee Related CN1114412C (en) | 1999-08-20 | 1999-08-20 | Medicine for treating epidemic poultry and animal diseases |
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| Country | Link |
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| CN (1) | CN1114412C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526054A (en) * | 2012-02-23 | 2012-07-04 | 广东大华农动物保健品股份有限公司 | Compound enrofloxacin pellets and preparation method thereof |
-
1999
- 1999-08-20 CN CN 99111531 patent/CN1114412C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526054A (en) * | 2012-02-23 | 2012-07-04 | 广东大华农动物保健品股份有限公司 | Compound enrofloxacin pellets and preparation method thereof |
| CN102526054B (en) * | 2012-02-23 | 2013-05-01 | 广东大华农动物保健品股份有限公司 | Compound enrofloxacin pellets and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1114412C (en) | 2003-07-16 |
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